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Douglas H. Smith

university of pennsylvania perelman school of medicine

102H-index
352Paper Count
3.7WCitation Count
Published Papers 160
Publication Date
Sex Influences Penumbral Leukocyte Mobilization after Severe TBI
err2026-07-09
err0
PREAI
errPatricia Santos Carlin; Priyanka Bele; Matthew Culkin; Michael Coons; Alexandra Kauffman; Patricia Martinez-Quiñonez; Anastasia Georges; Lewis J. Kaplan; Victoria Johnson; David Meaney; Douglas H. Smith; Gary A. Bass; Jose L. Pascual
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Brain age gap as a diffusion MRI-based marker of traumatic brain injury-related brain changes and associated outcomes
err2026-07-01
err0
errOAAI
errLivia Rodrigues; Drew Parker; Nima Broomand Lomer; Alexa E Walter; Daniel Brennan; Douglas H Smith; Jeffrey Ware; Andrea L C Schneider; Ramon Diaz-Arrastia; Ragini Verma
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FRESH FROZEN PLASMA AFTER TBI IMPROVES GLOBAL NEUROLOGIC RECOVERY BUT WORSENS SPATIAL LEARNING
err2026-03-01
err0
PREAI
errKauffman, Alexandra; Carlin, Patricia Santos; Georges, Anastasia; Coons, Michael; Augustin, Daunel; Kaplan, Lewis; Meaney, David; Smith, Douglas; Bass, Gary; Pascual-Lopez, Jose
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Chronic traumatic encephalopathy neuropathologic change is associated with highest stage limbic-predominant age-related TDP-43 encephalopathy
err2026-01-01
err0
errOAAI
errHailong Song, MD, PhD; Kamar E Ameen-Ali, PhD; Claire Kennedy-Dietrich, MSc; Jean-Pierre Dolle, PhD; Edward B Lee, MD, PhD; Douglas H Smith, MD; William Stewart, MBChB, PhD; the CONNECT-TBI Investigators; null
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IN MEMORIAM: Dr. Victoria E. Johnson
err2025-11-05
err0
errOAAI
errRebecca E. Lacher; Douglas H. Smith
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Traumatic brain injury or head impacts from contact sports are associated with tau astrogliopathy
errBRAIN
IF11.7
err2025-04-02
err0
PREAI
errArena, John D.; Stewart, William; Kovacs, Gabor G.; Lee, Edward B.; Robinson, John L.; Lee, Virginia M. Y.; Trojanowski, John Q.; Schneider, Andrea L. C.; Smith, Douglas H.; Johnson, Victoria E.
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No sex difference in the extent of acute mechanical blood-brain barrier disruption after experimental concussion
err2024-11-14
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PREAI
errSong, Hailong; Kantemneni, Eashwar; Qiu, Yue; Dolle, Jean-Pierre; Cullen, D. Kacy; Stewart, William; Smith, Douglas H.
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Daily quetiapine after severe TBI improves learning and memory
err2024-05-20
err0
PREAI
errBele, Priyanka; Thaploo, Advait; Coons, Michael; Culkin, Matthew C.; Santos, Patricia; Martinez-Quinones, Patricia; Georges, Anastasia P.; Anderson, Erin; Browne, Kevin D.; Jacovides, Christina; Kaplan, Lewis J.; Meaney, David F.; Smith, Douglas H.; Pascual, Jose L.
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Sex differences in the extent of acute axonal pathologies after experimental concussion
err2024-05-05
err3
errOAAI
errSong, Hailong; Tomasevich, Alexandra; Paolini, Andrew; Browne, Kevin D.; Wofford, Kathryn L.; Kelley, Brian; Kantemneni, Eashwar; Kennedy, Justin; Qiu, Yue; Schneider, Andrea L. C.; Dolle, Jean-Pierre; Cullen, D. Kacy; Smith, Douglas H.
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Dose-Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood-Brain Barrier Permeability Following Traumatic Brain Injury: An In Vivo Murine Study
err2024-03-05
err0
errOAAI
errCulkin, Matthew C.; Bele, Priyanka; Georges, Anastasia P.; Santos, Patricia; Niziolek, Grace; Kaplan, Lewis J.; Smith, Douglas H.; Pascual, Jose L.
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Delayed tranexamic acid after traumatic brain injury impedes learning and memory: Early tranexamic acid is favorable but not in sham animals
err2023-10-19
err1
PREAI
errCulkin, Matthew C.; Coons, Michael; Bele, Priyanka; Thaploo, Advait; Georges, Anastasia P.; Anderson, Erin; Browne, Kevin D.; Jacovides, Christina; Santos, Patricia; Kaplan, Lewis J.; Meaney, David F.; Smith, Douglas H.; Pascual, Jose L.
