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Sarah L. Gaffen

university of pittsburgh

76H-index
328Paper Count
2.4WCitation Count
Published Papers 138
Publication Date
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IL-1 family signalling drives mucosal defence against systemic Candida albicans infection
errNature Microbiology
IF19.4
err2026-08-05
err0
errOAAI
errJames S. Griffiths; Alexander Kempf; Robert J. Pickering; Emily L. Priest; Olivia K. A. Paulin; Léa Lortal; Andrew Donkin; Olivia W. Hepworth; Don N. Wickramasinghe; Aize Pellon; Paul A. Stevens; Leanne Farnan; Adrian Lau; Harun Papini; Pawan Dhami; Sarah L. Gaffen; Jonathan P. Richardson; Julian R. Naglik
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errSave
The tissue-specific regulation of immunobiology by IL-17 signaling
errScience Immunology
IF16.3
err2026-06-12
err0
PREAI
errYang Li; Shachi P. Vyas; Peter Draber; Rami Bechara; Sarah L. Gaffen
errShare
errSave
An IL-17-DUOX2 axis controls gastrointestinal colonization by Candida albicans
errNature Communications
IF15.7
err2026-05-04
err0
errOAAI
errPallavi Kakade; Juan F. Burgueno; Shabnam Sircaik; Nicole O. Ponde; Jinke Li; Iuliana V. Ene; Jiwoong Kim; Shen-Huan Liang; Rebecca Yunker; Ipsita Dey; Yasutada Akiba; Shipra Vaishnava; Jonathan D. Kaunitz; Sing Sing Way; Andrew Y. Koh; Sarah L. Gaffen; Maria T. Abreu; Richard J. Bennett
errShare
errSave
Non-canonical IL‑22 receptor signaling remodels the oral mucosal barrier during Candida albicans immunosurveillance
errNature Communications
IF15.7
err2026-04-03
err0
errOAAI
errNicolas Millet; Jinendiran Sekar; Norma V. Solis; Jian Miao; Antoine Millet; Felix E. Y. Aggor; Asia Wildeman; Melissa E. Cook; Amirhossein Davari; Brian M. Peters; Michail S. Lionakis; Sarah L. Gaffen; Nicholas Jendzjowsky; Scott G. Filler; Marc Swidergall
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errSave
The RNA binding protein Arid5a is an activator of TNF signaling in rheumatoid arthritis
errJCI Insight
IF6.1
err2026-01-23
err0
PREAI
errLi, Yang; Dey, Ipsita; Vyas, Shachi P.; Synackova, Alzbeta; Li, Decheng; Lubberts, Erik; Ascherman, Dana P.; Draber, Peter; Gaffen, Sarah L.
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errSave
Therapeutic delivery of CCL2 modulates immune response and restores host-microbe homeostasis
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-08-26
err0
PREAI
errShehabeldin, Mostafa; Gao, Jin; Cho, Yejin; Chong, Rong; Tabib, Tracy; Li, Lu; Smardz, Matthew; Gaffen, Sarah L.; Diaz, Patricia I.; Lafyatis, Robert; Little, Steven R.; Sfeir, Charles
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errSave
C/EBPB Mediates Immunity to Renal Autoinflammatory Disorders in a Stage-specific Manner
errJOURNAL OF IMMUNOLOGY
IF3.4
err2024-07-31
err1
PREAI
errDey, Ipsita; Li, Yang; Taylor, Tiffany C.; Peroumal, Doureradjou; Asada, Nariaki; Panzer, Ulf; Biswas, Partha S.; Sterneck, Esta; Gaffen, Sarah L.
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errSave
The RNA binding protein Arid5a drives IL-17-dependent autoantibody-induced glomerulonephritis
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2024-07-26
err2
PREAI
errLi, Yang; Vyas, Shachi P.; Mehta, Isha; Asada, Nariaki; Dey, Ipsita; Taylor, Tiffany C.; Bechara, Rami; Amatya, Nilesh; Aggor, Felix E. Y.; Coleman, Bianca M.; Li, De-Dong; Yamamoto, Kenta; Ezenwa, Ogechukwu; Sun, Yeque; Sterneck, Esta; McManus, C. Joel; Panzer, Ulf; Biswas, Partha S.; Savan, Ram; Das, Jishnu; Gaffen, Sarah L.
errShare
errSave
Combinatorial actions of IL-22 and IL-17 drive optimal immunity to oral candidiasis through SPRRs
errPLOS PATHOGENS
IF4.9
err2024-07-01
err3
errOAAI
errAggor, Felix E. Y.; Bertolini, Martinna; Coleman, Bianca M.; Taylor, Tiffany C.; Ponde, Nicole O.; Gaffen, Sarah L.
errShare
errSave
Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint
errSCIENCE SIGNALING
IF6.6
err2023-10-24
err0
errOAAI
errRevu, Shankar K.; Yang, Wenjuan; Rajasundaram, Dhivyaa; Brady, Alexander; Majumder, Saikat; Gaffen, Sarah L.; Hawse, William; Xia, Zongqi; McGeachy, Mandy J.
