Not logged inTumor-agnostic transcriptome-based classifier identifies spatial infiltration patterns of CD8+T cells in the tumor microenvironment and predicts clinical outcome in early-phase and late-phase clinical trials
Roller, Andreas; Davydov, Iakov I.; Schwalie, Petra C.; Serrano-Serrano, Martha L.; Heller, Astrid; Staedler, Nicolas; Ferreira, Claudia S.; Dietmann, Gabriele; Klaman, Irina; Valdeolivas, Alberto; Korski, Konstanty; Cannarile, Michael A. .png)
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SaveImage-based multiplex immune profiling of cancer tissues: translational implications. A report of the International Immuno-oncology Biomarker Working Group on Breast CancerJahangir, Chowdhury Arif; Page, David B.; Broeckx, Glenn; Gonzalez, Claudia A.; Burke, Caoimbhe; Murphy, Clodagh; Reis-Filho, Jorge S.; Ly, Amy; Harms, Paul W.; Gupta, Rajarsi R.; Vieth, Michael; Hida, Akira, I; Kahila, Mohamed; Kos, Zuzana; van Diest, Paul J.; Verbandt, Sara; Thagaard, Jeppe; Khiroya, Reena; Abduljabbar, Khalid; Haab, Gabriela Acosta; Acs, Balazs; Adams, Sylvia; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R. M.; Fujimoto, Luciana Botinelly Mendonca; Burgues, Octavio; Chardas, Alexandros; Cheang, Maggie Chon U.; Ciompi, Francesco; Cooper, Lee A. D.; Coosemans, An; Corredor, German; Portela, Flavio Luis Dantas; Deman, Frederik; Demaria, Sandra; Dudgeon, Sarah N.; Elghazawy, Mahmoud; Fernandez-Martin, Claudio; Fineberg, Susan; Fox, Stephen B.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula, I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hart, Steven N.; Hartman, Johan; Hewitt, Stephen; Horlings, Hugo M.; Husain, Zaheed; Irshad, Sheeba; Janssen, Emiel A. M.; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Khramtsov, Andrey, I; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Akturk, Guray; Scott, Ely; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Madabhushi, Anant; Maley, Sai K.; Narasimhamurthy, Vidya Manur; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Kharidehal, Durga; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Ribeiro, Joana M.; Rimm, David; Vincent-Salomon, Anne; Saltz, Joel; Sayed, Shahin; Hytopoulos, Evangelos; Mahon, Sarah; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; van Der Laak, Jeroen; Verghese, Gregory E.; Viale, Giuseppe; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Stovgaard, Elisabeth Specht; Salgado, Roberto; Gallagher, William M.; Rahman, Arman Share Save Pitfalls in machine learning-based assessment of tumor-infiltrating lymphocytes in breast cancer: a report of the international immuno-oncology biomarker working groupThagaard, Jeppe; Broeckx, Glenn; Page, David B.; Jahangir, Chowdhury Arif; Verbandt, Sara; Kos, Zuzana; Gupta, Rajarsi; Khiroya, Reena; Abduljabbar, Khalid; Acosta Haab, Gabriela; Acs, Balazs; Akturk, Guray; Almeida, Jonas S.; Alvarado-Cabrero, Isabel; Amgad, Mohamed; Azmoudeh-Ardalan, Farid; Badve, Sunil; Baharun, Nurkhairul Bariyah; Balslev, Eva; Bellolio, Enrique R.; Bheemaraju, Vydehi; Blenman, Kim R. M.; Botinelly Mendonca Fujimoto, Luciana; Bouchmaa, Najat; Burgues, Octavio; Chardas, Alexandros; Cheang, Maggie U.; Ciompi, Francesco; Cooper, Lee A. D.; Coosemans, An; Corredor, German; Dahl, Anders B.; Dantas Portela, Flavio