chance and necessity in evolutionyeast as an experimental systemmutation rate, molecular spectrum, and fitness effectepistasis and fitness landscapespleiotropy and evolutionary impactsgene expression evolutiongenomic basis of adaptationexperimental speciationexperimental evolutionmutation accumulationgenome and transcriptome sequencinggenome editingcomputational evolutionary genomicsplasticitygene expression and expression noiseposttranscriptional modificationconvergent evolutionnatural and sexual selectionhuman phenotypic variation and evolutionevolutionary genetics and genomicsmolecular and genome evolution