Simon T. Barry - Publications, H-index & Citations

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Simon T. Barry

astrazeneca

57H-index

552Paper Count

1.4WCitation Count

Published Papers 146

Publication Date

Harnessing myeloid cell plasticity for cancer therapy

Nature Cancer

IF28.5

2026-05-12

PREAI

Emilio Sanseviero; Simon T. Barry; Dmitry I. Gabrilovich

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Probing intratumoral metabolic compartmentalisation in a patient with fumarate hydratase-deficient renal cancer using clinical hyperpolarised 13C-MRI and mass spectrometry imaging

Communications Medicine

IF6.3

2026-01-13

OAAI

Ines Horvat-Menih; Ruth Casey; James Denholm; Gregory Hamm; Heather Hulme; John Gallon; Alixander S. Khan; Joshua Kaggie; Andrew B. Gill; Andrew N. Priest; Joao A. G. Duarte; Cissy Yong; Cara Brodie; James Whitworth; Simon T. Barry; Richard J. A. Goodwin; Shubha Anand; Marc Dodd; Katherine Honan; Sarah J. Welsh; Anne Y. Warren; Tevita Aho; Grant D. Stewart; Thomas J. Mitchell; Mary A. McLean; Ferdia A. Gallagher

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PARP inhibition generates enhanced CD8+ central memory T cells by transcriptional and metabolic reprogramming

Nature Immunology

IF27.6

2026-01-12

PREAI

Wael Traboulsi; Pankaj Gaur; Subhadip Kundu; Zainab Ramlaoui; Christopher Priestley-Milianta; Aishwariya Iyengar; Nour Shobaki; Dareen Sarhan; Min-Jung Lee; Jung-Min Lee; George N. Pavlakis; Mikayel Mkrtichyan; Viia E. Valge-Archer; Simon T. Barry; Vivek Verma; Seema Gupta; Samir N. Khleif

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MAPK-driven epithelial cell plasticity drives colorectal cancer therapeutic resistance

Nature

IF48.5

2025-11-24

PREAI

Mark White; Megan L. Mills; Laura M. Millett; Kathryn Gilroy; Yourae Hong; Lucas B. Zeiger; Rosalin J. Simpson; Shania M. Corry; Amelia Ligeza; Tamsin R. M. Lannagan; Susanti Susanti; Rachel A. Ridgway; Ayse S. Yazgili; Lucile Grzesiak; Raheleh Amirkhah; Catriona A. Ford; Nikola Vlahov; Hannah Tovell; Leah Officer-Jones; Catherine Ficken; Rachel Pennie; Arafath K. Najumudeen; Alexander Raven; Nadia Nasreddin; Ekansh Chauhan; Andrew S. Papanastasiou; Colin Nixon; Vivienne Morrison; Rene Jackstadt; Janet S. Graham; Crispin J. Miller; Sarah J. Ross; Simon T. Barry; Valeria Pavet; Richard H. Wilson; John Le Quesne; Philip D. Dunne; Sabine Tejpar; Simon Leedham; Andrew D. Campbell; Owen J. Sansom

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Tumor-associated neutrophil precursors impair homologous DNA repair and promote sensitivity to PARP inhibition

Nature Communications

IF15.7

2025-07-30

OAAI

Siddhartha Mukherjee; Cindy Garda; Letizia Boffa; Angela Rita Elia; Matteo Massara; Maria Teresa Balia; Daniela Brina; Simone Mosole; Anna Campagnari; Giada Andrea Cassanmagnago; Andrea Rinaldi; Giacomo Lazzaroni; David Jarrossay; Diego Morone; Ilaria Ceppi; Riccardo De Sillo; Isabella Giacomini; Ilaria Craparotta; Laura Di Rito; Simon Barry; Endre Laczko; Sebastian Streb; Francesco Meani; Simona Di Lascio; Nancy Hynes; Enrico Lugli; Simone Puccio; Stephen-John Sammut; Ulrike Perriard; Yves Harder; Lorenzo Rossi; Maria Luisa Gasparri; Marco Bolis; Petr Cejka; Arianna Calcinotto

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Virtual histological staining as a tool for extending renal segmentation across stains∗

Modern Pathology

IF5.5

2025-07-23

OAAI

James Denholm; Azam Hamidinekoo; Nikolay Burlutskiy; Laura C. Setyo; Irina Zhang; Fariba Yousefi; Jack Mortimer; Joana Palés Huix; Christopher Bagnall; Arthur Lewis; Heather E. Hulme; Robert Unwin; Simon T. Barry; Richard J.A. Goodwin; Ferdia A. Gallagher; Magnus Söderberg; Talha Qaiser