Luis; Deman, Frederik; Demaria, Sandra; Dore Hansen, Johan; Dudgeon, Sarah N.; Ebstrup, Thomas; Elghazawy, Mahmoud; Fernandez-Martin, Claudio; Fox, Stephen B.; Gallagher, William M.; Giltnane, Jennifer M.; Gnjatic, Sacha; Gonzalez-Ericsson, Paula, I; Grigoriadis, Anita; Halama, Niels; Hanna, Matthew G.; Harbhajanka, Aparna; Hart, Steven N.; Hartman, Johan; Hauberg, Soren; Hewitt, Stephen; Hida, Akira, I; Horlings, Hugo M.; Husain, Zaheed; Hytopoulos, Evangelos; Irshad, Sheeba; Janssen, Emiel A. M.; Kahila, Mohamed; Kataoka, Tatsuki R.; Kawaguchi, Kosuke; Kharidehal, Durga; Khramtsov, Andrey, I; Kiraz, Umay; Kirtani, Pawan; Kodach, Liudmila L.; Korski, Konstanty; Kovacs, Aniko; Laenkholm, Anne-Vibeke; Lang-Schwarz, Corinna; Larsimont, Denis; Lennerz, Jochen K.; Lerousseau, Marvin; Li, Xiaoxian; Ly, Amy; Madabhushi, Anant; Maley, Sai K.; Manur Narasimhamurthy, Vidya; Marks, Douglas K.; McDonald, Elizabeth S.; Mehrotra, Ravi; Michiels, Stefan; Minhas, Fayyaz ul Amir Afsar; Mittal, Shachi; Moore, David A.; Mushtaq, Shamim; Nighat, Hussain; Papathomas, Thomas; Penault-Llorca, Frederique; Perera, Rashindrie D.; Pinard, Christopher J.; Pinto-Cardenas, Juan Carlos; Pruneri, Giancarlo; Pusztai, Lajos; Rahman, Arman; Rajpoot, Nasir Mahmood; Rapoport, Bernardo Leon; Rau, Tilman T.; Reis-Filho, Jorge S.; Ribeiro, Joana M.; Rimm, David; Roslind, Anne; Vincent-Salomon, Anne; Salto-Tellez, Manuel; Saltz, Joel; Sayed, Shahin; Scott, Ely; Siziopikou, Kalliopi P.; Sotiriou, Christos; Stenzinger, Albrecht; Sughayer, Maher A.; Sur, Daniel; Fineberg, Susan; Symmans, Fraser; Tanaka, Sunao; Taxter, Timothy; Tejpar, Sabine; Teuwen, Jonas; Thompson, E. Aubrey; Tramm, Trine; Tran, William T.; van Der Laak, Jeroen; van Diest, Paul J.; Verghese, Gregory E.; Viale, Giuseppe; Vieth, Michael; Wahab, Noorul; Walter, Thomas; Waumans, Yannick; Wen, Hannah Y.; Yang, Wentao; Yuan, Yinyin; Zin, Reena Md; Adams, Sylvia; Bartlett, John; Loibl, Sibylle; Denkert, Carsten; Savas, Peter; Loi, Sherene; Salgado, Roberto; Specht Stovgaard, Elisabeth Share Save TUMOR AGNOSTIC CD8 IMMUNE-PHENOTYPE RELATED GENE SIGNATURE DEFINES CLINICAL OUTCOME ACROSS EARLY AND LATE PHASE CLINICAL TRIALSRoller, Andreas; Davydov, Iakov; Serrano-Serrano, Martha; Heller, Astrid; Staedler, Nicolas; Ferreira, Claudia; Dietmann, Gabriele; Klaman, Irina; Korski, Konstanty; Schwalie, Petra; Cannarile, Michael Share Save Immune contexture of paediatric cancersDas Thakur, Meghna; Franz, Carl J.; Brennan, Laura; Brouwer-Visser, Jurriaan; Tam, Rachel; Korski, Konstanty; Koeppen, Hartmut; Ziai, James; Babitzki, Galina; Ranchere-Vince, Dominique; Vasiljevic, Alexandre; Dijoud, Frederique; Marec-Berard, Perrine; Rochet, Isabelle; Cannarile, Michael A.; Marabelle, Aurelien Share Save Anti-CSF-1R emactuzumab in combination with anti-PD-L1 atezolizumab in advanced solid tumor patients naive or experienced for immune checkpoint blockadeGomez-Roca, Carlos; Cassier, Philippe; Zamarin, Dmitriy; Machiels, Jean-Pascal; Perez Gracia, Jose Luis; Hodi, F. Stephen; Taus, Alvaro; Martinez Garcia, Maria; Boni, Valentina; Eder, Joseph P.; Hafez, Navid; Sullivan, Ryan; Mcdermott, David; Champiat, Stephane; Aspeslagh, Sandrine; Terret, Catherine; Jegg, Anna-Maria; Jacob, Wolfgang; Cannarile, Michael