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SaveTHE ONCOMETABOLITE D-2-HYDROXYGLUTARATE PROMOTES DNA HYPERMETHYLATION AT LINEAGE-SPECIFIC ENHANCERS CONTROLLING MICROGLIAL ACTIVATION IN IDH-MUTATED GLIOMAS
Laurenge, A.; Pugliese, P.; Mathon, B.; Richard, Q.; Jouannet, S.; Hayat, Y.; Scuderi, S.; Marijon, P.; Labreche, K.; Alentorn, A.; Verreault, M.; Idbaih, A.; Birzu, C.; Huillard, E.; Pottier, N.; Desmons, A.; Fayache, I; Kaas, G. A.; Kingsley, P. J.; Marnett, L. J.; Duplus, E.; El-Habr, E.; Salas, L. A.; Mokhtari, K.; Tran, S.; Suva, M. L.; Iavarone, A.; Ceccarelli, M.; Touat, M.; Bielle, F.; Mallat, M.; Sanson, M.; Castro-Vega, L. Share Save INTEGRATED DIGITAL PATHOLOGY AND TRANSCRIPTOMIC ANALYSIS OF ADULT GLIOMAS WITH HIGH LYMPHOCYTE INFILTRATION IDENTIFIES CELLULAR AND SPATIAL DETERMINANTS OF IMMUNE INFILTRATION WITH PROGNOSTIC VALUESalhi, L.; Lerond, J.; Nadaradjane, A. A.; Drouiche, L.; Pizarro, M. M. Otero; Sakr, L. Hanna Doumit; Labreche, K.; Kacimi, S. E. O.; Bellamy, C.; Picca, A.; Stimmer, L.; Brocic, J.; Letourneur, Q.; Barka, B.; Carpentier, C.; Marie, Y.; Madry, H.; Bhalshankar, J.; Nicolle, R.; Malaize, H.; Mathon, B.; Mokhtari, K.; Idbaih, A.; Hoang-Xuan, K.; Sanson, M.; Alentorn, A.; Duval, A.; Le Rouzic, P.; Dieu-Nosjean, M.; Bloch, I; Touat, M.; Bielle, F. Share Save Microsatellite instability at U2AF-binding polypyrimidic tract sites perturbs alternative splicing during colorectal cancer initiationJonchere, Vincent; Montemont, Hugo; Le Scanf, Enora; Siret, Aurelie; Letourneur, Quentin; Tubacher, Emmanuel; Battail, Christophe; Fall, Assane; Labreche, Karim; Renault, Victor; Ratovomanana, Toky; Buhard, Olivier; Jolly, Ariane; Le Rouzic, Philippe; Feys, Cody; Despras, Emmanuelle; Zouali, Habib; Nicolle, Remy; Cervera, Pascale; Svrcek, Magali; Bourgoin, Pierre; Blanche, Helene; Boland, Anne; Lefevre, Jeremie; Parc, Yann; Touat, Mehdi; Bielle, Franck; Arzur, Danielle; Cueff, Gwennina; Le Jossic-Corcos, Catherine; Quere, Gael; Dujardin, Gwendal; Blondel, Marc; Le Marechal, Cedric; Cohen, Romain; Andre, Thierry; Coulet, Florence; de la Grange, Pierre; de Reynies, Aurelien; Flejou, Jean-Francois; Renaud, Florence; Alentorn, Agusti; Corcos, Laurent; Deleuze, Jean-Francois; Collura, Ada; Duval, Alex Share Save Epstein-Barr virus and immune status imprint the immunogenomics of non-Hodgkin lymphomas occurring in immune-suppressed environmentsBaron, Marine; Labreche, Karim; Veyri, Marianne; Desire, Nathalie; Bouzidi, Amira; Seck-Thiam, Fatou; Charlotte, Frederic; Rousseau, Alice; Morin, Veronique; Nakid-Cordero, Cecilia; Abbar, Baptiste; Picca, Alberto; Le Cann, Marie; Balegroune, Noureddine; Gauthier, Nicolas; Theodorou, Ioannis; Touat, Mehdi; Morel, Veronique; Bielle, Franck; Samri, Assia; Alentorn, Agusti; Sanson, Marc; Roos-Weil, Damien; Haioun, Corinne; Poullot, Elsa; de Septenville, Anne Langlois; Davi, Frederic; Guihot, Amelie; Boelle, Pierre-Yves; Leblond, Veronique; Coulet, Florence; Spano, Jean-Philippe; Choquet, Sylvain; Autran, Brigitte; IDeATIon