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D

Daniel B. Graham

massachusetts general hospital

47H-index
153Paper Count
1.2WCitation Count
Published Papers 71
Publication Date
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Population-scale immune multiome atlas reveals regulatory disease mechanisms
errNature
IF48.5
err2026-09-30
err0
PREAI
errMasahiro Kanai; Toni M. Delorey; Jarno Honkanen; Rodosthenis S. Rodosthenous; Julianna Juvila; Shane Murphy; Isabella Teixeira-Soldano; Hee Seung Hwang; Juha Karjalainen; Jussi Halonen; Georgia Panagiotaropoulou; Yuanxiang Zhang; Cristin McCabe; Eric Chen; Kosaku Nanki; Toshimi Yoshida; Kai Liu; Marla Glean; Nitya Mehrotra; Emily P. Finan; Daniel Chafamo; Yixiao Zhu; Mikko Arvas; Sanni Ruotsalainen; Zhili Zheng; Yoshihiko Tomofuji; Daiki Tokuyasu; Shinichi Namba; Kyuto Sonehara; Yukinori Okada; Mary Pat Reeve; Mitja Kurki; Caroline B. M. Porter; Orr Ashenberg; Wei Zhou; Kimmo Pitkänen; Jukka Partanen; Aarno Palotie; Daniel B. Graham; Mark J. Daly; Ramnik J. Xavier
errShare
errSave
A structure-informed deep learning framework for modeling TCR-peptide-HLA interactions
errNature Communications
IF15.7
err2026-09-25
err0
errOAAI
errKai Cao; Rui Li; Martin Stražar; Eric M. Brown; Phuong N. U. Nguyen; Marie-Madlen Pust; Jihye Park; Daniel B. Graham; Orr Ashenberg; Caroline Uhler; Ramnik J. Xavier
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errSave
Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology
errImmunity
IF26.3
err2026-04-27
err0
PREAI
errDaniel B. Graham; Ramnik J. Xavier
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errSave
Identifying microbial protease allergens through protein language model-guided homology
errCell Systems
IF7.7
err2026-02-20
err0
errOAAI
errKumar Thurimella; Elena Wu; Chenhao Li; Daniel B. Graham; Róisín M. Owens; Damian R. Plichta; Caroline L. Sokol; Ramnik J. Xavier; Sergio Bacallado
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errSave
Genome-wide association analyses of autoimmune hypothyroidism reveal autoimmune and thyroid-specific contributions and an inverse relationship with cancer risk
errNature Genetics
IF29
err2026-02-01
err0
errOAAI
errReeve, Mary Pat; Kanai, Masahiro; Graham, Daniel B.; Karjalainen, Juha; Luo, Shuang; Kolosov, Nikita; Adams, Cameron; Ritari, Jarmo; Karczewski, Konrad J.; Kiiskinen, Tuomo; Jiang, Yu; Fuller, Zachary; Mehtonen, Juha; Kurki, Mitja I.; Khan, Zia; Daly, Mark J.; Partanen, Jukka; McCarthy, Mark I.; Artomov, Mykyta; Palotie, Aarno; Tuomi, Tiinamaija; Pirinen, Matti; Kero, Jukka; Xavier, Ramnik J.; Ripatti, Samuli
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errSave
Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell circuit
errNature
IF48.5
err2026-01-07
err0
errOAAI
errVladislav Pokatayev; Alok Jaiswal; Angela R. Shih; Åsa Segerstolpe; Bihua Li; Elizabeth A. Creasey; Yanhua Zhao; Crystal Lin; Shane Murphy; Chih-Hung Chou; Daniel B. Graham; Ramnik J. Xavier
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errSave
Real-World Treatment Patterns and Burden of Chronic Thromboembolic Pulmonary Hypertension Patients across Consultation Settings in the USA
errPulmonary Therapy
IF3
err2025-12-01
err0
errOAAI
errRivera-Lebron, Belinda; Witkin, Alison; Paoli, Carly J.; Small, Mark; Harvey, Mia; Graham, Daniel; Panjabi, Sumeet; Rendon, Gabriela Gomez; Rodriguez-Lopez, Josanna
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errSave
Allosteric modulation of the solute carrier transporter SLC39A8 potentiates manganese and cadmium uptake
