Not logged in Acyl-CoA Synthetase 5 Knockout and Inhibitors Protect Against Diet-Induced Obesity in Mice by Activating the Ileal Brake Powell, David R.; Van Sligtenhorst, Isaac; Main, Alan; Jin, Haihong; Carson, Kenneth G.; Shi, Zhi-Cai; Swaffield, Jonathan; Smith, Melinda; Harris, Angela; Gopinathan, Suma; Platt, Kenneth A.; Wade, Jeffrey; Zambrowicz, Brian; Mcdonald, Patricia; Orton, Darren; Kuttippurathu, Lakshmi; Mullens, Michael; Greer, Jennifer; Yang, Qi Melissa; Ding, Zhi-Ming Share Save
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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model Kojak, Nada; Kuno, Junko; Fittipaldi, Kristina E.; Khan, Ambereen; Wenger, David; Glasser, Michael; Donnianni, Roberto A.; Tang, Yajun; Zhang, Jade; Huling, Katie; Ally, Roxanne; Mujica, Alejandro O.; Turner, Terrence; Magardino, Gina; Huang, Pei Yi; Kerk, Sze Yen; Droguett, Gustavo; Prissette, Marine; Rojas, Jose; Gomez, Teodoro; Gagliardi, Anthony; Hunt, Charleen; Rabinowitz, Jeremy S.; Gong, Guochun; Poueymirou, William; Chiao, Eric; Zambrowicz, Brian; Siao, Chia-Jen; Kajimura, Daisuke Share Save
IL-6-GP130 signaling protects human hepatocytes against lipid droplet accumulation in humanized liver models Carbonaro, Marisa; Wang, Kehui; Huang, Hui; Frleta, Davor; Patel, Aditi; Pennington, Alexander; Desclaux, Mathieu; Moller-Tank, Sven; Grindley, Justin; Altarejos, Judith; Zhong, Jun; Polites, Greg; Poueymirou, William; Jaspers, Stephen; Kyratsous, Christos; Zambrowicz, Brian; Murphy, Andrew; Lin, John C.; Macdonald, Lynn E.; Daly, Christopher; Sleeman, Mark; Thurston, Gavin; Li, Zhe Share Save
Production of large, defined genome modifications in rats by targeting rat embryonic stem cells Lee, Jeffrey; Wang, Jingjing; Ally, Roxanne; Trzaska, Sean; Hickey, Joseph; Mujica, Alejo; Miloscio, Lawrence; Mastaitis, Jason; Morse, Brian; Smith, Janell; Atanasio, Amanda; Chiao, Eric; Chen, Henry; Latuszek, Adrianna; Hu, Ying; Valenzuela, David; Romano, Carmelo; Zambrowicz, Brian; Auerbach, Wojtek Share Save
Efficient engraftment and viral transduction of human hepatocytes in an FRG rat liver humanization model Carbonaro, Marisa; Lee, Jeffrey; Pefanis, Evangelos; Desclaux, Mathieu; Wang, Kehui; Pennington, Alexander; Huang, Hui; Mujica, Alejo; Rojas, Jose; Ally, Roxanne; Kennedy, Daniel; Brown, Michael; Rogulin, Vitaliy; Moller-Tank, Sven; Sabin, Leah; Zambrowicz, Brian; Thurston, Gavin; Li, Zhe Share Save
Disruption of nuclear envelope integrity as a possible initiating event in tauopathies Prissette, Marine; Fury, Wen; Koss, Matthew; Racioppi, Claudia; Fedorova, Daria; Dragileva, Ella; Clarke, Georgia; Pohl, Taylor; Dugan, John; Ahrens, Diana; Chiu, Joyce; Hunt, Charleen; Siao, Chia-Jen; Young, Tara; Bhowmick, Arijit; Rogulin, Vitaliy; Desclaux, Mathieu; Hayden, Eric Y.; Podgorski, Michael; Gao, Min; Macdonald, Lynn E.; Frendewey, David; Yancopoulos, George D.; Zambrowicz, Brian Share Save
