Jonathan G. Seidman - Publications, H-index & Citations

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Jonathan G. Seidman

Harvard University

132H-index

534Paper Count

9.3WCitation Count

Published Papers 217

Publication Date

Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy

Science

IF45.8

2026-01-15

PREAI

Wei, Eric Q.; Beyer, Martin; Brown, Kemar J.; Bansbach, Alexander J.; Gorham, Joshua M.; Mcdonough, Barbara; Chen, Huachen; Khoramjoo, Mobin; Zhang, Anran; Bishop, Brian; Ahmad, Ferhaan; Del Rio, Carlos; Chang, Ching-Pin; Ryba, David M.; Day, Sharlene M.; Fatkin, Diane; Oudit, Gavin Y.; Seidman, Christine E.; Seidman, Jonathan G.

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Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

Science

IF45.8

2025-09-04

PREAI

Huihui Huang; Yi Wang; Zsuzsanna K. Zsengeller; Joshua M. Gorham; Vamsidhara Vemireddy; Amanda J. Clark; Hui Pan; Jonathan M. Dreyfuss; Vasantha Jotwani; Michael G. Shlipak; Mark J. Sarnak; Chirag R. Parikh; Heather Thiessen-Philbrook; Ronit Katz; Sushrut S. Waikar; Nicole J. Lake; Monkol Lek; Wen Shi; Daniela Puiu; Yun Soo Hong; Jonathan G. Seidman; Dan E. Arking; Samir M. Parikh

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Endocardial primary cilia and blood flow regulate EndoMT during endocardial cushion development

cardiovascular research

IF10.8

2025-08-26

OAAI

Kathryn Berg; Joshua Gorham; Faith Lundt; Jonathan Seidman; Martina Brueckner

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Genome sequencing is critical for forecasting outcomes following congenital cardiac surgery

Nature Communications

IF15.7

2025-07-10

OAAI

W. Scott Watkins; Edgar J. Hernandez; Thomas A. Miller; Nathan R. Blue; Raquel Mae Zimmerman; Eric R. Griffiths; Erwin Frise; Daniel Bernstein; Marko T. Boskovski; Martina Brueckner; Wendy K. Chung; J. William Gaynor; Bruce D. Gelb; Elizabeth Goldmuntz; Peter J. Gruber; Jane W. Newburger; Amy E. Roberts; Sarah U. Morton; John E. Mayer; Christine E. Seidman; Jonathan G. Seidman; Yufeng Shen; Michael Wagner; H. Joseph Yost; Mark Yandell; Martin Tristani-Firouzi

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Regulatory T cells attenuate chronic inflammation and cardiac fibrosis in hypertrophic cardiomyopathy

Science Translational Medicine

IF14.6

2025-07-09

PREAI

Ying-Jie Wang; Kamayani Singh; Adam B. Lokman; Siwei Deng; Balaraju Sunitha; Jose Coelho Lima Jr.; Julia Beglov; Matthew Kelly; Andrew Blease; Jacky C. K. Fung; Anan Huang; Moustafa Attar; Lee-Anne Stork; Mahon L. Maguire; Jürgen E. Schneider; Steve B. Marston; Elizabeth J. Soilleux; Calliope A. Dendrou; Mark Coles; Christopher D. Buckley; Jonathan G. Seidman; Christine E. Seidman; Charles Redwood; Houman Ashrafian; Hugh Watkins

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Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model

EUROPEAN HEART JOURNAL

IF35.6

2025-05-21

OAAI

Baka, Tomas; Moore, Jarrod; Qin, Fuzhong; Yurista, Salva R.; Zhang, Aifeng; He, Huamei; Chambers, Jordan M.; Croteau, Dominique; Goel, Raghuveera K.; Smith, Hunter; Wang, Miranda C.; Chen, Christopher S.; Hobai, Ion A.; Rombaldova, Martina; Kuda, Ondrej; Tardiff, Jil C.; Balschi, James A.; Pimentel, David R.; Seidman, Christine E.; Seidman, Jonathan G.; Emili, Andrew; Colucci, Wilson S.; Luptak, Ivan