study group, Isabelle; Brocheriou, Isabelle; Cadranel, Jacques; Denis, Jerome; Guillerm, Erell; Ibdaih, Ahmed; Jouannet, Stephanie; Lacorte, Jean-Marc; Marcelin, Anne-Genevieve; Belkhir, Kahina Share Save A DETECTABLE ANTITUMOR IMMUNE RESPONSE IS PRESENT IN GLIOMAS, BUT IS PROFOUNDLY DAMPED BY CHEMOTHERAPYPicca, A.; Baron, M.; Labreche, K.; Bouzidi, A.; Rousseau, A.; Morin, V.; Bielle, F.; Touat, M.; Sanson, M.; Autran, B. Share Save CELL-EXTRINSIC D-2-HYDROXYGLUTARATE PROMOTES HYPERMETHYLATION AT LINEAGE-SPECIFIC REGULATORY REGIONS TO PREVENT MICROGLIAL ACTIVATION IN IDH-MUTANT GLIOMASLaurenge, A.; Pugliese, P.; Richard, Q.; Picca, A.; Jouannet, S.; Labreche, K.; Bielle, F.; Iavarone, A.; Ceccarelli, M.; Mallat, M.; Sanson, M.; Castro-Vega, L. Share Save OVERALL SURVIVAL ASSOCIATED WITH FIRST-LINE PCV OR TEMOZOLOMIDE IN COMBINATION WITH RADIOTHERAPY IN PATIENTS WITH IDH-MUTANT, 1P/19Q CODELETED, GRADE 3 OLIGODENDROGLIOMA: ANALYSIS FROM THE POLA COHORTKacimi, S. E. O.; Dehais, C.; Carpentier, C.; Chinot, O.; Bronnimann, C.; Vauleon, E.; Djelad, A.; Moyal, E. C.; Campone, M.; Ducloie, M.; Noel, G.; Cuzzubbo, S.; Thaillandier, L.; Ramirez, C.; Colin, C.; Appay, R.; Tabouret, E.; Nichelli, L.; Mathon, B.; Thomas, A.; Tran, S.; Bielle, F.; Alentor, A.; Labreche, K.; Idbaih, A.; Figarella-Branger, D.; Ducray, F.; Touat, M. Share Save Prediction of response to immune checkpoint blockade in patients with metastatic colorectal cancer with microsatellite instabilityRatovomanana, T.; Nicolle, R.; Cohen, R.; Diehl, A.; Siret, A.; Letourneur, Q.; Buhard, O.; Perrier, A.; Guillerm, E.; Coulet, F.; Cervera, P.; Benusiglio, P.; Labreche, K.; Colle, R.; Collura, A.; Despras, E.; Le Rouzic, P.; Renaud, F.; Cros, J.; Alentorn, A.; Touat, M.; Ayadi, M.; Bourgoin, P.; Prunier, C.; Tournigand, C.; de la Fouchardiere, C.; Tougeron, D.; Jonchere, V.; Bennouna, J.; de Reynies, A.; Flejou, J. -f.; Svrcek, M.; Andre, T.; Duval, A. Share Save Lynch syndrome: influence of additional susceptibility variants on cancer riskVibert, Roseline; Hasnaoui, Jasmine; Perrier, Alexandre; Lefebvre, Alexandra; Colas, Chrystelle; Dhooge, Marion; Basset, Noemie; Chansavang, Albain; Desseignes, Camille; Duval, Alex; Farelly, Solenne; Hamzaoui, Nadim; Laurent-Puig, Pierre; Metras, Julie; Moliere, Diane; Muleris, Martine; Netter, Jeanne; Touat, Mehdi; Bielle, Franck; Labreche, Karim; Nicolle, Romain; Perkins, Geraldine; Warcoin, Mathilde; Coulet, Florence; Benusiglio, Patrick R. Share Save Pan-cancer landscape of AID-related mutations, composite mutations, and their potential role in the ICI responseHernandez-Verdin, Isaias; Akdemir, Kadir C.; Ramazzotti, Daniele; Caravagna, Giulio; Labreche, Karim; Mokhtari, Karima; Hoang-Xuan, Khe; Peyre, Matthieu; Bielle, Franck; Touat, Mehdi; Idbaih, Ahmed; Duval, Alex; Sanson, Marc; Alentorn, Agusti Share Save Somatic PIK3CA Mutations in Sporadic Cerebral Cavernous MalformationsPeyre, Matthieu; Miyagishima, Danielle; Bielle, Franck; Chapon, Francoise; Sierant, Michael; Venot, Quitterie; Lerond, Julie; Marijon, Pauline; Abi-Jaoude, Samiya; Le