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The PD-1-and LAG-3-targeting bispecific molecule tebotelimab in solid tumors and hematologic cancers: a phase 1 trial
err2023-10-19
err32
errOAAI
errLuke, Jason J.; Patel, Manish R.; Blumenschein, George R.; Hamilton, Erika; Chmielowski, Bartosz; Ulahannan, Susanna V.; Connolly, Roisin M.; Santa-Maria, Cesar A.; Wang, Jie; Bahadur, Shakeela W.; Weickhardt, Andrew; Asch, Adam S.; Mallesara, Girish; Clingan, Philip; Dlugosz-Danecka, Monika; Tomaszewska-Kiecana, Monika; Pylypenko, Halyna; Hamad, Nada; Kindler, Hedy L.; Sumrow, Bradley J.; Kaminker, Patrick; Chen, Francine Z.; Zhang, Xiaoyu; Shah, Kalpana; Smith, Douglas H.; De Costa, Anushka; Li, Jonathan; Li, Hua; Sun, Jichao; Moore, Paul A.
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Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2
err2023-08-25
err8
PREAI
errSong, Hailong; Tomasevich, Alexandra; Acheampong, Kofi K.; Schaff, Dylan L.; Shaffer, Sydney M.; Dolle, Jean-Pierre; Johnson, Victoria E.; Mikytuck, Bailey; Lee, Edward B.; Nolan, Amber; Keene, C. Dirk; Weiss, Susan R.; Stewart, William; Smith, Douglas H.
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Neuronal somatic plasmalemmal permeability and dendritic beading caused by head rotational traumatic brain injury in pigs-An exploratory study
err2023-07-13
err4
errOAAI
errHarris, James P.; Mietus, Constance J.; Browne, Kevin D.; Wofford, Kathryn L.; Keating, Carolyn E.; Brown, Daniel P.; Johnson, Brian N.; Wolf, John A.; Smith, Douglas H.; Cohen, Akiva S.; Duda, John E.; Cullen, D. Kacy
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The perils of contact sport: pathologies of diffuse brain swelling and chronic traumatic encephalopathy neuropathologic change in a 23-year-old rugby union player
err2023-04-22
err3
errOAAI
errLee, Edward B.; Kennedy-Dietrich, Claire; Geddes, Jennian F.; Nicoll, James A. R.; Revesz, Tamas; Smith, Douglas H.; Stewart, William
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Early posttraumatic brain injury tranexamic acid prevents blood-brain barrier hyperpermeability and improves surrogates of neuroclinical recovery
err2023-04-11
err5
PREAI
errCulkin, Matthew C.; Bele, Priyanka; Georges, Anastasia P.; Lopez, Alfonso J.; Niziolek, Grace; Jacovides, Christina L.; Song, Hailong; Johnson, Victoria E.; Kaplan, Lewis J.; Smith, Douglas H.; Pascual, Jose L.
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Tissue-engineered grafts exploit axon-facilitated axon regeneration and pathway protection to enable recovery after 5-cm nerve defects in pigs
err2022-11-04
err16
errOAAI
errSmith, Douglas H.; Burrell, Justin C.; Browne, Kevin D.; Katiyar, Kritika S.; Ezra, Mindy I.; Dutton, John L.; Morand, Joseph P.; Struzyna, Laura A.; Laimo, Franco A.; Chen, H. Isaac; Wolf, John A.; Kaplan, Hilton M.; Rosen, Joseph M.; Ledebur, Harry C.; Zager, Eric L.; Ali, Zarina S.; Cullen, D. Kacy
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Traumatic brain injury recapitulates developmental changes of axons
err2022-10-01
err10
errOAAI
errSong, Hailong; Chen, Chen; Kelley, Brian; Tomasevich, Alexandra; Lee, Hyoungjoo; Dolle, Jean-Pierre; Cheng, Jianlin; Garcia, Benjamin; Meaney, David F.; Smith, Douglas H.
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Concussion leads to widespread axonal sodium channel loss and disruption of the node of Ranvier
err2022-09-15
err14
errOAAI
errSong, Hailong; McEwan, Przemyslaw P.; Ameen-Ali, Kamar E.; Tomasevich, Alexandra; Kennedy-Dietrich, Claire; Palma, Alexander; Arroyo, Edgardo J.; Dolle, Jean-Pierre; Johnson, Victoria E.; Stewart, William; Smith, Douglas H.
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