Zifu Zhong - Publications, H-index & Citations

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Zifu Zhong

ghent university

20H-index

60Paper Count

1.5KCitation Count

Published Papers 44

Publication Date

Multivalent Antibody-Recruiters Targeting Fibroblast Activation Protein for Innate Immune Killing

Biomacromolecules

IF5.4

2026-05-11

PREAI

Weiwei Mu; Yong Chen; Zifu Zhong; Jamie De Baere; Heleen Lauwers; Demi Defreyne; Haixia Peng; Bruno G. De Geest; Benoit Louage

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Lipid-based delivery systems for dendritic cell targeting: Formulation strategies and cancer applications

Journal of Controlled Release

IF11.5

2026-03-10

PREAI

Luna Fredericq; Ahmed E.I. Hamouda; Zifu Zhong; Jo A. Van Ginderachter; Bruno G. De Geest; Damya Laoui

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Impact of pre-existing anti-replicase immunity on the efficacy of self-amplifying mRNA vaccines

Nature Communications

IF15.7

2025-12-06

OAAI

Xiaole Cui; Laura Amelinck; Oriane Gillon; João Paulo Portela Catani; Ya Gao; Qing Sun; Elisabeth De Sutter; Pieter Vervaeke; Janne Snoeck; Stefan Lienenklaus; Xavier Saelens; Zifu Zhong; Niek N. Sanders

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Combinatorial Synthesis and Evaluation of Trialkyl Galloyl Amidoamine Ionizable Lipids for mRNA Formulation

Journal of the American Chemical Society

IF15.6

2025-07-21

PREAI

Bianka Golba; Irene De Franceschi; Zifu Zhong; Martijn J. Schuijs; Claudia M. Brenis Gomez; Heleen Lauwers; Benoit Louage; Iasona Sheshi; Nezha Badi; Bruno G. De Geest; Filip E. Du Prez

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Admixing of mRNA with Pre-Formed Lipid Nanoparticles Containing a Slightly-Cationic Ionizable Lipid Allows for Efficient mRNA Transfection In Vitro and In Vivo

Advanced Healthcare Materials

IF9.6

2025-06-25

PREAI

Haixiu Wang; Heleen Lauwers; Mark Gontsarik; Yong Chen; Niek N. Sanders; Miffy Hok Yan Cheng; Bruno G. De Geest; Zifu Zhong

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Thioamides Adjacent to the Ionizable Amine Headgroup in Ionizable Lipids Reduce the pKa of Lipid Nanoparticles and Enhance mRNA Transfection Efficiency in Vitro and in Vivo

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2025-05-19

PREAI

Yong Chen; Emily De Lombaerde; Aimée Bugler-Lamb; Zifu Zhong; Martijn J. Schuijs; Claudia M. Brenis Gomez; Jamie De Baere; Mark Gontsarik

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Cyclic Poly(2-methyl-2-oxazoline)-Lipid Conjugates Are Good Alternatives to Poly(ethylene glycol)-Lipids for Lipid Nanopartcile mRNA Formulation

BIOMACROMOLECULES

IF5.4

2025-02-19

PREAI

Golba, Bianka; Zhong, Zifu; Romio, Matteo; Almey, Ruben; Deforce, Dieter; Dhaenens, Maarten; Sanders, Niek N.; Benetti, Edmondo M.; De Geest, Bruno G.

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A Genetically Encoded Endogenous Antibody Recruitment Strategy for Innate Immune-Mediated Killing of Cancer Cells

ADVANCED MATERIALS

IF26.8

2025-02-09

PREAI

Aelvoet, J; Zhong, ZF; Gomez, CMB; Aegerter, H; Louage, B; Lambrecht, BN; De Geest, BG; Schuijs, MJ

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Galloyl Dialkyl Lipids Drive Encapsulation of Peptides into Lipid Nanoparticles by Hydrogen Bonding

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IF15.6

2024-12-19

PREAI

Ye, Tingting; Chen, Yong; Zhong, Zifu; Huang, Yi; De Baere, Jamie; Gontsarik, Mark; Deswarte, Kim; Golba, Bianka; Risseeuw, Martijn; Van Calenbergh, Serge; Lambrecht, Bart N.; De Geest, Bruno G.

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CO-DELIVERY of glutamic acid-extended peptide antigen and imidazoquinoline TLR7/8 agonist via ionizable lipid nanoparticles induces protective anti-tumor immunity

BIOMATERIALS

IF12.9

2024-12-01

PREAI

Ye, Tingting; Zhong, Zifu; Cappellesso, Federica; Deswarte, Kim; Chen, Yong; Lauwers, Heleen; De Lombaerde, Emily; Gontsarik, Mark; Lienenklaus, Stefan; Van Lysebetten, Dorien; Sanders, Niek N.; Lambrecht, Bart N.; De Koker, Stefaan; Laoui, Damya; De Geest, Bruno G.

