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SaveThe CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer
Adam, Salome; Rossi, Silvia Emma; Moatti, Nathalie; Zompit, Mara De Marco; Xue, Yibo; Ng, Timothy F.; Alvarez-Quilon, Alejandro; Desjardins, Jessica; Bhaskaran, Vivek; Martino, Giovanni; Setiaputra, Dheva; Noordermeer, Sylvie M.; Ohsumi, Toshiro K.; Hustedt, Nicole; Szilard, Rachel K.; Chaudhary, Natasha; Munro, Meagan; Veloso, Artur; Melo, Henrique; Yin, Shou Yun; Papp, Robert; Young, Jordan T. F.; Zinda, Michael; Stucki, Manuel; Durocher, Daniel Share Save A substrate binding model for the KEOPS tRNA modifying complexBeenstock, Jonah; Ona, Samara Mishelle; Porat, Jennifer; Orlicky, Stephen; Wan, Leo C. K.; Ceccarelli, Derek F.; Maisonneuve, Pierre; Szilard, Rachel K.; Yin, Zhe; Setiaputra, Dheva; Mao, Daniel Y. L.; Khan, Morgan; Raval, Shaunak; Schriemer, David C.; Bayfield, Mark A.; Durocher, Daniel; Sicheri, Frank Share Save Share Save Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7Wan, Leo C. K.; Maisonneuve, Pierre; Szilard, Rachel K.; Lambert, Jean-Philippe; Ng, Timothy F.; Manczyk, Noah; Huang, Hao; Laister, Rob; Caudy, Amy A.; Gingras, Anne-Claude; Durocher, Daniel; Sicheri, Frank Share Save OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function (vol 45, pg 384, 2012)Juang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Dan; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme FunctionJuang, Yu-Chi; Landry, Marie-Claude; Sanches, Mario; Vittal, Vinayak; Leung, Charles C. Y.; Ceccarelli, Derek F.; Mateo, Abigail-Rachele F.; Pruneda, Jonathan N.; Mao, Daniel Y. L.; Szilard, Rachel K.; Orlicky, Stephen; Munro, Meagan; Brzovic, Peter S.; Klevit, Rachel E.; Sicheri, Frank; Durocher, Daniel Share Save Share Save The MMS22L-TONSL Complex Mediates Recovery from Replication Stress and Homologous RecombinationO'Donnell, Lara; Panier, Stephanie; Wildenhain, Jan; Tkach, Johnny M.; Al-Hakim, Abdallah; Landry, Marie-Claude; Escribano-Diaz, Cristina; Szilard, Rachel K.; Young, Jordan T. F.; Munro, Meagan; Canny, Marella D.; Kolas, Nadine K.; Zhang, Wei; Harding, Shane M.; Ylanko, Jarkko; Mendez, Megan; Mullin, Michael; Sun, Thomas; Habermann, Bianca; Datti, Alessandro; Bristow, Robert G.; Gingras, Anne-Claude; Tyers, Michael D.; Brown, Grant W.; Durocher, Daniel Share Save Systematic identification of fragile sites via genome-wide location analysis of γ-H2AXSzilard, Rachel K.; Jacques, Pierre-Etienne; Laramee, Louise; Cheng, Benjamin; Galicia, Sarah; Bataille, Alain R.; Yeung, ManTek; Mendez, Megan; Bergeron, Maxime; Robert, Francois; Durocher, Daniel Share Save Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase-Containing Molecular MachineMao, Daniel Y. L.; Neculai, Dante; Downey, Michael; Orlicky, Stephen; Haffani, Yosr Z.; Ceccarelli, Derek F.; Ho, Jenny S. L.; Szilard, Rachel K.; Zhang, Wei; Ho, Cynthia S.; Wan, Leo; Fares, Christophe; Rumpel, Sigrun; Kurinov, Igor; Arrowsmith, Cheryl H.; Durocher, Daniel; Sicheri, Frank Share Save A screen for suppressors of gross chromosomal Rearrangements identifies a conserved role for PLP in preventing DNA lesionsKanellis, Pamela; Gagliardi, Mark; Banath, Judit P.; Szilard, Rachel K.; Nakada, Shinichiro; Galicia, Sarah; Sweeney, Frederic D.; Cabelof, Diane C.; Olive, Peggy L.; Durocher, Daniel Share Save Share Save Share Save Share Save Share Save Share Save 
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