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D

Douglas A. Melton

Harvard University

122H-index
280Paper Count
7.3WCitation Count
Published Papers 90
Publication Date
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Improving cellular fitness of human stem cell-derived islets under hypoxia
errNATURE COMMUNICATIONS
IF15.7
err2025-05-23
err0
errOAAI
errWang, Xi; Brielle, Shlomi; Kenty-Ryu, Jennifer; Korover, Nataly; Bavli, Danny; Pop, Ramona; Melton, Douglas A.
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errSave
Repurposing the Antihypertensive Agent Hydralazine As an Inhibitor of the Base Excision Repair Enzyme APE1
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2024-12-24
err0
PREAI
errIslam, Tanhaul; Nunna, Venkatrao; Liyanarachchi, Don Pivithuru; Melton, Douglas; Lewis, Calvin D.; Gates, Kent S.
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errSave
Ultrafast Reaction of the Drug Hydralazine with Apurinic/Apyrimidinic Sites in DNA Gives Rise to a Stable Triazolo[3,4-a]phthalazine Adduct
errCHEMICAL RESEARCH IN TOXICOLOGY
IF3.8
err2024-05-14
err4
PREAI
errIslam, Tanhaul; Shim, Garam; Melton, Douglas; Lewis, Calvin D.; Lei, Zhentian; Gates, Kent S.
errShare
errSave
Glucose-Dependent Insulin Production and Insulin-Independence in Type 1 Diabetes from Stem Cell-Derived, Fully Differentiated Islet Cells-Updated Data from the VX-880 Clinical Trial
errDIABETES
IF7.5
err2023-06-23
err28
PREAI
errReichman, Trevor W.; Ricordi, Camillo; Naji, Ali; Markmann, James F.; Perkins, Bruce A.; Wijkstrom, Martin; Paraskevas, Steven; Bruinsma, Bote; Marigowda, Gautham; Shih, Judy L.; Wang, Chenkun; Melton, Douglas; Pagliuca, Felicia; Sanna, Bastiano; Kean, Leslie S.; Peters, Anne L.; Witkowski, Piotr; Rickels, Michael R.
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errSave
Matters arising: Insufficient evidence that pancreatic b cells are derived from adult ductal Neurog3-expressing progenitors
errCELL STEM CELL
IF20.4
err2023-04-01
err7
errOAAI
errMagenheim, Judith; Maestro, Miguel Angel; Sharon, Nadav; Herrera, Pedro L.; Murtaugh, L. Charles; Kopp, Janel; Sander, Maike; Gu, Guoqiang; Melton, Douglas A.; Ferrer, Jorge; Dor, Yuval
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errSave
Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
errCELL REPORTS MEDICINE
IF10.6
err2023-01-01
err27
errOAAI
errGerace, Dario; Zhou, Qua; Kenty, Jennifer Hyoje-Ryu; Veres, Adrian; Sintov, Elad; Wang, Xi; Boulanger, Kyle R.; Li, Hongfei; Melton, Douglas A.
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errSave
Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets
errSTEM CELL REPORTS
IF5.1
err2022-09-01
err25
errOAAI
errSintov, Elad; Nikolskiy, Igor; Barrera, Victor; Kenty, Jennifer Hyoje-Ryu; Atkin, Alexander S.; Gerace, Dario; Sui, Shannan J. Ho; Boulanger, Kyle; Melton, Douglas A.
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errSave
Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro
errSTEM CELL REPORTS
IF5.1
err2022-04-01
err18
errOAAI
errLeite, Nayara C.; Pelayo, Gabriela C.; Melton, Douglas A.
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errSave
A therapeutic convection-enhanced macroencapsulation device for enhancing β cell viability and insulin secretion
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2021-09-09
err32
errOAAI
errYang, Kisuk; O'Cearbhaill, Eoin D.; Liu, Sophie S.; Zhou, Angela; Chitnis, Girish D.; Hamilos, Allison E.; Xu, Jun; Verma, Mohan K. S.; Giraldo, Jaime A.; Kudo, Yoshimasa; Lee, Eunjee A.; Lee, Yuhan; Pop, Ramona; Langer, Robert; Melton, Douglas A.; Greiner, Dale L.; Karp, Jeffrey M.
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errSave
The promise of stem cell-derived islet replacement therapy
errDIABETOLOGIA
IF10.2
err2021-01-16
err63
errOAAI
errMelton, Douglas
errShare
errSave
