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H

Hung‐wen Liu

Purdue University System

59H-index
343Paper Count
1.2WCitation Count
Published Papers 171
Publication Date
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A Novel Amidation Reaction Couples Siderophore Bait with the SB-217452 Warhead to Complete the Biosynthesis of the Trojan-Horse Antibiotic Albomycin δ2
errJournal of the American Chemical Society
IF15.6
err2026-05-20
err0
PREAI
errHouyuan Zhao; Hung-wen Liu
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Transfer RNA deacylases as beacons for non-canonical amino acid biosynthesis
errNature Chemistry
IF20.2
err2026-05-01
err0
PREAI
errLee, Yu-Hsuan; Liu, Hung-wen
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Fluorogenic Aptamer Optimization on a Massively Parallel Sequencing Platform
errACS Sensors
IF9.1
err2026-05-01
err0
PREAI
errKuo, Yu-An; Chen, Yuan-, I; Siraj, Naseem; He, Yujie; Yang, Zhenglin; Wang, Yanxing; Batchelder-Schwab, Emile J.; Korkmaz, Zeynep; Yonas, Siem; Nguyen, Trung D.; Hong, Soonwoo; Nguyen, Anh-Thu; Kim, Sohyun; Seifi, Saeed; Fan, Po-Hsun; Wu, Yuting; Liu, Hung-Wen; Lu, Yi; Ren, Pengyu; Mao, Chengde; Yeh, Hsin-Chih
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The Radical SAM Enzyme BlsE Can Operate as a Dehydratase; Dehydrogenase; or Epimerase upon Mutation of a Single Active Site Serine Residue
errJournal of the American Chemical Society
IF15.6
err2026-02-10
err0
PREAI
errYu-Hsuan Lee; Ziyang Zheng; Baixu Ma; Daan Ren; Mark W. Ruszczycky; Lizhi Tao; Hung-wen Liu
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Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs
errJournal of the American Chemical Society
IF15.6
err2025-12-02
err0
PREAI
errRichiro Ushimaru; Ridao Chen; Po-Hsun Fan; Xiao Liu; Mark W. Ruszczycky; Hung-wen Liu
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Pyrazofurin Biosynthesis Involves Nonenzymatic Ring Contraction of a Pyridazine Intermediate Triggered by a Rieske Enzyme-Catalyzed Oxygenation
errJournal of the American Chemical Society
IF15.6
err2025-10-29
err0
PREAI
errZiyang Zheng; Yu-Hsuan Lee; Daan Ren; Hung-wen Liu
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A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical S-Adenosyl Methionine Enzyme AbmM
errJournal of the American Chemical Society
IF15.6
err2025-10-29
err0
PREAI
errZiyang Zheng; Yu-Hsuan Lee; Hung-wen Liu
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Characterization of C3’ Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin δ2 Catalyzed by the Radical S-Adenosylmethionine Enzyme AbmJ
errACS Catalysis
IF13.1
err2025-10-17
err0
PREAI
errHouyuan Zhao; Zhang Chen; Joseph L. Franklin; Hung-Wen Liu
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Structure-Guided Mechanistic Investigation of Stereochemical Inversion during the Octose Formation Catalyzed by an Atypical Transaldolase AprG in the Biosynthesis of Apramycin
errACS Catalysis
IF13.1
err2025-07-25
err0
PREAI
errWantae Kim; Po-Hsun Fan; Junling Bu; Hung-wen Liu; Y. Jessie Zhang
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Radical S-adenosyl-l-methionine FeS cluster implicated as the sulfur donor during albomycin biosynthesis
errNature Catalysis
IF44.6
err2025-07-15
err0
PREAI
errRichiro Ushimaru; Ziyang Zheng; Jin Xiong; Takahiro Mori; Ikuro Abe; Yisong Guo; Hung-wen Liu
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errSave
A [2.1.0]-Fused Bicyclic Intermediate Is Produced during the Biosynthesis of Oxetane Nucleosides
errJournal of the American Chemical Society
IF15.6
err2025-07-11
err0
PREAI
errYu-Hsuan Lee; Po-Hsun Fan; Yu-Cheng Yeh; Mark W. Ruszczycky; Yujie Geng; Aoshu Zhong; Hung-wen Liu
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Blasticidin S Biosynthesis Involves a Unique Interplay between a Radical SAM Dehydratase, a Transaminase and an ATP-Grasp Ligase in Order to Avoid a Futile Cycle
errACS CATALYSIS
IF13.1
err2025-01-30
err0
PREAI
errLee, YH; Ren, D; Chen, RD; Liu, X; Engstrom, A; Liu, HW
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Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical S-Adenosyl Methionine Dehydrogenase That May Have Evolved from an Epimerase (vol 144, pg 9910, 2022)
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2025-01-10
err0
PREAI
errZhang, Jiawei; Hou, Xueli; Chen, Zhang; Ko, Yeonjin; Ruszczycky, Mark W.; Chen, Yutian; Zhou, Jiahai; Liu, Hung-wen
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In Vitro Characterization of Kitasetaline Biosynthesis Reveals a Bifunctional P450 Decarboxylase and a Vinyl β-Carboline Intermediate Susceptible to Nonenzymatic Thiol Addition
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-10-03
err0
PREAI
errZheng, Ziyang; Choi, Heewon; Liu, Hung-wen
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Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-07-23
err1
errOAAI
errZheng, Ziyang; Clardy, Jon; Liu, Hung-wen
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Mechanistic Insights from the Crystal Structure and Computational Analysis of the Radical SAM Deaminase DesII
errADVANCED SCIENCE
IF14.1
err2024-06-28
err0
errOAAI
errHou, Xueli; Feng, Jianqiang; Franklin, Joseph Livy; Russo, Ryan; Guo, Zhiyong; Zhou, Jiahai; Gao, Jin-Ming; Liu, Hung-wen; Wang, Binju
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Complete In Vitro Reconstitution of the Apramycin Biosynthetic Pathway Demonstrates the Unusual Incorporation of a β-d-Sugar Nucleotide in the Final Glycosylation Step
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-03-28
err1
errOAAI
errSato, Shusuke; Fan, Po-Hsun; Yeh, Yu-Cheng; Liu, Hung-wen
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Complete in vitro reconstitution of the apramycin biosynthetic pathway demonstrates incorporation of a β-D-sugar nucleotide
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-03-01
err0
errOAAI
errSato, Shusuke; Fan, Po-Hsun; Yeh, Yu-Cheng; Liu, Hung-wen
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Mechanistic studies of the radical SAM enzyme OxsB in oxentanocin A biosynthesis
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2024-03-01
err0
errOAAI
errLiu, Hung-Wen
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errSave
Biosynthetic Origin of the Octose Core and Its Mechanism of Assembly during Apramycin Biosynthesis
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2023-09-21
err3
errOAAI
errFan, Po-Hsun; Sato, Shusuke; Yeh, Yu-Cheng; Liu, Hung-wen
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Research Directions

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Co-authors
Cooperation Journals
仉华 cover
仉华 (Hua Zhang)
H-index: 205 · Papers: 2.7K
K
K. N. Houk
H-index: 157 · Papers: 2.6K
J
Jon Clardy
H-index: 137 · Papers: 1.4K
L
Lawrence Que
H-index: 116 · Papers: 823
张
张立欣 (Lixin Zhang)
H-index: 104 · Papers: 1.2K
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