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André Guillouzo

universite de rennes

64H-index
300Paper Count
1.3WCitation Count
Published Papers 70
Publication Date
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
errNATURE REVIEWS DRUG DISCOVERY
IF101.8
err2019-11-20
err156
errOAAI
errWeaver, Richard J.; Blomme, Eric A.; Chadwick, Amy E.; Copple, Ian M.; Gerets, Helga H. J.; Goldring, Christopher E.; Guillouzo, Andre; Hewitt, Philip G.; Ingelman-Sundberg, Magnus; Jensen, Klaus Gjervig; Juhila, Satu; Klingmuller, Ursula; Labbe, Gilles; Liguori, Michael J.; Lovatt, Cerys A.; Morgan, Paul; Naisbitt, Dean J.; Pieters, Raymond H. H.; Snoeys, Jan; van de Water, Bob; Williams, Dominic P.; Park, B. Kevin
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Predictive Value of Cellular Accumulation of Hydrophobic Bile Acids As a Marker of Cholestatic Drug Potential
errTOXICOLOGICAL SCIENCES
IF4.1
err2019-01-10
err9
errOAAI
errBurban, Audrey; Sharanek, Ahmad; Humbert, Lydie; Eguether, Thibaut; Guguen-Guillouzo, Christiane; Rainteau, Dominique; Guillouzo, Andre
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errSave
Endoplasmic reticulum stress precedes oxidative stress in antibiotic-induced cholestasis and cytotoxicity in human hepatocytes
errFREE RADICAL BIOLOGY AND MEDICINE
IF8.2
err2018-02-01
err49
PREAI
errBurban, Audrey; Sharanek, Ahmad; Guguen-Guillouzo, Christiane; Guillouzo, Andre
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errSave
A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells
errTOXICOLOGICAL SCIENCES
IF4.1
err2017-09-18
err7
errOAAI
errKaschek, Daniel; Sharanek, Ahmad; Guillouzo, Andre; Timmer, Jens; Weaver, Richard J.
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errSave
Hypothermic storage and cryopreservation of hepatocytes:: The protective effect of alginate gel against cell damages
errCELL TRANSPLANTATION
IF3.2
err2017-06-22
err75
PREAI
errMahler, S; Desille, M; Frémond, B; Chesné, C; Guillouzo, A; Campion, JP; Clément, B
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errSave
Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways
errSCIENTIFIC REPORTS
IF3.9
err2017-05-12
err25
errOAAI
errBurban, Audrey; Sharanek, Ahmad; Hue, Romain; Gay, Marion; Routier, Sylvain; Guillouzo, Andre; Guguen-Guillouzo, Christiane
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errSave
Mechanistic Insights in Cytotoxic and Cholestatic Potential of the Endothelial Receptor Antagonists Using HepaRG Cells
errTOXICOLOGICAL SCIENCES
IF4.1
err2017-03-24
err15
errOAAI
errBurbank, Matthew Gibson; Sharanek, Ahmad; Burban, Audrey; Mialanne, Herve; Aerts, Helene; Guguen-Guillouzo, Christiane; Weaver, Richard John; Guillouzo, Andre
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errSave
Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs
errSCIENTIFIC REPORTS
IF3.9
err2016-05-12
err68
errOAAI
errSharanek, Ahmad; Burban, Audrey; Burbank, Matthew; Le Guevel, Remy; Li, Ruoya; Guillouzo, Andre; Guguen-Guillouzo, Christiane
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errSave
Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes
errTOXICOLOGICAL SCIENCES
IF4.1
err2015-07-20
err46
errOAAI
errSharanek, Ahmad; Burban, Audrey; Humbert, Lydie; Bachour-El Azzi, Pamela; Felix-Gomes, Neuza; Rainteau, Dominique; Guillouzo, Andre
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errSave
Comparative Localization and Functional Activity of the Main Hepatobiliary Transporters in HepaRG Cells and Primary Human Hepatocytes
errTOXICOLOGICAL SCIENCES
IF4.1
err2015-02-17
err69
errOAAI