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Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis

JOURNAL OF THE AMERICAN HEART ASSOCIATION

IF5.3

2025-03-04

PREAI

Ward, Tarsha; Morton, Sarah U.; Venturini, Gabriela; Tai, Warren; Jang, Min Young; Gorham, Joshua; Delaughter, Dan; Wasson, Lauren K.; Khazal, Zahra; Homsy, Jason; Gelb, Bruce D.; Chung, Wendy K.; Bruneau, Benoit G.; Brueckner, Martina; Tristani-Firouzi, Martin; Depalma, Steven R.; Seidman, Christine; Seidman, J. G.

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Predictive modeling of endocardial fibroelastosis recurrence in patients with congenital heart disease

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

IF4.4

2025-02-01

PREAI

Diaz-Gil, Daniel; Silva-Gomez, Natalia; Morton, Sarah U.; Seidman, Jonathan G.; Seidman, Christine E.; Zurakowski, David; Staffa, Steven J.; Marx, Gerald R.; Emani, Sitaram M.; Nido, Pedro J. del; Friehs, Ingeborg

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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy

SCIENTIFIC REPORTS

IF3.9

2025-01-16

OAAI

Raj Murthi, Sarala; Petry, Andreas; Shashikadze, Bachuki; Stoeckl, Jan B.; Schmid, Manuel; Santamaria, Gianluca; Klingel, Karin; Kracun, Damir; Chen, Xinpei; Bauer, Sabine; Schmitt, Joachim P.; Flenkenthaler, Florian; Gorham, Josh; Toepfer, Christopher N.; Potesil, David; Hruska, Pavel; Zdrahal, Zbynek; Mayer, Zsuzsanna; Klop, Mathieu; Lehmann, Luisa; Qin, Yishi; Papanakli, Laura; Spielmann, Nadine; Moretti, Alessandra; Froehlich, Thomas; Ewert, Peter; Holdenrieder, Stefan; Seidman, Jonathan G.; Seidman, Christine E.; Goerlach, Agnes; Wolf, Cordula M.

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Single-Nucleus RNA Sequencing Reveals Region-Specific Cell Composition and Transcriptional Variations in Cardiac Sarcoidosis

CIRCULATION

IF38.6

2024-11-12

PREAI

Neyazi, Meraj; Kim, Yuri; Brown, Kemar; Barish, Syndi; Gorham, Joshua; Layton, Olivia; Viveiros, Anissa; DeLaughter, Daniel; Beyer, Martin; Strohmenger, Viktoria; Reichart, Daniel; Bowles, Dawn; Glass, Carolyn; Oudit, Gavin; Seidman, Jonathan; Seidman, Christine

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Cellular Crosstalk in Endocardial Fibroelastosis: NRG Signaling Dysregulation Contributes to Fibrosis and Myocardial Dysfunction in Hypoplastic Left Heart Complex

CIRCULATION

IF38.6

2024-11-12

PREAI

Diaz-Gil, Daniel; Morton, Sarah; Brown, Kemar; Wei, Eric; Saraci, Kerstin; von Piechowski, Magnus; Emani, Sitaram; Del Nido, Pedro; Seidman, Jonathan; Seidman, Christine; Friehs, Ingeborg

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Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling

SCIENCE ADVANCES

IF12.5

2024-10-18

OAAI

Ewoldt, Jourdan K.; Wang, Miranda C.; McLellan, Micheal A.; Cloonan, Paige E.; Chopra, Anant; Gorham, Joshua; Li, Linqing; DeLaughter, Daniel M.; Gao, Xining; Lee, Joshua H.; Willcox, Jon A. L.; Layton, Olivia; Luu, Rebeccah J.; Toepfer, Christopher N.; Eyckmans, Jeroen; Seidman, Christine E.; Seidman, Jonathan G.; Chen, Christopher S.

