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Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model Baka, Tomas; Moore, Jarrod; Qin, Fuzhong; Yurista, Salva R.; Zhang, Aifeng; He, Huamei; Chambers, Jordan M.; Croteau, Dominique; Goel, Raghuveera K.; Smith, Hunter; Wang, Miranda C.; Chen, Christopher S.; Hobai, Ion A.; Rombaldova, Martina; Kuda, Ondrej; Tardiff, Jil C.; Balschi, James A.; Pimentel, David R.; Seidman, Christine E.; Seidman, Jonathan G.; Emili, Andrew; Colucci, Wilson S.; Luptak, Ivan Share Save
Efficient identification of de novo mutations in family trios: a consensus-based informatic approach Shadrina, Mariya; Kalay, Ozem; Demirkaya-Budak, Sinem; Leduc, Charles A.; Chung, Wendy K.; Turgut, Deniz; Budak, Gungor; Arslan, Elif; Semenyuk, Vladimir; Davis-Dusenbery, Brandi; Seidman, Christine E.; Yost, H. Joseph; Jain, Amit; Gelb, Bruce D. Share Save
Modeling SMAD2 Mutations in Induced Pluripotent Stem Cells Provides Insights Into Cardiovascular Disease Pathogenesis Ward, Tarsha; Morton, Sarah U.; Venturini, Gabriela; Tai, Warren; Jang, Min Young; Gorham, Joshua; Delaughter, Dan; Wasson, Lauren K.; Khazal, Zahra; Homsy, Jason; Gelb, Bruce D.; Chung, Wendy K.; Bruneau, Benoit G.; Brueckner, Martina; Tristani-Firouzi, Martin; Depalma, Steven R.; Seidman, Christine; Seidman, J. G. Share Save
Deciphering the digenic architecture of congenital heart disease using trio exome sequencing data Kars, Meltem Ece; Stein, David; Stenson, Peter D.; Cooper, David N.; Chung, Wendy K.; Gruber, Peter J.; Seidman, Christine E.; Shen, Yufeng; Tristani-Firouzi, Martin; Gelb, Bruce D.; Itan, Yuval Share Save
Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy Raj Murthi, Sarala; Petry, Andreas; Shashikadze, Bachuki; Stoeckl, Jan B.; Schmid, Manuel; Santamaria, Gianluca; Klingel, Karin; Kracun, Damir; Chen, Xinpei; Bauer, Sabine; Schmitt, Joachim P.; Flenkenthaler, Florian; Gorham, Josh; Toepfer, Christopher N.; Potesil, David; Hruska, Pavel; Zdrahal, Zbynek; Mayer, Zsuzsanna; Klop, Mathieu; Lehmann, Luisa; Qin, Yishi; Papanakli, Laura; Spielmann, Nadine; Moretti, Alessandra; Froehlich, Thomas; Ewert, Peter; Holdenrieder, Stefan; Seidman, Jonathan G.; Seidman, Christine E.; Goerlach, Agnes; Wolf, Cordula M. Share Save
Single-Nucleus RNA Sequencing Reveals Region-Specific Cell Composition and Transcriptional Variations in Cardiac Sarcoidosis Neyazi, Meraj; Kim, Yuri; Brown, Kemar; Barish, Syndi; Gorham, Joshua; Layton, Olivia; Viveiros, Anissa; DeLaughter, Daniel; Beyer, Martin; Strohmenger, Viktoria; Reichart, Daniel; Bowles, Dawn; Glass, Carolyn; Oudit, Gavin; Seidman, Jonathan; Seidman, Christine Share Save
Hypertrophic cardiomyopathy-associated mutations drive stromal activation via EGFR-mediated paracrine signaling Ewoldt, Jourdan K.; Wang, Miranda C.; McLellan, Micheal A.; Cloonan, Paige E.; Chopra, Anant; Gorham, Joshua; Li, Linqing; DeLaughter, Daniel M.; Gao, Xining; Lee, Joshua H.; Willcox, Jon A. L.; Layton, Olivia; Luu, Rebeccah J.; Toepfer, Christopher N.; Eyckmans, Jeroen; Seidman, Christine E.; Seidman, Jonathan G.; Chen, Christopher S. Share Save