errBachour-El Azzi, Pamela; Sharanek, Ahmad; Burban, Audrey; Li, Ruoya; Le Guevel, Remy; Abdel-Razzak, Ziad; Stieger, Bruno; Guguen-Guillouzo, Christiane; Guillouzo, Andre
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errSave
Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells
errTOXICOLOGICAL SCIENCES
IF4.1
err2014-09-12
err54
errOAAI
errSharanek, Ahmad; Bachour-El Azzi, Pamela; Al-Attrache, Houssein; Savary, Camille C.; Humbert, Lydie; Rainteau, Dominique; Guguen-Guillouzo, Christiane; Guillouzo, Andre
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errSave
PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2014-04-01
err59
errOAAI
errRogue, Alexandra; Antherieu, Sebastien; Vluggens, Aurore; Umbdenstock, Thierry; Claude, Nancy; de la Moureyre-Spire, Catherine; Weaver, Richard J.; Guillouzo, Andre
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Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells
errHEPATOLOGY
IF15.8
err2013-04-01
err116
errOAAI
errAntherieu, Sebastien; Bachour-El Azzi, Pamela; Dumont, Julie; Abdel-Razzak, Ziad; Guguen-Guillouzo, Christiane; Fromenty, Bernard; Robin, Marie-Anne; Guillouzo, Andre
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Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2012-01-01
err49
PREAI
errJosse, Rozenn; Dumont, Julie; Fautrel, Alain; Robin, Marie-Anne; Guillouzo, Andre
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errSave
Induction of Vesicular Steatosis by Amiodarone and Tetracycline Is Associated with Up-regulation of Lipogenic Genes in HepaRG Cells
errHEPATOLOGY
IF15.8
err2011-06-01
err137
errOAAI
errAntherieu, Sebastien; Rogue, Alexandra; Fromenty, Bernard; Guillouzo, Andre; Robin, Marie-Anne
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errSave
Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2010-11-15
err28
PREAI
errDumont, Julie; Josse, Rozenn; Lambert, Carine; Antherieu, Sebastien; Laurent, Veronique; Loyer, Pascal; Robin, Marie-Anne; Guillouzo, Andre
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errSave
Differential toxicity of heterocyclic aromatic amines and their mixture in metabolically competent HepaRG cells
errTOXICOLOGY AND APPLIED PHARMACOLOGY
IF3.4
err2010-06-01
err48
PREAI
errDumont, Julie; Josse, Rozenn; Lambert, Carine; Antherieu, Sebastien; Le Hegarat, Ludovic; Aninat, Caroline; Robin, Marie-Anne; Guguen-Guillouzo, Christiane; Guillouzo, Andre
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errSave
Stem cell-derived hepatocytes and their use in toxicology
errTOXICOLOGY
IF4.6
err2010-03-01
err77
PREAI
errGuguen-Guillouzo, Christiane; Corlu, Anne; Guillouzo, Andre
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errSave
Involvement of Nrf2 activation in resistance to 5-fluorouracil in human colon cancer HT-29 cells
errEUROPEAN JOURNAL OF CANCER
IF7.1
err2009-08-01
err114
PREAI
errAkhdar, Hanane; Loyer, Pascal; Rauch, Claudine; Corlu, Anne; Guillouzo, Andre; Morel, Fabrice
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errSave
The sulphonylurea glibenclamide inhibits multidrug resistance protein (MRP1) activity in human lung cancer cells
errBRITISH JOURNAL OF PHARMACOLOGY
IF7.7
err2009-01-29
err96
errOAAI
errPayen, L; Delugin, L; Courtois, A; Trinquart, Y; Guillouzo, A; Fardel, O
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Research Directions

No research directions
Co-authors
Cooperation Journals
F
F. Peter Guengerich
H-index: 140 · Papers: 1.2K
E
Elisabeth G.E. de Vries
H-index: 121 · Papers: 1.7K
M
Magnus Ingelman‐Sundberg
H-index: 115 · Papers: 705
J
Jan G. Hengstler
H-index: 94 · Papers: 1.1K
B
Bruno Stieger
H-index: 89 · Papers: 707
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