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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, Peter; Glaser, Stefan P.; Han, Jing; Popa, Alexandra; Pisarsky, Laura; Feng, Ningping; Geyer, Antonia; Haderk, Franziska; Alpar, Donat; Bristow, Christopher; Schmittner, Susanne; Traexler, Paula-Elena; Mahendra, Mikhila; Poehn, Birgit; Gandhi, Poojabahen; Fiorelli, Roberto; Awate, Sanket; Budano, Nicole; Martin, Florian; Albrecht, Christoph; Drobits-Handl, Barbara; Anand, Sathanandam S.; Kasturirangan, Srinath; Trapani, Francesca; Schweifer, Norbert; Marszalek, Joseph R.; Tontsch-Grunt, Ulrike; Pearson, Mark; Heffernan, Timothy P.; Kraut, Norbert; Vellano, Christopher P.; Garcia-Martinez, Juan Manuel Share Save
CBX250 Is a Novel Cathepsin G Peptide-HLA-Targeting T Cell Engager That Exhibits High Tumor Antigen and Potent Antileukemic In Vivo Lee, Benjamin H.; Paulus, Geraldine; Helble, Jennifer; Sankaran, Preethi; Rahman, Tanzila; O'Connor, Delainey; Bikowitz, Melissa; Jaffe, Sarah; Kulesha, Alona; Ban, Bhupal; Mak, Nga Sze Amanda; Princiotta, Michael; Shi, Chunhua; Yan, Jun; He, Hong; Feng, Ningping; Molldrem, Jeffrey J.; Heffernan, Timothy; Alatrash, Gheath; Wiederschain, Dmitri Share Save
A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer Jung, P.; Glaser, S. P.; Han, J.; Popa, A.; Pisarsky, L.; Feng, N.; Geyer, A.; Haderk, F.; Alpar, D.; Bristow, C.; Drobits-Handl, B.; Kasturirangan, S.; Trapani, F.; Marszalek, J. R.; Tontsch-Grunt, U.; Pearson, M.; Heffernan, T. P.; Kraut, N.; Vellano, C. P.; Garcia-Martinez, J. M. Share Save
Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance Thatikonda, Venu; Lyu, Hengyu; Jurado, Sabine; Kostyrko, Kaja; Bristow, Christopher A.; Albrecht, Christoph; Alpar, Donat; Arnhof, Heribert; Bergner, Oliver; Bosch, Karin; Feng, Ningping; Gao, Sisi; Gerlach, Daniel; Gmachl, Michael; Hinkel, Melanie; Lieb, Simone; Jeschko, Astrid; Machado, Annette A.; Madensky, Thomas; Marszalek, Ethan D.; Mahendra, Mikhila; Melo-Zainzinger, Gabriella; Molkentine, Jessica M.; Jaeger, Philipp A.; Peng, David H.; Schenk, Robyn L.; Sorokin, Alexey; Strauss, Sandra; Trapani, Francesca; Kopetz, Scott; Vellano, Christopher P.; Petronczki, Mark; Kraut, Norbert; Heffernan, Timothy P.; Marszalek, Joseph R.; Pearson, Mark; Waizenegger, Irene C.; Hofmann, Marco H. Share Save
Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer Dilly, Julien; Hoffman, Megan T.; Abbassi, Laleh; Li, Ziyue; Paradiso, Francesca; Parent, Brendan D.; Hennessey, Connor J.; Jordan, Alexander C.; Morgado, Micaela; Dasgupta, Shatavisha; Uribe, Giselle A.; Yang, Annan; Kapner, Kevin S.; Hambitzer, Felix P.; Qiang, Li; Feng, Hanrong; Geisberg, Jacob; Wang, Junning; Evans, Kyle E.; Lyu, Hengyu; Schalck, Aislyn; Feng, Ningping; Lopez, Anastasia M.; Bristow, Christopher A.; Kim, Michael P.; Rajapakshe, Kimal I.; Bahrambeigi, Vahid; Roth, Jennifer A.; Garg, Kavita; Guerrero, Paola A.; Stanger, Ben Z.; Cristea, Simona; Lowe, Scott W.; Baslan, Timour; Van Allen, Eliezer M.; Mancias, Joseph D.; Chan, Emily; Anderson, Abraham; Katlinskaya, Yuliya V.; Shalek, Alex K.; Hong, David S.; Pant, Shubham; Hallin, Jill; Anderes, Kenna; Olson, Peter; Heffernan, Timothy P.; Chugh, Seema; Christensen, James G.; Maitra, Anirban; Wolpin, Brian M.; Raghavan, Srivatsan; Nowak, Jonathan A.; Winter, Peter S.; Dougan, Stephanie K.; Aguirre, Andrew J. Share Save