An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury Fleischer, Sharon; Nash, Trevor R.; Tamargo, Manuel A.; Lock, Roberta I.; Venturini, Gabriela; Morsink, Margaretha; Graney, Pamela L.; Li, Vanessa; Lamberti, Morgan J.; Liberman, Martin; Kim, Youngbin; Tavakol, Daniel N.; Zhuang, Richard Z.; Whitehead, Jaron; Friedman, Richard A.; Soni, Rajesh K.; Seidman, Jonathan G.; Seidman, Christine E.; Geraldino-Pardilla, Laura; Winchester, Robert; Vunjak-Novakovic, Gordana Share Save
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CHD4 and SMYD1 repress common transcriptional programs in the developing heart Shi, Wei; Wasson, Lauren K.; Dorr, Kerry M.; Robbe, Zachary L.; Wilczewski, Caralynn M.; Hepperla, Austin J.; Davis, Ian J.; Seidman, Christine E.; Seidman, Jonathan G.; Conlon, Frank L. Share Save
Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution Chen, Jian; Zhang, Xiaoran; DeLaughter, Daniel M.; Trembley, Michael A.; Saifee, Shaila; Xiao, Feng; Chen, Jiehui; Zhou, Pingzhu; Seidman, Christine E.; Seidman, Jonathan G.; Pu, William T. Share Save
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease Xiao, Feng; Zhang, Xiaoran; Morton, Sarah U.; Kim, Seong Won; Fan, Youfei; Gorham, Joshua M.; Zhang, Huan; Berkson, Paul J.; Mazumdar, Neil; Cao, Yangpo; Chen, Jian; Hagen, Jacob; Liu, Xujie; Zhou, Pingzhu; Richter, Felix; Shen, Yufeng; Ward, Tarsha; Gelb, Bruce D.; Seidman, Jonathan G.; Seidman, Christine E.; Pu, William T. Share Save
Direct reprogramming of non-limb fibroblasts to cells with properties of limb progenitors Atsuta, Yuji; Lee, Changhee; Rodrigues, Alan R.; Colle, Charlotte; Tomizawa, Reiko R.; Lujan, Ernesto G.; Tschopp, Patrick; Galan, Laura; Zhu, Meng; Gorham, Joshua M.; Vannier, Jean-Pierre; Seidman, Christine E.; Seidman, Jonathan G.; Ros, Marian A.; Pourquie, Olivier; Tabin, Clifford J. Share Save
The H2Bub1-deposition complex is required for human and mouse cardiogenesis Barish, Syndi; Berg, Kathryn; Drozd, Jeffrey; Berglund-Brown, Isabella; Khizir, Labeeqa; Wasson, Lauren K.; Seidman, Christine E.; Seidman, Jonathan G.; Chen, Sidi; Brueckner, Martina Share Save
SGLT2 Inhibitor Empagliflozin Increases Fatty Acid Oxidation, Coupling Between Glycolysis and Glucose Oxidation, and Decreases Left Ventricular Hypertrophy in Mice With Hypertrophic Cardiomyopathy Due to Myosin R403Q Mutation Baka, Tomas; Moore, Jarrod; Qin, Fuzhong; He, Huamei; Chambers, Jordan M.; Croteau, Dominique; Goel, Raghuveera; Zhang, Aifeng; Smith, Hunter; Balschi, James A.; Pimentel, David R.; Seidman, Christine E.; Seidman, Jonathan G.; Emili, Andrew; Colucci, Wilson S.; Luptak, Ivan Share Save
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Unraveling Postoperative Atrial Fibrillation at the Single-Cell Level Tiwari, Sameeksha; DeLaughter, Daniel; Yazdani, Azam; Gorham, Joshua; Aranki, Sary; Pesce, Lorenzo; Seidman, Christine E.; Seidman, Jonathan G.; Stranger, Barbara; Muehlschlegel, Danny J. Share Save
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