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DIVERGENT MEDULLOBLASTOMA CHROMATIN STATES DISCLOSE KDM2B AS A SELECTIVE DEPENDENCY Tao, Ran; Erkek-Ozhan, Serap; Xu, Beisi; Matsui, Yurika; Mittal, Priya; Smith, Kyle; Li, Yiran; Gao, Qingsong; Darrow, Emily; Xu, Ruijie; Djekidel, Nadhir; Bajpai, Richa; Kumar, Rahul; Reilly, Colleen; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Bhanu, Natarajan; Gudenas, Brian; Paul, Leena; Lin, Hong; Lowe, Kim; Kutscher, Lena; Garcia, Benjamin; Pruett-Miller, Shondra; Zhou, Xin; Orr, Brent; Robinson, Giles; Wu, Gang; Korbel, Jan; Peng, Jamy; Pfister, Stefan; Northcott, Paul Share Save
AN ONCOGENIC PHOTORECEPTOR PROGRAM UNIFIES DISTINCT CENTRAL NERVOUS SYSTEM TUMORS Gudenas, Brian; Ahmad, Shiekh; Englinger, Bernhard; Liu, Anthony; Zhao, Miao; Paul, Leena; Hadley, Jennifer; Lin, Hong; Li, Yiran; Batts, Melissa; Mittal, Priya; Wu, Stephanie; Lewis, Sara; Han, Katie; Soliman, Taha; Janke, Laure; Meredith, David; Pfaff, Elke; Gojo, Johannes; Cotter, Jennifer; Klimo, Paul; Boop, Frederick; Gajjar, Amar; Robinson, Giles; Rosen, Gabriela; Alexandrescu, Sanda; Jones, David; Orr, Brent; Swartling, Fredrik; Filbin, Mariella; Northcott, Paul Share Save
DISSECTING MYC-DRIVEN EPIGENETIC MECHANISMS THAT PROMOTE GROUP 3 MEDULLOBLASTOMA UTILIZING HUMANIZED IPSC MODELS Qadeer, Zulekha; Hou, Elise; Siegel, Dara; Westelman, Samantha; Gudenas, Brian; Smith, Kyle; Ismail, Wazim Mohammed; Wang, Linyu; Beytagh, Mary Clare; Phua, Ronald; Hendrikse, Liam; Huang, Miller; Gaspar-Maia, Alexandre; Northcott, Paul; Taylor, Michael; Weiss, William Share Save
Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target Ahmad, Shiekh Tanveer; Li, Yiran; Garcia-Lopez, Jesus; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Wu, Stephanie; Refaat, Alaa; Kojic, Marija; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Arnskotter, Frederik; Zindy, Frederique; Jones, Alun; Twarog, Nathaniel; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Lewis, Sara; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Shelat, Anang; Waszak, Sebastian; Kutscher, Lena; Lin, Hong; Northcott, Paul Share Save
INTEGRATED MULTI-OMIC PROFILING REVEALS PROTEOMIC HETEROGENEITY AND PATHWAY DYNAMICS IN MEDULLOBLASTOMA Li, Yiran; North, Kelsey; Lin, Hong; Wu, Stephine; Gudenas, Brian; Smith, Kyle; Yuan, Zuo-Fei; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Dhanda, Sandeep; Atkinson, Natasha; Mercer, Kimberly; High, Andy; Wang, Xusheng; Peng, Junmin; Roussel, Martine; Robinson, Giles; Orr, Brent; Northcott, Paul Share Save
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GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA Tanveer Ahmad, Shiekh; Garcia-Lopez, Jesus; Li, Yiran; Hadley, Jennifer; Paul, Leena; Gudenas, Brian; Batts, Melissa; Soliman, Taha; Pitre, Aaron; Kojic, Marija; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura Janke; Lu, Meifen; Onar-Thomas, Arzu; Pfister, Stefan; Gajjar, Amar; Baker, Suzanne; Roussel, Martine; Rankovic, Zoran; Robinson, Giles; Orr, Brent; Wainwright, Brandon; Kutscher, Lena; Waszak, Sebastian; Lin, Hong; Northcott, Paul Share Save
