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Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery Buniello, Annalisa; Suveges, Daniel; Cruz-Castillo, Carlos; Llinares, Manuel Bernal; Cornu, Helena; Lopez, Irene; Tsukanov, Kirill; Roldan-Romero, Juan Maria; Mehta, Chintan; Fumis, Luca; Mcneill, Graham; Hayhurst, James D.; Osorio, Ricardo Esteban Martinez; Barkhordari, Ehsan; Ferrer, Javier; Carmona, Miguel; Uniyal, Prashant; Falaguera, Maria J.; Rusina, Polina; Smit, Ines; Schwartzentruber, Jeremy; Alegbe, Tobi; Ho, Vivien W.; Considine, Daniel; Ge, Xiangyu; Szyszkowski, Szymon; Tsepilov, Yakov; Ghoussaini, Maya; Dunham, Ian; Hulcoop, David G.; Mcdonagh, Ellen M.; Ochoa, David Share Save
Artificial intelligence for dementia genetics and omics Bettencourt, Conceicao; Skene, Nathan; Bandres-Ciga, Sara; Anderson, Emma M.; Winchester, Laura F.; Foote, Isabelle; Schwartzentruber, Jeremy A.; Botia, Juan; Nalls, Mike; Singleton, Andrew M.; Schilder, Brian; Humphrey, Jack J.; Marzi, Sarah E.; Toomey, Christina; Al Kleifat, Ahmad L.; Harshfield, Eric; Garfield, Victoria; Sandor, Cynthia; Keat, Samuel; Tamburin, Stefano; Frigerio, Carlo Sala; Lourida, Ilianna; Ranson, Janice M.; Llewellyn, David Share Save
Mapping interindividual dynamics of innate immune response at single-cell resolution Kumasaka, Natsuhiko; Rostom, Raghd; Huang, Ni; Polanski, Krzysztof; Meyer, Kerstin B.; Patel, Sharad; Boyd, Rachel; Gomez, Celine; Barnett, Sam N.; Panousis, Nikolaos, I; Schwartzentruber, Jeremy; Ghoussaini, Maya; Lyons, Paul A.; Calero-Nieto, Fernando J.; Gottgens, Berthold; Barnes, Josephine L.; Worlock, Kaylee B.; Yoshida, Masahiro; Nikolic, Marko Z.; Stephenson, Emily; Reynolds, Gary; Haniffa, Muzlifah; Marioni, John C.; Stegle, Oliver; Hagai, Tzachi; Teichmann, Sarah A. Share Save
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The next-generation Open Targets Platform: reimagined, redesigned, rebuilt Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Baker, Jarrod; Malangone, Cinzia; Lopez, Irene; Miranda, Alfredo; Cruz-Castillo, Carlos; Fumis, Luca; Bernal-Llinares, Manuel; Tsukanov, Kirill; Cornu, Helena; Tsirigos, Konstantinos; Razuvayevskaya, Olesya; Buniello, Annalisa; Schwartzentruber, Jeremy; Karim, Mohd; Ariano, Bruno; Osorio, Ricardo Esteban Martinez; Ferrer, Javier; Ge, Xiangyu; Machlitt-Northen, Sandra; Gonzalez-Uriarte, Asier; Saha, Shyamasree; Tirunagari, Santosh; Mehta, Chintan; Roldan-Romero, Juan Maria; Horswell, Stuart; Young, Sarah; Ghoussaini, Maya; Hulcoop, DavidG; Dunham, Ian; McDonagh, EllenM Share Save
Genetic variants associated with psychiatric disorders are enriched at epigenetically active sites in lymphoid cells Lynall, Mary-Ellen; Soskic, Blagoje; Hayhurst, James; Schwartzentruber, Jeremy; Levey, Daniel F.; Pathak, Gita A.; Polimanti, Renato; Gelernter, Joel; Stein, Murray B.; Trynka, Gosia; Clatworthy, Menna R.; Bullmore, Ed Share Save
Multi-ancestry Mendelian randomization of omics traits revealing drug targets of COVID-19 severity Zheng, Jie; Zhang, Yuemiao; Zhao, Huiling; Liu, Yi; Baird, Denis; Karim, Mohd Anisul; Ghoussaini, Maya; Schwartzentruber, Jeremy; Dunham, Ian; Elsworth, Benjamin; Roberts, Katherine; Compton, Hannah; Miller-Molloy, Felix; Liu, Xingzi; Wang, Lin; Zhang, Hong; Smith, George Davey; Gaunt, Tom R. Share Save