Germline Mutations in CIDEB and Protection against Liver Disease Verweij, N.; Haas, M. E.; Nielsen, J. B.; Sosina, O. A.; Kim, M.; Akbari, P.; De, T.; Hindy, G.; Bovijn, J.; Persaud, T.; Miloscio, L.; Germino, M.; Panagis, L.; Watanabe, K.; Mbatchou, J.; Jones, M.; LeBlanc, M.; Balasubramanian, S.; Lammert, C.; Enhorning, S.; Melander, O.; Carey, D. J.; Still, C. D.; Mirshahi, T.; Rader, D. J.; Parasoglou, P.; Walls, J. R.; Overton, J. D.; Reid, J. G.; Economides, A.; Cantor, M. N.; Zambrowicz, B.; Murphy, A. J.; Abecasis, G. R.; Ferreira, M. A. R.; Smagris, E.; Gusarova, V; Sleeman, M.; Yancopoulos, G. D.; Marchini, J.; Kang, H. M.; Karalis, K.; Shuldiner, A. R.; Della Gatta, G.; Locke, A. E.; Baras, A.; Lotta, L. A. Share Save
Population-scale analysis of common and rare genetic variation associated with hearing loss in adults Praveen, Kavita; Dobbyn, Lee; Gurski, Lauren; Ayer, Ariane H.; Staples, Jeffrey; Mishra, Shawn; Bai, Yu; Kaufman, Alexandra; Moscati, Arden; Benner, Christian; Chen, Esteban; Chen, Siying; Popov, Alexander; Smith, Janell; Melander, Olle; Jones, Marcus; Marchini, Jonathan; Balasubramanian, Suganthi; Zambrowicz, Brian; Drummond, Meghan; Baras, Aris; Abecasis, Goncalo R.; Ferreira, Manuel A.; Stahl, Eli A.; Coppola, Giovanni Share Save
Homozygous ALS-linked FUS P525L mutations cell- autonomously perturb transcriptome profile and chemoreceptor signaling in human iPSC microglia Kerk, Sze Yen; Bai, Yu; Smith, Janell; Lalgudi, Pranav; Hunt, Charleen; Kuno, Junko; Nuara, John; Yang, Tao; Lanza, Kathryn; Chan, Newton; Coppola, Angel; Tang, Qian; Espert, Jennifer; Jones, Henderson; Fannell, Casey; Zambrowicz, Brian; Chiao, Eric Share Save
CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis Gillmore, Julian D.; Gane, Ed; Taubel, Jorg; Kao, Justin; Fontana, Marianna; Maitland, Michael L.; Seitzer, Jessica; O'Connell, Daniel; Walsh, Kathryn R.; Wood, Kristy; Phillips, Jonathan; Xu, Yuanxin; Amaral, Adam; Boyd, Adam P.; Cehelsky, Jeffrey E.; McKee, Mark D.; Schiermeier, Andrew; Harari, Olivier; Murphy, Andrew; Kyratsous, Christos A.; Zambrowicz, Brian; Soltys, Randy; Gutstein, David E.; Leonard, John; Sepp-Lorenzino, Laura; Lebwohl, David Share Save
Tissue-specific activation of gene expression by the Synergistic Activation Mediator (SAM) CRISPRa system in mice Hunt, Charleen; Hartford, Suzanne A.; White, Derek; Pefanis, Evangelos; Hanna, Timothy; Herman, Clarissa; Wiley, Jarrell; Brown, Heather; Su, Qi; Xin, Yurong; Voronin, Dennis; Nguyen, Hien; Altarejos, Judith; Crosby, Keith; Haines, Jeffery; Cancelarich, Sarah; Drummond, Meghan; Moller-Tank, Sven; Malpass, Ryan; Buckley, Jacqueline; Molina-Portela, Maria Del Pilar; Droguett, Gustavo; Frendewey, David; Chiao, Eric; Zambrowicz, Brian; Gong, Guochun Share Save
