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D

David Brough

University of Manchester

59H-index
207Paper Count
1.2WCitation Count
Published Papers 97
Publication Date
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Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions
errBrain, Behavior, and Immunity
IF0
err2025-11-19
err0
errOAAI
errMadeleine Hurry; David A. Posner; Raymond Wong; Alba Grayston; Laura Díaz-Marugan; Xiaotong Zhang; Bianca De Leon; Corinne Benakis; Ari Waisman; Laura McCulloch; Stuart M. Allan; Catherine B. Lawrence; David Brough; Matthew R. Hepworth
errShare
errSave
Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage
errDISEASE MODELS & MECHANISMS
IF3.3
err2025-10-01
err1
errOAAI
errBarrington, Jack; Rivers-Auty, Jack; Strangward, Patrick; Tamburrano, Sabrina; Lenart, Nikolett; Swanton, Tessa; Lemarchand, Eloise; Parry-Jones, Adrian R.; Denes, Adam; Brough, David; Allan, Stuart M.
errShare
errSave
Dehydroisohispanolone alleviates NLRP3-driven inflammation in gout arthritis
errBiochemical Pharmacology
IF5.6
err2025-07-05
err0
errOAAI
errLaura González-Cofrade; Jack P. Green; Beatriz de las Heras; María Carmen Terencio; Sonsoles Hortelano; David Brough; Ana Estévez-Braun; María Luisa Ferrándiz; Irene Cuadrado
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errSave
The secretion of interleukin-1β
errCytokine & Growth Factor Reviews
IF11.8
err2025-05-22
err0
PREAI
errSusanna G. Ford; Patrick Caswell; David Brough; Paula I. Seoane
errShare
errSave
Spatial mapping of immune cell environments in NF2-related schwannomatosis vestibular schwannoma
errNATURE COMMUNICATIONS
IF15.7
err2025-03-26
err0
errOAAI
errJones, Adam P.; Haley, Michael J.; Meadows, Miriam H.; Gregory, Grace E.; Hannan, Cathal J.; Simmons, Ana K.; Bere, Leoma D.; Lewis, Daniel G.; Oliveira, Pedro; Smith, Miriam J.; King, Andrew T.; Evans, D. Gareth R.; Paszek, Pawel; Brough, David; Pathmanaban, Omar N.; Couper, Kevin N.
errShare
errSave
Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke
errJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
IF4.5
err2025-03-01
err0
PREAI
errLemarchand, Eloise; Grayston, Alba; Wong, Raymond; Rogers, Miyako; Ouvrier, Blake; Llewellyn, Benjamin; Webb, Freddie; Lenart, Nikolett; Denes, Adam; Brough, David; Allan, Stuart M.; Bix, Gregory J.; Pinteaux, Emmanuel
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errSave
Skull-meninges-brain connectivity and extra-axial brain tumours
errBRAIN COMMUNICATIONS
IF4.5
err2025-01-01
err0
errOAAI
errIslim, Abdurrahman I.; Vyziotis, Alexandros; Pathmanaban, Omar N.; Coope, David J.; King, Andrew T.; Brough, David; Jardine, Laura; Couper, Kevin N.; Greenhalgh, Andrew D.
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errSave
Alternatively activated macrophages are associated with faster growth rate in vestibular schwannoma
errBRAIN COMMUNICATIONS
IF4.5
err2024-11-12
err0
errOAAI
errGregory, Grace E.; Haley, Michael J.; Jones, Adam P.; Hannan, Cathal J.; Evans, D. Gareth; King, Andrew T.; Paszek, Pawel; Pathmanaban, Omar N.; Couper, Kevin N.; Brough, David
errShare
errSave
C9orf72 dipeptides activate the NLRP3 inflammasome
errBRAIN COMMUNICATIONS
IF4.5
err2024-08-20
err1
errOAAI
errRivers-Auty, Jack; Hoyle, Christopher; Pointer, Ayesha; Lawrence, Catherine; Pickering-Brown, Stuart; Brough, David; Ryan, Sarah
errShare
errSave
Proximity labelling of pro-interleukin-1α reveals evolutionary conserved nuclear interactions
errNATURE COMMUNICATIONS
IF15.7
err2024-08-08
err0
errOAAI
errWellens, Rose; Tapia, Victor S.; Seoane, Paula I.; Bennett, Hayley; Adamson, Antony; Coutts, Graham; Rivers-Auty, Jack; Lowe, Martin; Green, Jack P.; Lopez-Castejon, Gloria; Brough, David; Hoyle, Christopher
errShare
errSave
Pyroptosis leads to loss of centrosomal integrity in macrophages
errCELL DEATH DISCOVERY
IF7
err2024-08-08
err0
errOAAI
errBai, Siyi; Martin-Sanchez, Fatima; Brough, David; Lopez-Castejon, Gloria
