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Multi-omic analysis of Huntington's disease reveals a compensatory astrocyte state Paryani, Fahad; Kwon, Ji-Sun; Ng, Christopher W.; Jakubiak, Kelly; Madden, Nacoya; Ofori, Kenneth; Tang, Alice; Lu, Hong; Xia, Shengnan; Li, Juncheng; Mahajan, Aayushi; Davidson, Shawn M.; Basile, Anna O.; Mchugh, Caitlin; Vonsattel, Jean Paul; Hickman, Richard; Zody, Michael C.; Housman, David E.; Goldman, James E.; Yoo, Andrew S.; Menon, Vilas; Al-Dalahmah, Osama Share Save
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Osteopontin drives neuroinflammation and cell loss in MAPT-N279K frontotemporal dementia patient neurons Al-Dalahmah, Osama; Lam, Matti; McInvale, Julie J.; Qu, Wenhui; Nguyen, Trang; Mun, Jeong-Yeon; Kwon, Sam; Ifediora, Nkechime; Mahajan, Aayushi; Humala, Nelson; Winters, Tristan; Angeles, Ellen; Jakubiak, Kelly A.; Kuhn, Rebekka; Kim, Yoon A.; De Rosa, Maria Caterina; Doege, Claudia A.; Paryani, Fahad; Flowers, Xena; Dovas, Athanassios; Mela, Angeliki; Lu, Hong; DeTure, Michael A.; Vonsattel, Jean Paul; Wszolek, Zbigniew K.; Dickson, Dennis W.; Kuhlmann, Tanja; Zaehres, Holm; Schoeler, Hans R.; Sproul, Andrew A.; Siegelin, Markus D.; De Jager, Philip L.; Goldman, James E.; Menon, Vilas; Canoll, Peter; Hargus, Gunnar Share Save
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Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy Miller, Katherine E.; Rivaldi, Adithe C.; Shinagawa, Noriyuki; Sran, Sahib; Navarro, Jason B.; Westfall, Jesse J.; Miller, Anthony R.; Roberts, Ryan D.; Akkari, Yassmine; Supinger, Rachel; Hester, Mark E.; Marhabaie, Mohammad; Gade, Meethila; Lu, Jinfeng; Rodziyevska, Olga; Bhattacharjee, Meenakshi B.; Von Allmen, Gretchen K.; Yang, Edward; Lidov, Hart G. W.; Harini, Chellamani; Shah, Manish N.; Leonard, Jeffrey; Pindrik, Jonathan; Shaikhouni, Ammar; Goldman, James E.; Pierson, Christopher R.; Thomas, Diana L.; Boue, Daniel R.; Ostendorf, Adam P.; Mardis, Elaine R.; Poduri, Annapurna; Koboldt, Daniel C.; Heinzen, Erin L.; Bedrosian, Tracy A. Share Save
The stability of the myelinating oligodendrocyte transcriptome is regulated by the nuclear lamina Pruvost, Mathilde; Patzig, Julia; Yattah, Camila; Selcen, Ipek; Hernandez, Marylens; Park, Hye-Jin; Moyon, Sarah; Liu, Shibo; Morioka, Malia S.; Shopland, Lindsay; Al-Dalahmah, Osama; Bendl, Jaroslav; Fullard, John F.; Roussos, Panos; Goldman, James; He, Ye; Dupree, Jeffrey L.; Casaccia, Patrizia Share Save
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TMEM106B Puncta Is Increased in Multiple Sclerosis Plaques, and Reduced Protein in Mice Results in Delayed Lipid Clearance Following CNS Injury Shafit-Zagardo, Bridget; Sidoli, Simone; Goldman, James E.; DuBois, Juwen C.; Corboy, John R.; Strittmatter, Stephen M.; Guzik, Hillary; Edema, Ukuemi; Arackal, Anita G.; Botbol, Yair M.; Merheb, Emilio; Nagra, Rashed M.; Graff, Sarah Share Save
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation Lim, Ryan G.; Al-Dalahmah, Osama; Wu, Jie; Gold, Maxwell P.; Reidling, Jack C.; Tang, Guomei; Adam, Miriam; Dansu, David K.; Park, Hye-Jin; Casaccia, Patrizia; Miramontes, Ricardo; Reyes-Ortiz, Andrea M.; Lau, Alice; Hickman, Richard A.; Khan, Fatima; Paryani, Fahad; Tang, Alice; Ofori, Kenneth; Miyoshi, Emily; Michael, Neethu; McClure, Nicolette; Flowers, Xena E.; Vonsattel, Jean Paul; Davidson, Shawn; Menon, Vilas; Swarup, Vivek; Fraenkel, Ernest; Goldman, James E.; Thompson, Leslie M. Share Save
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Oligodendroglial macroautophagy is essential for myelin sheath turnover to prevent neurodegeneration and death Aber, Etan R.; Griffey, Christopher J.; Davies, Tim; Li, Alice M.; Yang, Young Joo; Croce, Katherine R.; Goldman, James E.; Grutzendler, Jaime; Canman, Julie C.; Yamamoto, Ai Share Save
COVID-19 induces CNS cytokine expression and loss of hippocampal neurogenesis Soung, Allison L.; Vanderheiden, Abigail; Nordvig, Anna S.; Sissoko, Cheick A.; Canoll, Peter; Mariani, Madeline B.; Jiang, Xiaoping; Bricker, Traci; Rosoklija, Gorazd B.; Arango, Victoria; Underwood, Mark; Mann, J. John; Dwork, Andrew J.; Goldman, James E.; Boon, Adrianus C. M.; Boldrini, Maura; Klein, Robyn S. Share Save
Synaptic hyperexcitability of cytomegalic pyramidal neurons contributes to epileptogenesis in tuberous sclerosis complex Wu, Xiaoping; Sosunov, Alexander A.; Lado, Wudu; Teoh, Jia Jie; Ham, Ahrom; Li, Hongyu; Al-Dalahmah, Osama; Gill, Brian J. A.; Arancio, Ottavio; Schevon, Catherine A.; Frankel, Wayne N.; McKhann, Guy M.; Sulzer, David; Goldman, James E.; Tang, Guomei Share Save
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Somatic variants in diverse genes leads to a spectrum of focal cortical malformations Lai, Dulcie; Gade, Meethila; Yang, Edward; Koh, Hyun Yong; Lu, Jinfeng; Walley, Nicole M.; Buckley, Anne F.; Sands, Tristan T.; Akman, Cigdem, I; Mikati, Mohamad A.; McKhann, Guy M.; Goldman, James E.; Canoll, Peter; Alexander, Allyson L.; Park, Kristen L.; Von Allmen, Gretchen K.; Rodziyevska, Olga; Bhattacharjee, Meenakshi B.; Lidov, Hart G. W.; Vogel, Hannes; Grant, Gerald A.; Porter, Brenda E.; Poduri, Annapurna H.; Crino, Peter B.; Heinzen, Erin L. Share Save
Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis Heaven, Michael R.; Herren, Anthony W.; Flint, Daniel L.; Pacheco, Natasha L.; Li, Jiangtao; Tang, Alice; Khan, Fatima; Goldman, James E.; Phinney, Brett S.; Olsen, Michelle L. Share Save
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