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M

Mark D. Minden

ontario cancer institute

92H-index
1.3KPaper Count
4.4WCitation Count
Published Papers 234
Publication Date
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Targeting ABCD1 inhibits peroxisomal fatty acid oxidation to selectively eliminate acute myeloid leukemia cells
errBlood
IF23.1
err2026-03-02
err0
PREAI
errEkaterina N. Parfenova; Nikolina Vrdoljak; Drake A. Mosca; Juan J. Aristizabal-Henao; Michael A. Kiebish; Mark D. Minden; Paul A. Spagnuolo
errShare
errSave
Metabolism-specific drug-repurposing screen reveals itraconazole as a potent OXPHOS inhibitor in acute myeloid leukaemia
errBlood
IF23.1
err2026-02-26
err0
errOAAI
errEkaterini Himonas; Lucie de Beauchamp; Desiree Zerbst; Eudoxie Desmares-Romain; Daniele Sarnello; Eric R. Kalkman; Kevin M. Rattigan; Daniel James; Engy Shokry; Mhairi Copland; Emmanuel Griessinger; Christian Récher; Véronique de Mas; Francois Vergez; David Sumpton; Aaron D. Schimmer; Mark D. Minden; Eyal Gottlieb; Emma Shanks; Jean-Emmanuel Sarry
errShare
errSave
A Stem and Progenitor Cell-Derived Gene Expression Signature is Prognostic for Survival in Myelofibrosis
errBlood
IF23.1
err2026-01-06
err0
errOAAI
errJessie J.F. Medeiros; Andy G.X. Zeng; Suraj Bansal; Hyerin Kim; Michelle Chan-Seng Yue; Tristan Woo; Jessica L. McLeod; Sagar Kothari; Andrea Arruda; Hubert Tsui; Jaime O. Claudio; Dawn Maze; Hassan Sibai; Mark D. Minden; James A. Kennedy; Christopher Famulare; Raajit K. Rampal; Jean C.Y. Wang; John E. Dick; Vikas Gupta
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errSave
What is the prognostic relevance of responses less than a CR to initial AML treatment?
errClinical Lymphoma Myeloma and Leukemia
IF2.7
err2025-10-24
err0
PREAI
errAkhil Rajendra; Elliot Smith; Eshetu G. Atenafu; Aniket Bankar; Steven Chan; Marta Davidson; Vikas Gupta; Mark D. Minden; Maria Agustina Perusini; Guillaume Richard-Carpentier; Aaron Schimmer; Andre C. Schuh; Hassan Sibai; Karen Yee; Dawn Maze
errShare
errSave
Enasidenib plus venetoclax in patients with IDH2-mutated relapsed or refractory acute myeloid leukaemia or myelodysplastic syndrome (ENAVEN-AML): a multicentre, single-arm, phase 1b/2 trial
errThe Lancet Haematology
IF0
err2025-10-08
err0
PREAI
errGuillaume Richard-Carpentier; Gopila Gupta; Charina Koraksic; Severine Cathelin; Lisa Wang; Aniket Bankar; Marta Davidson; Vikas Gupta; Dawn Maze; Mark D Minden; Tracy Murphy; Aaron D Schimmer; Andre C Schuh; Hassan Sibai; Karen Yee; Courtney D DiNardo; Joseph Brandwein; Caroline J McNamara; Steven M Chan
errShare
errSave
CEBPA repression by MECOM blocks differentiation to drive aggressive leukemias
errBlood
IF23.1
err2025-09-26
err0
errOAAI
errTravis J. Fleming; Mateusz Antoszewski; Sander Lambo; Michael C. Gundry; Riccardo Piussi; Lara Wahlster; Sanjana Shah; Fiona E. Reed; Kevin D. Dong; Joao A. Paulo; Steven P. Gygi; Claudia Mimoso; Seth R. Goldman; Karen Adelman; Jennifer A. Perry; Yana Pikman; Kimberly Stegmaier; Maria N. Barrachina; Kellie R. Machlus; Volker Hovestadt; Andrea Arruda; Mark D. Minden; Richard A. Voit; Vijay G. Sankaran
errShare
errSave
Plasma lipid levels predict chemotherapy response and survival in acute myeloid leukemia
errBlood
IF23.1
err2025-08-28
err0
errOAAI
