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A

Alfred Wittinghofer

Max Planck Society

105H-index
514Paper Count
3.9WCitation Count
Published Papers 114
Publication Date
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Conformational switch and role of phosphorylation in PAK activation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err99
errOAAI
errBuchwald, G; Hostinova, E; Rudolph, MG; Kraemer, A; Sickmann, A; Meyer, HE; Scheffzek, K; Wittinghofer, A
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The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-28
err57
errOAAI
errDaub, M; Jöckel, J; Quack, T; Weber, CK; Schmitz, F; Rapp, UR; Wittinghofer, A; Block, C
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Biochemical characterization of the Ran-RanBP1-RanGAP system:: Are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction?
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err60
errOAAI
errSeewald, MJ; Kraemer, A; Farkasovsky, M; Körner, C; Wittinghofer, A; Vetter, IR
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Structure of the human BBSome core complex
errELIFE
IF0
err2020-01-17
err60
errOAAI
errKlink, Bjoern Udo; Gatsogiannis, Christos; Hofnagel, Oliver; Wittinghofer, Alfred; Raunser, Stefan
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errSave
Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells
errCELL CHEMICAL BIOLOGY
IF7.2
err2019-06-01
err8
errOAAI
errGarivet, Guillaume; Hofer, Walter; Konitsiotis, Antonios; Klein, Christian; Kaiser, Nadine; Mejuch, Tom; Fansa, Eyad; Alsaabi, Rania; Wittinghofer, Alfred; Bastiaens, Philippe I. H.; Waldmann, Herbert
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Characterization of a novel RP2-OSTF1 interaction and its implication for actin remodelling
errJOURNAL OF CELL SCIENCE
IF3.6
err2018-02-20
err7
errOAAI
errLyraki, Rodanthi; Lokaj, Mandy; Soares, Dinesh C.; Little, Abigail; Vermeren, Matthieu; Marsh, Joseph A.; Wittinghofer, Alfred; Hurd, Toby
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errSave
A recombinant BBSome core complex and how it interacts with ciliary cargo
errELIFE
IF0
err2017-11-15
err67
errOAAI
errKlink, Bjoern Udo; Zent, Eldar; Juneja, Puneet; Kuhlee, Anne; Raunser, Stefan; Wittinghofer, Alfred
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errSave
Small-Molecule Inhibition of the UNC119-Cargo Interaction
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2017-05-04
err16
PREAI
errMejuch, Tom; Garivet, Guillaume; Hofer, Walter; Kaiser, Nadine; Fansa, Eyad K.; Ehrt, Christiane; Koch, Oliver; Baumann, Matthias; Ziegler, Slava; Wittinghofer, Alfred; Waldmann, Herbert
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Covalent Protein Labeling at Glutamic Acids
errCELL CHEMICAL BIOLOGY
IF7.2
err2017-05-01
err75
errOAAI
errMartin-Gago, Pablo; Fansa, Eyad K.; Winzker, Michael; Murarka, Sandip; Janning, Petra; Schultz-Fademrecht, Carsten; Baumann, Matthias; Wittinghofer, Alfred; Waldmann, Herbert
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A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2017-01-20
err75
PREAI
errMartin-Gago, Pablo; Fansa, Eyad K.; Klein, Christian H.; Murarka, Sandip; Janning, Petra; Schuermann, Marc; Metz, Malte; Ismail, Shehab; Schultz-Fademrecht, Carsten; Baumann, Matthias; Bastiaens, Philippe I. H.; Wittinghofer, Alfred; Waldmann, Herbert
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Development of Pyridazinone Chemotypes Targeting the PDE Prenyl Binding Site
errCHEMISTRY-A EUROPEAN JOURNAL
IF3.7
err2016-11-03
err26
PREAI
errMurarka, Sandip; Martin-Gago, Pablo; Schultz-Fademrecht, Carsten; Al Saabi, Alaa; Baumann, Matthias; Fansa, Eyad K.; Ismail, Shehab; Nussbaumer, Peter; Wittinghofer, Alfred; Waldmann, Herbert
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Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2016-09-01
err46
errOAAI
errJaiswal, Mamta; Fansa, Eyad K.; Koesling, Stefanie K.; Mejuch, Tom; Waldmann, Herbert; Wittinghofer, Alfred
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errSave
GTP and ATP Hydrolysis in Biology
errBIOPOLYMERS
IF3.2
err2016-05-20
err10
errOAAI
errWittinghofer, Alfred
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errSave
Identification of pyrazolopyridazinones as PDEd inhibitors
errNATURE COMMUNICATIONS
IF15.7
err2016-04-20
err147
errOAAI
errPapke, Bjoern; Murarka, Sandip; Vogel, Holger A.; Martin-Gago, Pablo; Kovacevic, Marija; Truxius, Dina C.; Fansa, Eyad K.; Ismail, Shehab; Zimmermann, Gunther; Heinelt, Kaatje; Schultz-Fademrecht, Carsten; Al Saabi, Alaa; Baumann, Matthias; Nussbaumer, Peter; Wittinghofer, Alfred; Waldmann, Herbert; Bastiaens, Philippe I. H.
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Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering
errSCIENTIFIC REPORTS
IF3.9
err2016-04-18
err69
errOAAI
errBlazevits, Olga; Mideksa, Yonatan G.; Solman, Maja; Ligabue, Alessio; Ariotti, Nicholas; Nakhaeizadeh, Hossein; Fansa, Eyad K.; Papageorgiou, Anastassios C.; Wittinghofer, Alfred; Ahmadian, Mohammad R.; Abankwa, Daniel
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PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
errNATURE COMMUNICATIONS
IF15.7
err2016-04-11
err63
errOAAI
errFansa, Eyad Kalawy; Koesling, Stefanie Kristine; Zent, Eldar; Wittinghofer, Alfred; Ismail, Shehab
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A G-protein activation cascade from Arl13B to Arl3 and implications for ciliary targeting of lipidated proteins
errELIFE
IF0
err2015-11-09
err135
errOAAI
errGotthardt, Katja; Lokaj, Mandy; Koerner, Carolin; Falk, Nathalie; Giessl, Andreas; Wittinghofer, Alfred
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The N- and C-terminal ends of RPGR can bind to PDE6δ
errEMBO REPORTS
IF6.2
err2015-11-09
err15
errOAAI
errFansa, Eyad Kalawy; O'Reilly, Nicola J.; Ismail, Shehab; Wittinghofer, Alfred
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errSave
Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations
errBIOSCIENCE REPORTS
IF4.7
err2015-10-08
err20
errOAAI
errRudi, Katharina; Ho, Franz Y.; Gilsbach, Bernd K.; Pots, Henderikus; Wittinghofer, Alfred; Kortholt, Arjan; Klare, Johann P.
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Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Ar12/3
errBIOPHYSICAL JOURNAL
IF3.1
err2015-10-01
err13
errOAAI
errKapoor, Shobhna; Fansa, Eyad K.; Moebitz, Simone; Ismail, Shehab A.; Winter, Roland; Wittinghofer, Alfred; Weise, Katrin
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Dario R. Alessi
H-index: 141 · Papers: 541
S
Shuh Narumiya
H-index: 138 · Papers: 867
F
Frank McCormick
H-index: 130 · Papers: 786
A
Alfonso Valencia
H-index: 127 · Papers: 866
H
Helmut E. Meyer
H-index: 111 · Papers: 1.2K
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