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LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models Puca, Loredana; Dowless, Michele S.; Perez-Ferreiro, Carmen M.; Ortiz-Ruiz, Maria Jesus; Donoho, Gregory P.; Capen, Andrew; Huber, Lysiane; Bogner, Sarah M.; Fei, Dongling; Manro, Jason R.; Yu, Chun Ping; Xu, Wei Guo; Wang, Rui; Chen, Shuang; Hicks, Mark A.; Zolfaghari, Parisa; Faber, Andrew; Gilmour, Raymond; Ramstetter, Monica D.; Chang, Matthew T.; Lallena, Maria Jose; Gong, Xuequian; Hyman, David M.; Smyth, Lillian M.; Brandhuber, Barbara J.; Taylor, Barry S.; Klippel, Anke Share Save
Phase I, first-in-human study of MSC-1 (AZD0171), a humanized anti-leukemia inhibitory factor monoclonal antibody, for advanced solid tumors Borazanci, E.; Schram, A. M.; Garralda, E.; Brana, I; Villar, M. Vieito; Spreafico, A.; Oliva, M.; Lakhani, N. J.; Hoffman, K.; Hallett, R. M.; Maetzel, D.; Hua, F.; Hilbert, J.; Giblin, P.; Anido, J.; Kelly, A.; Vickers, P. J.; Wasserman, R.; Seoane, J.; Siu, L. L.; Hyman, D. M.; Hoff, D., V; Tabernero, J. Share Save
AKT mutant allele-specific activation dictates pharmacologic sensitivities Bhattarai, Tripti Shrestha; Shamu, Tambudzai; Gorelick, Alexander N.; Chang, Matthew T.; Chakravarty, Debyani; Gavrila, Elena, I; Donoghue, Mark T. A.; Gao, JianJong; Patel, Swati; Gao, Sizhi Paul; Reynolds, Margaret H.; Phillips, Sarah M.; Soumerai, Tara; Abida, Wassim; Hyman, David M.; Schram, Alison M.; Solit, David B.; Smyth, Lillian M.; Taylor, Barry S. Share Save
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers (vol 13, 1450, 2022) Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srushti; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander Share Save
The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers Rosen, Ezra Y.; Won, Helen H.; Zheng, Youyun; Cocco, Emiliano; Selcuklu, Duygu; Gong, Yixiao; Friedman, Noah D.; de Bruijn, Ino; Sumer, Onur; Bielski, Craig M.; Savin, Casey; Bourque, Caitlin; Falcon, Christina; Clarke, Nikeysha; Jing, Xiaohong; Meng, Fanli; Zimel, Catherine; Shifman, Sophie; Kittane, Srusthi; Wu, Fan; Ladanyi, Marc; Ebata, Kevin; Kherani, Jennifer; Brandhuber, Barbara J.; Fagin, James; Sherman, Eric J.; Rekhtman, Natasha; Berger, Michael F.; Scaltriti, Maurizio; Hyman, David M.; Taylor, Barry S.; Drilon, Alexander Share Save
OncoTree: A Cancer Classification System for Precision Oncology Kundra, Ritika; Zhang, Hongxin; Sheridan, Robert; Sirintrapun, Sahussapont Joseph; Wang, Avery; Ochoa, Angelica; Wilson, Manda; Gross, Benjamin; Sun, Yichao; Madupuri, Ramyasree; Satravada, Baby A.; Reales, Dalicia; Vakiani, Efsevia; Al-Ahmadie, Hikmat A.; Dogan, Ahmet; Arcila, Maria; Zehir, Ahmet; Maron, Steven; Berger, Michael F.; Viaplana, Cristina; Janeway, Katherine; Ducar, Matthew; Sholl, Lynette; Dogan, Snjezana; Bedard, Philippe; Surrey, Lea F.; Sanchez, Iker Huerga; Syed, Aijaz; Rema, Anoop Balakrishnan; Chakravarty, Debyani; Suehnholz, Sarah; Nissan, Moriah; Iyer, Gopakumar, V; Murali, Rajmohan; Bouvier, Nancy; Soslow, Robert A.; Hyman, David; Younes, Anas; Intlekofer, Andrew; Harding, James J.; Carvajal, Richard D.; Sabbatini, Paul J.; Abou-Alfa, Ghassan K.; Morris, Luc; Janjigian, Yelena Y.; Gallagher, Meighan M.; Soumerai, Tara A.; Mellinghoff, Ingo K.; Hakimi, Abraham A.; Fury, Matthew; Huse, Jason T.; Bagrodia, Aditya; Hameed, Meera; Thomas, Stacy; Gardos, Stuart; Cerami, Ethan; Mazor, Tali; Kumari, Priti; Raman, Pichai; Shivdasani, Priyanka; MacFarland, Suzanne; Newman, Scott; Waanders, Angela; Gao, Jianjiong; Solit, David; Schultz, Nikolaus Share Save