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Introducing Degradable Cationic Nanogels Carrying TLR9 Stimulating Oligonucleotides

SMALL

IF12.1

2024-12-01

PREAI

Fuchs, Alexander; Czysch, Christian; Maxeiner, Konrad; Winterwerber, Pia; Schmitt, Sascha; Stickdorn, Judith; Zhong, Zifu; Medina-Montano, Carolina; Raeder, Hans-Joachim; Bros, Matthias; De Geest, Bruno G.; Koynov, Kaloian; Grabbe, Stephan; Nuhn, Lutz

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A Fentanyl Hapten-Displaying Lipid Nanoparticle Vaccine that Non-Covalently Encapsulates a TLR7/8 Agonist and T-Helper Epitope Induces Protective Anti-Fentanyl Immunity

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

IF16.9

2024-11-21

PREAI

Zhong, Zifu; Deventer, Marie H.; Chen, Yong; Vanhee, Stijn; Lammens, Ines; Deswarte, Kim; Huang, Yi; Ye, Tingting; Wang, Haixiu; Nuhn, Lutz; Vandeputte, Marthe M.; Gontsarik, Mark; Cui, Xiaole; Sanders, Niek N.; Lienenklaus, Stefan; Lambrecht, Bart N.; Baptista, Antonio P.; Stove, Christophe P.; G. De Geest, Bruno

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HER2 Nanobody-Poly(rhamnose) Conjugates Efficiently Recruit Anti-Rhamnose Antibodies from Serum to the Surface of HER2-Expressing Cells

CHEMISTRY OF MATERIALS

IF7

2024-10-10

PREAI

Mu, Weiwei; Chen, Yong; Zhong, Zifu; Louage, Benoit; Lauwers, Heleen; Devoogdt, Nick; Haustraete, Jurgen; De Geest, Bruno G.

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Amplification of Protein Expression by Self-Amplifying mRNA Delivered in Lipid Nanoparticles Containing a β-Aminoester Ionizable Lipid Correlates with Reduced Innate Immune Activation

ACS NANO

IF16

2024-10-01

PREAI

De Lombaerde, Emily; Cui, Xiaole; Chen, Yong; Zhong, Zifu; Deckers, Julie; Mencarelli, Giulia; Opsomer, Lisa; Wang, Haixiu; De Baere, Jamie; Lienenklaus, Stefan; Lambrecht, Bart N.; Sanders, Niek N.; De Geest, Bruno G.

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PH-Triggered, Lymph Node Focused Immunodrug Release by Polymeric 2-Propionic-3-Methyl-maleic Anhydrides with Cholesteryl End Groups

ADVANCED HEALTHCARE MATERIALS

IF9.6

2024-09-23

OAAI

Heck, Alina G.; Medina-Montano, Carolina; Zhong, Zifu; Deswarte, Kim; Eigen, Katharina; Stickdorn, Judith; Kockelmann, Johannes; Scherger, Maximilian; Sanders, Niek N.; Lienenklaus, Stefan; Lambrecht, Bart N.; Grabbe, Stephan; De Geest, Bruno G.; Nuhn, Lutz

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Exploration of Solid Phase Peptoid Synthesis for the Design of Trifunctional Hapten-Lipid-TLR7/8 Agonist Antibody-Recruiting Oligomers That Combine Innate Effector with Innate Activation Function

ACS APPLIED BIO MATERIALS

IF4.7

2024-09-17

PREAI

Peng, HX; Martens, S; Uvyn, A; Chen, Y; Zhong, ZF; Louage, B; De Geest, BG

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Immunogenicity and biodistribution of lipid nanoparticle formulated self-amplifying mRNA vaccines against H5 avian influenza

NPJ VACCINES

IF6.5

2024-08-03

OAAI

Cui, Xiaole; Vervaeke, Pieter; Gao, Ya; Opsomer, Lisa; Sun, Qing; Snoeck, Janne; Devriendt, Bert; Zhong, Zifu; Sanders, Niek N.

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Combinatorial Screening of Biscarbamate Ionizable Lipids Identifies a Low Reactogenicity Lipid for Lipid Nanoparticle mRNA Delivery

ADVANCED FUNCTIONAL MATERIALS

IF19

2024-02-01

OAAI

De Lombaerde, Emily; Chen, Yong; Ye, Tingting; Deckers, Julie; Mencarelli, Giulia; De Swarte, Kim; Lauwers, Heleen; De Coen, Ruben; Kasmi, Sabah; Bevers, Sanne; Kuchmiy, Anna; Bogaert, Bram; Baekens, Lies; Zhong, Zifu; Lamoot, Alexander; Sanders, Niek N.; Lambrecht, Bart N.; Baptista, Antonio P.; De Koker, Stefaan; De Geest, Bruno G.

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Lipid Nanoparticle Encapsulation Empowers Poly(I:C) to Activate Cytoplasmic RLRs and Thereby Increases Its Adjuvanticity

SMALL

IF12.1

2023-10-22

OAAI

Lamoot, Alexander; Jangra, Sonia; Laghlali, Gabriel; Warang, Prajakta; Singh, Gagandeep; Chang, Lauren A.; Park, Seok-Chan; De Swarte, Kim; Zhong, Zifu; Louage, Benoit; De Lombaerde, Emily; Ye, Tingting; Chen, Yong; Cuadrado-Castano, Sara; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; Garcia-Sastre, Adolfo; Schotsaert, Michael; De Geest, Bruno G.

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Lipid Nanoparticle Delivery Alters the Adjuvanticity of the TLR9 Agonist CpG by Innate Immune Activation in Lymphoid Tissue

ADVANCED HEALTHCARE MATERIALS

IF9.6

2023-10-11

OAAI

Zhong, Zifu; Chen, Yong; Deswarte, Kim; Lauwers, Heleen; De Lombaerde, Emily; Cui, Xiaole; Van Herck, Simon; Ye, Tingting; Gontsarik, Mark; Lienenklaus, Stefan; Sanders, Niek N.; Lambrecht, Bart N.; De Koker, Stefaan; De Geest, Bruno G.

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Research Directions