errCristiana O’Brien; Nirvana Nursimulu; Anit Tyagi; Rachel Culp-Hill; Andrea Arruda; Tracy Murphy; Mark D. Minden; Andrew Kent; Brett Stevens; Daniel A. Pollyea; Kristin Hope; Sushant Kumar; Julie A. Reisz; Angelo D'Alessandro; Courtney L. Jones
errShare
errSave
Who truly benefits from gilteritinib combinations in FLT3-mutated relapsed-refractory(R/R) AML: a Canadian single center analysis
errBlood Cancer Journal
IF11.6
err2025-08-26
err0
errOAAI
errAkhil Rajendra; Elliot Smith; Maria Agustina Perusini; Kenny Tang; Eshetu G. Atenafu; Aniket Bankar; Steven Chan; Marta B. Davidson; Vikas Gupta; Dawn Maze; Mark D. Minden; Guillaume Richard-Carpentier; Aaron D. Schimmer; Andre C. Schuh; Karen Yee; Hassan Sibai
errShare
errSave
Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models
errScience Translational Medicine
IF14.6
err2025-08-06
err0
PREAI
errXinyue Zhou; Steven Moreira; Cecilia Restelli; Hong Wang; Soheil Jahangiri; Sajesan Aryal; Emily Tsao; Pengcheng Zhang; Mingming Niu; Harish Kumar; Zaldy Balde; Ana Vujovic; Lina Liu; Nicholas Wong; Andrea Arruda; Mark D. Minden; Yang Zhou; Bhatia Ravi; Jun Qi; Chunliang Li; Kristin J. Hope; Rui Lu
errShare
errSave
Identifying Risk Factors and Outcome for CNS involvement in AML
errclinical lymphoma myeloma leukemia
IF0
err2025-06-24
err0
PREAI
errJack T. Seki; Georgina S. Daher-Reyes; Eshetu G. Atenafu; Jad Sibai; Aniket Bankar; Tayler Young; Steven Chan; Karen Yee; Vikas Gupta; Mark D. Minden; Dawn Maze; Andre Schuh; Aaron Schimmer; Hassan Sibai
errShare
errSave
Mutant IDH1 cooperates with NPM1c or FLT3ITD to drive distinct myeloid diseases and molecular outcomes
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-16
err0
errOAAI
errSakamoto, Takashi; Leca, Julie; Zhang, Xin; Meydan, Cem; Foox, Jonathan; Ramachandran, Parameswaran; Hendrikse, Liam D.; Zhou, Wenjing; Berger, Thorsten; Fortin, Jerome; Chan, Steven M.; Chiang, Ming-Feng; Inoue, Satoshi; Li, Wanda Y.; Chu, Mandy F.; Duncan, Gordon S.; Wakeham, Andrew; Lemonnier, Francois; Tobin, Chantal; Mcwilliam, Ryan; Colonna, Isabelle; Bontoux, Christophe; Jafari, Soode Moghadas; Bowman, Robert L.; Nicolay, Brandon; Ronseaux, Sebastien; Narayanaswamy, Rohini; Levine, Ross L.; Melnick, Ari M.; Mason, Christopher E.; Minden, Mark D.
errShare
errSave
Utilizing insights of DNA repair machinery to discover MMEJ deletions and novel mechanisms
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-11-28
err0
errOAAI
errKadam, Aditee; Shilo, Shay; Naor, Hadas; Wainstein, Alexander; Brilon, Yardena; Feldman, Tzah; Minden, Mark; Kaushansky, Nathali; Chapal-Ilani, Noa; Shlush, Liran
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errSave
The Mitochondrial Unfolded Protein Response (UPRmt) Is Upregulated in Acute Myeloid Leukemia (AML) and Inhibiting the UPRmt Protease, LONP1, Leads to Mitochondrial Protein Aggregation and Cell Death Selectively in AML
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errTcheng, Matthew; Voisin, Veronique; Gronda, Marcela; Hurren, Rose; Ling, Dakai; Yan, Yongran; Zhang, Lan Xin; Feng, Yue; Mamai, Zaynab; Jitkova, Yulia; Sarathy, Chaitra; Arruda, Andrea; Kornblau, Steven M.; Minden, Mark D.; Schimmer, Aaron
errShare
errSave
Single-Cell Proteogenomic Analysis of Clonal Evolution in Patient-Derived Xenograft Models of AML Treated with IDH Inhibitors