Sky-1214, a Small Molecule Splicing Modulator Targeting FANCL and Fanci, Provides a New Mechanism of Action Targeting Multiple Myeloma and Non-Hodgkin's Lymphoma Rauch, Simone; Reber, Stefan; Perez-Salvia, Montserrat; Pregnolato, Marco; Liu, Botao; Berry, Loren; Buiakova, Olesia; Ratni, Hasane; Gudenas, Brian; Cusulin, Carlo; Shanahan, Lauren; Faller, Douglas, V; Costa, Veronica; Paushkin, Sergey Share Save
Preclinical characterization of SKY-1214, a small molecule splicing modulator of Fanconi Anemia pathway members for the treatment of multiple myeloma and non-Hodgkin's lymphoma Rauch, S.; Reber, S.; Salvia, M. Perez; Pregnolato, M.; Botao, L.; Berry, L.; Buiakova, O.; Ratni, H.; Gudenas, B.; Cusulin, C.; Shanahan, L.; Costa, V.; Paushkin, S. Share Save
PRDM6 promotes medulloblastoma by repressing chromatin accessibility and altering gene expression Schmidt, Christin; Cohen, Sarah; Gudenas, Brian L.; Husain, Sarah; Carlson, Annika; Westelman, Samantha; Wang, Linyu; Phillips, Joanna J.; Northcott, Paul A.; Weiss, William A.; Schwer, Bjoern Share Save
PRDM6 PROMOTES MEDULLOBLASTOMA FORMATION IN NEUROEPITHELIAL STEM CELLS AND IS A CHROMATIN REPRESSOR BY BINDING TO HISTONE H3 LYSINE 27 TRIMETHYLATION MARKS Schmidt, Christin; Cohen, Sarah; Gudenas, Brian L.; Husain, Sarah; Carlson, Annika; Westelman, Samantha; Wang, Linyu; Phillips, Joanna J.; Northcott, Paul A.; Weiss, William A.; Schwer, Bjoern Share Save
THE SINGLE-CELL LANDSCAPE OF PINEOBLASTOMA IDENTIFIES AN ONCOGENIC PHOTORECEPTOR PROGRAM AS A TUMORIGENIC VULNERABILITY UNIFYING DISTINCT EMBRYONAL CNS TUMOR ENTITIES Gudenas, Brian; Englinger, Bernhard; Liu, Anthony P. Y.; Ahmad, Sheikh Tanveer; Zhao, Miao; Meredith, David; Pfaff, Elke; Paul, Leena; Hadley, Jennifer; Batts, Melissa; Klimo, Paul, Jr.; Boop, Frederick A.; Gajjar, Amar; Robinson, Giles W.; Orr, Brent A.; Lin, Hong; Alexandrescu, Sanda; Jones, David T. W.; Swartling, Fredrik; Filbin, Mariella G.; Northcott, Paul A. Share Save
GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA Ahmad, Shiekh Tanveer; Garcia-Lopez, Jesus; Li, Yiran; Gudenas, Brian; Hadley, Jennifer; Paul, Leena; Batts, Melissa; Soliman, Taha; Kojic, Marija; Pitre, Aaron; Manz, Frederik; Zindy, Frederique; Jones, Alun; Mayasundari, Anand; Bianski, Brandon; Tinkle, Christopher; Shirinifard, Abbas; Janke, Laura; Lu, Meifen; Pfister, Stefan M.; Gajjar, Amar; Baker, Suzanne J.; Roussel, Martine F.; Rankovic, Zoran; Waszak, Sebastian M.; Robinson, Giles W.; Orr, Brent A.; Wainwright, Brandon; Kutscher, Lena M.; Lin, Hong; Northcott, Paul A. Share Save
INTEGRATIVE PROTEO-GENOMICS TO DECIPHER MOLECULAR MECHANISMS UNDERLYING SUBGROUP-SPECIFIC HETEROGENEITY IN MEDULLOBLASTOMA Li, Yiran; Gudenas, Brian L.; Smith, Kyle S.; Lin, Hong; North, Kelsey C.; Soliman, Taha; Hadley, Jennifer; Batts, Melissa; Dhanda, Sandeep K.; Atkinson, Natasha; Mercer, Kimberly S.; High, Anthony; Yuan, Zuo-Fei; Wang, Xusheng; Peng, Junmin; Roussel, Martine F.; Robinson, Giles W.; Orr, Brent A.; Northcott, Paul A. Share Save
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LOSS OF MICRORNAS COOPERATES WITH TUMOR SUPPRESSORS TO INITIATE MYC-DEPENDENT METASTATIC MEDULLOBLASTOMA Llaguno, Sheila Alcantara; Nazarenko, Inga; Chen, Yuntao; Sun, Daochun; Gudenas, Brian; Saulnier, Olivier; La Rocca, Gaspare; Pedraza, Alicia; Burns, Dennis; Bale, Tejus; Ventura, Andrea; Northcott, Paul; Taylor, Michael; Parada, Luis Share Save
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