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E

Eric O. Freed

national cancer institute

77H-index
289Paper Count
2.1WCitation Count
Published Papers 142
Publication Date
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The Central Pore of HIV-1 Capsomers Promotes Sustained Stability of the Viral Capsid
errJournal of Molecular Biology
IF4.5
err2026-07-16
err0
errOAAI
errAlex B. Kleinpeter; Donna L. Mallery; Anna Albecka; Ryan C. Burdick; Nadine Renner; J. Ole Klarhof; Boglarka Vamos; Vinay K. Pathak; Leo C. James; Eric O. Freed
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errSave
Mechanisms of HIV-1 assembly, release and maturation
errNature Reviews Microbiology
IF103.3
err2026-06-11
err0
PREAI
errAlex B. Kleinpeter; Eric O. Freed
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errSave
Elucidating the mechanism by which HIV-1 nucleocapsid mutations confer resistance to integrase strand transfer inhibitors
errScience Advances
IF12.5
err2025-09-12
err0
errOAAI
errYuta Hikichi; Ryan C. Burdick; Sean C. Patro; Si-Yuan Ding; Brian T. Luke; Erin D. Clark; Sherimay D. Ablan; Xiaolin Wu; Vinay K. Pathak; Eric O. Freed
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errSave
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging
errNature Communications
IF15.7
err2025-09-01
err0
errOAAI
errYanan Zhu; Alex B. Kleinpeter; Juan S. Rey; Juan Shen; Yao Shen; Jialu Xu; Nathan Hardenbrook; Long Chen; Anka Lucic; Juan R. Perilla; Eric O. Freed; Peijun Zhang
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errSave
Author Correction: HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
errNature Structural & Molecular Biology
IF10.1
err2025-08-29
err0
PREAI
errNadine Renner; Alex Kleinpeter; Donna L. Mallery; Anna Albecka; K. M. Rifat Faysal; Till Böcking; Adolfo Saiardi; Eric O. Freed; Leo C. James
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errSave
Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir
errMBIO
IF4.7
err2025-05-14
err0
errOAAI
errBriganti, Lorenzo; Annamalai, Arun S.; Bester, Stephanie M.; Wei, Guochao; Andino-Moncada, Jonathan R.; Singh, Satya P.; Kleinpeter, Alex B.; Tripathi, Meghna; Nguyen, Binh; Radhakrishnan, Rajalingam; Singh, Parmit K.; Greenwood, Juliet; Schope, Lauren I.; Haney, Reed; Huang, Szu-Wei; Freed, Eric O.; Engelman, Alan N.; Francis, Ashwanth C.; Kvaratskhelia, Mamuka
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A monomeric envelope glycoprotein cytoplasmic tail is sufficient for HIV-1 Gag lattice trapping and incorporation
errJOURNAL OF VIROLOGY
IF3.8
err2025-04-01
err0
errOAAI
errGroves, Nicholas S.; Clark, Austin R.; Aguilar, Rebekah S.; Hikichi, Yuta; Kostenko, Anastasiia; Bruns, Merissa M.; Aron, Alegra T.; Freed, Eric O.; van Engelenburg, Schuyler B.
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errSave
Guanylate-binding protein 5 antagonizes viral glycoproteins independently of furin processing
errMBIO
IF4.7
err2024-10-16
err3
errOAAI
errVeler, Hana; Lun, Cheng Man; Waheed, Abdul A.; Freed, Eric O.
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errSave
HIV-1 adapts to lost IP6 coordination through second-site mutations that restore conical capsid assembly
errNATURE COMMUNICATIONS
IF15.7
err2024-09-13
err0
errOAAI
errKleinpeter, Alex; Mallery, Donna L.; Renner, Nadine; Albecka, Anna; Klarhof, J. Ole; Freed, Eric O.; James, Leo C.
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errSave
Exploring HIV-1 Maturation: A New Frontier in Antiviral Development
errVIRUSES-BASEL
IF3.5
err2024-09-06
err2
errOAAI
errMcGraw, Aidan; Hillmer, Grace; Medehincu, Stefania M.; Hikichi, Yuta; Gagliardi, Sophia; Narayan, Kedhar; Tibebe, Hasset; Marquez, Dacia; Bose, Lilia Mei; Keating, Adleigh; Izumi, Coco; Peese, Kevin; Joshi, Samit; Krystal, Mark; DeCicco-Skinner, Kathleen L.; Freed, Eric O.; Sardo, Luca; Izumi, Taisuke
