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Valerie L. Sim

university of alberta

23H-index
79Paper Count
2.7KCitation Count
Published Papers 31
Publication Date
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Understanding the Phenotypic Heterogeneity Within the Sporadic Creutzfeldt–Jakob Disease MV1 Subtype
errNeuropathology and Applied Neurobiology
IF3.4
err2026-05-05
err0
errOAAI
errSatish K. Nemani; Leonardo M. Cortez; Jennifer Myskiw; Ignazio Cali; Stephanie A. Booth; Gerard H. Jansen; Valerie L. Sim
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Gangliosides modulate the secretion of extracellular vesicles and their misfolded protein cargo
errScience Advances
IF12.5
err2025-09-17
err0
errOAAI
errJohn Monyror; Vaibhavi Kadam; Luis Carlos Morales; Diego Ordóñez; Jeremies Ibanga; Asifa K. Zaidi; Emily McNamara; Desmond Pink; Magnus Stenlund; Ken Reyes; Aislinn D. Maguire; Jing Huang; Leonardo M. Cortez; Valerie L. Sim; Sue-Ann Mok; Elena Posse de Chaves; Simonetta Sipione
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errSave
Distinct patterns of prion strain deposition and toxicity in a novel whole brain organotypic slice culture system
errSCIENTIFIC REPORTS
IF3.9
err2025-02-08
err0
errOAAI
errPineau, Hailey; Sim, Valerie L.
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Histamine stimulates human microglia to alter cellular prion protein expression via the HRH2 histamine receptor
errSCIENTIFIC REPORTS
IF3.9
err2024-10-26
err0
errOAAI
errPehar, Marcus; Hewitt, Melissa; Wagner, Ashley; Sandhu, Jagdeep K.; Khalili, Aria; Wang, Xinyu; Cho, Jae-Young; Sim, Valerie L.; Kulka, Marianna
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Alzheimer's disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD mice
errMOLECULAR NEURODEGENERATION
IF17.5
err2024-05-27
err2
errOAAI
errEskandari-Sedighi, Ghazaleh; Crichton, Madeline; Zia, Sameera; Gomez-Cardona, Erik; Cortez, Leonardo M.; Patel, Zain H.; Takahashi-Yamashiro, Kei; St. Laurent, Chris D.; Sidhu, Gaurav; Sarkar, Susmita; Aghanya, Vivian; Sim, Valerie L.; Tan, Qiumin; Julien, Olivier; Plemel, Jason R.; Macauley, Matthew S.
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PrP is cleaved from the surface of mast cells by ADAM10 and proteases released during degranulation
errJOURNAL OF LEUKOCYTE BIOLOGY
IF3.1
err2024-05-10
err0
errOAAI
errWillows, Steven D.; Vliagoftis, Harissios; Sim, Valerie L.; Kulka, Marianna
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Rational design of structure-based vaccines targeting misfolded alpha-synuclein conformers of Parkinson's disease and related disorders
errBIOENGINEERING & TRANSLATIONAL MEDICINE
IF5.7
err2024-04-09
err0
errOAAI
errFlores-Fernandez, Jose Miguel; Pesch, Verena; Sriraman, Aishwarya; Chimal-Juarez, Enrique; Amidian, Sara; Wang, Xiongyao; Duckering, Caleb; Fang, Andrew; Reithofer, Sara; Ma, Liang; Cortez, Leonardo M.; Sim, Valerie L.; Tamgueney, Gueltekin; Wille, Holger
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Mast Cell Proteases Cleave Prion Proteins and a Recombinant Ig against PrP Can Activate Human Mast Cells
errJOURNAL OF IMMUNOLOGY
IF3.4
err2023-03-20
err4
errOAAI
errWillows, Steven D.; Semenchenko, Valentyna; Norman, Grant; Woodside, Michael T.; Sim, Valerie L.; Kulka, Marianna
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Histamine activates human microglial cells and increases prion protein expression; A role for prion protein in neuroinflammation?
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2023-01-01
err0
errOAAI
errPehar, Marcus; Wagner, Ashley; Willows, Steven; Kulka, Marianna; Sim, Valerie
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errSave
Implications of exosomes derived from cholesterol-accumulated astrocytes in Alzheimer's disease pathology
errDISEASE MODELS & MECHANISMS
IF3.3
err2021-10-26
err16
errOAAI
errWu, Qi; Cortez, Leonardo; Kamali-Jamil, Razieh; Sim, Valerie; Wille, Holger; Kar, Satyabrata
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Asymmetric-flow field-flow fractionation of prions reveals a strain-specific continuum of quaternary structures with protease resistance developing at a hydrodynamic radius of 15 nm
errPLOS PATHOGENS
IF4.9
err2021-06-28
err16
