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Bradley T. Hyman

massachusetts general hospital

187H-index
1.1KPaper Count
17.9WCitation Count
Published Papers 450
Publication Date
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GFAP upregulation by astrocytes attenuates tau neurofibrillary tangle pathology in a mouse model of tauopathy
errMolecular Neurodegeneration
IF17.5
err2026-08-25
err0
errOAAI
errClara Muñoz-Castro; Molly A. Healey; Ayush Noori; Methasit Jaisa-aad; Paula Gómez-Méndez; Rojashree Jayakumar; Srinija Alla; Zane D. Kashlan; Zhanyun Fan; Eric F. Zaniewski; Sambhavi Animesh; Robert T. Morris; Maria Calvo-Rodriguez; Eloise Hudry; Sudeshna Das; Wilhelm Haas; Bradley T. Hyman; Alberto Serrano-Pozo
errShare
errSave
The ligand preference of LRP1 is regulated by O-glycans
errScience Advances
IF12.5
err2026-06-05
err0
errOAAI
errJohn Hintze; Asli B. Topaktas; Thomas D. Madsen; Shifa Jebari-Benslaiman; Bethany H. Claridge; Silvia D’Andrea; Noortje de Haan; Lasse H. Hansen; Rob Baars; Noé Quittot; Cesar Martin; Zhang Yang; Sergey Y. Vakhrushev; Rebecca L. Miller; Dudley K. Strickland; Bradley Hyman; Elisa Fadda; Katrine T. Schjoldager
errShare
errSave
Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner
errNature Neuroscience
IF20
err2026-05-29
err0
PREAI
errVictoria Paradise; Kalin D. Konrad-Vicario; Chi Nguyen; Nyle A. Sharif; Xiao Wang; Rijuta D. Mukim; Malavika Sabu; Bianca T. Corjuc; Joanna Bafia; Jack Fu; Gabriella C. Maldonado; Michael Strickland; Sarah L. Grauman; Helen Figueroa; Bradley T. Hyman; David M. Holtzman; Tal Nuriel; Kapil V. Ramachandran
errShare
errSave
PolyGR-containing aggregates link with pathology and clinical features of Alzheimer's disease
errACTA NEUROPATHOLOGICA
IF9.3
err2025-11-08
err0
errOAAI
errPhuong, Huong T.; Tomas, Rodrigo F.; Akmese, Cemal; Mijares, Ana; Gerstin, Isabella M.; Guo, Shu; Bell, Logan R.; Ellwood, Ross; Yegorova, Svitlana; Ng, Stefani K.; Massey, Grace; Phillips, Jennifer; Melloni, Alexandra; Pletnikova, Olga; Lou, Xiangyang; Clark, H. Brent; Troncoso, Juan C.; Hyman, Bradley T.; Prokop, Stefan; Ranum, Laura P. W.; Nguyen, Lien
errShare
errSave
α-Synuclein purification significantly impacts seed amplification assay performance and consistency
errActa Neuropathologica Communications
IF5.7
err2025-11-06
err0
errOAAI
errZaid A. M. Al-Azzawi; Nicholas R. G. Silver; Surabhi Mehra; Simeng Niu; Christopher Situ; Wen Luo; Irina Shlaifer; Martin Ingelsson; Bradley T. Hyman; Jean-François Trempe; Thomas M. Durcan; Joel C. Watts; Edward A. Fon
errShare
errSave
Tau biology, biomarkers, and therapeutics
errAlzheimer's & Dementia: Translational Research & Clinical Interventions
IF0
err2025-10-21
err0
errOAAI
errBess Frost; Hartmuth Kolb; Alicia Algeciras-Schimnich; Tobey J. Betthauser; Sarah DeVos; Rebecca M. Edelmayer; Fiona Elwood; Adam S. Fleisher; David Henley; Kanta Horie; Bradley Hyman; William Charles Kreisl; Luka Kulic; Antoine Leuzy; Jose-Alberto Palma; Sophie Parmentier-Batteur; Maria-Magdalena Patru; Gil D. Rabinovici; Larisa Reyderman; Reisa A. Sperling; Serge Van Der Geyten; Kristin R. Wildsmith; Simin Mahinrad; Maria C. Carrillo; Christopher J. Weber
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errSave
APP family is a regulator of endo-lysosomal membrane vulnerability
errJournal of Biological Chemistry
IF3.9
err2025-09-27
err0
errOAAI
errBrianna Lundin; Natalia Wieckiewicz; Midori Yokomizo; Michael Sadek; Desmond Owusu Kwarteng; John R. Dickson; Robert G.R. Sobolewski; Victoria Derosla; Gokce Armagan; Florian Perrin; Bradley T. Hyman; Oksana Berezovska; Masato Maesako
errShare
errSave
Molecular polymorphism of tau aggregates in pick's disease
errNeurobiology of Disease
IF5.6
err2025-09-14
err0
errOAAI
errJiliang Liu; Theresa Connors Stewart; Derek H. Oakley; Bradley T. Hyman; Manfred Burghammer; Marine Cotte; Lee Makowski
errShare
errSave
Oligodendroglia vulnerability in the human dorsal striatum in Parkinson's disease
errACTA NEUROPATHOLOGICA
IF9.3
err2025-05-05
err0
errOAAI
errBarba-Reyes, JM; Harder, L; Salas, SM; Jaisa-aad, M; Muñoz-Castro, C; Garma, LD; Rafati, N; Nilsson, M; Hyman, BT; Serrano-Pozo, A; Muñoz-Manchado, AB
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errSave
Single- cell elderly blood-CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-05-05
err0
errOAAI
