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Paul R. Heath

University of Sheffield

53H-index
202Paper Count
9.3KCitation Count
Published Papers 70
Publication Date
Human amyotrophic lateral sclerosis/motor neuron disease: The disease-associated microglial pathway is upregulated while APOE genotype governs risk and survival
err2025-06-12
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errBridget A. Ashford; Julie E. Simpson; Charlotte Dawson; Delphine Boche; Johnathan Cooper-Knock; Paul R. Heath; Daniel Fillingham; Charlie Appleby-Mallinder; Wenbin Wei; Mark Dunning; J. Robin Highley
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Verification of molecular subtyping of bladder cancer in the GUSTO clinical trial
err2024-02-01
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errGriffin, Jon; Down, Jenny; Quayle, Lewis A.; Heath, Paul R.; Gibb, Ewan A.; Davicioni, Elai; Liu, Yang; Zhao, Xin; Swain, Jayne; Wang, Dennis; Hussain, Syed; Crabb, Simon; Catto, James W. F.
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Establishing mRNA and microRNA interactions driving disease heterogeneity in amyotrophic lateral sclerosis patient survival
err2023-12-07
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errWaller, Rachel; Bury, Joanna J.; Appleby-Mallinder, Charlie; Wyles, Matthew; Loxley, George; Babel, Aditi; Shekari, Saleh; Kazoka, Mbombe; Wollff, Helen; Al-Chalabi, Ammar; Heath, Paul R.; Shaw, Pamela J.; Kirby, Janine
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A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations
err2023-05-11
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errAllen, Scott P. P.; Al Sultan, Afnan; Kibirige, Elaine Kabucho; Tonkiss, Erin; Hamer, Keaton J. J.; Castelli, Lydia M. M.; Lin, Ya-Hui; Roscoe, Sarah; Stefanidis, Nikolaos; Mead, Richard J. J.; Highley, J. Robin; Cooper-Knock, Johnathan; Hautbergue, Guillaume M. M.; Heath, Paul R. R.; Kirby, Janine; Shaw, Pamela J. J.
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Spermatozoa, acts as an external cue and alters the cargo and production of the extracellular vesicles derived from oviductal epithelial cells in vitro
err2022-12-05
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errReshi, Qurat Ul Ain; Godakumara, Kasun; Ord, James; Dissanayake, Keerthie; Hasan, Mohammad Mehedi; Andronowska, Aneta; Heath, Paul; Fazeli, Alireza
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Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures
err2022-05-31
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errWaller, Rachel; Hase, Yoshiki; Simpson, Julie E.; Heath, Paul R.; Wyles, Matthew; Kalaria, Rajesh N.; Wharton, Stephen B.
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Sorting nexin 24 is required for α-granule biogenesis and cargo delivery in megakaryocytes
err2022-01-13
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errLacey, Joanne; Webster, Simon J.; Heath, Paul R.; Hill, Chris J.; Nicholson-Goult, Lucinda; Wagner, Bart E.; Khan, Abdullah O.; Morgan, Neil, V; Makris, Michael; Daly, Martina E.
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SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis
err2021-08-10
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errCastelli, Lydia M.; Cutillo, Luisa; Souza, Cleide Dos Santos; Sanchez-Martinez, Alvaro; Granata, Ilaria; Lin, Ya-Hui; Myszczynska, Monika A.; Heath, Paul R.; Livesey, Matthew R.; Ning, Ke; Azzouz, Mimoun; Shaw, Pamela J.; Guarracino, Mario R.; Whitworth, Alexander J.; Ferraiuolo, Laura; Milo, Marta; Hautbergue, Guillaume M.
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IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer
err2021-07-21
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errTulotta, Claudia; Lefley, Diane V.; Moore, Charlotte K.; Amariutei, Ana E.; Spicer-Hadlington, Amy R.; Quayle, Lewis A.; Hughes, Russell O.; Ahmed, Khawla; Cookson, Victoria; Evans, Catherine A.; Vadakekolathu, Jayakumar; Heath, Paul; Francis, Sheila; Pinteaux, Emmanuel; Pockley, A. Graham; Ottewell, Penelope D.
