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N

N.S. Laursen

commit biologics

20H-index
65Paper Count
3.1KCitation Count
Published Papers 28
Publication Date
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Curbing Autoimmunity: A New Fab Fragment Targeting CD40-CD40L Halts B-Cell Activation and Differentiation
errEuropean Journal of Immunology
IF3.7
err2026-02-25
err0
errOAAI
errKathrine Pedersen; Kenneth Green; Emil L. Kristoffersen; Thea Schinkel; Annette G. Hansen; Yaseelan Palarasah; Anne B. Rovsing; Ebbe S. Andersen; Julián Valero; Laia Civit; Nick S. Laursen; Anne Troldborg; Søren E. Degn; Steffen Thiel
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Transition metal transporting P-type ATPases: terminal metal-binding domains serve as sensors for autoinhibitory tails
errFEBS JOURNAL
IF4.2
err2024-11-28
err0
PREAI
errHu, Qiaoxia; Sitsel, Oleg; Bagenholm, Viktoria; Gronberg, Christina; Lyu, Pin; Svane, Anna Sigrid Pii; Andersen, Kasper Rojkjaer; Laursen, Nick Stub; Meloni, Gabriele; Nissen, Poul; Juhl, Dennis W.; Nielsen, Jakob Toudahl; Nielsen, Niels Chr.; Gourdon, Pontus
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Bispecific Complement Engagers for Targeted Complement Activation
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-08-01
err6
PREAI
errPedersen, Dennis, V; Gytz, Heidi; Winkler, Mikael B. L.; Zarantonello, Alessandra; Baumann, Niklas; Hansen, Annette G.; Thiel, Steffen; Andersen, Gregers R.; Valerius, Thomas; Laursen, Nick S.
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Nanobody-mediated complement activation to kill HIV-infected cells
errEMBO MOLECULAR MEDICINE
IF8.3
err2023-02-17
err4
errOAAI
errPedersen, Maria Lange; Pedersen, Dennis Vestergaard; Winkler, Mikael Becher Lykkegaard; Olesen, Heidi Gytz; Sogaard, Ole Schmeltz; Ostergaard, Lars; Laursen, Nick Stub; Rahimic, Anna Halling Folkmar; Tolstrup, Martin
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A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement (vol 293, pg 6269, 2018)
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-02-01
err1
errOAAI
errJensen, Rasmus K.; Pihl, Rasmus; Gadeberg, Trine A. F.; Jensen, Jan K.; Andersen, Kasper R.; Thiel, Steffen; Laursen, Nick S.; Andersen, Gregers R.
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Structural insights into the function-modulating effects of nanobody binding to the integrin receptor αMβ2
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-08-01
err6
errOAAI
errJensen, Rasmus K.; Pedersen, Henrik; Lorentzen, Josefine; Laursen, Nick Stub; Vorup-Jensen, Thomas; Andersen, Gregers Rom
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errSave
Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2022-07-22
err5
errOAAI
errPedersen, Henrik; Jensen, Rasmus Kjeldsen; Hansen, Annette Gudmann; Petersen, Steen Vang; Thiel, Steffen; Laursen, Nick Stub; Andersen, Gregers Rom
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errSave
Nanobody-based human antibody formats act as IgE surrogate in hymenoptera venom allergy
errALLERGY
IF12
err2022-06-09
err6
errOAAI
errAagaard, Josephine Baunvig; Sivelle, Coline; Fischer, Michaela; Byskov, Kristina; Laursen, Nick S.; Pfutzner, Wolfgang; Jakob, Thilo; Moebs, Christian; Miehe, Michaela; Spillner, Edzard
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A Complement C3-Specific Nanobody for Modulation of the Alternative Cascade Identifies the C-Terminal Domain of C3b as Functional in C5 Convertase Activity
errJOURNAL OF IMMUNOLOGY
IF3.4
err2020-10-15
err10
errOAAI
errPedersen, Henrik; Jensen, Rasmus K.; Jensen, Jens Magnus B.; Fox, Rachel; Pedersen, Dennis, V; Olesen, Heidi G.; Hansen, Annette G.; Christiansen, Dorte; Mazarakis, Sofia M. M.; Lojek, Neal; Hansen, Pernille; Gadeberg, Trine A. F.; Zarantonello, Alessandra; Laursen, Nick S.; Mollnes, Tom Eirik; Johnson, Matthew B.; Stevens, Beth; Thiel, Steffen; Andersen, Gregers R.
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An Ultrahigh-Affinity Complement C4b-Specific Nanobody Inhibits In Vivo Assembly of the Classical Pathway Proconvertase
errJOURNAL OF IMMUNOLOGY
IF3.4
err2020-09-15
err11
errOAAI
errZarantonello, Alessandra; Presumey, Jessy; Simoni, Lea; Yalcin, Esra; Fox, Rachel; Hansen, Annette; Olesen, Heidi Gytz; Thiel, Steffen; Johnson, Matthew B.; Stevens, Beth; Laursen, Nick Stub; Carroll, Michael C.; Andersen, Gregers R.
