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Bernhardt L. Trout

massachusetts institute of technology

68H-index
256Paper Count
1.5WCitation Count
Published Papers 122
Publication Date
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Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling
errACS Omega
IF4.3
err2026-04-27
err0
errOAAI
errSaikat Mukherjee; Sunkyu Shin; Cedric Devos; Aniket Udepurkar; Peter Sagmeister; Bernhardt L. Trout; Allan S. Myerson; Richard D. Braatz
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Modular Design of Vacuum Systems for Lyophilization
errIndustrial and Engineering Chemistry Research
IF3.9
err2026-03-12
err0
errOAAI
errLorenzo Stratta; Rohan P. Kadambi; Lorena Pasero; Steven J. Burcat; Richard D. Braatz; Bernhardt L. Trout; Alexander H. Slocum; Roberto Pisano
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errSave
Continuous lyophilization of suspended vials with per-vial inline analytics
errJournal of Pharmaceutical Sciences
IF3.8
err2026-01-10
err0
PREAI
errBernhardt L. Trout; Steven J. Burcat; Rohan P. Kadambi; Lorenzo J. Stratta; Richard D. Braatz; Roberto Pisano; Alexander H. Slocum
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errSave
End-to-end digital twin software for continuous mRNA manufacturing
errInternational Journal of Pharmaceutics
IF5.2
err2025-10-22
err0
PREAI
errMohammed Aatif Shahab; Nathan Merica Stover; Hasan Al-Mahayni; Prakitr Srisuma; Jie Wang; Sunkyu Shin; Anish Dighe; Bernhardt L. Trout; Allan S. Myerson; Richard D. Braatz
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errSave
Forced Gas Convection for Uniform Freezing of Lyophilization Vials
errJournal of Pharmaceutical Innovation
IF2.7
err2025-07-29
err0
errOAAI
errSteven J. Burcat; Rohan P. Kadambi; Lorenzo Stratta; Richard D. Braatz; Roberto Pisano; Alexander H. Slocum; Bernhardt L. Trout
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errSave
Vacuum compatible spring wire system for mass measurement of vials during lyophilization
errnanotechnology and precision engineering
IF0
err2025-07-25
err0
PREAI
errSteven J. Burcat; Rohan P. Kadambi; Lorenzo Stratta; Richard D. Braatz; Roberto Pisano; Bernhardt L. Trout; Alexander H. Slocum
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errSave
Mechanistic modeling of lipid nanoparticle formation for the delivery of nucleic acid therapeutics
errBiotechnology Advances
IF12.5
err2025-07-25
err0
errOAAI
errPavan K. Inguva; Saikat Mukherjee; Pierre J. Walker; Vico Tenberg; Cedric Devos; Sunkyu Shin; Yanchen Wu; Srimanta Santra; Jie Wang; Shalini Singh; Mona A. Kanso; Shin Hyuk Kim; Bernhardt L. Trout; Martin Z. Bazant; Allan S. Myerson; Richard D. Braatz
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errSave
Developing ultra-high concentration formulations of human immune globulins for subcutaneous injectables
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2025-02-01
err1
PREAI
errYadav, Jayprakash; Uddin, Shihab; Civati, Francesco; Ma, Wenchuan; Liebminger, Andreas; Teschner, Wolfgang; Andre, Guillaume; Trout, Bernhardt L.; Braatz, Richard D.; Myerson, Allan S.
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Emerging Applications and Regulatory Strategies for Advanced Medicines Manufacturing - Towards the Development of a Platform Approach
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2024-07-01
err2
PREAI
errSrai, Jagjit Singh; Bauer, Paul; Badman, Clive; Bresciani, Massimo; Cooney, Charles L.; Florence, Alastair; Hausner, Doug; Konstantinov, Konstantin; Lee, Sau L.; Mascia, Salvatore; Nasr, Moheb; Trout, Bernhardt L.
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Machine learning prediction of antibody aggregation and viscosity for high concentration formulation development of protein therapeutics