errDuy, Phan Q.; Kiziltug, Emre; Greenberg, Ana B. W.; Mehta, Neel H.; Hao, Le T.; Fortes, Carla; Mullany, Susan; Fan, Baojian; Manichaikul, Ani; Teich, Andrew F.; Chan, Diane; Alper, Seth L.; Hyman, Bradley T.; Arnold, Steven E.; Mckhann, Guy M.; Frosch, Matthew P.
errShare
errSave
Alzheimer disease-associated tau post-translational modification mimics impact tau propagation and uptake
errJOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
IF3
err2025-02-21
err0
errOAAI
errDickson, John R.; Sobolewski, Robert G. R.; Fernandes, Analiese R.; Cooper, Joanna M.; Fan, Zhanyun; Chung, Mirra; Donahue, Cameron; Oakley, Derek H.; Strickland, Dudley K.; Hyman, Bradley T.
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errSave
CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2025-02-12
err0
errOAAI
errNguyen, Lien; Ajredini, Ramadan; Guo, Shu; Romano, Lisa E. L.; Tomas, Rodrigo F.; Bell, Logan R.; Ranum, Paul T.; Zu, Tao; Coronel, Monica Banez; Kelley, Chase P.; Redding-Ochoa, Javier; Nizamis, Evangelos; Melloni, Alexandra; Connors, Theresa R.; Gaona, Angelica; Thangaraju, Kiruphagaran; Pletnikova, Olga; Clark, H. Brent; Davidson, Beverly L.; Yachnis, Anthony T.; Golde, Todd E.; Lou, Xiangyang; Wang, Eric T.; Renton, Alan E.; Goate, Alison; Valdmanis, Paul N.; Prokop, Stefan; Troncoso, Juan C.; Hyman, Bradley T.; Ranum, Laura P. W.
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errSave
Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs
errSCIENTIFIC REPORTS
IF3.9
err2024-11-28
err0
errOAAI
errSolano-Aguilar, Gloria; Matuszek, Gregory; Matthan, Nirupa R.; Lichtenstein, Alice H.; Wang, Xuedi; Lakshman, Sukla; Barger, Kathryn; Urban, Joseph F.; Molokin, Aleksey; Bennett, Rachel E.; Hyman, Bradley T.; Lamon-Fava, Stefania
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errSave
Tau, synapse loss and gliosis progress in an Alzheimer's mouse model after amyloid-β immunotherapy
errBRAIN
IF11.7
err2024-11-06
err0
errOAAI
errWelikovitch, Lindsay A.; de Gerando, Anastasie Mate; Khasnavis, Anita; Bhavsar, Harshil; Meltzer, Jonah C.; Buee, Luc; Chibnik, Lori B.; Bussiere, Thierry; Hyman, Bradley T.
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errSave
Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer's disease tau seeds have distinct properties
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2024-09-09
err1
errOAAI
errde Gerando, Anastasie Mate; Khasnavis, Anita; Welikovitch, Lindsay A.; Bhavsar, Harshil; Glynn, Calina; Quittot, Noe; Perbet, Romain; Hyman, Bradley T.
errShare
errSave
Pathways to personalized medicine-Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease
errALZHEIMERS & DEMENTIA
IF11.1
err2024-09-06
err1
errOAAI
errArnold, Steven E.; Hyman, Bradley T.; Betensky, Rebecca A.; Dodge, Hiroko H.
errShare
errSave
Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2024-08-14
err0
errOAAI
errJackson, Rosemary J.; Melloni, Alexandra; Fykstra, Dustin P.; Serrano-Pozo, Alberto; Shinobu, Leslie; Hyman, Bradley T.
errShare
errSave
Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology
errCELL REPORTS
IF6.9
err2024-08-01
err1
errOAAI
errZwang, Theodore J.; del Sastre, Eric; Wolf, Nina; Ruiz-Uribe, Nancy; Woost, Benjamin; Hoglund, Zachary; Fan, Zhanyun; Bailey, Joshua; Nfor, Lois; Buee, Luc; Nilsson, K. Peter R.; Hyman, Bradley T.; Bennett, Rachel E.
errShare
errSave
Interneuron diversity in the human dorsal striatum
errNATURE COMMUNICATIONS
IF15.7
err2024-07-22
err2
errOAAI
errGarma, Leonardo D.; Harder, Lisbeth; Barba-Reyes, Juan M.; Marco Salas, Sergio; Diez-Salguero, Monica; Nilsson, Mats; Serrano-Pozo, Alberto; Hyman, Bradley T.; Munoz-Manchado, Ana B.
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errSave
In situ seeding assay: A novel technique for direct tissue localization of bioactive tau
errJOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
IF3
err2024-06-25
err0
PREAI
errPerbet, Romain; de Gerando, Anastasie Mate; Glynn, Calina; Donahue, Cameron; Gaona, Angelica; Taddei, Raquel N.; Gomez-Isla, Teresa; Lathuiliere, Aurelien; Hyman, Bradley T.
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Research Directions

No research directions
Co-authors
Cooperation Journals
J
John Q. Trojanowski
H-index: 255 · Papers: 1.8K
C
Cornelia M. van Duijn
H-index: 238 · Papers: 1.9K
A
André G. Uitterlinden
H-index: 234 · Papers: 2.0K
D
Dennis W. Dickson
H-index: 218 · Papers: 2.3K
E
Eric Boerwinkle
H-index: 215 · Papers: 2.0K
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