Patrick E. MacDonald - Publications, H-index & Citations

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Patrick E. MacDonald

University of Alberta

61H-index

268Paper Count

1.5WCitation Count

Published Papers 116

Publication Date

TBL1X/TBL1XR1 govern β-cell identity through a PAX6-containing gene regulatory network

Nature Communications

IF15.7

2026-04-23

OAAI

Alina A. Walth-Hummel; Celine Jouffe; Peter Weber; Karsten Motzler; Julia Geppert; Michael Sterr; Wei Gan; Iwona Szczerbinska; Ann-Christine König; Stefanie M. Hauck; Raul Terron-Exposito; Daniela Hass; Congcong Wang; Kenneth A. Dyar; James G. Lyon; Heiko Lickert; Carina Ämmälä; Stephan Herzig; Frances M. Ashcroft; Mostafa Bakhti; Patrick E. MacDonald; Maria Rohm

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Persistent organic pollutant concentrations in human pancreas correlate with markers of beta cell dysfunction

Nature Communications

IF15.7

2026-04-15

OAAI

Myriam P. Hoyeck; Ma. Enrica Angela Ching; Jana Palaniyandi; Evgenia Fadzeyeva; Jelena Kolic; Jillian Ashley-Martin; James Lyon; Nancy Smith; Erin E. Mulvihill; James D. Johnson; Jocelyn E. Manning Fox; Patrick E. MacDonald; Jennifer E. Bruin

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CK2 regulates somatostatin expression in pancreatic delta cells

Islets

IF1.7

2025-12-31

PREAI

Wrublewsky, Selina; Clemenz, Annika; Boewe, Anne S.; Wilden, Cedric; Bickelmann, Caroline; Goetz, Claudia; MacDonald, Patrick E.; Laschke, Matthias W.; Ampofo, Emmanuel

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Altered immune and metabolic molecular pathways drive islet cell dysfunction in human type 1 diabetes

JOURNAL OF CLINICAL INVESTIGATION

IF13.6

2025-12-01

OAAI

Dos Santos, Theodore; Dai, Xiao-Qing; Jones, Robert C.; Spigelman, Aliya F.; Mummey, Hannah M.; Ewald, Jessica D.; Ellis, Cara E.; Lyon, James G.; Smith, Nancy; Bautista, Austin; Fox, Jocelyn E. Manning; Neff, Norma F.; Detweiler, Angela M.; Tan, Michelle; Arrojo e Drigo, Rafael; Xia, Jianguo; Camunas-Soler, Joan; Gaulton, Kyle J.; Quake, Stephen R.; Macdonald, Patrick E.

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Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets

Science Advances

IF12.5

2025-08-08

OAAI

Selina Wrublewsky; Sandra Rother; Franziska Pohlemann; Toni Radanovic; Fabian Junker; Anne S. Boewe; Stefan Schunk; Leticia P. Roma; Gloria Ruiz-Gómez; M. Teresa Pisabarro; Patrick E. MacDonald; Michael D. Menger; Matthias W. Laschke; Emmanuel Ampofo

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Spatially Bound Functional Heterogeneity Drives Modular Organization in Beta Cell Networks

Biophysical Journal

IF3.1

2025-08-05

OAAI

Maja Duh; Marko Šterk; Lidija Križančić Bombek; Patrick E. MacDonald; Andraž Stožer; Marko Gosak

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Scale up manufacturing approach for production of human induced pluripotent stem cell-derived islets using Vertical Wheel® bioreactors

npj Regenerative Medicine

IF6.5

2025-05-29

OAAI

Nidheesh Dadheech; Mario Bermúdez de León; Zofia Czarnecka; Nerea Cuesta-Gomez; Ila Tewari Jasra; Rena Pawlick; Braulio Marfil-Garza; Sandhya Sapkota; Kevin Verhoeff; Haide Razavy; Perveen Anwar; Abhineet Singh; Nilanjan Ray; Doug O’ Gorman; Glen Jickling; James Lyon; Patrick MacDonald; A. M. James Shapiro

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Cisplatin Exposure Dysregulates Insulin Secretion in Male and Female Mice

DIABETES

IF7.5

2025-01-14

PREAI

Basu, Lahari; Grieco-St-Pierre, Lili; Ching, Ma. Enrica Angela; Stead, John D. H.; Hanson, Antonio A.; Palaniyandi, Jana; van Zyl, Erin; Hoyeck, Myriam P.; Mckay, Kelsea S.; van Allen, Kyle A.; Lee, Hyojin; Dai, Xiao-Qing; Bautista, Austin; Fadzeyeva, Evgenia; Mulvihill, Erin E.; Yauk, Carole L.; Mennigen, Jan A.; Macdonald, Patrick E.; Bruin, Jennifer E.

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An INSULIN and IAPP dual reporter enables tracking of functional maturation of stem cell- derived insulin producing cells

MOLECULAR METABOLISM

IF6.6

2024-11-01

OAAI

Bayly, Carmen L.; Dai, Xiao-Qing; Nian, Cuilan; Orban, Paul C.; Verchere, C. Bruce; MacDonald, Patrick E.; Lynn, Francis C.