Autophagy protects tumors from T cell-mediated cytotoxicity via inhibition of TNFα-induced apoptosis Young, Tara M.; Reyes, Claudia; Pasnikowski, Elizabeth; Castanaro, Carla; Wong, Chung; Decker, Corinne E.; Chiu, Joyce; Song, Hang; Wei, Yi; Bai, Yu; Zambrowicz, Brian; Thurston, Gavin; Daly, Christopher Share Save
Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy Devalaraja-Narashimha, Kishor; Meagher, Karoline; Luo, Yifan; Huang, Cong; Kaplan, Theodore; Muthuswamy, Anantharaman; Halasz, Gabor; Casanova, Sarah; O'Brien, John; Peyser Boiarsky, Rebecca; McWhirter, John; Gartner, Hans; Bai, Yu; MacDonnell, Scott; Liu, Chien; Hu, Ying; Latuszek, Adrianna; Wei, Yi; Prasad, Srinivasa; Huang, Tammy; Yancopoulos, George; Murphy, Andrew; Olson, William; Zambrowicz, Brian; Macdonald, Lynn; Morton, Lori G. Share Save
NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity Nistala, Harikiran; Dronzek, John; Gonzaga-Jauregui, Claudia; Chim, Shek Man; Rajamani, Saathyaki; Nuwayhid, Samer; Delgado, Dennis; Burke, Elizabeth; Karaca, Ender; Franklin, Matthew C.; Sarangapani, Prasad; Podgorski, Michael; Tang, Yajun; Dominguez, Melissa G.; Withers, Marjorie; Deckelbaum, Ron A.; Scheonherr, Christopher J.; Gahl, William A.; Malicdan, May C.; Zambrowicz, Brian; Gale, Nicholas W.; Gibbs, Richard A.; Chung, Wendy K.; Lupski, James R.; Economides, Aris N. Share Save
Sotagliflozin Decreases Postprandial Glucose and Insulin Concentrations by Delaying Intestinal Glucose Absorption Powell, David R.; Zambrowicz, Brian; Morrow, Linda; Beysen, Carine; Hompesch, Marcus; Turner, Scott; Hellerstein, Marc; Banks, Phillip; Strumph, Paul; Lapuerta, Pablo Share Save
Multifunctional Alleles: A novel method for the generation of All-In-One null and conditional alleles Pefanis, Evangelos; Schoenherr, Christopher; Persaud, Trikaldarshi; Zhang, Yuhong; Golubov, Jacquelynn; Wang, Bei; Skokos, Dimitris; Zambrowicz, Brian; Murphy, Andrew J.; Economides, Aris N. Share Save
NOTUM inhibition increases endocortical bone formation and bone strength Brommage, Robert; Liu, Jeff; Vogel, Peter; Mseeh, Faika; Thompson, Andrea Y.; Potter, David G.; Shadoan, Melanie K.; Hansen, Gwenn M.; Jeter-Jones, Sabrina; Cui, Jie; Bright, Dawn; Bardenhagen, Jennifer P.; Doree, Deon D.; Moverare-Skrtic, Sofia; Nilsson, Karin H.; Henning, Petra; Lerner, Ulf H.; Ohlsson, Claes; Sands, Arthur T.; Tarver, James E.; Powell, David R.; Zambrowicz, Brian; Liu, Qingyun Share Save
Novel approaches for modeling C3 glomerulopathy in mouse and rat Devalaraja-Narashimha, Kishor; Luo, Yifan; Huang, Cong; Kaplan, Theodore; O'Brien, John; Lorn, Dara; Lee, Jeffery; MacDonnell, Scott; Peyser, Rebecca; Halasz, Gabor; Meagher, Karoline; Casanova, Sarah; McWhirter, John; Wang, Jingjing; Hickey, Joseph; Roos, Michael; Poueymirou, William; Chiao, Eric; Auerbach, Wojtek; Olson, William; Macdonald, Lynn; Zambrowicz, Brian; Murphy, Andrew; Yancopoulos, George; Morton, Lori Share Save
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