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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

Cancer Cell

IF44.5

2025-07-10

OAAI

Ana Galan-Cobo; Natalie I. Vokes; Yu Qian; David Molkentine; Kavya Ramkumar; Alvaro G. Paula; Marlese Pisegna; Daniel J. McGrail; Alissa Poteete; Sungnam Cho; Minh Truong Do; Amirali Karimi; Yifan Kong; Anisha Solanki; Ankur Karmokar; Nicolas Floc’h; Adina Hughes; Rebecca Sargeant; Lucy Young; Li Shen; Gozde Kar; Caezaan Keshvani; Claudio Arrechedera; Sharia Hernandez; Katharina Schlacher; Jing Wang; Sonia Iyer; James Conway; Mohamed Reda Keddar; Marta Milo; Ilario de Toma; Susan E. Critchlow; J. Carl Barrett; Jan Cosaert; Alan Lau; Viia Valge-Archer; Lauren A. Byers; Simon T. Barry; John V. Heymach

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A linear ontogeny accounts for the development of naive; memory; and tumor-infiltrating regulatory T cells in mice

Science Immunology

IF16.3

2025-06-20

PREAI

Sanmoy Pathak; Thea Hogan; Sanket Rane; Yundi Huang; Claire Pearson; Charles Sinclair; Simon Barry; Larissa Carnevalli; Andrew J. Yates; Benedict Seddon

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The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

NPJ BREAST CANCER

IF7.6

2025-04-22

OAAI

Cutano, Valentina; Chia, Ming Li; Wigmore, Eleanor M.; Hopcroft, Lorna; Williamson, Stuart C.; Christie, Amanda L.; Willis, Brandon; Kerr, James; Ashforth, Jenny; Fox, Rhys; D'Arcy, Sophie; Bradshaw, Lauren; Blaker, Catherine; Eberlein, Cath; Montava-Garriga, Lambert; de Bruin, Elza C.; Critchlow, Susan E.; Brindle, Kevin M.; Barry, Simon T.; Ros, Susana

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Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition

DISEASE MODELS & MECHANISMS

IF3.3

2025-02-28

OAAI

Ling, Stephanie; Dexter, Alex; Race, Alan M.; Sharma, Shreya; Hamm, Gregory; Polanska, Urszula M.; Marshall, John F.; Takats, Zoltan; Brindle, Kevin; Yuneva, Mariia O.; Poulogiannis, George; Campbell, Andrew D.; Sansom, Owen J.; Goodwin, Richard J. A.; Bunch, Josephine; Barry, Simon T.

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Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer

NATURE COMMUNICATIONS

IF15.7

2024-11-22

OAAI

Elorbany, Samar; Berlato, Chiara; Carnevalli, Larissa S.; Maniati, Eleni; Barry, Simon T.; Wang, Jun; Manchanda, Ranjit; Kzhyshkowska, Julia; Balkwill, Frances

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Hepatocellular senescence induces multi-organ senescence and dysfunction via TGFβ

NATURE CELL BIOLOGY

IF19.1

2024-11-13

OAAI

Kiourtis, Christos; Terradas-Terradas, Maria; Gee, Lucy M.; May, Stephanie; Georgakopoulou, Anastasia; Collins, Amy L.; O'Sullivan, Eoin D.; Baird, David P.; Hassan, Mohsin; Shaw, Robin; Tan, Ee Hong; Mueller, Miryam; Engelmann, Cornelius; Andreola, Fausto; Hsieh, Ya-Ching; Reed, Lee H.; Borthwick, Lee A.; Nixon, Colin; Clark, William; Hanson, Peter S.; Sumpton, David; Mackay, Gillian; Suzuki, Toshiyasu; Najumudeen, Arafath K.; Inman, Gareth J.; Campbell, Andrew; Barry, Simon T.; Quaglia, Alberto; Morris, Christopher M.; Lebeau, Fiona E. N.; Sansom, Owen J.; Kirschner, Kristina; Jalan, Rajiv; Oakley, Fiona; Bird, Thomas G.