Building Biomimetic Potency Tests for Islet Transplantation
errDIABETES
IF7.5
err2021-01-14
err14
errOAAI
errGlieberman, Aaron L.; Pope, Benjamin D.; Melton, Douglas A.; Parker, Kevin Kit
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errSave
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells
errSCIENCE ADVANCES
IF12.5
err2020-11-20
err24
errOAAI
errYang, Kisuk; Lee, Miseon; Jones, Peter Anthony; Liu, Sophie S.; Zhou, Angela; Xu, Jun; Sreekanth, Vedagopuram; Wu, Jamie L. Y.; Vo, Lillian; Lee, Eunjee A.; Pop, Ramona; Lee, Yuhan; Wagner, Bridget K.; Melton, Douglas A.; Choudhary, Amit; Karp, Jeffrey M.
errShare
errSave
Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells
errCELL REPORTS
IF6.9
err2020-07-01
err59
errOAAI
errLeite, Nayara C.; Sintov, Elad; Meissner, Torsten B.; Brehm, Michael A.; Greiner, Dale L.; Harlan, David M.; Melton, Douglas A.
errShare
errSave
A method for the generation of human stem cell-derived alpha cells
errNATURE COMMUNICATIONS
IF15.7
err2020-05-07
err57
errOAAI
errPeterson, Quinn P.; Veres, Adrian; Chen, Lihua; Slama, Michael Q.; Kenty, Jennifer H. R.; Hassoun, Shaimaa; Brown, Matthew R.; Dou, Haiqiang; Duffy, Caden D.; Zhou, Quan; Matveyenko, Aleksey V.; Tyrberg, Bjoern; Soerhede-Winzell, Maria; Rorsman, Patrik; Melton, Douglas A.
errShare
errSave
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion
errCELL METABOLISM
IF30.9
err2020-05-01
err91
errOAAI
errHelman, Aharon; Cangelosi, Andrew L.; Davis, Jeffrey C.; Quan Pham; Rothman, Arielle; Faust, Aubrey L.; Straubhaar, Juerg R.; Sabatini, David M.; Melton, Douglas A.
errShare
errSave
Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis
errCELL REPORTS
IF6.9
err2020-05-01
err75
errOAAI
errDavis, Jeffrey C.; Alves, Tiago C.; Helman, Aharon; Chen, Jonathan C.; Kenty, Jennifer H.; Cardone, Rebecca L.; Liu, David R.; Kibbey, Richard G.; Melton, Douglas A.
errShare
errSave
Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice
errSCIENTIFIC REPORTS
IF3.9
err2020-03-12
err21
errOAAI
errWalker, Ryan G.; Barrandon, Ornella; Poggioli, Tommaso; Dagdeviren, Sezin; Carroll, Shannon H.; Mills, Melanie J.; Mendello, Kourtney R.; Gomez, Yanet; Loffredo, Francesco S.; Pancoast, James R.; Macias-Trevino, Claudio; Marts, Colin; LeClair, Katherine B.; Noh, Hye-Lim; Kim, Taekyoon; Banks, Alexander S.; Kim, Jason K.; Cohen, David E.; Wagers, Amy J.; Melton, Douglas A.; Lee, Richard T.
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errSave
Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells
errCELL METABOLISM
IF30.9
err2020-02-01
err25
errOAAI
errRosado-Olivieri, Edwin A.; Aigha, Idil I.; Kenty, Jennifer H.; Melton, Douglas A.
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errSave
Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells via p53-Induced Quiescence
errCIRCULATION
IF38.6
err2020-01-28
err93
errOAAI
errGarbern, Jessica C.; Helman, Aharon; Sereda, Rebecca; Sarikhani, Mohsen; Ahmed, Aishah; Escalante, Gabriela O.; Ogurlu, Roza; Kim, Sean L.; Zimmerman, John F.; Cho, Alexander; MacQueen, Luke; Bezzerides, Vassilios J.; Parker, Kevin Kit; Melton, Douglas A.; Lee, Richard T.
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errSave
Midkine is a dual regulator of wound epidermis development and inflammation during the initiation of limb regeneration
errELIFE
IF0
err2020-01-14
err31
errOAAI
errTsai, Stephanie L.; Baselga-Garriga, Clara; Melton, Douglas A.
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errSave

Research Directions

No research directions
Co-authors
Cooperation Journals
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I
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R
Rudolf Jaenisch
H-index: 209 · Papers: 802
A
Andrew P. McMahon
H-index: 173 · Papers: 477
S
Stephen J. Elledge
H-index: 172 · Papers: 542
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