errOAAI
errCortez, Leonardo M.; Nemani, Satish K.; Duque Velasquez, Camilo; Sriraman, Aishwarya; Wang, YongLiang; Wille, Holger; McKenzie, Debbie; Sim, Valerie L.
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TREM2 expression in the brain and biological fluids in prion diseases
errACTA NEUROPATHOLOGICA
IF9.3
err2021-04-21
err20
errOAAI
errDiaz-Lucena, Daniela; Kruse, Niels; Thuene, Katrin; Schmitz, Matthias; Villar-Pique, Anna; Gomes da Cunha, Jose Eriton; Hermann, Peter; Lopez-Perez, Oscar; Andres-Benito, Pol; Ladogana, Anna; Calero, Miguel; Vidal, Enric; Riggert, Joachim; Pineau, Hailey; Sim, Valerie; Zetterberg, Henrik; Blennow, Kaj; Antonio del Rio, Jose; Marin-Moreno, Alba; Carlos Espinosa, Juan; Maria Torres, Juan; Sanchez-Valle, Raquel; Mollenhauer, Brit; Ferrer, Isidre; Zerr, Inga; Llorens, Franc
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Oral administration of repurposed drug targeting Cyp46A1 increases survival times of prion infected mice
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2021-04-01
err24
errOAAI
errAli, Tahir; Hannaoui, Samia; Nemani, Satish; Tahir, Waqas; Zemlyankina, Irina; Cherry, Pearl; Shim, Su Yeon; Sim, Valerie; Schaetzl, Hermann M.; Gilch, Sabine
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errSave
Exposure Risk of Chronic Wasting Disease in Humans
errVIRUSES-BASEL
IF3.5
err2020-12-17
err10
errOAAI
errNemani, Satish K.; Myskiw, Jennifer L.; Lamoureux, Lise; Booth, Stephanie A.; Sim, Valerie L.
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errSave
Creutzfeldt-Jakob Disease with a Five-Year Clinical Course, Multicentric Cerebellar Prion Plaques and Prior History of Biopsy-Proven Primary Angiitis of the Central Nervous System: A Case for Iatrogenic Exposure?
errVIRUSES-BASEL
IF3.5
err2020-12-08
err0
errOAAI
errJeon, Kristina; Joseph, Jeffrey T.; Jansen, Gerard H.; Peterson, Anne; Knox, J. David; Sim, Valerie L.
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A novel mechanism of phenotypic heterogeneity in Creutzfeldt-Jakob disease
errACTA NEUROPATHOLOGICA COMMUNICATIONS
IF5.7
err2020-06-19
err12
errOAAI
errNemani, Satish K.; Xiao, Xiangzhu; Cali, Ignazio; Cracco, Laura; Puoti, Gianfranco; Nigro, Massimiliano; Lavrich, Jody; Bharara Singh, Anuradha; Appleby, Brian S.; Sim, Valerie L.; Notari, Silvio; Surewicz, Witold K.; Gambetti, Pierluigi
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Native nanodiscs formed by styrene maleic acid copolymer derivatives help recover infectious prion multimers bound to brain-derived lipids
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2020-06-01
err15
errOAAI
errEsmaili, Mansoore; Tancowny, Brian P.; Wang, Xiongyao; Moses, Audric; Cortez, Leonardo M.; Sim, Valerie L.; Wille, Holger; Overduin, Michael
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Mycobacterium chimaera Encephalitis Following Cardiac Surgery: A New Syndrome
errCLINICAL INFECTIOUS DISEASES
IF7.3
err2019-06-18
err11
PREAI
errLau, Darren; Cooper, Ryan; Chen, Justin; Sim, Valerie L.; McCombe, Jennifer A.; Tyrrell, Gregory J.; Bhargava, Ravi; Adam, Benjamin; Chapman, Erin; Croxen, Matthew A.; Garady, Cherif; Antonation, Kym; van Landeghem, Frank K. H.; Ip, Shannon; Saxinger, Lynora
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Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein
errNATURE COMMUNICATIONS
IF15.7
err2016-06-27
err39
errOAAI
errGupta, Amar Nath; Neupane, Krishna; Rezajooei, Negar; Cortez, Leonardo M.; Sim, Valerie L.; Woodside, Michael T.
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Toll-like Receptor-mediated Immune Response Inhibits Prion Propagation
errGLIA
IF5.1
err2016-02-16
err20
PREAI
errKang, Sang-Gyun; Kim, Chiye; Cortez, Leonardo M.; Garza, Maria Carmen; Yang, Jing; Wille, Holger; Sim, Valerie L.; Westaway, David; McKenzie, Debbie; Aiken, Judd
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Research Directions

No research directions
Co-authors
Cooperation Journals
G
Guido Kroemer
H-index: 283 · Papers: 2.3K
K
Kaj Blennow
H-index: 214 · Papers: 3.6K
H
Henrik Zetterberg
H-index: 190 · Papers: 3.7K
I
Isidró Ferrer
H-index: 119 · Papers: 1.2K
P
Pierluigi Gambetti
H-index: 91 · Papers: 458
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