Not logged in Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer Zhong, Zheng; Cao, Xinang; Liao, Pei-Ju; Sethi, Raman; Klomp, Jeffrey A.; Stalnecker, Clint A.; Chen, Jinmiao; Wan, Yue; Der, Channing J.; Virshup, David M. Share Save
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Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer Hibshman, Priya S.; Stalnecker, Clint A.; Klomp, Jeffrey A.; Drizyte-Miller, Kristina; Klomp, Jennifer E.; Edwards, A. Cole; Pita, Lily M.; Hodge, Richard G.; Diehl, J. Nathaniel; Mouery, Ryan D.; Mouery, Brandon L.; Snare, Kayla R.; Waters, Andrew M.; Peng, Sen; Barker, Natalie K.; Pierobon, Mariaelena; Rashid, Naim U.; Tran, Nhan L.; Herring, Laura A.; Graves, Lee M.; Petricoin, Emanuel F.; Bryant, Kirsten L.; Cox, Adrienne D.; Der, Channing J. Share Save
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress Anand, Jay R.; Droby, Gaith N.; Joseph, Sayali; Patel, Urvi; Zhang, Xingyuan; Klomp, Jeffrey A.; Der, Channing J.; Purvis, Jeremy E.; Wolff, Samuel C.; Bowser, Jessica L.; Vaziri, Cyrus Share Save
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Concurrent inhibition of the RAS ERK-MAPK pathway and PIKfyve as a therapeutic strategy for pancreatic cancer DeLiberty, Jonathan M.; Roach, Mallory K.; Stalnecker, Clint A.; Robb, Ryan; Schechter, Elyse G.; Pieper, Noah L.; Yang, Runying; Bang, Scott; Taylor, Khalilah E.; Drizyte-Miller, Kristina; Morris, John P.; Der, Channing J.; Cox, Adrienne D.; Bryant, Kirsten L. Share Save
An open label, phase II trial of ERK inhibition alone and in combination with autophagy inhibition in patients with metastatic cancreatic cancer Surana, Rishi; Zheng, Hui; Wang, Junning; Morgado, Micaela; Brais, Lauren K.; Bryant, Kirsten L.; Somasundaram, Ashwin; Weekes, Colin D.; Bockorny, Bruno; Peters, Mary Linton B.; Bullock, Andrea J.; Zerillo, Jessica A.; Rattani, Ahmed A.; Sanoff, Hanna K.; Clark, Jeffrey W.; Parikh, Aparna R.; Yurgelun, Matthew B.; Patel, Anuj; Mayer, Robert J.; Cleary, James M.; Enzinger, Peter C.; Rubinson, Douglas A.; McCleary, Nadine J.; Enzinger, Andrea C.; Slater, Sarah E.; Ng, Kimmie; Abrams, Thomas A.; Biller, Leah; Raghavan, Srivatsan; Mancias, Joseph D.; Nowak, Jonathan O.; Aguirre, Andrew J.; Der, Channing J.; Wolpin, Brian M.; Perez, Kimberley Share Save
Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers Nussbaum, Daniel P.; Martz, Colin A.; Waters, Andrew M.; Barrera, Alejandro; Liu, Annie; Rutter, Justine C.; Cerda-Smith, Christian G.; Stewart, Amy E.; Wu, Chao; Cakir, Merve; Levandowski, Cecilia B.; Kantrowitz, David E.; Mccall, Shannon J.; Pierobon, Mariaelena; Petricoin III, Emanuel F.; Joshua Smith, J.; Reddy, Timothy E.; Der, Channing J.; Taatjes, Dylan J.; Wood, Kris C. Share Save
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Resistance to RAS-GTP inhibition in models of pancreatic ductal adenocarcinoma arises downstream of RAS effectors Wasko, Urszula N.; Jiang, Jingjing; Wang, Yingyun; Tomassoni, Lorenzo; Jiang, Lingyan; Menard, Marie; Curiel-Garcia, Alvaro; Dalton, Tanner C.; Orlen, Margo; Edwards, Cole; Stalnecker, Clint; Dilly, Julien; Chang, Stephanie; Sastra, Stephen A.; Palermo, Carmine F.; Baslan, Timour; Tian, Sha; Holderfield, Matthew; Quintana, Elsa; Wang, Zhengping; Smith, Jacqueline A.; Califano, Andrea; Wildes, David; Aguirre, Andrew J.; Vonderheide, Robert H.; Stanger, Ben Z.; Lowe, Scott W.; Der, Channing J.; Singh, Mallika; Olive, Kenneth P. Share Save
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Improving the efficacy of dual ERK-MAPK and autophagy inhibition as a therapeutic strategy for pancreatic ductal adenocarcinoma DeLiberty, Jonathan M.; Roach, Mallory K.; Pieper, Noah L.; Drizyte-Miller, Kristina; Schechter, Elyse G.; Yang, Runying; Der, Channing J.; Cox, Adrienne D.; Stalnecker, Clint A.; Bryant, Kirsten L. Share Save
Tumor-selective inhibition of active RAS in pancreatic ductal adenocarcinoma Wasko, Urszula N.; Jiang, Jingjing; Tomassoni, Lorenzo; Wang, Yingyun; Lee, Bianca; Orlen, Margo; Drizyte-Miller, Kristina; Menard, Marie; Dilly, Julien; Sastra, Steven A.; Palermo, Carmine F.; Chang, Stephanie; Aguirre, Andrew J.; Der, Channing J.; Vonderheide, Robert H.; Stanger, Ben Z.; Califano, Andrea; Singh, Mallika; Olive, Kenneth P. Share Save
The RAF/MEK clamp avutometinib as the backbone of therapy for pancreatic cancer: Novel combinations with standard of care chemotherapy, FAK inhibitors, KRAS G12D inhibitors and/or autophagy inhibitors Coma, Silvia; Liu, Xiuting; Pieper, Noah L.; Chang, Wen-Hsuan; Bryant, Kirsten L.; Der, Channing J.; DeNardo, David G.; Pachter, Jonathan A. Share Save
RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling Schaefer, Antje; Hodge, Richard G.; Zhang, Haisheng; Hobbs, G. Aaron; Dilly, Julien; Huynh, Minh V.; Goodwin, Craig M.; Zhang, Feifei; Diehl, J. Nathaniel; Pierobon, Mariaelena; Baldelli, Elisa; Javaid, Sehrish; Guthrie, Karson; Rashid, Naim U.; Petricoin, Emanuel F.; Cox, Adrienne D.; Hahn, William C.; Aguirre, Andrew J.; Bass, Adam J.; Der, Channing J. Share Save
TEAD Inhibition Overcomes YAP1/TAZ-Driven Primary and Acquired Resistance to KRASG12C Inhibitors Edwards, A. Cole; Stalnecker, Clint A.; Morales, Alexis Jean; Taylor, Khalilah E.; Klomp, Jennifer E.; Klomp, Jeffrey A.; Waters, Andrew M.; Sudhakar, Niranjan; Hallin, Jill; Tang, Tracy T.; Olson, Peter; Post, Leonard; Christensen, James G.; Cox, Adrienne D.; Der, Channing J. Share Save
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