errShare
errSave
The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome
errDISEASE MODELS & MECHANISMS
IF3.3
err2024-07-30
err1
errOAAI
errGleeson, Tara A.; Kaiser, Christina; Lawrence, Catherine B.; Brough, David; Allan, Stuart M.; Green, Jack P.
errShare
errSave
Hypoxia coordinates the spatial landscape of myeloid cells within glioblastoma to affect survival
errSCIENCE ADVANCES
IF12.5
err2024-05-17
err2
errOAAI
errHaley, Michael J.; Bere, Leoma; Minshull, James; Georgaka, Sokratia; Garcia-Martin, Natalia; Howell, Gareth; Coope, David J.; Roncaroli, Federico; King, Andrew; Wedge, David C.; Allan, Stuart M.; Pathmanaban, Omar N.; Brough, David; Couper, Kevin N.
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errSave
Lymphatic network drainage resolves cerebral edema and facilitates recovery from experimental cerebral malaria
errCELL REPORTS
IF6.9
err2024-05-01
err1
errOAAI
errHaley, Michael J.; Barroso, Ruben; Jasim, Dhifaf A.; Haigh, Megan; Green, Jack; Dickie, Ben; Craig, Alister G.; Brough, David; Couper, Kevin N.
errShare
errSave
Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium
errCELL DEATH DISCOVERY
IF7
err2023-12-22
err0
errOAAI
errSeoane, Paula I.; Beswick, James A.; Leach, Andrew G.; Swanton, Tessa; Morris, Lucy V.; Couper, Kevin; Lowe, Martin; Freeman, Sally; Brough, David
errShare
errSave
The comparable tumour microenvironment in sporadic and NF2-related schwannomatosis vestibular schwannoma
errBRAIN COMMUNICATIONS
IF4.5
err2023-07-21
err10
errOAAI
errGregory, Grace E.; Jones, Adam Paul; Haley, Michael J.; Hoyle, Christopher; Zeef, Leo A. H.; Lin, I-Hsuan; Coope, David J.; King, Andrew T.; Evans, D. Gareth; Paszek, Pawel; Couper, Kevin N.; Brough, David; Pathmanaban, Omar N.
errShare
errSave
The clinical, genetic, and immune landscape of meningioma in patients with NF2-schwannomatosis
errNEURO-ONCOLOGY ADVANCES
IF4.1
err2023-06-03
err4
errOAAI
errGregory, Grace E.; Islim, Abdurrahman I.; Hannan, Cathal John; Jones, Adam P.; Hammerbeck-Ward, Charlotte; Rutherford, Scott A.; Freeman, Simon R.; Lloyd, Simon; Kalamarides, Michel; Smith, Miriam J.; Couper, Kevin; McBain, Catherine A.; Jenkinson, Michael D.; Brough, David; King, Andrew T.; Evans, D. Gareth; Pathmanaban, Omar N.
errShare
errSave
Disruptions in endocytic traffic contribute to the activation of the NLRP3 inflammasome
errSCIENCE SIGNALING
IF6.6
err2023-02-21
err22
errOAAI
errLee, Bali; Hoyle, Christopher; Wellens, Rose; Green, Jack P.; Martin-Sanchez, Fatima; Williams, Daniel M.; Matchett, Billie J.; Seoane, Paula I.; Bennett, Hayley; Adamson, Antony; Lopez-Castejon, Gloria; Lowe, Martin; Brough, David
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errSave
Increased Circulating Chemokines and Macrophage Recruitment in Growing Vestibular Schwannomas
errNEUROSURGERY
IF3.9
err2022-12-12
err15
PREAI
errHannan, Cathal John; Lewis, Daniel; O'Leary, Claire; Waqar, Mueez; Brough, David; Couper, Kevin N.; Dyer, Douglas P.; Vail, Andy; Heal, Calvin; Macarthur, Joshua; Cooper, Christopher; Hammerbeck-Ward, Charlotte; Evans, D. Gareth; Rutherford, Scott A.; Lloyd, Simon K.; Mackenzie Freeman, Simon Richard; Coope, David John; King, Andrew T.; Pathmanaban, Omar Nathan
errShare
errSave
The two pore potassium channel THIK-1 regulates NLRP3 inflammasome activation
errGLIA
IF5.1
err2022-03-30
err31
errOAAI
errDrinkall, Samuel; Lawrence, Catherine B.; Ossola, Bernadino; Russell, Samuel; Bender, Clare; Brice, Nicola B.; Dawson, Lee A.; Harte, Michael; Brough, David
errShare
errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Guido Kroemer
H-index: 283 · Papers: 2.3K
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D. Gareth Evans
H-index: 182 · Papers: 2.5K
M
Mark J. Smyth
H-index: 172 · Papers: 1.4K
L
Laurence Zitvogel
H-index: 165 · Papers: 1.2K
M
Michael R. Hamblin
H-index: 160 · Papers: 1.5K
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