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J

John M. Gilchrist

Johns Hopkins University
H-index:15
Citation Count:1,015
Views:0

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Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa

ASIC3选择性肽WRPRFa的鉴定、表征及构效关系

Communications Chemistry
IF6.2
2025-12-120
OA
Chun Chien; Nien-Du Yang; Victoria Jiang; Shanti M. Amagasu; John M. Gilchrist
Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of ActionS
MOLECULAR PHARMACOLOGY
IF3
2024-03-0110
OAAI
Gilchrist, John M.; Yang, Nien-Du; Jiang, Victoria; Moyer, Bryan D.
Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7
BIOCHEMICAL PHARMACOLOGY
IF5.6
2020-11-0111
PREAI
Rupasinghe, Darshani B.; Herzig, Volker; Vetter, Irina; Dekan, Zoltan; Gilchrist, John; Bosmans, Frank; Alewood, Paul F.; Lewis, Richard J.; King, Glenn F.
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2019-06-1060
OAAI
Crottes, David; Lin, Yu-Hsiu T.; Peters, Christian J.; Gilchrist, John M.; Wiita, Arun P.; Jan, Yuh Nung; Jan, Lily Yeh
Nav 1.1 inhibition can reduce visceral hypersensitivity
JCI INSIGHT
IF6.1
2018-06-0734
OA
Salvatierra, Juan; Castro, Joel; Erickson, Andelain; Li, Qian; Braz, Joao; Gilchrist, John; Grundy, Luke; Rychkov, Grigori Y.; Deiteren, Annemie; Rais, Rana; King, Glenn F.; Slusher, Barbara S.; Basbaum, Allan; Pasricha, Pankaj J.; Brierley, Stuart M.; Bosmans, Frank
The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel
NEURON
IF15
2018-03-0167
OAAI
Peters, Christian J.; Gilchrist, John M.; Tien, Jason; Bethel, Neville P.; Qi, Lijun; Chen, Tingxu; Wang, Lynn; Jan, Yuh Nung; Grabe, Michael; Jan, Lily Y.
The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity
SCIENTIFIC REPORTS
IF3.9
2017-04-2023
OAAI
Wingerd, Joshua S.; Mozar, Christine A.; Ussing, Christine A.; Murali, Swetha S.; Chin, Yanni K. -Y.; Cristofori-Armstrong, Ben; Durek, Thomas; Gilchrist, John; Vaughan, Christopher W.; Bosmans, Frank; Adams, David J.; Lewis, Richard J.; Alewood, Paul F.; Mobli, Mehdi; Christie, Macdonald J.; Rash, Lachlan D.
Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami
SCIENTIFIC REPORTS
IF3.9
2016-07-0726
OAAI
Herzig, Volker; Ikonomopoulou, Maria; Smith, Jennifer J.; Dziemborowicz, Slawomir; Gilchrist, John; Kuhn-Nentwig, Lucia; Rezende, Fernanda Oliveira; Moreira, Luciano Andrade; Nicholson, Graham M.; Bosmans, Frank; King, Glenn F.
Binary architecture of the Nav1.2-β2 signaling complex
ELIFE
IF0
2016-02-1942
OA
Das, Samir; Gilchrist, John; Bosmans, Frank; Van Petegem, Filip
Binary Architecture of the Nav1.2-β2 Signaling Complex
BIOPHYSICAL JOURNAL
IF3.1
2016-02-010
OAAI
Gilchrist, John M.; Das, Samir; Van Petegem, Filip; Bosmans, Frank
Structural Comparisons of Immunoglobulin Folds of Human Navβ Subunits
BIOPHYSICAL JOURNAL
IF3.1
2016-02-010
OAAI
Das, Samir; Gilchrist, John; Bosmans, Frank; Van Petegem, Filip
A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a
NATURE COMMUNICATIONS
IF15.7
2014-07-1170
OAAI
Bende, Niraj S.; Dziemborowicz, Slawomir; Mobli, Mehdi; Herzig, Volker; Gilchrist, John; Wagner, Jordan; Nicholson, Graham M.; King, Glenn F.; Bosmans, Frank
Nav1.1 Modulation by a Novel Triazole Compound Attenuates Epileptic Seizures in Rodents
ACS CHEMICAL BIOLOGY
IF3.8
2014-03-3148
OAAI
Gilchrist, John; Dutton, Stacey; Diaz-Bustamante, Marcelo; McPherson, Annie; Olivares, Nicolas; Kalia, Jeet; Escayg, Andrew; Bosmans, Frank
β4 Modulates NaV1.2 Toxin Pharmacology
BIOPHYSICAL JOURNAL
IF3.1
2014-01-010
OAAI
Gilchrist, John M.; Das, Samir; Petegemn, Filip Va; Bosmans, Frank
Crystal Structure of the Navβ4 Extracellular Domain
BIOPHYSICAL JOURNAL
IF3.1
2014-01-010
OAAI
Das, Samir; Gilchrist, John; Bosmans, Frank; Van Petegem, Filip
Crystallographic insights into sodium-channel modulation by the β4 subunit

对 β4亚基钠通道调节的晶体学见解

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
2013-12-0286
OAAI
Gilchrist, John; Das, Samir; Van Petegem, Filip; Bosmans, Frank
Rufinamide Modifies the Gating Process of Human Voltage-Gated Sodium Channels
BIOPHYSICAL JOURNAL
IF3.1
2013-01-010
OAAI
Gilchrist, John; Bosmans, Frank
Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9

动物毒素可以改变Nav1.8和Nav1.9的功能

TOXINS
IF4
2012-08-1433
OAAI
Gilchrist, John; Bosmans, Frank

Research Directions

The data has not been retrieved yet.
F
Frank Bosmans
H-index:36Papers:111Citations:4,066
S
Samir Das
H-index:24Papers:308Citations:2,017
F
Filip Van Petegem
H-index:44Papers:314Citations:6,092
F
Frank Bosmans
H-index:4Papers:19Citations:264
G
Glenn F. King
H-index:81Papers:506Citations:2.1万
V
Volker Herzig
H-index:35Papers:140Citations:4,668
R
Richard J. Lewis
H-index:85Papers:673Citations:2.7万
P
Paul F. Alewood
H-index:76Papers:448Citations:2.0万
L
Lily Yeh Jan
H-index:170Papers:599Citations:8.1万
Y
Yuh Nung Jan
H-index:167Papers:529Citations:7.9万