Chromosome 3 copy number loss alone drives tumor evolution to aggressive disease in uveal melanoma Srinivasan, Sanjana; Rose, Johnathon; Minelli, Rosalba; Terranova, Christopher; Shah, Parth; Daniele, Joseph R.; Peoples, Michael; He, Meng; Liu, Chiu-Yi; Gay, Jason; Soeung, Melinda; Soni, Sanjay; Wang, Fangyang; Bristow, Christopher; Wani, Khalida; Perelli, Luigi; Loza, Dmitry; Feng, Ningping; Tarabichi, Maxime; Van Loo, Peter; Futreal, Andrew; Woodman, Scott; Lazar, Alexander; Vellano, Christopher P.; Marszalek, Joseph; Draetta, Giulio F.; Heffernan, Timothy; Carugo, Alessandro; Genovese, Giannicola; Giuliani, Virginia Share Save
Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia Paulus, Geraldine; Lee, Benjamin; Sankaran, Preethi; Rahman, Tanzila; Jimenez, Jessica; O'Connor, Delainey; Yue, Simon; Huang, Yu; Bikowitz, Melissa; Jaffe, Sarah; O'Malley, Shawn; Ban, Bhupal; Gabriely, Galina; Wang, Tao; Mak, Amanda; Princiotta, Michael; Shi, Chunhua; He, Helen; Feng, Ningping; Yan, Jun; Heffernan, Timothy; Alatrash, Gheath; Molldrem, Jeffrey; Wiederschain, Dmitri Share Save
IACS-16559, a CBP/P300 bromodomain inhibitor for the treatment of specific AML subsets Zanca, Ciro; Soth, Michael; Gao, Guang; Gay, Jason; Feng, Ningping; Bristow, Christopher; Le, Kang; Xu, Quanyun; Phuong Nguyen; Jiang, Yongying; Perry, Teresa; Mseeh, Faika; Leonard, Paul; Cross, Jason; Giuliani, Virginia; Marszalek, Joe; Jones, Philip; Heffernan, Tim Share Save
SOS1 inhibition in combination with HER2 inhibition in models of HER2driven cancer Schenk, Robyn L.; Kostyrko, Kaja; Popow, Johannes; Gewinner, Christina; Baum, Anke; Albrecht, Christoph; Hinkel, Melanie; Jacob, Robin; Madensky, Tom; Ruzicka, Regina; Strauss, Eva; Lyu, Hengyu; Lopez, Anastasia M.; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joseph R.; Heffernan, Timothy P.; Pearson, Mark; Hofmann, Marco H. Share Save
Chromosome 3 dosage-loss informs on the unique biology underlying ultra high-risk uveal melanoma Rose, Johnathon Lynn; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Terranova, Christopher; Gay, Jason; Daniele, Joseph R.; Dmitriy, Loza; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Shah, Parth; Soni, Sanjay; Bristow, Christopher; Wang, Fangyang; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Perelli, Luigi; Wani, Khalida; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
Development of advanced preclinical modeling for a comprehensive characterization of cardiac angiosarcoma biology Minelli, Rosalba; Perelli, Luigi; Bivona, Benjamin J.; Srinivasan, Sanjana; Catania, Desiree; Amador, Bianca E.; Robinson, Frederick S.; Rose, Johnathon L.; Terranova, Christopher T.; Martinez, Alejandro Hernandez; Deckard, Charles E.; Le, Courtney N.; Hsu, Kuo-Shun; Peoples, Michael; Subramaniam, Aparna; Beird, Hannah C.; Feng, Ningping; Daniele, Joseph R.; Vellano, Christopher; Marszalek, Joseph; Ravi, Vinod; Lazar, Alexander J.; Futreal, Andrew; Heffernan, Timothy P.; Genovese, Giannicola; Giuliani, Virginia Share Save
Hyperprogression due to myeloid mimicry in renal medullary carcinoma treated with nivolumab plus ipilimumab Soeung, Melinda; Yan, Xinmiao; Zhang, Li; Perelli, Luigi; Chen, Jianfeng; Tidwell, Becky Slack; Khan, Hania; Le, Courtney N.; Lam, Truong N.; Bhattacharya, Nirjar; Shah, Rutvi; Ho, I-Lin; Chen, Ziheng; Lundgren, Sebastian R.; Feng, Ningping; Zanca, Ciro; Karki, Menuka; Millward, Niki Marie Zacharias; He, Rong; Sheth, Rahul A.; Tharakeswara, Bathala K.; Rao, Priya; Daw, Najat C.; Tripathi, Durga N.; Walker, Cheryl L.; Han, Guangchun; Chu, Yanshuo; Wang, Ruiping; Dang, Minghao; Dai, Enyu; Peng, Fuduan; Liu, Yunhe; Jadhav, Akshaya S.; Lang, Wenhua; Arrechedera, Claudio A.; Clemente, Leticia Campos; Parra-Cuentas, Edwin R.; Lu, Hsinyi; Haymaker, Cara; Wistuba, Ignacio I.; Futreal, Andrew; Heffernan, Timothy; Viale, Andrea; Draetta, Giulio F.; Tannir, Nizar M.; Gao, Jianjun; Wang, Linghua; Genovese, Giannicola; Msaouel, Pavlos Share Save