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errSave
The 15th Anniversary of Viruses: An Unwavering Commitment to Serving the Virology Community
errVIRUSES-BASEL
IF3.5
err2024-03-22
err0
errOAAI
errFreed, Eric O.
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errSave
Epistatic pathways can drive HIV-1 escape from integrase strand transfer inhibitors
errSCIENCE ADVANCES
IF12.5
err2024-03-01
err4
errOAAI
errHikichi, Yuta; Grover, Jonathan R.; Schaefer, Alicia; Mothes, Walther; Freed, Eric O.
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errSave
Tribute to Dr. Judith G. Levin (1934-2023)
errVIRUSES-BASEL
IF3.5
err2024-01-25
err0
errOAAI
errMusier-Forsyth, Karin; Rein, Alan; Freed, Eric O.
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errSave
Neutral sphingomyelinase 2 is required for HIV-1 maturation
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-07-05
err8
errOAAI
errWaheed, Abdul A.; Zhu, Yanan; Agostino, Eva; Naing, Lwar; Hikichi, Yuta; Soheilian, Ferri; Yoo, Seung- Wan; Song, Yun; Zhang, Peijun; Slusher, Barbara S.; Haughey, Norman J.; Freed, Eric O.
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errSave
Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2023-07-05
err6
errOAAI
errYoo, Seung-Wan; Waheed, Abdul A.; Deme, Pragney; Tohumeken, Sehmus; Rais, Rana; Smith, Matthew D.; DeMarino, Catherine; Calabresi, Peter A.; Kashanchi, Fatah; Freed, Eric O.; Slusher, Barbara S.; Haughey, Norman J.
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errSave
Structural basis of HIV-1 maturation inhibitor binding and activity
errNATURE COMMUNICATIONS
IF15.7
err2023-03-04
err14
errOAAI
errSarkar, Sucharita; Zadrozny, Kaneil K.; Zadorozhnyi, Roman; Russell, Ryan W.; Quinn, Caitlin M.; Kleinpeter, Alex; Ablan, Sherimay; Meshkin, Hamed; Perilla, Juan R.; Freed, Eric O.; Ganser-Pornillos, Barbie K.; Pornillos, Owen; Gronenborn, Angela M.; Polenova, Tatyana
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errSave
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2023-01-09
err24
errOAAI
errRenner, Nadine; Kleinpeter, Alex; Mallery, Donna L.; Albecka, Anna; Faysal, Rifat K. M.; Bocking, Till; Saiardi, Adolfo; Freed, Eric O.; James, Leo C.
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errSave
Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4+ T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines
errJOURNAL OF VIROLOGY
IF3.8
err2022-12-14
err2
errOAAI
errde Cespedes, Melissa V. Fernandez V.; Hoffman, Huxley K.; Carter, Hannah; Simons, Lacy M.; Naing, Lwar; Ablan, Sherimay D.; Scheiblin, David A.; Hultquist, Judd F.; van Engelenburg, Schuyler B.; Freed, Eric O.
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Enhanced Transmissibility and Decreased Virulence of HIV-1 CRF07_BC May Explain Its Rapid Expansion in China
errMICROBIOLOGY SPECTRUM
IF3.8
err2022-08-31
err22
errOAAI
errCheng, Zetao; Yan, Huanchang; Li, Qingmei; Ablan, Sherimay D.; Kleinpeter, Alex; Freed, Eric O.; Wu, Hao; Dzakah, Emmanuel Enoch; Zhao, Jianhui; Han, Zhigang; Wang, Haiying; Tang, Shixing
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errSave
SARS-CoV-2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro (vol 13, 2056, 2021) (Expression of Concern of Vol 13, art no 2056, 2021)
errVIRUSES-BASEL
IF3.5
err2021-12-22
err1
errOAAI
errFreed, Eric O.; Schildgen, Oliver
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Research Directions

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Co-authors
Cooperation Journals
K
Klaus Schulten
H-index: 145 · Papers: 718
J
Jennifer Lippincott‐Schwartz
H-index: 134 · Papers: 444
A
Angela M. Gronenborn
H-index: 119 · Papers: 797
W
William A. Banks
H-index: 119 · Papers: 747
J
Juan S. Bonifacino
H-index: 117 · Papers: 404
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