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An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury

cardiovascular research

IF10.8

2024-08-15

OAAI

Fleischer, Sharon; Nash, Trevor R.; Tamargo, Manuel A.; Lock, Roberta I.; Venturini, Gabriela; Morsink, Margaretha; Graney, Pamela L.; Li, Vanessa; Lamberti, Morgan J.; Liberman, Martin; Kim, Youngbin; Tavakol, Daniel N.; Zhuang, Richard Z.; Whitehead, Jaron; Friedman, Richard A.; Soni, Rajesh K.; Seidman, Jonathan G.; Seidman, Christine E.; Geraldino-Pardilla, Laura; Winchester, Robert; Vunjak-Novakovic, Gordana

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CHD4 and SMYD1 repress common transcriptional programs in the developing heart

DEVELOPMENT

IF3.6

2024-05-03

OAAI

Shi, Wei; Wasson, Lauren K.; Dorr, Kerry M.; Robbe, Zachary L.; Wilczewski, Caralynn M.; Hepperla, Austin J.; Davis, Ian J.; Seidman, Christine E.; Seidman, Jonathan G.; Conlon, Frank L.

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Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution

CIRCULATION RESEARCH

IF16.2

2024-03-01

PREAI

Chen, Jian; Zhang, Xiaoran; DeLaughter, Daniel M.; Trembley, Michael A.; Saifee, Shaila; Xiao, Feng; Chen, Jiehui; Zhou, Pingzhu; Seidman, Christine E.; Seidman, Jonathan G.; Pu, William T.

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Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease

NATURE GENETICS

IF31.8

2024-02-20

OAAI

Xiao, Feng; Zhang, Xiaoran; Morton, Sarah U.; Kim, Seong Won; Fan, Youfei; Gorham, Joshua M.; Zhang, Huan; Berkson, Paul J.; Mazumdar, Neil; Cao, Yangpo; Chen, Jian; Hagen, Jacob; Liu, Xujie; Zhou, Pingzhu; Richter, Felix; Shen, Yufeng; Ward, Tarsha; Gelb, Bruce D.; Seidman, Jonathan G.; Seidman, Christine E.; Pu, William T.

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Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors

DEVELOPMENTAL CELL

IF8.7

2024-02-01

OAAI

Atsuta, Yuji; Lee, Changhee; Rodrigues, Alan R.; Colle, Charlotte; Tomizawa, Reiko R.; Lujan, Ernesto G.; Tschopp, Patrick; Galan, Laura; Zhu, Meng; Gorham, Joshua M.; Vannier, Jean-Pierre; Seidman, Christine E.; Seidman, Jonathan G.; Ros, Marian A.; Pourquie, Olivier; Tabin, Clifford J.

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The H2Bub1-deposition complex is required for human and mouse cardiogenesis

DEVELOPMENT

IF3.6

2023-12-01

OAAI

Barish, Syndi; Berg, Kathryn; Drozd, Jeffrey; Berglund-Brown, Isabella; Khizir, Labeeqa; Wasson, Lauren K.; Seidman, Christine E.; Seidman, Jonathan G.; Chen, Sidi; Brueckner, Martina

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SGLT2 Inhibitor Empagliflozin Increases Fatty Acid Oxidation, Coupling Between Glycolysis and Glucose Oxidation, and Decreases Left Ventricular Hypertrophy in Mice With Hypertrophic Cardiomyopathy Due to Myosin R403Q Mutation

CIRCULATION

IF38.6

2023-11-07

PREAI

Baka, Tomas; Moore, Jarrod; Qin, Fuzhong; He, Huamei; Chambers, Jordan M.; Croteau, Dominique; Goel, Raghuveera; Zhang, Aifeng; Smith, Hunter; Balschi, James A.; Pimentel, David R.; Seidman, Christine E.; Seidman, Jonathan G.; Emili, Andrew; Colucci, Wilson S.; Luptak, Ivan

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Myocardial Infiltration of the Epicardial Adipose Tissue in Human Heart Failure

CIRCULATION

IF38.6

2023-11-07

PREAI

Viveiros, Anissa; Brown, Kemar J.; Chen, Huachen; Zhang, Anran; Khoramjoo, Mobin; Kim, Yuri; Seidman, Jonathan G.; Seidman, Christine E.; Oudit, Gavin Y.

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Research Directions