Pak C. Sham - Publications, H-index & Citations

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Pak C. Sham

LKS Faculty of Medicine

135H-index

1.1KPaper Count

12.9WCitation Count

Published Papers 500

Publication Date

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study

Translational Psychiatry

IF6.2

2026-08-05

OAAI

Giulia Trotta; Isabelle Austin-Zimmerman; Edoardo Spinazzola; Lucia Sideli; Monica Aas; Victoria Rodriguez; Senta Haussler; Zhikun Li; Perry BM Leung; Qiang Li; Diego Quattrone; Teya Petrova; Craig Morgan; Michael O’Donovan; Pak C. Sham; Evangelos Vassos; Chloe CY Wong; Richard Bentall; Robin M. Murray; Luis Alameda; Marta Di Forti

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Genetic evidence for causal relationship between general cognition and treatment resistance in schizophrenia

Translational Psychiatry

IF6.2

2026-04-01

OAAI

Chao Li; Yuanxin Zhong; Pak Chung Sham; Sherry Kit Wa Chan

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DNA methylation signatures associated with early-onset schizophrenia in Chinese patients

Translational Psychiatry

IF6.2

2026-02-10

OAAI

Na Zhan; Perry B. M. Leung; Yuanxin Zhong; Kenneth C. Y. Wong; Tomy C. K. Hui; Hon-Cheong So; Pak C. Sham; Chloe C. Y. Wong; Simon S. Y. Lui

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Multidimensional mapping of stimulation-responsive regulatory elements and candidate causal variants in T cell activation

SCIENCE ADVANCES

IF12.5

2026-01-01

PREAI

Wang, Zhao; Dong, Wei; Feng, Xiangling; Xu, Xinran; An, Yao; Xiao, Huiling; Luo, Menghan; Liang, Qian; Bai, Ruoxuan; Zhao, Ke; Wu, Liuxing; Zhao, Lin; Zhou, Yao; Yi, Xianfu; Huang, Dandan; Sengupta, Kaustav; Plewczynski, Dariusz; Sham, Pak Chung; Liu, Chao; Yu, Yang; Li, Wei; Gong, Qing; Song, Weihong; Zhou, Wenhao; Li, Mulin Jun

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All-cause and cause-specific mortality in people with mental disorders: a population-based study on risk evaluation, effect modifiers and excess life-years lost in Hong Kong

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2025-12-01

PREAI

Chan, Joe Kwun-Nam; Li, Ryan Cheuk-Yin; Plana-Ripoll, Oleguer; Momen, Natalie C.; Correll, Christoph U.; Solmi, Marco; Wong, Corine Sau-Man; Ku, Kam-Ming; Mahboobani, Vanessa Ramesh; Chung, Albert Kar-Kin; Lui, Simon Sai-Yu; Sham, Pak-Chung; Chang, Wing-Chung

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Stratifying variant deleteriousness and trait-modulating effect under human recent adaptation using the FIND model

Genome Biology

IF9.4

2025-10-30

OAAI

Xutong Fan; Dandan Huang; Zhikun Wu; Xinran Dong; Jianhua Wang; Shijie Zhang; Xiaobao Dong; Xiaoqiong Gu; Miaoxin Li; Pak Chung Sham; Xianfu Yi; Wenhao Zhou; Mulin Jun Li

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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

Cell Genomics

IF9

2025-08-28

OAAI

Ke Zhao; Yao Zhou; Xueqi Wang; Zhao Wang; Xinran Xu; Yichen Chen; Lin Zhao; Chengyue Wu; Jianhua Wang; Hongcheng Yao; Xin Cheng; Wei Wang; Xinlei Chu; Weixin Wang; Xianfu Yi; Yupeng Chen; Miaoxin Li; Wange Lu; Kexin Chen; Pak Chung Sham; Dandan Huang; Jing Zhang; Mulin Jun Li

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Autism epidemiology in Hong Kong children and youths aged 6–17: Implications on autism screening and sex differences in the community

Autism

IF5.6

2025-07-27

PREAI

Oscar WH Wong; Sandra SM Chan; Steven WH Chau; Winnie CW Chu; Carol SW Ho; Stephy WS Ho; Se Fong Hung; Samara Hussain; Kelly YC Lai; Angela MW Lam; Holly HL Lo; Karen KY Ma; Suk Ling Ma; Flora YM Mo; Pak Chung Sham; Caroline KS Shea; Suzanne HW So; Kelvin KF Tsoi; Patrick WL Leung

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Characterizing the HLA region’s genetic architecture through local heritability and correlation analyses across complex traits in diverse ancestries

Human Genetics

IF3.6

2025-07-17

PREAI

Menghan Wei; Yunjia Liu; Yunqi Huang; Ana Vazquez; Xing Zhao; Miaoxin Li; Pak-Chung Sham; Hongsheng Gui; Qiang Wang

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TransferTWAS: A transfer learning framework for cross-tissue transcriptome-wide association study

american journal of human genetics

IF0

2025-06-30

PREAI

Daoyuan Lai; Han Wang; Tian Gu; Siqi Wu; Dajiang J. Liu; Pak Chung Sham; Yan Dora Zhang

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Twelve-month prevalence of DSM-5 mental disorders and the psychosocial correlates- a child and adolescent psychiatric epidemiologic survey in Hong Kong SAR

LANCET REGIONAL HEALTH-WESTERN PACIFIC

IF8.1

2025-04-01

OAAI

Chan, Sandra S. M.; Wong, Oscar W. H.; Hussain, Samara; Tsoi, Kelvin K. F.; Ma, Karen K. Y.; Chau, Steven W. H.; Ma, Suk Ling; Lai, Kelly Y. C.; Chu, Winnie C. W.; Lo, Holly H. L.; Ho, Stephy W. S.; Leung, Ching Chi; Yiu, Karen K. L.; So, Suzanne H. W.; Sham, Pak C.; Hung, Se Fong; Leung, Patrick W. L.