The context-specific role of germline pathogenicity in tumorigenesis Srinivasan, Preethi; Bandlamudi, Chaitanya; Jonsson, Philip; Kemel, Yelena; Chavan, Shweta S.; Richards, Allison L.; Penson, Alexander, V; Bielski, Craig M.; Fong, Christopher; Syed, Aijazuddin; Jayakumaran, Gowtham; Prasad, Meera; Hwee, Jason; Sumer, Selcuk Onur; de Bruijn, Ino; Li, Xiang; Gao, JianJiong; Schultz, Nikolaus; Cambria, Roy; Galle, Jesse; Mukherjee, Semanti; Vijai, Joseph; Cadoo, Karen A.; Carlo, Maria, I; Walsh, Michael F.; Mandelker, Diana; Ceyhan-Birsoy, Ozge; Shia, Jinru; Zehir, Ahmet; Ladanyi, Marc; Hyman, David M.; Zhang, Liying; Offit, Kenneth; Robson, Mark E.; Solit, David B.; Stadler, Zsofia K.; Berger, Michael F.; Taylor, Barry S. Share Save
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Selective AKT kinase inhibitor capivasertib in combination with fulvestrant in PTEN-mutant ER-positive metastatic breast cancer Smyth, Lillian M.; Batist, Gerald; Meric-Bernstam, Funda; Kabos, Peter; Spanggaard, Iben; Lluch, Ana; Jhaveri, Komal; Varga, Andrea; Wong, Andrea; Schram, Alison M.; Ambrose, Helen; Carr, T. Hedley; de Bruin, Elza C.; Salinas-Souza, Carolina; Foxley, Andrew; Hauser, Joana; Lindemann, Justin P. O.; Maudsley, Rhiannon; McEwen, Robert; Moschetta, Michele; Nikolaou, Myria; Schiavon, Gaia; Razavi, Pedram; Banerji, Udai; Baselga, Jose; Hyman, David M.; Chandarlapaty, Sarat Share Save
TRK xDFG Mutations Trigger a Sensitivity Switch from Type I to II Kinase Inhibitors Cocco, Emiliano; Lee, Ji Eun; Kannan, Srinivasaraghavan; Schram, Alison M.; Won, Helen H.; Shifman, Sophie; Kulick, Amanda; Baldino, Laura; Toska, Eneda; Arruabarrena-Aristorena, Amaia; Kittane, Srushti; Wu, Fan; Cai, Yanyan; Arena, Sabrina; Mussolin, Benedetta; Kannan, Ram; Vasan, Neil; Gorelick, Alexander N.; Berger, Michael F.; Novoplansky, Ofra; Jagadeeshan, Sankar; Liao, Yi; Rix, Uwe; Misale, Sandra; Taylor, Barry S.; Bardelli, Alberto; Hechtman, Jaclyn F.; Hyman, David M.; Elkabets, Moshe; de Stanchina, Elisa; Verma, Chandra S.; Ventura, Andrea; Drilon, Alexander; Scaltriti, Maurizio Share Save
Characterization and management of ERK inhibitor associated dermatologic adverse events: analysis from a nonrandomized trial of ulixertinib for advanced cancers Wu, J.; Liu, D.; Offin, M.; Lezcano, C.; Torrisi, J. M.; Brownstein, S.; Hyman, D. M.; Gounder, M. M.; Abida, W.; Drilon, A.; Harding, J. J.; Sullivan, R. J.; Janku, F.; Welsch, D.; Varterasian, M.; Groover, A.; Li, B. T.; Lacouture, M. E. Share Save
Cancer therapy shapes the fitness landscape of clonal hematopoiesis Bolton, Kelly L.; Ptashkin, Ryan N.; Gao, Teng; Braunstein, Lior; Devlin, Sean M.; Kelly, Daniel; Patel, Minal; Berthon, Antonin; Syed, Aijazuddin; Yabe, Mariko; Coombs, Catherine C.; Caltabellotta, Nicole M.; Walsh, Mike; Offit, Kenneth; Stadler, Zsofia; Mandelker, Diana; Schulman, Jessica; Patel, Akshar; Philip, John; Bernard, Elsa; Gundem, Gunes; Ossa, Juan E. Arango; Levine, Max; Martinez, Juan S. Medina; Farnoud, Noushin; Glodzik, Dominik; Li, Sonya; Robson, Mark E.; Lee, Choonsik; Pharoah, Paul D. P.; Stopsack, Konrad H.; Spitzer, Barbara; Mantha, Simon; Fagin, James; Boucai, Laura; Gibson, Christopher J.; Ebert, Benjamin L.; Young, Andrew L.; Druley, Todd; Takahashi, Koichi; Gillis, Nancy; Ball, Markus; Padron, Eric; Hyman, David M.; Baselga, Jose; Norton, Larry; Gardos, Stuart; Klimek, Virginia M.; Scher, Howard; Bajorin, Dean; Paraiso, Eder; Benayed, Ryma; Arcila, Maria E.; Ladanyi, Marc; Solit, David B.; Berger, Michael F.; Tallman, Martin; Garcia-Closas, Montserrat; Chatterjee, Nilanjan; Diaz, Luis A., Jr.; Levine, Ross L.; Morton, Lindsay M.; Zehir, Ahmet; Papaemmanuil, Elli Share Save