Van, Tuan; Labreche, Karim; Houlston, Richard; Faisant, Maxime; Clemenceau, Stephane; Boch, Anne-Laure; Nouet, Aurelien; Carpentier, Alexandre; Boetto, Julien; Louvi, Angeliki; Kalamarides, Michel Share Save Mendelian randomisation study of the relationship between vitamin D and risk of glioma (vol 8, 2339, 2018)Takahashi, Hannah; Cornish, Alex J.; Sud, Amit; Law, Philip J.; Kinnersley, Ben; Ostrom, Quinn T. .; Labreche, Karim; Eckel-Passow, Jeanette E.; Armstrong, Georgina N.; Claus, Elizabeth B.; Il'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S.; Olson, Sara H.; Bernstein, Jonine L.; Lai, Rose K.; Schoemaker, Minouk J.; Simon, Matthias; Hoffmann, Per; Noethen, Markus M.; Joeckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B.; Melin, Beatrice S.; Wrensch, Margaret R.; Sanson, Marc; Bondy, Melissa L.; Turnbull, Clare; Houlston, Richard S. Share Save A genome-wide association study identifies susceptibility loci for primary central nervous system lymphoma at 6p25.3 and 3p22.1: a LOC Network studyLabreche, Karim; Daniau, Mailys; Sud, Amit; Law, Philip J.; Royer-Perron, Louis; Holroyd, Amy; Broderick, Peter; Went, Molly; Benazra, Marion; Ahle, Guido; Soubeyran, Pierre; Taillandier, Luc; Chinot, Olivier L.; Casasnovas, Olivier; Bay, Jacques-Olivier; Jardin, Fabrice; Oberic, Lucie; Fabbro, Michel; Damaj, Gandhi; Brion, Annie; Mokhtari, Karima; Philippe, Cathy; Sanson, Marc; Houillier, Caroline; Soussain, Carole; Hoang-Xuan, Khe; Houlston, Richard S.; Alentorn, Agusti; Moles-Moreau, Marie-Pierre; Gressin, Remy; Delwail, Vincent; Morschhauser, Franck; Agape, Philippe; Jaccard, Arnaud; Ghesquieres, Herve; Tempescul, Adrian; Gyan, Emmanuel; Marolleau, Jean-Pierre; Houot, Roch; Fornecker, Luc; Di Stefano, Anna-Luisa; Detrait, Ines; Rahimian, Amithys; Lathrop, Mark; Genet, Diane; Davi, Frederic; Cassoux, Nathalie; Touitou, Valerie; Choquet, Sylvain; Vital, Anne; Polivka, Marc; Figarella-Branger, Dominique; Benouaich-Amiel, Alexandra; Campello, Chantal; Charlotte, Frederic; Martin-Duverneuil, Nadine; Feuvret, Loic; Kas, Aurelie; Navarro, Soledad; Villa, Chiara; Bielle, Franck; Chretien, Fabrice; Tortel, Marie Christine; Gauchotte, Guillaume; Uro-Coste, Emmanuelle; Godfrain, Catherine; Rigau, Valerie; Costopoulos, Myrto; Le Garff-Tavernier, Magalie; Meyronnet, David; Rousseau, Audrey; Adam, Clovis; Lamy, Thierry; Chabrot, Cecile; Boyle, Eileen M.; Blonski, Marie; Schmitt, Anna Share Save Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for GliomaAtkins, Isabelle; Kinnersley, Ben; Ostrom, Quinn T.; Labreche, Karim; Il'yasova, Dora; Armstrong, Georgina N.; Eckel-Passow, Jeanette E.; Schoemaker, Minouk J.; Nothen, Markus M.; Barnholtz-Sloan, Jill S.; Swerdlow, Anthony J.; Simon, Matthias; Rajaraman, Preetha; Chanock, Stephen J.; Shildkraut, Joellen; Bernstein, Jonine L.; Hoffman, Per; Jockel, Karl-Heinz; Lai, Rose K.; Claus, Elizabeth B.; Olson, Sara H.; Johansen, Christoffer; Wrensch, Margaret