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Recruitment of properdin by bi-specific nanobodies activates the alternative pathway of complement
errMOLECULAR IMMUNOLOGY
IF3
err2020-08-01
err12
PREAI
errPedersen, Dennis, V; Roesner, Thies; Hansen, Annette G.; Andersen, Kasper R.; Thiel, Steffen; Andersen, Gregers R.; Valerius, Thomas; Laursen, Nick S.
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errSave
Structural signatures in EPR3 define a unique class of plant carbohydrate receptors
errNATURE COMMUNICATIONS
IF15.7
err2020-07-30
err33
errOAAI
errWong, Jaslyn E. M. M.; Gysel, Kira; Birkefeldt, Thea G.; Vinther, Maria; Muszynski, Artur; Azadi, Parastoo; Laursen, Nick S.; Sullivan, John T.; Ronson, Clive W.; Stougaard, Jens; Andersen, Kasper R.
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errSave
Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2020-07-17
err22
errOAAI
errLaursen, Nick S.; Pedersen, Dennis V.; Gytz, Heidi; Zarantonello, Alessandra; Bernth Jensen, Jens Magnus; Hansen, Annette G.; Thiel, Steffen; Andersen, Gregers R.
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errSave
A C3-specific nanobody that blocks all three activation pathways in the human and murine complement system
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-06-01
err22
errOAAI
errPedersen, Henrik; Jensen, Rasmus K.; Hansen, Annette G.; Gadeberg, Trine A. F.; Thiel, Steffen; Laursen, Nick S.; Andersen, Gregers R.
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errSave
Introduction of an Aldehyde Handle on Nanobodies by Affinity-Guided Labeling
errBIOCONJUGATE CHEMISTRY
IF3.9
err2020-04-22
err9
PREAI
errMortensen, Michael R.; Skovsgaard, Mikkel B.; Marcher, Anders; Andersen, Veronica L.; Palmfeldt, Johan; Nielsen, Thorbjorn B.; Torring, Thomas; Laursen, Nick S.; Andersen, Kasper R.; Kjems, Jorgen; Gothelf, Kurt, V
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Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2019-08-22
err52
errOAAI
errPedersen, Dennis V.; Gadeberg, Trine A. F.; Thomas, Caroline; Wang, Yong; Joram, Nicolas; Jensen, Rasmus K.; Mazarakis, Sofia M. M.; Revel, Margot; El Sissy, Carine; Petersen, Steen V.; Lindorff-Larsen, Kresten; Thiel, Steffen; Laursen, Nick S.; Fremeaux-Bacchi, Veronique; Andersen, Gregers R.
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Two potent C4 and C4b nanobodies inhibiting the classical pathway of the complement system
errMOLECULAR IMMUNOLOGY
IF3
err2018-10-01
err0
PREAI
errZarantonello, Alessandra; Laursen, Nick Stub; Gadeberg, Trine Amalie Fogh; Pedersen, Dennis Vestergaard; Hansen, Annette Gudmann; Schar, Christine; Thiel, Steffen; Andersen, Gregers Rom
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errSave
Potent activation of the classical pathway by bispecific antibodies
errMOLECULAR IMMUNOLOGY
IF3
err2018-10-01
err1
PREAI
errLaursen, Nick; Pedersen, Dennis; Roesner, Thies; Hansen, Annette; Valerius, Thomas; Thiel, Steffen; Andersen, Gregers
errShare
errSave
A potent complement factor C3-specific nanobody inhibiting multiple functions in the alternative pathway of human and murine complement
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2018-04-01
err42
errOAAI
errJensen, Rasmus K.; Pihl, Rasmus; Gadeberg, Trine A. F.; Jensen, Jan K.; Andersen, Kasper R.; Thiel, Steffen; Laursen, Nick S.; Andersen, Gregers R.
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errSave
Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts FcεRI interaction
errNATURE COMMUNICATIONS
IF15.7
err2018-01-02
err49
errOAAI
errJabs, Frederic; Plum, Melanie; Laursen, Nick S.; Jensen, Rasmus K.; Molgaard, Brian; Miehe, Michaela; Mandolesi, Marco; Rauber, Michele M.; Pfuetzner, Wolfgang; Jakob, Thilo; Moebs, Christian; Andersen, Gregers R.; Spillner, Edzard
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Research Directions

No research directions
Co-authors
Cooperation Journals
I
Ian A. Wilson
H-index: 179 · Papers: 1.7K
A
Andrew B. Ward
H-index: 109 · Papers: 1.0K
J
Jørgen Kjems
H-index: 100 · Papers: 791
M
Michael C. Carroll
H-index: 98 · Papers: 443
J
James E. Crowe
H-index: 98 · Papers: 1.3K
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