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Amyotrophic lateral sclerosis transcriptomics reveals immunological effects of low-dose interleukin-2
err2021-06-29
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errGiovannelli, Ilaria; Bayatti, Nadhim; Brown, Abigail; Wang, Dennis; Mickunas, Marius; Camu, William; Veyrune, Jean-Luc; Payan, Christine; Garlanda, Cecilia; Locati, Massimo; Juntas-Morales, Raul; Pageot, Nicolas; Malaspina, Andrea; Andreasson, Ulf; Suehs, Carey; Saker, Safa; Masseguin, Christophe; de Vos, John; Zetterberg, Henrik; Al-Chalabi, Ammar; Leigh, P. Nigel; Tree, Timothy; Bensimon, Gilbert; Heath, Paul R.; Shaw, Pamela J.; Kirby, Janine
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Integrative molecular characterization of pediatric spinal ependymoma: the UK Children's Cancer and Leukaemia Group study
err2021-03-08
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errAhmad, Omar; Chapman, Rebecca; Storer, Lisa C.; Luo, Li; Heath, Paul R.; Resar, Linda; Cohen, Kenneth J.; Grundy, Richard G.; Lourdusamy, Anbarasu
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Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer's and small vessel disease pathologies
err2021-02-15
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errWaller, Rachel; Narramore, Ruth; Simpson, Julie E.; Heath, Paul R.; Verma, Nikita; Tinsley, Megan; Barnes, Jordan R.; Haris, Hanna T.; Henderson, Frances E.; Matthews, Fiona E.; Richardson, Connor D.; Brayne, Carol; Ince, Paul G.; Kalaria, Raj N.; Wharton, Stephen B.
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Value of systematic genetic screening of patients with amyotrophic lateral sclerosis
err2021-02-14
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errShepheard, Stephanie R.; Parker, Matthew D.; Cooper-Knock, Johnathan; Verber, Nick S.; Tuddenham, Lee; Heath, Paul; Beauchamp, Nick; Place, Elsie; Sollars, Elizabeth S. A.; Turner, Martin R.; Malaspina, Andrea; Fratta, Pietro; Hewamadduma, Channa; Jenkins, Thomas M.; McDermott, Christopher J.; Wang, Dennis; Kirby, Janine; Shaw, Pamela J.
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Comparison and optimisation of microRNA extraction from the plasma of healthy pregnant women
err2021-02-05
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errParker, Victoria L.; Cushen, Bryony F.; Gavriil, Eleftherios; Marshall, Benjamin; Waite, Sarah; Pacey, Allan; Heath, Paul R.
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Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropatho-logic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort
err2020-08-07
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errChambers, Annabelle; Bury, Joanna J.; Minett, Thais; Richardson, Connor D.; Brayne, Carol; Ince, Paul G.; Shaw, Pamela J.; Garwood, Claire J.; Heath, Paul R.; Simpson, Julie E.; Matthews, Fiona E.; Wharton, Stephen B.
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Review: Microglia in motor neuron disease
err2020-07-21
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errAshford, B. A.; Boche, D.; Cooper-Knock, J.; Heath, P. R.; Simpson, J. E.; Highley, J. R.
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TDP43 proteinopathy is associated with aberrant DNA methylation in human amyotrophic lateral sclerosis
err2020-05-19
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errAppleby-Mallinder, C.; Schaber, E.; Kirby, J.; Shaw, P. J.; Cooper-Knock, J.; Heath, P. R.; Highley, J. R.
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Neuropathological characterization of a novel TANK binding kinase (TBK1) gene loss of function mutation associated with amyotrophic lateral sclerosis
err2019-10-28
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errWeinreich, M.; Shepheard, S. R.; Verber, N.; Wyles, M.; Heath, P. R.; Highley, J. R.; Kirby, J.; Shaw, P. J.
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C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis
errBRAIN
IF11.7
err2019-10-24
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errAllen, Scott P.; Hall, Benjamin; Woof, Ryan; Francis, Laura; Gatto, Noemi; Shaw, Allan C.; Myszczynska, Monika; Hemingway, Jordan; Coldicott, Ian; Willcock, Amelia; Job, Lucy; Hughes, Rachel M.; Boschian, Camilla; Bayatti, Nadhim; Heath, Paul R.; Bandmann, Oliver; Mortiboys, Heather; Ferraiuolo, Laura; Shaw, Pamela J.
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