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2025-11-03
err0
PREAI
errDamm-Ganamet, Kelly L.; Moon, Clara; Wickenden, Alan D.; Tichenor, Mark; Ge, Yunhui; Mercado-Marin, Eduardo, V; Chiou, Brian; Manughian-Peter, Ayla; Mirzadegan, Taraneh; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.; Graham, Daniel B.; Perrigoue, Jacqueline
errShare
errSave
Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation
errScience
IF45.8
err2025-10-30
err0
PREAI
errPeng Tan; Alok Jaiswal; Shane P. Murphy; Eric M. Brown; Hailey Wheeler; Chien-Wen Su; Emily P. Finan; Guadalupe J. Jasso; Hai Ning Shi; Daniel B. Graham; Toni M. Delorey; Jacques Deguine; Ramnik J. Xavier
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errSave
Autoimmune disease risk gene ANKRD55 promotes TH17 effector function through metabolic modulation
errJOURNAL OF EXPERIMENTAL MEDICINE
IF10.6
err2025-09-11
err0
PREAI
errXu, Jinjin; Kong, Lingjia; Creasey, Elizabeth A.; Rath, Sneha; Deng, Lei; Avila-Pacheco, Julian; Li, Chenhao; Oliver, Blayne A.; Dao, Tyler T.; Shih, Angela R.; Daly, Mark J.; Shalek, Alex K.; Clish, Clary B.; Graham, Daniel B.; Deguine, Jacques; Xavier, Ramnik J.
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errSave
Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network
errNature Genetics
IF0
err2025-06-25
err0
PREAI
errLingjia Kong; Sathish Subramanian; Åsa Segerstolpe; Vy Tran; Angela R. Shih; Grace T. Carter; Hiroko Kunitake; Shaina W. Twardus; Jasmine Li; Shivam Gandhi; Marco E. Kaper; Christy Cauley; Eric J. Chen; Caroline B. M. Porter; Toni M. Delorey; Liliana Bordeianou; Rocco Ricciardi; Ashwin N. Ananthakrishnan; Helena Lau; Daniel B. Graham; Richard Hodin; Jacques Deguine; Christopher S. Smillie; Ramnik J. Xavier
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errSave
Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway
errCell Host & Microbe
IF18.7
err2025-05-30
err0
PREAI
errEric M. Brown; Emily R. Temple; Sarah Jeanfavre; Julian Avila-Pacheco; Noel Taylor; Kai Liu; Phuong N.U. Nguyen; Ahmed M.T. Mohamed; Panhasith Ung; Rebecca A. Walker; Daniel B. Graham; Clary B. Clish; Ramnik J. Xavier
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errSave
The Ulcerative Colitis-Associated Gene NXPE1 Catalyzes Glycan Modifications on Colonic Mucin
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2025-03-11
err0
errOAAI
errHumeidi, Ranad; Oshiro-Rapley, Noriko; Gu, Xiebin; An, Joon Soo; Ananthakrishnan, Ashwin N.; Creasey, Elizabeth A.; Daly, Mark J.; Schreiber, Stuart L.; Graham, Daniel B.; Seyedsayamdost, Mohammad R.; Xavier, Ramnik J.
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errSave
Extraaxial Poorly Differentiated Chordoma: Clinicopathologic and Molecular Genetic Characterization
errMODERN PATHOLOGY
IF5.5
err2025-03-01
err0
PREAI
errSande, William J.; Folpe, Andrew L.; O'Connor, Paige; Graham, Daniel; Molligan, Jeremy F.; Lo, Ying-Chun; Cheung, Yvonne Y.; Ameline, Baptiste; Baumhoer, Daniel; Harder, Dorothee; Raskin, Kevin A.; Mount, Christopher W.; Hung, Yin P.; Nielsen, Gunnlaugur Petur; Kerr, Darcy A.; Buehler, Darya; Wenger, Doris E.; Thangaiah, Judith Jebastin
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errSave
Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation
errSCIENCE ADVANCES
IF12.5
err2024-07-19
err1
errOAAI
errNeale, Ilona; Reddy, Clark; Tan, Zher Yin; Li, Bihua; Nag, Partha P.; Park, Joshua; Park, Jihye; Carey, Kimberly L.; Graham, Daniel B.; Xavier, Ramnik J.