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Scalable Bioreactor-based Suspension Approach to Generate Stem Cell-derived Islets From Healthy Donor-derived iPSCs

TRANSPLANTATION

IF5

2024-07-18

PREAI

Verhoeff, Kevin; Cuesta-Gomez, Nerea; Maghera, Jasmine; Dadheech, Nidheesh; Pawlick, Rena; Smith, Nancy; O'Gorman, Doug; Razavy, Haide; Marfil-Garza, Braulio; Young, Lachlan G.; Thiesen, Aducio; Macdonald, Patrick E.; Shapiro, A. M. James

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Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease

CELL METABOLISM

IF30.9

2024-07-01

OAAI

Kolic, Jelena; Sun, WenQing Grace; Cen, Haoning Howard; Ewald, Jessica D.; Rogalski, Jason C.; Sasaki, Shugo; Sun, Han; Rajesh, Varsha; Xia, Yi Han; Moravcova, Renata; Skovso, Sos; Spigelman, Aliya F.; Fox, Jocelyn E. Manning; Lyon, James; Beet, Leanne; Xia, Jianguo; Lynn, Francis C.; Gloyn, Anna L.; Foster, Leonard J.; Macdonald, Patrick E.; Johnson, James D.

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MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation

NUCLEIC ACIDS RESEARCH

IF13.1

2024-04-08

135

OAAI

Pang, Zhiqiang; Lu, Yao; Zhou, Guangyan; Hui, Fiona; Xu, Lei; Viau, Charles; Spigelman, Aliya F.; Macdonald, Patrick E.; Wishart, David S.; Li, Shuzhao; Xia, Jianguo

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CK2 activity is crucial for proper glucagon expression

DIABETOLOGIA

IF10.2

2024-03-20

OAAI

Ampofo, Emmanuel; Pack, Mandy; Wrublewsky, Selina; Boewe, Anne S.; Spigelman, Aliya F.; Koch, Hanna; Macdonald, Patrick E.; Laschke, Matthias W.; Montenarh, Mathias; Goetz, Claudia

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Web-based multi-omics integration using the Analyst software suite

NATURE PROTOCOLS

IF16

2024-02-14

PREAI

Ewald, Jessica D.; Zhou, Guangyan; Lu, Yao; Kolic, Jelena; Ellis, Cara; Johnson, James D.; Macdonald, Patrick E.; Xia, Jianguo

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A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

NATURE COMMUNICATIONS

IF15.7

2024-01-06

OAAI

Lin, Haopeng; Suzuki, Kunimasa; Smith, Nancy; Li, Xi; Nalbach, Lisa; Fuentes, Sonia; Spigelman, Aliya F.; Dai, Xiao-Qing; Bautista, Austin; Ferdaoussi, Mourad; Aggarwal, Saloni; Pepper, Andrew R.; Roma, Leticia P.; Ampofo, Emmanuel; Li, Wen-hong; MacDonald, Patrick E.

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HNF1α maintains pancreatic α and β cell functions in primary human islets

JCI INSIGHT

IF6.1

2023-12-22

OAAI

Qian, Mollie F.; Bevacqua, Romina J.; Coykendall, Vy M. N.; Liu, Xiong; Zhao, Weichen; Chang, Charles A.; Gu, Xueying; Dai, Xiao-Qing; MacDonald, Patrick E.; Kim, Seung K.

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RFX6 Maintains Gene Expression and Function of Adult Human Islet α-Cells

DIABETES

IF7.5

2023-12-08

OAAI

Coykendall, Vy M. N.; Qian, Mollie F.; Tellez, Krissie; Bautista, Austin; Bevacqua, Romina J.; Gu, Xueying; Hang, Yan; Neukam, Martin; Zhao, Weichen; Chang, Charles; MacDonald, Patrick E.; Kim, Seung K.

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Modulation of insulin secretion by RBFOX2-mediated alternative splicing

NATURE COMMUNICATIONS

IF15.7

2023-11-25

OAAI

Moss, Nicole D.; Wells, Kristen L.; Theis, Alexandra; Kim, Yong-Kyung; Spigelman, Aliya F.; Liu, Xiong; Macdonald, Patrick E.; Sussel, Lori

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Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice

DIABETES

IF7.5

2023-06-26

OAAI

Chen, Yi-Chun; Taylor, Austin J.; Fulcher, James M.; Swensen, Adam C.; Dai, Xiao-Qing; Komba, Mitsuhiro; Wrightson, Kenzie L. C.; Fok, Kenny; Patterson, Annette E.; Klein Geltink, Ramon I.; MacDonald, Patrick E.; Qian, Wei-Jun; Verchere, C. Bruce

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Mapping Cis-Regulatory Programs Affecting Diabetes Risk in Pancreatic Islet Cell Types Using Single-Cell Multimodal Profiling

DIABETES

IF7.5

2023-06-20

PREAI

Mummey, Hannah; Elison, Weston; Korgaonkar, Katha; Lee, Yun S.; Ashmus, Jacklyn M. Newsome; Benaglio, Paola; Miller, Michael T.; Fox, Jocelyn E. Manning; Gloyn, Anna L.; Macdonald, Patrick; Preissl, Sebastian; Gaulton, Kyle J.

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Research Directions