Not logged inA combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer
Kendzia, Sandra; Franke, Susanne; Kroehler, Tarek; Golob-Schwarzl, Nicole; Schweiger, Caroline; Toeglhofer, Anna M.; Skofler, Christina; Uranitsch, Stefan; El-Heliebi, Amin; Fuchs, Julia; Punschart, Andreas; Stiegler, Philipp; Keil, Marlen; Hoffmann, Jens; Henderson, David; Lehrach, Hans; Yaspo, Marie-Laure; Reinhard, Christoph; Schaefer, Reinhold; Keilholz, Ulrich; Regenbrecht, Christian; Schicho, Rudolf; Fickert, Peter; Lax, Sigurd F.; Erdmann, Frank; Schulz, Marcel H.; Kiemer, Alexandra K.; Haybaeck, Johannes; Kessler, Sonja M. .png)
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SaveHigh Yap and Mll1 promote a persistent regenerative cell state induced by Notch signaling and loss of p53Heuberger, Julian; Grinat, Johanna; Kosel, Frauke; Liu, Lichao; Kunz, Severine; Vidal, Ramon Oliveira; Keil, Marlen; Haybaeck, Johannes; Robine, Sylvie; Louvard, Daniel; Regenbrecht, Christian; Sporbert, Anje; Sauer, Sascha; von Eyss, Bjorn; Sigal, Michael; Birchmeier, Walter Share Save Share Save Modulating chemoresistance: Uncovering the role of mutant SMAD4R361Hin colorectal cancer using PDO and PDX modelsPfohl, Ulrike; Silvestri, Alessandra; Schumacher, Dirk; Boehnke, Karsten; Haybaeck, Johannes; Bashir, Sanam; Kuehn, Ralf; Keil, Marlen; Schaefer, Reinhold; Walther, Wolfgang; Regenbrecht, Christian Share Save Heterogeneous pathway activation and drug response modelled in colorectal-tumor-derived 3D culturesSchumacher, Dirk; Andrieux, Geoffroy; Boehnke, Karsten; Keil, Marlen; Silvestri, Alessandra; Silvestrov, Maxine; Keilholz, Ulrich; Haybaeck, Johannes; Erdmann, Gerrit; Sachse, Christoph; Templin, Markus; Hoffmann, Jens; Boerries, Melanie; Schaefer, Reinhold; Regenbrecht, Christian R. A. Share Save Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitorsSchuette, Moritz; Risch, Thomas; Abdavi-Azar, Nilofar; Boehnke, Karsten; Schumacher, Dirk; Keil, Marlen; Yildirimman, Reha; Jandrasits, Christine; Borodina, Tatiana; Amstislavskiy, Vyacheslav; Worth, Catherine L.; Schweiger, Caroline; Liebs, Sandra; Lange, Martin; Warnatz, Hans-Joerg; Butcher, Lee M.; Barrett, James E.; Sultan, Marc; Wierling, Christoph; Golob-Schwarzl, Nicole; Lax, Sigurd; Uranitsch, Stefan; Becker, Michael; Welte, Yvonne; Regan, Joseph Lewis; Silvestrov, Maxine; Kehler, Inge; Fusi, Alberto; Kessler, Thomas; Herwig, Ralf; Landegren, Ulf; Wienke, Dirk; Nilsson, Mats; Velasco, Juan A.; Garin-Chesa, Pilar; Reinhard, Christoph; Beck, Stephan; Schaefer, Reinhold; Regenbrecht, Christian R. A.; Henderson, David; Lange, Bodo; Haybaeck, Johannes; Keilholz, Ulrich; Hoffmann, Jens; Lehrach, Hans; Yaspo, Marie-Laure Share Save Share Save A pipeline within the OncoTrack project for generating Patient-tumor-derived 3D cell cultures (PT3DC) and their application for individualized, targeted drug sensitivity assaysSchumacher, Dirk; Boehnke, Karsten; Lange, Martin; Welte, Yvonne; Davies, Cathrin; Rivera, Maria; Keil, Marlen; Keilholz, Ulrich; Haybaeck, Johannes; Angel Velasco, Juan; Yaspo, Marie-Laure; Lehrach, Hans; Henderson, David; Reinhard, Christoph; Hoffmann, Jens; Schaefer, Reinhold; Regenbrecht, Christian Share Save Generation of drug response data from 57 new patient-derived colon cancer xenografts and 3D cell cultures for systematic correlation with tumor biology within the OncoTrack* projectRivera, Maria; Keil, Marlen; Boehnke, Karsten; Lange, Martin; Schumacher, Dirk; Schaefer, Reinhold; Regenbrecht, Christian R.; Henderson, David; Keilholz, Ulrich; Kuehn, Alexander; El-Heliebi, Amin; Hohensee, Tabea; Haybaeck, Johannes; Reinhard, Christoph; Velasco, Juan A.; Lehrach, Hans; Garin-Chesa, Pilar; Beran, Garry; Hoffmann, Jens Share Save 
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