Clonal dominance defines metastatic dissemination in pancreatic cancer Ho, I-Lin; Li, Chieh-Yuan; Wang, Fuchenchu; Zhao, Li; Liu, Jingjing; Yen, Er-Yen; Dyke, Charles A.; Shah, Rutvi; Liu, Zhaoliang; Cetin, Ali Osman; Chu, Yanshuo; Citron, Francesca; Attanasio, Sergio; Corti, Denise; Darbaniyan, Faezeh; Del Poggetto, Edoardo; Loponte, Sara; Liu, Jintan; Soeung, Melinda; Chen, Ziheng; Jiang, Shan; Jiang, Hong; Inoue, Akira; Gao, Sisi; Deem, Angela; Feng, Ningping; Ying, Haoqiang; Kim, Michael; Giuliani, Virginia; Genovese, Giannicola; Zhang, Jianhua; Futreal, Andrew; Maitra, Anirban; Heffernan, Timothy; Wang, Linghua; Do, Kim-Anh; Gargiulo, Gaetano; Draetta, Giulio; Carugo, Alessandro; Lin, Ruitao; Viale, Andrea Share Save
EXCITATORY NEURONS IN HUMAN MEDIODORSAL THALAMUS ARE IMPLICATED IN GENETIC RISK FOR SERIOUS MENTAL ILLNESS Schulmann, Anton; Marenco, Stefano; Auluck, Pavan K.; Patel, Yash; Feng, Ningping; Xu, Qing; Mukherjee, Arghya; Komal, Ruchi; Gao, Claire; Leng, Yan; Akula, Nirmala; Halassa, Michael M.; Hattar, Samer; Penzo, Mario A.; McMahon, Francis J. Share Save
DECIPHERING THE TRANSCRIPTOMIC IMPACTS OF HIGH-RISK COPY NUMBER VARIANTS IN THE HUMAN BRAIN AT SINGLE CELL RESOLUTION Dugan, Gabrielle; Akula, Nirmala; Marenco, Stefano; Auluck, Pavan; Raznahan, Armin; Liu, Siyuan; DeCasien, Alex R.; Xu, Qing; Feng, Ningping; Kolachana, Bhaskar; Jiang, Xueying; Gregory, Michael D.; Berman, Karen F.; McMahon, Francis J.; Schulmann, Anton Share Save
SMARCB1 regulates the hypoxic stress response in sickle cell trait Soeung, Melinda; Perelli, Luigi; Chen, Ziheng; Dondossola, Eleonora; Ho, -Lin; Carbone, Federica; Zhang, Li; Khan, Hania; Le, Courtney N.; Zhu, Cihui; Peoples, Michael D.; Feng, Ningping; Jiang, Shan; Zacharias, Niki Millward; Minelli, Rosalba; Shapiro, Daniel D.; Deem, Angela K.; Gao, Sisi; Cheng, Emily H.; Lucchetti, Donatella; Walker, Cheryl L.; Carugo, Alessandro; Giuliani, Virginia; Heffernan, Timothy P.; Viale, Andrea; Tannir, Nizar M.; Draetta, Giulio F.; Msoue, Pavlo; Genovese, Giannicola Share Save
TAS2940 inhibits intracranial tumor growth and prolongs survival in HER2-aberrant and EGFR-amplified patient-derived xenograft models Han, Jing; Mahendra, Mikhila; Gandhi, Poojabahen; Daniele, Joseph R.; Carrillo, Caroline C.; Bivona, Benjamin J.; Feng, Ningping; Heymach, John V.; Meric-Bernstam, Funda; Oguchi, Kei; Mizuarai, Shinji; Heffernan, Timothy P.; Vellano, Christopher P.; Marszalek, Joseph R. Share Save
Advanced preclinical modeling reveals unique monosomy 3 associated biology in late-stage uveal melanoma Rose, Johnathon L.; Srinivasan, Sanjana; He, Meng; Minelli, Rosalba; Liu, Chiu-Yi; Gay, Jason; Daniele, Joseph R.; Peoples, Michael; Soeung, Melinda; Ramamoorthy, Vandhana; Lopez, Anastasia; Deckard, Charles; Meyers, Brooke; Del Poggetto, Edoardo; Zamler, Daniel; Huang, Justin; Perelli, Luigi; Wani, Khalida; Bristow, Christopher; Feng, Ningping; Vellano, Christopher P.; Marszalek, Joe; Lazar, Alexander J.; Futreal, Andrew; Draetta, Giulio F.; Woodman, Scott E.; Heffernan, Timothy; Genovese, Giannicola; Carugo, Alessandro; Giuliani, Virginia Share Save
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