R.; Melin, Beatrice; Jenkins, Robert B.; Sanson, Marc; Bondy, Melissa L.; Houlston, Richard S. Share Save Impact of atopy on risk of glioma: a Mendelian randomisation studyDisney-Hogg, Linden; Cornish, Alex J.; Sud, Amit; Law, Philip J.; Kinnersley, Ben; Jacobs, Daniel I.; Ostrom, Quinn T.; Labreche, Karim; Eckel-Passow, Jeanette E.; Armstrong, Georgina N.; Claus, Elizabeth B.; Il'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S.; Olson, Sara H.; Bernstein, Jonine L.; Lai, Rose K.; Schoemaker, Minouk J.; Simon, Matthias; Hoffmann, Per; Noethen, Markus M.; Joeckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B.; Melin, Beatrice S.; Wrensch, Margaret R.; Sanson, Marc; Bondy, Melissa L.; Houlston, Richard S. Share Save Influence of obesity-related risk factors in the aetiology of gliomaDisney-Hogg, Linden; Sud, Amit; Law, Philip J.; Cornish, Alex J.; Kinnersley, Ben; Ostrom, Quinn T.; Labreche, Karim; Eckel-Passow, Jeanette E.; Armstrong, Georgina N.; Claus, Elizabeth B.; Il'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S.; Olson, Sara H.; Bernstein, Jonine L.; Lai, Rose K.; Swerdlow, Anthony J.; Simon, Matthias; Hoffmann, Per; Noethen, Markus M.; Joeckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B.; Melin, Beatrice S.; Wrensch, Margaret R.; Sanson, Marc; Bondy, Melissa L.; Houlston, Richard S. Share Save Diffuse gliomas classified by 1p/19q co-deletion, TERT promoter and IDH mutation status are associated with specific genetic risk lociLabreche, Karim; Kinnersley, Ben; Berzero, Giulia; Di Stefano, Anna Luisa; Rahimian, Amithys; Detrait, Ines; Marie, Yannick; Grenier-Boley, Benjamin; Hoang-Xuan, Khe; Delattre, Jean-Yves; Idbaih, Ahmed; Houlston, Richard S.; Sanson, Marc Share Save Identification of novel recurrent ETV6-IgH fusions in primary central nervous system lymphomaBruno, Aurelie; Labreche, Karim; Daniau, Mailys; Boisselier, Blandine; Gauchotte, Guillaume; Royer-Perron, Louis; Rahimian, Amithys; Lemoine, Frederic; de la Grange, Pierre; Guegan, Justine; Bielle, Franck; Polivka, Marc; Adam, Clovis; Meyronet, David; Figarella-Branger, Dominique; Villa, Chiara; Chretien, Fabrice; Eimer, Sandrine; Davi, Frederic; Rousseau, Audrey; Houillier, Caroline; Soussain, Carole; Mokhtari, Karima; Hoang-Xuan, Khe; Alentorn, Agusti Share Save Mendelian randomisation study of the relationship between vitamin D and risk of gliomaTakahashi, Hannah; Cornish, Alex J.; Sud, Amit; Law, Philip J.; Kinnersley, Ben; Ostrom, Quinn T.; Labreche, Karim; Eckel-Passow, Jeanette E.; Armstrong, Georgina N.; Claus, Elizabeth B.; Il'yasova, Dora; Schildkraut, Joellen; Barnholtz-Sloan, Jill S.; Olson, Sara H.; Bernstein, Jonine L.; Lai, Rose K.; Schoemaker, Minouk J.; Simon, Matthias; Hoffmann, Per; Noethen, Markus M.; Joeckel, Karl-Heinz; Chanock, Stephen; Rajaraman, Preetha; Johansen, Christoffer; Jenkins, Robert B.; Melin, Beatrice S.; Wrensch, Margaret R.; Sanson, Marc; Bondy, Melissa L.; Turnbull, Clare; Houlston, Richard S. 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