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errLiu, Alex; Cathelin, Severine; Yang, Yitong; Aboualizadeh, Farzaneh; Abow, Amina; Basi, Gurbaksh; Li, Lance; Dai, David L.; Maher, Abdula; Grignano, Eric; Hosseini, Mohsen; Ayyathan, Dhanoop Manikoth; Wang, Vivian; Ketela, Troy; Marchione, Dylan; Tron, Adriana; Arruda, Andrea; Minden, Mark D.; Chan, Steven M.
errShare
errSave
The Exportin, CSE1L, Regulates Ribosome Biogenesis and Is a Selective Dependency in Childhood and Young Adult Acute Myeloid Leukemia
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errEgan, Grace; Kumar, Amit; Voisin, Veronique; Hurren, Rose; Chegini, Ali; Ling, Dakai; Thomas, Geethu Emily; Yan, Youngran; Feng, Yue; Bansal, Suraj; Zeng, Andy G. X.; Arruda, Andrea; Dick, John Edgar; Bader, Gary D.; Minden, Mark D.; Schimmer, Aaron D.
errShare
errSave
FLAG-IDA Plus Venetoclax in High-Risk Newly Diagnosed and Relapsed or Refractory Acute Myeloid Leukemia: The Princess Margaret Cancer Center Experience
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errAl-Shaibani, Eshrak; Davidson, Marta Beata; Bankar, Aniket; Chan, Steven M.; Sibai, Hassan; Maze, Dawn C.; Schimmer, Aaron; Minden, Mark D.; Yee, Karen; Gupta, Vikas; Schuh, Andre C.; Richard-Carpentier, Guillaume
errShare
errSave
What Is the Prognostic Relevance of Responses Less Than a CR(Sub-CR) to Initial AML Treatment?
errBLOOD
IF23.1
err2024-11-05
err0
PREAI
errRajendra, Akhil; Smith, Elliot; Atenafu, Eshetu; Bankar, Aniket; Chan, Steven M.; Davidson, Marta Beata; Gupta, Vikas; Minden, Mark D.; Perusini, Maria Agustina; Richard-Carpentier, Guillaume; Schimmer, Aaron; Schuh, Andre C.; Sibai, Hassan; Yee, Karen; Maze, Dawn C.
errShare
errSave
Leptin-Enhanced JAK-STAT Signaling in Acute Myeloid Leukemia-Derived Mesenchymal Stromal Cells and Its Implications for Disease Progression
errBLOOD
IF23.1
err2024-11-05
err1
PREAI
errBhatti, Muzaffar; Travas, Anthea; Ayansola, Oyeronke; Ambalavanan, Amirthagowri; Kim, Jaeyoon John; Pyne, Danielle; Ketela, Troy; Arruda, Andrea; Minden, Mark D.; Keating, Armand; Kim, Dennis Dong Hwan
errShare
errSave
Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia
errEBIOMEDICINE
IF10.8
err2024-10-01
err0
errOAAI
errBorek, Weronika E.; Nobre, Luis; Pedicona, S. Federico; Campbell, Amy E.; Christopher, Josie A.; Nawaz, Nazrath; Perkins, David N.; Moreno-Cardoso, Pedro; Kelsall, Janet; Ferguson, Harriet R.; Patel, Bela; Gallipoli, Paolo; Arruda, Andrea; Ambinder, Alex J.; Thompson, Andrew; Williamson, Andrew; Ghiaur, Gabriel; Minden, Mark D.; Gribben, John G.; Britton, David J.; Cutillas, Pedro R.; Dokal, Arran D.
errShare
errSave
Spermidine metabolism regulates leukemia stem and progenitor cell function through KAT7 expression in patient-derived mouse models
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-09-25
err0
PREAI
errRondeau, Vincent; Berman, Jacob M.; Ling, Tianyi; O'Brien, Cristiana; Culp-Hill, Rachel; Reisz, Julie A.; Wunderlich, Mark; Chueh, Yun; Jimenez-Camacho, Karina E.; Sexton, Christina; Carter, Katharine M.; Stillwell, Cody; St-Germain, Jonathan; Yendi, Duhan; Gupta, Aarushi; Shi, Mary; Bourdine, Aleksandra; Paralkar, Vikram R.; Jahangiri, Soheil; Hope, Kristin J.; Tikhonova, Anastasia N.; Arruda, Andrea; Minden, Mark D.; Raught, Brian; D'Alessandro, Angelo; Jones, Courtney L.
errShare
errSave

Research Directions

No research directions
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