errMABS
IF7.3
err2022-01-25
err42
errOAAI
errLai, Pin-Kuang; Gallegos, Austin; Mody, Neil; Sathish, Hasige A.; Trout, Bernhardt L.
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errSave
Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
errMABS
IF7.3
err2021-11-08
err17
errOAAI
errLai, Pin-Kuang; Ghag, Gaurav; Yu, Yao; Juan, Veronica; Fayadat-Dilman, Laurence; Trout, Bernhardt L.
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errSave
Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters
errMABS
IF7.3
err2021-04-09
err35
errOAAI
errLai, Pin-Kuang; Swan, James W.; Trout, Bernhardt L.
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errSave
Machine Learning Feature Selection for Predicting High Concentration Therapeutic Antibody Aggregation
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2021-04-01
err27
PREAI
errLai, Pin-Kuang; Fernando, Amendra; Cloutier, Theresa K.; Kingsbury, Jonathan S.; Gokarn, Yatin; Halloran, Kevin T.; Calero-Rubio, Cesar; Trout, Bernhardt L.
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errSave
Molecular computations of preferential interactions of proline, arginine.HCl, and NaCl with IgG1 antibodies and their impact on aggregation and viscosity
errMABS
IF7.3
err2020-09-17
err21
errOAAI
errCloutier, Theresa K.; Sudrik, Chaitanya; Mody, Neil; Hasige, Sathish A.; Trout, Bernhardt L.
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In Silico Engineering of Hydrate Anti-agglomerant Molecules Using Bias-Exchange Metadynamics Simulations
errJOURNAL OF PHYSICAL CHEMISTRY C
IF3.2
err2020-08-05
err12
PREAI
errMehrabian, Hadi; Trout, Bernhardt L.
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errSave
Why We Need Continuous Pharmaceutical Manufacturing and How to Make It Happen
errJOURNAL OF PHARMACEUTICAL SCIENCES
IF3.8
err2019-11-01
err101
errOAAI
errBadman, Clive; Cooney, Charles L.; Florence, Alastair; Konstantinov, Konstantin; Krumme, Markus; Mascia, Salvatore; Nasr, Moheb; Trout, Bernhardt L.
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errSave
In Silico Analysis of the Effect of Alkyl Tail Length on Antiagglomerant Adsorption to Natural Gas Hydrates in Brine
errJOURNAL OF PHYSICAL CHEMISTRY C
IF3.2
err2019-06-24
err13
PREAI
errMehrabian, Hadi; Walsh, Matthew R.; Trout, Bernhardt L.
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errSave
On computing the solubility of molecular systems subject to constraints using the extended Einstein crystal method
errJOURNAL OF CHEMICAL PHYSICS
IF3.1
err2019-05-31
err5
errOAAI
errGobbo, Gianpaolo; Ciccotti, Giovanni; Trout, Bernhardt L.
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errSave
Understanding the Role of Preferential Exclusion of Sugars and Polyols from Native State IgG1 Monoclonal Antibodies and its Effect on Aggregation and Reversible Self-Association
errPHARMACEUTICAL RESEARCH
IF4.3
err2019-05-24
err36
PREAI
errSudrik, Chaitanya M.; Cloutier, Theresa; Mody, Neil; Sathish, Hasige A.; Trout, Bernhardt L.
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errSave
Solubility of paracetamol in ethanol by molecular dynamics using the extended Einstein crystal method and experiments
errJOURNAL OF CHEMICAL PHYSICS
IF3.1
err2019-03-05
err21
errOAAI
errBellucci, Michael A.; Gobbo, Gianpaolo; Wijethunga, Tharanga K.; Ciccotti, Giovanni; Trout, Bernhardt L.
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errSave

Research Directions

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Co-authors
Cooperation Journals
A
Alexis T. Bell
H-index: 133 · Papers: 1.0K
K
Klavs F. Jensen
H-index: 126 · Papers: 813
E
Enrico Drioli
H-index: 116 · Papers: 1.4K
J
Jim Yang Lee
H-index: 109 · Papers: 432
G
Gregg T. Beckham
H-index: 107 · Papers: 552
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