Characterization of on-target adverse events caused by TRK inhibitor therapy Liu, D.; Flory, J.; Lin, A.; Offin, M.; Falcon, C. J.; Murciano-Goroff, Y. R.; Rosen, E.; Guo, R.; Basu, E.; Li, B. T.; Harding, J. J.; Iyer, G.; Jhaveri, K.; Gounder, M. M.; Shukla, N. N.; Roberts, S. S.; Glade-Bender, J.; Kaplanis, L.; Schram, A.; Hyman, D. M.; Drilon, A. Share Save
Clinical implications of drug-induced liver injury in early-phase oncology clinical trials Mondaca, Sebastian P.; Liu, Dazhi; Flynn, Jessica R.; Badson, Sandy; Hamaway, Stefan; Gounder, Mrinal M.; Khalil, Danny N.; Drilon, Alexander E.; Li, Bob T.; Jhaveri, Komal L.; Schram, Alison M.; Kargus, Katherine E.; Kasler, Mary Kate; Blauvelt, Natalie M.; Segal, Neil H.; Capanu, Marinela; Callahan, Margaret K.; Hyman, David M.; Gambarin-Gelwan, Maya; Harding, James J. Share Save
The utility of plasma ctDNA for detection of KRAS G12C and other mutations in lung cancers Murciano-Goroff, Yonina R.; Arbour, Kathryn C.; Offin, Michael D.; Tu, Hai-Yan Y.; Lebow, Emily S.; Shaffer, Tristan S.; Bertucci, Caterina; Hosseini, Syed A.; Garg, Kavita; Lim, Lee P.; Li, Mark; Chang, Jason C.; Reis-Filho, Jorge S.; Razavi, Pedram; Isbell, James M.; Riely, Gregory J.; Hyman, David M.; Lito, Piro; Li, Bob T. Share Save
TRK xDFG mutations trigger a sensitivity switch from type I to II kinase inhibitors Cocco, Emiliano; Lee, Ji Eun; Kannan, Srinivasaraghavan; Schram, Alison M.; Won, Helen H.; Shifman, Sophie; Kulick, Amanda; Baldino, Laura; Toska, Eneda; Arena, Sabrina; Mussolin, Benedetta; Kannan, Ram; Vasan, Neil; Gorelick, Alexander N.; Berger, Michael F.; Liao, Yi; Rix, Uwe; Bardelli, Alberto; Hechtman, Jacklyn; de Stanchina, Elisa; Hyman, David M.; Verma, Chandra; Ventura, Andrea; Drilon, Alexander; Scaltriti, Maurizio Share Save
Kinase fusions drive endocrine resistance in estrogen receptor-positive breast cancer Liu, Bo; Ross, Dara S.; Schram, Alison M.; Razavi, Pedram; Lagana, Stephen M.; Zhang, Yanming; Scaltriti, Maurizio; Bromberg, Jacqueline F.; Ladanyi, Marc; Hyman, David M.; Drilon, Alexander; Zahir, Ahmet; Benayed, Ryma; Hechtman, Jaclyn F.; Chandarlapaty, Sarat Share Save
Oncologic therapy shapes the fitness landscape of clonal hematopoiesis Bolton, Kelly L.; Ptashkin, Ryan N.; Gao, Teng; Braunstein, Lior; Devlin, Sean M.; Patel, Minal; Berthon, Antonin; Syed, Aijazuddin; Yabe, Mariko; Coombs, Catherine; Caltabellotta, Nicole M.; Walsh, Mike; Offit, Ken; Stadler, Zsofia; Lee, Choonsik; Pharoah, Paul; Stopsack, Konrad H.; Spitzer, Barbara; Mantha, Simon; Fagin, James; Boucai, Laura; Gibson, Christopher J.; Ebert, Benjamin; Young, Andrew L.; Druley, Todd; Takahashi, Koichi; Gillis, Nancy; Ball, Markus; Padron, Eric; Hyman, David; Baselga, Jose; Norton, Larry; Gardos, Stuart; Klimek, Virginia; Scher, Howard; Bajorin, Dean; Paraiso, Eder; Benayed, Ryma; Arcilla, Maria; Ladanyi, Marc; Solit, David; Berger, Michael; Tallman, Martin; Garcia-Closas, Montserrat; Chatterjee, Nilanjan; Diaz, Luis; Levine, Ross; Morton, Lindsay; Zehir, Ahmet; Papaemmanuil, Elli Share Save
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