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Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma

LEUKEMIA

IF13.4

2024-09-16

OAAI

Willis, Brandon S.; Mongeon, Kevin; Dry, Hannah; Neveras, India L.; Bryan, Nadezda; Pandya, Meghana; Roderick-Richardson, Justine; Xu, Wendan; Yang, Li; Rosen, Alan; Reimer, Corinne; Tuskova, Liliana; Klener, Pavel; Mettetal, Jerome T.; Lenz, Georg; Barry, Simon T.

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Exploring the benefit of combining paclitaxel with capivasertib treatment in PI3K/AKT/PTEN-altered and non-altered TNBC preclinical models

ANNALS OF ONCOLOGY

IF65.4

2024-09-01

PREAI

Eberlein, C. A.; Vasiliauskaite, L.; Kerr, J.; Blaker, C.; Williamson, S.; Hopcroft, L.; Ros, S.; Moss, J.; De Bruin, E.; Rooney, C.; Willis, B.; Dunn, S.; Barry, S.

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Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

CANCER RESEARCH

IF16.6

2024-07-18

OAAI

Hillis, Alissandra L.; Martin, Timothy D.; Manchester, Haley E.; Hogstrom, Jenny; Zhang, Na; Lecky, Emmalyn; Kozlova, Nina; Lee, Jonah; Persky, Nicole S.; Root, David E.; Brown, Myles; Cichowski, Karen; Elledge, Stephen J.; Muranen, Taru; Fruman, David A.; Barry, Simon T.; Clohessy, John G.; Madsen, Ralitsa R.; Toker, Alex

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Metabolic imaging across scales reveals distinct prostate cancer phenotypes

NATURE COMMUNICATIONS

IF15.7

2024-07-16

OAAI

Sushentsev, Nikita; Hamm, Gregory; Flint, Lucy; Birtles, Daniel; Zakirov, Aleksandr; Richings, Jack; Ling, Stephanie; Tan, Jennifer Y.; Mclean, Mary A.; Ayyappan, Vinay; Horvat Menih, Ines; Brodie, Cara; Miller, Jodi L.; Mills, Ian G.; Gnanapragasam, Vincent J.; Warren, Anne Y.; Barry, Simon T.; Goodwin, Richard J. A.; Barrett, Tristan; Gallagher, Ferdia A.

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Morphological and molecular preservation through universal preparation of fresh-frozen tissue samples for multimodal imaging workflows

NATURE PROTOCOLS

IF16

2024-05-28

PREAI

Dannhorn, Andreas; Kazanc, Emine; Flint, Lucy; Guo, Fei; Carter, Alfie; Hall, Andrew R.; Jones, Stewart A.; Poulogiannis, George; Barry, Simon T.; Sansom, Owen J.; Bunch, Josephine; Takats, Zoltan; Goodwin, Richard J. A.

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A retrospective review of pathological complete response and toxicity rates to a modified version of TCHP (Paclitaxel, Trastuzumab, Pertuzumab, Carboplatin) for HER2 positive breast cancer stage II and III

CANCER RESEARCH

IF16.6

2024-05-02

PREAI

Moloney, Carolyn; O'Connor, Maggie Louise; O'Leary, Caroline; Reilly, Aislinn; Barry, Simon; O'Reilly, David; Bredin, Philip; Paryani, Hadia; Solaligue, David; Hennessy, Bryan; Greally, Megan; Morris, Patrick G.

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Histopathological biomarkers for predicting the tumour accumulation of nanomedicines

NATURE BIOMEDICAL ENGINEERING

IF26.6

2024-04-08

OAAI

May, Jan-Niklas; Moss, Jennifer I.; Mueller, Florian; Golombek, Susanne K.; Biancacci, Ilaria; Rizzo, Larissa; Elshafei, Asmaa Said; Gremse, Felix; Pola, Robert; Pechar, Michal; Etrych, Tomas; Becker, Svea; Trautwein, Christian; Buelow, Roman D.; Boor, Peter; Knuechel, Ruth; von Stillfried, Saskia; Storm, Gert; Puri, Sanyogitta; Barry, Simon T.; Schulz, Volkmar; Kiessling, Fabian; Ashford, Marianne B.; Lammers, Twan

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Strong antitumor effect elicited by inhibition of AKT or FOXP3 in combination with anti-PD-L1 in Pten mutant lung squamous cell carcinoma

CANCER RESEARCH

IF16.6

2024-04-05

PREAI

Houry, Maeva; Redrado, Miriam; Carnevalli, Larissa; Barry, Simon; Galan, Nuria; Otegui, Nerea; Leon, Sergio; Montuenga, Luis; Exposito, Francisco; Calvo, Alfonso

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Research Directions