A.; Ries, Carola; Korski, Konstanty; Michielin, Francesca; Christen, Randolph; Babitzki, Galina; Watson, Carl; Meneses-Lorente, Georgina; Weisser, Martin; Ruettinger, Dominik; Delord, Jean-Pierre; Marabelle, Aurelien Share Save Share Save Share Save Share Save Phase Ib study of anti-CSF-1R antibody emactuzumab in combination with CD40 agonist selicrelumab in advanced solid tumor patientsMachiels, Jean-Pascal; Gomez-Roca, Carlos; Michot, Jean-Marie; Zamarin, Dmitriy; Mitchell, Tara; Catala, Gaetan; Eberst, Lauriane; Jacob, Wolfgang; Jegg, Anna-Maria; Cannarile, Michael A.; Watson, Carl; Babitzki, Galina; Korski, Konstanty; Klaman, Irina; Teixeira, Priscila; Hoves, Sabine; Ries, Carola; Meneses-Lorente, Georgina; Michielin, Francesca; Christen, Randolph; Ruttinger, Dominik; Weisser, Martin; Delord, Jean-Pierre; Cassier, Philippe Share Save Share Save The Society for Immunotherapy of Cancer statement on best practices for multiplex immunohistochemistry (IHC) and immunofluorescence (IF) staining and validationTaube, Janis M.; Akturk, Guray; Angelo, Michael; Engle, Elizabeth L.; Gnjatic, Sacha; Greenbaum, Shirley; Greenwald, Noah F.; Hedvat, Cyrus, V; Hollmann, Travis J.; Juco, Jonathan; Parra, Edwin R.; Rebelatto, Marlon C.; Rimm, David L.; Rodriguez-Canales, Jaime; Schalper, Kurt A.; Stack, Edward C.; Ferreira, Claudia S.; Korski, Konstanty; Lako, Ana; Rodig, Scott J.; Schenck, Emanuel; Steele, Keith E.; Surace, Michael J.; Tetzlaff, Michael T.; von Loga, Katharina; Wistuba, Ignacio I.; Bifulco, Carlo B. Share Save Share Save Share Save Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain TumorsHendry, Shona; Salgado, Roberto; Gevaert, Thomas; Russell, Prudence A.; John, Tom; Thapa, Bibhusal; Christie, Michael; van de Vijver, Koen; Estrada, M. V.; Gonzalez-Ericsson, Paula I.; Sanders, Melinda; Solomon, Benjamin; Solinas, Cinzia; Van den Eynden, Gert G. G. M.; Allory, Yves; Preusser, Matthias; Hainfellner, Johannes; Pruneri, Giancarlo; Vingiani, Andrea; Demaria, Sandra; Symmans, Fraser; Nuciforo, Paolo; Comerma, Laura; Thompson, E. A.; Lakhani, Sunil; Kim, Seong-Rim; Schnitt, Stuart; Colpaert, Cecile; Sotiriou, Christos; Scherer, Stefan J.; Ignatiadis, Michail; Badve, Sunil; Pierce, Robert H.; Viale, Giuseppe; Sirtaine, Nicolas; Penault-Llorca, Frederique; Sugie, Tomohagu; Fineberg, Susan; Paik, Soonmyung; Srinivasan, Ashok; Richardson, Andrea; Wang, Yihong; Chmielik, Ewa; Brock, Jane; Johnson, Douglas B.; Balko, Justin; Wienert, Stephan; Bossuyt, Veerle; Michiels, Stefan; Ternes, Nils; Burchardi, Nicole; Luen, Stephen J.; Savas, Peter; Klauschen, Frederick; Watson, Peter H.; Nelson, Brad H.; Criscitiello, Carmen; O'Toole, Sandra; Larsimont, Denis; de Wind, Roland; Curigliano, Giuseppe; Andre, Fabrice; Lacroix-Triki, Magali; van de Vijver, Mark; Rojo, Federico; Floris, Giuseppe; Bedri, Shahinaz; Sparano, Joseph; Rimm, David; Nielsen, Torsten; Kos, Zuzana; Hewitt, Stephen; Singh, Baljit; Farshid, Gelareh; Loibl, Sibylle; Allison, Kimberly H.; Tung, Nadine; Adams, Sylvia; Willard-Gallo, Karen; Horlings, Hugo M.; Gandhi, Leena; Moreira, Andre; Hirsch, Fred; Dieci, Maria V.; Urbanowicz, Maria; Brcic, Iva; Korski, Konstanty; Gaire, Fabien; Koeppen, Hartmut; Lo, Amy; Giltnane, Jennifer; Rebelatto, Marlon C.; Steele, Keith E.; Zha, Jiping; Emancipator, Kenneth; Juco, Jonathan