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Screening of candidate analgesics using a patient-derived human iPSC model of nociception identifies putative compounds for therapeutic treatment Thornton, Jack R.; Capurro, Alberto; Harwood, Sally; Henderson, Thomas C.; Unsworth, Adrienne; Gortler, Franziska; Nagaraja-Grellscheid, Sushma; Telezhkin, Vsevolod; Lako, Majlinda; Sernagor, Evelyne; Armstrong, Lyle Share Save
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Unravelling genotype-phenotype correlations in Stargardt disease using patient-derived retinal organoids Watson, Avril; Queen, Rachel; Ferrandez-Peral, Luis; Dorgau, Birthe; Collin, Joseph; Nelson, Andrew; Hussain, Rafiqul; Coxhead, Jonathan; Mccorkindale, Michael; Atkinson, Robert; Zerti, Darin; Chichagova, Valeria; Conesa, Ana; Armstrong, Lyle; Cremers, Frans P. M.; Lako, Majlinda Share Save
Deciphering the impact of PROM1 alternative splicing on human photoreceptor development and maturation Moya-Molina, Marina; Dorgau, Birthe; Flood, Emily; Letteboer, Stef J. F.; Lorentzen, Esben; Coxhead, Jonathan; Smith, Graham; Roepman, Ronald; Nagaraja Grellscheid, Sushma; Armstrong, Lyle; Lako, Majlinda Share Save
Retinal cells derived from patients with DRAM2-dependent CORD21 dystrophy exhibit key lysosomal enzyme deficiency and lysosomal content accumulation Tsikandelova, Rozaliya; Galo, Eldo; Cerniauskas, Edvinas; Hallam, Dean; Georgiou, Maria; Cerna-Chavez, Rodrigo; Atkinson, Robert; Palmowski, Pavel; Burte, Florence; Davies, Tracey; Steel, David H.; McKibbin, Martin; Bond, Jacquelyn; Haggarty, Jennifer; Whitfield, Phil; Korolchuk, Viktor; Armstrong, Lyle; Yang, Chunbo; Dorgau, Birthe; Kurzawa-Akanbi, Marzena; Lako, Majlinda Share Save
Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retina Dorgau, Birthe; Collin, Joseph; Rozanska, Agata; Zerti, Darin; Unsworth, Adrienne; Crosier, Moira; Hussain, Rafiqul; Coxhead, Jonathan; Dhanaseelan, Tamil; Patel, Aara; Sowden, Jane C.; FitzPatrick, David R.; Queen, Rachel; Lako, Majlinda Share Save
PRPF8-mediated dysregulation of hBrr2 helicase disrupts human spliceosome kinetics and 5-splice-site selection causing tissue-specific defects Atkinson, Robert; Georgiou, Maria; Yang, Chunbo; Szymanska, Katarzyna; Lahat, Albert; Vasconcelos, Elton J. R.; Ji, Yanlong; Molina, Marina Moya; Collin, Joseph; Queen, Rachel; Dorgau, Birthe; Watson, Avril; Kurzawa-Akanbi, Marzena; Laws, Ross; Saxena, Abhijit; Beh, Chia Shyan; Siachisumo, Chileleko; Goertler, Franziska; Karwatka, Magdalena; Davey, Tracey; Inglehearn, Chris F.; Mckibbin, Martin; Luehrmann, Reinhard; Steel, David H.; Elliott, David J.; Armstrong, Lyle; Urlaub, Henning; Ali, Robin R.; Grellscheid, Sushma-Nagaraja; Johnson, Colin A.; Mozaffari-Jovin, Sina; Lako, Majlinda Share Save
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Single-cell RNA sequencing reveals transcriptional changes of human choroidal and retinal pigment epithelium cells during fetal development, in healthy adult and intermediate age-related macular degeneration Collin, Joseph; Hasoon, Megan S. R.; Zerti, Darin; Hammadi, Sarah; Dorgau, Birthe; Clarke, Lucy; Steel, David; Hussain, Rafiqul; Coxhead, Jonathan; Lisgo, Steven; Queen, Rachel; Lako, Majlinda Share Save
Retinal pigment epithelium extracellular vesicles are potent inducers of age-related macular degeneration disease phenotype in the outer retina Kurzawa-Akanbi, Marzena; Whitfield, Phillip; Burte, Florence; Bertelli, Pietro Maria; Pathak, Varun; Doherty, Mary; Hilgen, Birthe; Gliaudelyte, Lina; Platt, Mark; Queen, Rachel; Coxhead, Jonathan; Porter, Andrew; Oberg, Maria; Fabrikova, Daniela; Davey, Tracey; Beh, Chia Shyan; Georgiou, Maria; Collin, Joseph; Boczonadi, Veronika; Hartlova, Anetta; Taggart, Michael; Al-Aama, Jumana; Korolchuk, Viktor, I; Morris, Christopher M.; Guduric-Fuchs, Jasenka; Steel, David H.; Medina, Reinhold J.; Armstrong, Lyle; Lako, Majlinda Share Save
Conjunctival epithelial cells resist productive SARS-CoV-2 infection Jackson, Robert M.; Hatton, Catherine F.; Spegarova, Jarmila Stremenova; Georgiou, Maria; Collin, Joseph; Stephenson, Emily; Verdon, Bernard; Haq, Iram J.; Hussain, Rafiqul; Coxhead, Jonathan M.; Mudhar, Hardeep-Singh; Wagner, Bart; Hasoon, Megan; Davey, Tracey; Rooney, Paul; Khan, C. M. Anjam; Ward, Chris; Brodlie, Malcolm; Haniffa, Muzlifah; Hambleton, Sophie; Armstrong, Lyle; Figueiredo, Francisco; Queen, Rachel; Duncan, Christopher J. A.; Lako, Majlinda Share Save
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pRB-Depleted Pluripotent Stem Cell Retinal Organoids Recapitulate Cell State Transitions of Retinoblastoma Development and Suggest an Important Role for pRB in Retinal Cell Differentiation Rozanska, Agata; Cerna-Chavez, Rodrigo; Queen, Rachel; Collin, Joseph; Zerti, Darin; Dorgau, Birthe; Beh, Chia Shyan; Davey, Tracey; Coxhead, Jonathan; Hussain, Rafiqul; Al-Aama, Jumana; Steel, David H.; Benvenisty, Nissim; Armstrong, Lyle; Parulekar, Manoj; Lako, Majlinda Share Save
Activation of autophagy reverses progressive and deleterious protein aggregation in PRPF31 patient-induced pluripotent stem cell-derived retinal pigment epithelium cells Georgiou, Maria; Yang, Chunbo; Atkinson, Robert; Pan, Kuan-Ting; Buskin, Adriana; Molina, Marina Moya; Collin, Joseph; Al-Aama, Jumana; Goertler, Franziska; Ludwig, Sebastian E. J.; Davey, Tracey; Luhrmann, Reinhard; Nagaraja-Grellscheid, Sushma; Johnson, Colin A.; Ali, Robin; Armstrong, Lyle; Korolchuk, Viktor; Urlaub, Henning; Mozaffari-Jovin, Sina; Lako, Majlinda Share Save
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: a Comprehensive Validation Using Drugs and Compounds Affecting the Retina Dorgau, Birthe; Georgiou, Maria; Chaudhary, Alexander; Moya-Molina, Marina; Collin, Joseph; Queen, Rachel; Hilgen, Gerrit; Davey, Tracey; Hewitt, Philip; Schmitt, Michael; Kustermann, Stefan; Pognan, Francois; Steel, David H.; Sernagor, Evelyne; Armstrong, Lyle; Lako, Majlinda Share Save
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