Missense mutations in ITPR1 cause autosomal dominant congenital nonprogressive spinocerebellar ataxia (vol 7, 67, 2012) Huang, Lijia; Warman-Chardon, Jodi; Carter, Melissa T.; Friend, Kathie L.; Dudding, Tracy E.; Schwartzentruber, Jeremy; Zou, Ruobing; Schofield, Peter W.; Douglas, Stuart; Bulman, Dennis E.; Boycott, Kym M. Share Save
A map of transcriptional heterogeneity and regulatory variation in human microglia Young, Adam M. H.; Kumasaka, Natsuhiko; Calvert, Fiona; Hammond, Timothy R.; Knights, Andrew; Panousis, Nikolaos; Park, Jun Sung; Schwartzentruber, Jeremy; Liu, Jimmy; Kundu, Kousik; Segel, Michael; Murphy, Natalia A.; McMurran, Christopher E.; Bulstrode, Harry; Correia, Jason; Budohoski, Karol P.; Joannides, Alexis; Guilfoyle, Mathew R.; Trivedi, Rikin; Kirollos, Ramez; Morris, Robert; Garnett, Matthew R.; Timofeev, Ivan; Jalloh, Ibrahim; Holland, Katherine; Mannion, Richard; Mair, Richard; Watts, Colin; Price, Stephen J.; Kirkpatrick, Peter J.; Santarius, Thomas; Mountjoy, Edward; Ghoussaini, Maya; Soranzo, Nicole; Bayraktar, Omer A.; Stevens, Beth; Hutchinson, Peter J.; Franklin, Robin J. M.; Gaffney, Daniel J. Share Save
Genome-wide meta-analysis, fine-mapping and integrative prioritization implicate new Alzheimer's disease risk genes (Feb, 10.1038/s41588-020-00776-w, 2021) Schwartzentruber, Jeremy; Cooper, Sarah; Liu, Jimmy Z.; Barrio-Hernandez, Inigo; Bello, Erica; Kumasaka, Natsuhiko; Young, Adam M. H.; Franklin, Robin J. M.; Johnson, Toby; Estrada, Karol; Gaffney, Daniel J.; Beltrao, Pedro; Bassett, Andrew Share Save
Open Targets Platform: supporting systematic drug-target identification and prioritisation Ochoa, David; Hercules, Andrew; Carmona, Miguel; Suveges, Daniel; Gonzalez-Uriarte, Asier; Malangone, Cinzia; Miranda, Alfredo; Fumis, Luca; Carvalho-Silva, Denise; Spitzer, Michaela; Baker, Jarrod; Ferrer, Javier; Raies, Arwa; Razuvayevskaya, Olesya; Faulconbridge, Adam; Petsalaki, Eirini; Mutowo, Prudence; Machlitt-Northen, Sandra; Peat, Gareth; McAuley, Elaine; Ong, Chuang Kee; Mountjoy, Edward; Ghoussaini, Maya; Pierleoni, Andrea; Papa, Eliseo; Pignatelli, Miguel; Koscielny, Gautier; Karim, Mohd; Schwartzentruber, Jeremy; Hulcoop, David G.; Dunham, Ian; McDonagh, Ellen M. Share Save
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Open Targets Genetics: systematic identification of trait-associated genes using large-scale genetics and functional genomics Ghoussaini, Maya; Mountjoy, Edward; Carmona, Miguel; Peat, Gareth; Schmidt, Ellen M.; Hercules, Andrew; Fumis, Luca; Miranda, Alfredo; Carvalho-Silva, Denise; Buniello, Annalisa; Burdett, Tony; Hayhurst, James; Baker, Jarrod; Ferrer, Javier; Gonzalez-Uriarte, Asier; Jupp, Simon; Karim, Mohd Anisul; Koscielny, Gautier; Machlitt-Northen, Sandra; Malangone, Cinzia; Pendlington, Zoe May; Roncaglia, Paola; Suveges, Daniel; Wright, Daniel; Vrousgou, Olga; Papa, Eliseo; Parkinson, Helen; MacArthur, Jacqueline A. L.; Todd, John A.; Barrett, Jeffrey C.; Schwartzentruber, Jeremy; Hulcoop, David G.; Ochoa, David; McDonagh, Ellen M.; Dunham, Ian Share Save
Molecular and functional variation in iPSC-derived sensory neurons (vol 50, pg 54, 2017) Schwartzentruber, Jeremy; Foskolou, Stefanie; Kilpinen, Helena; Rodrigues, Julia; Alasoo, Kaur; Knights, Andrew J.; Patel, Minal; Goncalves, Angela; Ferreira, Rita; Benn, Caroline Louise; Wilbrey, Anna; Bictash, Magda; Impey, Emma; Cao, Lishuang; Lainez, Sergio; Loucif, Alexandre Julien; Whiting, Paul John; Gutteridge, Alex; Gaffney, Daniel J. Share Save
Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5 Hatzikotoulas, Konstantinos; Roposch, Andreas; Shah, Karan M.; Clark, Matthew J.; Bratherton, Selina; Limbani, Vasanti; Steinberg, Julia; Zengini, Eleni; Warsame, Kaltuun; Ratnayake, Madhushika; Tselepi, Maria; Schwartzentruber, Jeremy; Loughlin, John; Eastwood, Deborah M.; Zeggini, Eleftheria; Wilkinson, J. Mark; Wainwright, Andrew; Theologis, Tim; Clarke, Nicholas M. P.; Dwyer, Jonathan S. M.; Hashemi-Nejad, Aresh; Kiely, Nigel; Katchburian, Marcos; Nicolaou, Nicolas; Page, Johnathan; Gargan, Martin; Bruce, Colin; Sanghrajka, Anish; Marshall, Paul; Flowers, Mark; Malaga-Shaw, Olivia; Mitche, Piers; Holroyd, Ben; Ramachandran, Manoj Share Save
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits Tachmazidou, Ioanna; Suveges, Daniel; Min, Josine L.; Ritchie, Graham R. S.; Steinberg, Julia; Walter, Klaudia; Iotchkova, Valentina; Schwartzentruber, Jeremy; Huang, Jie; Memari, Yasin; McCarthy, Shane; Crawford, Andrew A.; Bombieri, Cristina; Cocca, Massimiliano; Farmaki, Aliki-Eleni; Gaunt, Tom R.; Jousilahti, Pekka; Kooijman, Marjolein N.; Lehne, Benjamin; Malerba, Giovanni; Mannisto, Satu; Matchan, Angela; Medina-Gomez, Carolina; Metrustry, Sarah J.; Nag, Abhishek; Ntalla, Ioanna; Paternoster, Lavinia; Rayner, Nigel W.; Sala, Cinzia; Scott, William R.; Shihab, Hashem A.; Southam, Lorraine; St Pourcain, Beate; Traglia, Michela; Trajanoska, Katerina; Zaza, Gialuigi; Zhang, Weihua; Artigas, Maria S.; Bansal, Narinder; Benn, Marianne; Chen, Zhongsheng; Danecek, Petr; Lin, Wei-Yu; Locke, Adam; Luan, Jian'an; Manning, Alisa K.; Mulas, Antonella; Sidore, Carlo; Tybjaerg-Hansen, Anne; Varbo, Anette; Zoledziewska, Magdalena; Finan, Chris; Hatzikotoulas, Konstantinos; Hendricks, Audrey E.; Kemp, John P.; Moayyeri, Alireza; Panoutsopoulou, Kalliope; Szpak, Michal; Wilson, Scott G.; Boehnke, Michael; Cucca, Francesco; Di Angelantonio, Emanuele; Langenberg, Claudia; Lindgren, Cecilia; McCarthy, Mark I.; Morris, Andrew P.; Nordestgaard, Borge G.; Scott, Robert A.; Tobin, Martin D.; Wareham, Nicholas J.; Burton, Paul; Chambers, John C.; Smith, George Davey; Dedoussis, George; Felix, Janine F.; Franco, Oscar H.; Gambaro, Giovanni; Gasparini, Paolo; Hammond, Christopher J.; Hofman, Albert; Jaddoe, Vincent W. V.; Kleber, Marcus; Kooner, Jaspal S.; Perola, Markus; Relton, Caroline; Ring, Susan M.; Rivadeneira, Fernando; Salomaa, Veikko; Spector, Timothy D.; Stegle, Oliver; Toniolo, Daniela; Uitterlinden, Andre G.; Barroso, Ines; Greenwood, Celia M. T.; Perry, John R. B.; Walker, Brian R.; Butterworth, Adam S.; Xue, Yali; Durbin, Richard; Small, Kerrin S.; Soranzo, Nicole; Timpson, Nicholas J.; Zeggini, Eleftheria Share Save
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits Southam, Lorraine; Gilly, Arthur; Suveges, Daniel; Farmaki, Aliki-Eleni; Schwartzentruber, Jeremy; Tachmazidou, Ioanna; Matchan, Angela; Rayner, Nigel W.; Tsafantakis, Emmanouil; Karaleftheri, Maria; Xue, Yali; Dedoussis, George; Zeggini, Eleftheria Share Save
NATIONAL CLINICAL AUDIT DATA DECODES THE GENETIC ARCHITECTURE OF DEVELOPMENTAL DYSPLASIA OF THE HIP Hatzikotoulas, K.; Roposch, A.; Shah, K. M.; Clark, M. J.; Bratherton, S.; Limbani, V.; Warsame, K.; Ratnayake, M.; Tselepi, M.; Schwartzentruber, J.; Steinberg, J.; Loughlin, J.; Eastwood, D. M.; Zeggini, E.; Wilkinson, J. M. Share Save
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