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MAAT: a new nonparametric Bayesian framework for incorporating multiple functional annotations in transcriptome-wide association studies

GENOME BIOLOGY

IF9.4

2025-02-04

OAAI

Wang, Han; Li, Xiang; Li, Teng; Li, Zhe; Sham, Pak Chung; Zhang, Yan Dora

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Excess mortality and life-years lost in people diagnosed with depression: A 20-year population-based cohort study of 126,573 depressed individuals followed for 1,139,073 persons-years

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2025-02-01

PREAI

Lo, Heidi Ka Ying; Chan, Joe Kwun Nam; Wong, Corine Sau Man; Chung, Ka Fai; Correll, Christoph U.; Solmi, Marco; Baum, Lawrence W.; Thach, Thuan Quoc; Sham, Pak Chung; Chang, Wing Chung

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Polygenic and Polyenvironment Interplay in Schizophrenia-Spectrum Disorder and Affective Psychosis; the EUGEI First Episode Study

SCHIZOPHRENIA BULLETIN

IF4.8

2024-12-10

OAAI

Rodriguez, Victoria; Alameda, Luis; Aas, Monica; Gayer-Anderson, Charlotte; Trotta, Giulia; Spinazzola, Edoardo; Quattrone, Diego; Tripoli, Giada; Jongsma, Hannah E.; Stilo, Simona; La Cascia, Caterina; Ferraro, Laura; La Barbera, Daniele; Lasalvia, Antonio; Tosato, Sarah; Tarricone, Ilaria; Bonora, Elena; Jamain, Stephane; Selten, Jean-Paul; Velthorst, Eva; de Haan, Lieuwe; Llorca, Pierre-Michel; Arrojo, Manuel; Bobes, Julio; Bernardo, Miguel; Arango, Celso; Kirkbride, James; Jones, Peter B.; Rutten, Bart P.; Richards, Alexander; Sham, Pak C.; O'Donovan, Michael; Van Os, Jim; Morgan, Craig; Di Forti, Marta; Murray, Robin M.; Vassos, Evangelos

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Integrated Transcriptome Analysis Reveals Novel Molecular Signatures for Schizophrenia Characterization

ADVANCED SCIENCE

IF14.1

2024-11-20

OAAI

Ni, Tong; Sun, Yu; Li, Zefeng; Tan, Tao; Han, Wei; Li, Miao; Zhu, Li; Xiao, Jing; Wang, Huiying; Zhang, Wenpei; Ma, Yitian; Wang, Biao; Wen, Di; Chen, Teng; Tubbs, Justin; Zeng, Xiaofeng; Yan, Jiangwei; Gui, Hongsheng; Sham, Pak; Guan, Fanglin

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Estimation of causal effects of genes on complex traits using a Bayesian-network-based framework applied to GWAS data

NATURE MACHINE INTELLIGENCE

IF23.9

2024-10-17

PREAI

Yin, Liangying; Feng, Yaning; Shi, Yujia; Lau, Alexandria; Qiu, Jinghong; Sham, Pak-Chung; So, Hon-Cheong

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INTERACTION ANALYSIS IN THE OMICS ERA

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2024-10-01

PREAI

Vassos, Evangelos; Thuan Quoc Thach; Sham, Pak

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GENETIC EVIDENCE FOR CAUSAL RELATIONSHIP BETWEEN GENERAL COGNITIVE FUNCTION AND TREATMENT RESISTANCE IN SCHIZOPHRENIA

EUROPEAN NEUROPSYCHOPHARMACOLOGY

IF6.7

2024-10-01

PREAI

Li, Chao; Chan, Sherry Kit Wa; Sham, Pak

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Unraveling NEK4 as a Potential Drug Target in Schizophrenia and Bipolar I Disorder: A Proteomic and Genomic Approach

SCHIZOPHRENIA BULLETIN

IF4.8

2024-06-13

PREAI

Zhang, Chengcheng; Yang, ZhiHui; Li, Xiaojing; Zhao, Liansheng; Guo, Wanjun; Deng, Wei; Wang, Qiang; Hu, Xun; Li, Ming; Sham, Pak Chung; Xiao, Xiao; Li, Tao

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Whole-exome sequencing in a Chinese sample provides preliminary evidence for the link between rare/low-frequency immune-related variants and early-onset schizophrenia

ASIAN JOURNAL OF PSYCHIATRY

IF4.5

2024-06-01

PREAI

Zhong, Yuanxin; Tubbs, Justin D.; Leung, Perry B. M.; Zhan, Na; Hui, Tomy C. K.; Ho, Karen K. Y.; Hung, Karen S. Y.; Cheung, Eric F. C.; So, Hon-Cheong; Lui, Simon S. Y.; Sham, Pak C.

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Research Directions