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errSave
An esophagus cell atlas reveals dynamic rewiring during active eosinophilic esophagitis and remission
errNATURE COMMUNICATIONS
IF15.7
err2024-04-18
err8
errOAAI
errDing, Jiarui; Garber, John J.; Uchida, Amiko; Lefkovith, Ariel; Carter, Grace T.; Vimalathas, Praveen; Canha, Lauren; Dougan, Michael; Staller, Kyle; Yarze, Joseph; Delorey, Toni M.; Rozenblatt-Rosen, Orit; Ashenberg, Orr; Graham, Daniel B.; Deguine, Jacques; Regev, Aviv; Xavier, Ramnik J.
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errSave
Atypical Spindle Cell/Pleomorphic Lipomatous Tumor With Sarcomatous Transformation: Clinicopathologic and Molecular Analysis of 4 Cases
errMODERN PATHOLOGY
IF5.5
err2024-04-01
err1
PREAI
errPerret, Raul; Charville, Gregory W.; Alame, Melissa; Rebier, Flora; Soubeyran, Isabelle; Gross, John M.; Graham, Daniel; Green, Donald C.; Kerr, Darcy A.; Khan, Wahab A.; Cloutier, Jeffrey M.
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errSave
Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses
errCELL REPORTS
IF6.9
err2024-03-01
err0
errOAAI
errBrandt, Marta; Cao, Zhifang; Krishna, Chirag; Reedy, Jennifer L.; Gu, Xiebin; Dutko, Richard A.; Oliver, Blayne A.; Tusi, Betsabeh Khoramian; Park, Jihye; Richey, Lauren; Segerstolpe, Asa; Litwiler, Scott; Creasey, Elizabeth A.; Carey, Kimberly L.; Vyas, Jatin M.; Graham, Daniel B.; Xavier, Ramnik J.
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errSave
Identification of highly selective SIK 1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-12-26
err7
errOAAI
errBabbe, Holger; Sundberg, Thomas B.; Tichenor, Mark; Seierstad, Mark; Bacani, Genesis; Berstler, James; Chai, Wenying; Chang, Leon; Chung, De Michael; Coe, Kevin; Collins, Bernard; Finley, Michael; Guletsky, Alexander; Lemke, Christopher T.; Mak, Puiying A.; Mathur, Ashok; Mercado-Marin, Eduardo, V; Metkar, Shailesh; Raymond, Donald D.; Rives, Marie -Laure; Rizzolio, Michele; Shaffer, Paul L.; Smith, Russell; Smith, Jacqueline; Steele, Ruth; Steffens, Helena; Suarez, Javier; Tian, Gaochao; Majewski, Nathan; Volak, Laurie P.; Wei, Jianmei; Desai, Prerak T.; Ong, Luvena L.; Koudriakova, Tatiana; Goldberg, Steven D.; Hirst, Gavin; Kaushik, Virendar K.; Ort, Tatiana; Seth, Nilufer; Graham, Daniel B.; Plevy, Scott; Venable, Jennifer D.; Xavier, Ramnik J.; Towne, Jennifer E.
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The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon (vol 56, pg 444, 2023)
errIMMUNITY
IF26.3
err2023-12-01
err3
errOAAI
errKong, Lingjia; Pokatayev, Vladislav; Lefkovith, Ariel; Carter, Grace T.; Creasey, Elizabeth A.; Krishna, Chirag; Subramanian, Sathish; Kochar, Bharati; Ashenberg, Orr; Lau, Helena; Ananthakrishnan, Ashwin N.; Graham, Daniel B.; Deguine, Jacques; Xavier, Ramnik J.
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Research Directions

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Co-authors
Cooperation Journals
M
Mark J. Daly
H-index: 224 · Papers: 1.2K
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Stacey Gabriel
H-index: 220 · Papers: 938
A
Aviv Regev
H-index: 208 · Papers: 965
C
Charles A. Dinarello
H-index: 196 · Papers: 1.2K
S
Stefan Schreiber
H-index: 192 · Papers: 1.9K
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