W.; Denkert, Carsten; Reis-Filho, Jorge; Loi, Sherene; Fox, Stephen B. Share Save Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further ResearchHendry, Shona; Salgado, Roberto; Gevaert, Thomas; Russell, Prudence A.; John, Tom; Thapa, Bibhusal; Christie, Michael; van de Vijver, Koen; Estrada, M. V; Gonzalez-Ericsson, Paula I; Sanders, Melinda; Solomon, Benjamin sss; Solinas, Cinzia; Van den Eynden, Gert G. G. M.; Allory, Yves; Preusser, Matthias; Hainfellner, Johannes; Pruneri, Giancarlo; Vingiani, Andrea; Demaria, Sandra; Symmans, Fraser; Nuciforo, Paolo; Comerma, Laura; Thompson, E. A.; Lakhani, Sunil; Kim, Seong-Rim; Schnitt, Stuart; Colpaert, Cecile; Sotiriou, Christos; Scherer, Stefan J.; Ignatiadis, Michail; Badve, Sunil; Pierce, Robert H.; Viale, Giuseppe; Sirtaine, Nicolas; Penault-Llorca, Frederique; Sugie, Tomohagu; Fineberg, Susan; Paik, Soonmyung; Srinivasan, Ashok; Richardson, Andrea; Wang, Yihong; Chmielik, Ewa; Brock, Jane; Johnson, Douglas B.; Balko, Justin; Wienert, Stephan; Bossuyt, Veerle; Michiels, Stefan; Ternes, Nils; Burchardi, Nicole; Luen, Stephen J.; Savas, Peter; Klauschen, Frederick; Watson, Peter H.; Nelson, Brad H.; Criscitiello, Carmen; O'Toole, Sandra; Larsimont, Denis; de Wind, Roland; Curigliano, Giuseppe; Andre, Fabrice; Lacroix-Triki, Magali; van de Vijver, Mark; Rojo, Federico; Floris, Giuseppe; Bedri, Shahinaz; Sparano, Joseph; Rimm, David; Nielsen, Torsten; Kos, Zuzana; Hewitt, Stephen; Singh, Baljit; Farshid, Gelareh; Loibl, Sibylle; Allison, Kimberly H.; Tung, Nadine; Adams, Sylvia; Willard-Gallo, Karen; Horlings, Hugo M.; Gandhi, Leena; Moreira, Andre; Hirsch, Fred; Dieci, Maria V.; Urbanowicz, Maria; Brcic, Iva; Korski, Konstanty; Gaire, Fabien; Koeppen, Hartmut; Lo, Amy; Giltnane, Jennifer; Rebelatto, Marlon C.; Steele, Keith E.; Zha, Jiping; Emancipator, Kenneth; Juco, Jonathan W.; Denkert, Carsten; Reis-Filho, Jorge; Loi, Sherene; Fox, Stephen B. Share Save The molecular basis of breast cancer pathological phenotypesHeng, Yujing J.; Lester, Susan C.; Tse, Gary M. K.; Factor, Rachel E.; Allison, Kimberly H.; Collins, Laura C.; Chen, Yunn-Yi; Jensen, Kristin C.; Johnson, Nicole B.; Jeong, Jong Cheol; Punjabi, Rahi; Shin, Sandra J.; Singh, Kamaljeet; Krings, Gregor; Eberhard, David A.; Tan, Puay Hoon; Korski, Konstanty; Waldman, Frederic M.; Gutman, David A.; Sanders, Melinda; Reis-Filho, Jorge S.; Flanagan, Sydney R.; Gendoo, Deena M. A.; Chen, Gregory M.; Haibe-Kains, Benjamin; Ciriello, Giovanni; Hoadley, Katherine A.; Perou, Charles M.; Beck, Andrew H. Share Save Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinomaWallin, Jeffrey J.; Bendell, Johanna C.; Funke, Roel; Sznol, Mario; Korski, Konstanty; Jones, Suzanne; Hernandez, Genevive; Mier, James; He, Xian; Hodi, F. Stephen; Denker, Mitchell; Leveque, Vincent; Canamero, Marta; Babitski, Galina; Koeppen, Hartmut; Ziai, James; Sharma, Neeraj; Gaire, Fabien; Chen, Daniel S.; Waterkamp, Daniel; Hegde, Priti S.; McDermott, David F. Share Save Share Save Applying TCGA data for breast cancer diagnostics and pathway analysisAndersen, Jannik; Shah, Parantu; Ibbs, Matthew; Filas, Violetta; Korski, Konstanty; Marszalek, Andrzej; Wu, Yuanqing; Chang, Edward; Toniatti, Carlo; Draetta, Giulio; Wiznerowicz, Maciej Share Save 
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