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errSave
SARS-CoV-2 ORF8 Mediates Signals in Macrophages and Monocytes through MyD88 Independently of the IL-17 Receptor
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-06-02
err7
errOAAI
errPonde, Nicole O.; Shoger, Karsen E.; Khatun, Mst Shamima; Sarkar, Mrinal K.; Dey, Ipsita; Taylor, Tiffany C.; Cisney, Rylee N.; Arunkumar, Samyuktha P.; Gudjonsson, Johann E.; Kolls, Jay K.; Gottschalk, Rachel A.; Gaffen, Sarah L.
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errSave
1,25-Dihydroxyvitamin D3 Ameliorates Th17 Autoimmunity via Transcriptional Modulation of Interleukin-17A
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-20
err421
errOAAI
errJoshi, Sneha; Pantalena, Luiz-Carlos; Liu, Xikui K.; Gaffen, Sarah L.; Liu, Hong; Rohowsky-Kochan, Christine; Ichiyama, Kenji; Yoshimura, Akihiko; Steinman, Lawrence; Christakos, Sylvia; Youssef, Sawsan
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errSave
Receptor-kinase EGFR-MAPK adaptor proteins mediate the epithelial response to Candida albicans via the cytolytic peptide toxin, candidalysin
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2022-10-01
err13
errOAAI
errPonde, Nicole O.; Lortal, Lea; Tsavou, Antzela; Hepworth, Olivia W.; Wickramasinghe, Don N.; Ho, Jemima; Richardson, Jonathan P.; Moyes, David L.; Gaffen, Sarah L.; Naglik, Julian R.
errShare
errSave
A gut-oral microbiome-driven axis controls oropharyngeal candidiasis through retinoic acid
errJCI INSIGHT
IF6.1
err2022-09-22
err10
errOAAI
errAggor, Felix E. Y.; Bertolini, Martinna; Zhou, Chunsheng; Taylor, Tiffany C.; Abbott, Darryl A.; Musgrove, Javonn; Bruno, Vincent M.; Hand, Timothy W.; Gaffen, Sarah L.
errShare
errSave
Arid5a Mediates an IL-17-Dependent Pathway That Drives Autoimmunity but Not Antifungal Host Defense
errJOURNAL OF IMMUNOLOGY
IF3.4
err2022-09-15
err4
errOAAI
errTaylor, Tiffany C.; Li, Yang; Li, De-Dong; Majumder, Saikat; McGeachy, Mandy J.; Biswas, Partha S.; Gingras, Sebastien; Gaffen, Sarah L.
errShare
errSave
Th17-driven immunity to oral candidiasis is dependent on the microbiome and can be triggered by mono-colonization with segmented filamentous bacteria
errJOURNAL OF IMMUNOLOGY
IF3.4
err2022-05-01
err1
PREAI
errAggor, Felix E. Y.; Zhou, Chunsheng; Abbott, Darryl; Musgrove, Javonn; Bruno, Vincent; Hand, Timothy W.; Gaffen, Sarah L.
errShare
errSave
The Candida albicans toxin candidalysin mediates distinct epithelial inflammatory responses through p38 and EGFR-ERK pathways
errSCIENCE SIGNALING
IF6.6
err2022-04-05
err26
errOAAI
errNikou, Spyridoula-Angeliki; Zhou, Chunsheng; Griffiths, James S.; Kotowicz, Natalia K.; Coleman, Bianca M.; Green, Mary J.; Moyes, David L.; Gaffen, Sarah L.; Naglik, Julian R.; Parker, Peter J.
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errSave
Regnase-1 Deficiency Restrains Klebsiella pneumoniae Infection by Regulation of a Type I Interferon Response
errMBIO
IF4.7
err2022-02-22
err2
errOAAI
errTrevejo-Nunez, Giraldina; Lin, Becky; Fan, Li; Aggor, Felix E. Y.; Biswas, Partha S.; Chen, Kong; Gaffen, Sarah L.
errShare
errSave
The RNA-binding protein IMP2 drives a stromal-Th17 cell circuit in autoimmune neuroinflammation
errJCI INSIGHT
IF6.1
err2022-02-08
err11
errOAAI
errBechara, Rami; Amatya, Nilesh; Majumder, Saikat; Zhou, Chunsheng; Li, Yang; Liu, Qixing; McGeachy, Mandy J.; Gaffen, Sarah L.
errShare
errSave
IL-17RA-signaling in Lgr5+ intestinal stem cells induces expression of transcription factor ATOH1 to promote secretory cell lineage commitment
errIMMUNITY
IF26.3
err2022-02-01
err42
errOAAI
errLin, Xun; Gaudino, Stephen J.; Jang, Kyung Ku; Bahadur, Tej; Singh, Ankita; Banerjee, Anirban; Beaupre, Michael; Chu, Timothy; Wong, Hoi Tong; Kim, Chang-Kyung; Kempen, Cody; Axelrad, Jordan; Huang, Huakang; Khalid, Saba; Shah, Vyom; Eskiocak, Onur; Parks, Olivia B.; Berisha, Artan; McAleer, Jeremy P.; Good, Misty; Hoshino, Miko; Blumberg, Richard; Bialkowska, Agnieszka B.; Gaffen, Sarah L.; Kolls, Jay K.; Yang, Vincent W.; Beyaz, Semir; Cadwell, Ken; Kumar, Pawan
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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Y
Yoichiro Iwakura
H-index: 143 · Papers: 946
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Lawrence Steinman
H-index: 129 · Papers: 781
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