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SaveThe binding and mechanism of a positive allosteric modulator of Kv3 channels
Liang, Qiansheng; Chi, Gamma; Cirqueira, Leonardo; Zhi, Lianteng; Marasco, Agostino; Pilati, Nadia; Gunthorpe, Martin J.; Alvaro, Giuseppe; Large, Charles H.; Sauer, David B.; Treptow, Werner; Covarrubias, Manuel Share Save Targeted therapy improves cellular dysfunction, ataxia, and seizure susceptibility in a model of a progressive myoclonus epilepsyFeng, Huijie; Clatot, Jerome; Kaneko, Keisuke; Flores-Mendez, Marco; Wengert, Eric R.; Koutcher, Carly; Hoddeson, Emily; Lopez, Emily; Lee, Demetrius; Arias, Leroy; Liang, Qiansheng; Zhang, Xiaohong; Somarowthu, Ala; Covarrubias, Manuel; Gunthorpe, Martin J.; Large, Charles H.; Akizu, Naiara; Goldberg, Ethan M. Share Save A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunctionClatot, Jerome; Currin, Christopher B.; Liang, Qiansheng; Pipatpolkai, Tanadet; Massey, Shavonne L.; Helbig, Ingo; Delemotte, Lucie; Vogels, Tim P.; Covarrubias, Manuel; Goldberg, Ethan M. Share Save Share Save Intestinal neuropod cell GUCY2C regulates visceral painBarton, Joshua R.; Londregran, Annie K.; Alexander, Tyler D.; Entezari, Ariana A.; Bar-Ad, Shely; Cheng, Lan; Lepore, Angelo C.; Snook, Adam E.; Covarrubias, Manuel; Waldman, Scott A. Share Save Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domainChi, Gamma; Liang, Qiansheng; Sridhar, Akshay; Cowgill, John B.; Sader, Kasim; Radjainia, Mazdak; Qian, Pu; Castro-Hartmann, Pablo; Venkaya, Shayla; Singh, Nanki Kaur; McKinley, Gavin; Fernandez-Cid, Alejandra; Mukhopadhyay, Shubhashish M. M.; Burgess-Brown, Nicola A.; Delemotte, Lucie; Covarrubias, Manuel; Durr, Katharina L. Share Save Share Save Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium ChannelsYang, Elaine; Bu, Weiming; Suma, Antonio; Carnevale, Vincenzo; Grasty, Kimberly C.; Loll, Patrick J.; Woll, Kellie; Bhanu, Natarajan; Garcia, Benjamin A.; Eckenhoff, Roderic G.; Covarrubias, Manuel Share Save Share Save Share Save Share Save Share Save Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sitesWang, Yali; Yang, Elaine; Wells, Marta M.; Bondarenko, Vasyl; Woll, Kellie; Carnevale, Vincenzo; Granata, Daniele; Klein, Michael L.; Eckenhoff, Roderic G.; Dailey, William P.; Covarrubias, Manuel; Tang, Pei; Xu, Yan Share Save Share Save Share Save Photoaffinity Ligand for the Inhalational Anesthetic Sevoflurane Allows Mechanistic Insight into Potassium Channel ModulationWoll, Kellie A.; Peng, Wesley; Liang, Qiansheng; Zhi, Lianteng; Jacobs, Jack A.; Maciunas, Lina; Bhanu, Natarajan; Garcia, Benjamin A.; Covarrubias, Manuel; Loll, Patrick J.; Dailey, William P.; Eckenhoff, Roderic G. Share Save Share Save Share Save A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of γ-Aminobutyric Acid, Type A (GABAA), Receptor Subunit Binding Selectivity in SynaptosomesWoll, Kellie A.; Murlidaran, Sruthi; Pinch, Benika J.; Henin, Jerome; Wang, Xiaoshi; Salari, Reza; Covarrubias, Manuel; Dailey, William P.; Brannigan, Grace; Garcia, Benjamin A.; Eckenhoff, Roderic G. Share Save 
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