Eric D. Brown - Publications, H-index & Citations

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Eric D. Brown

mcmaster university

64H-index

306Paper Count

2.6WCitation Count

Published Papers 123

Publication Date

A Streptomyces megacluster encodes synergistic biotin-targeting antibiotics

Nature

IF48.5

2026-06-24

PREAI

R. Gordzevich; M. Xu; W. Wang; M. A. Cook; D. Hackenberger; J. P. Deisinger; M. M. Tu; L. A. Carfrae; M. George; K. Rachwalski; K. Koteva; D. Sychantha; A. Wei; G. D. Wright; E. D. Brown

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SyntheMol-RL: a flexible reinforcement learning framework for designing easily synthesizable antibiotics

Molecular Systems Biology

IF7.7

2026-04-23

OAAI

Kyle Swanson; Gary Liu; Denise B Catacutan; Stewart McLellan; Autumn Arnold; Megan M Tu; Eric D Brown; James Zou; Jonathan M Stokes

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Butyrolactol A enhances caspofungin efficacy via flippase inhibition in drug-resistant fungi

Cell

IF42.5

2026-01-01

PREAI

Chen, Xuefei; Duan, H. Diessel; Hoy, Michael J.; Koteva, Kalinka; Spitzer, Michaela; Guitor, Allison K.; Puumala, Emily; Fiebig, Aline A.; Hu, Guanggan; Yiu, Bonnie; Chou, Sommer; Bian, Zhuyun; Choi, Yeseul; Guo, Amelia Bing Ya; Wang, Wenliang; Sun, Sheng; Robbins, Nicole; Averette, Anna Floyd; Cook, Michael A.; Truant, Ray; Macneil, Lesley T.; Brown, Eric D.; Kronstad, James W.; Coombes, Brian K.; Cowen, Leah E.; Heitman, Joseph; Li, Huilin; Wright, Gerard D.

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Evaluation of Azithromycin-Bicarbonate against Multidrug-Resistant Pathogens in Topical Murine Models of Infection

ACS Infectious Diseases

IF3.8

2025-12-10

PREAI

Maya A. Farha; Megan M. Tu; Lindsey Carfrae; Ashelyn E. Sidders; Rodion Gordzevich; Adele Girgis-Gabardo; Julia P. Deisinger; J. Z. Alex Cheong; Ting Y. Wong; Mariel G. Escatte; Stephen Hur; Yonas A. Alamneh; Rania Abu-Taleb; Wanwen Su; Christine Czintos; Lindsay R. Kalan; Daniel Vincent Zurawski; Eric D. Brown

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Author Correction: Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic

Nature Microbiology

IF19.4

2025-10-24

OAAI

Denise B. Catacutan; Vian Tran; Autumn Arnold; Jeremie Alexander; Gabriele Corso; Yeganeh Yousefi; Megan M. Tu; Stewart McLellan; Dominique Tertigas; Kimberly Corneil; Jakob Magolan; Michael G. Surette; Eric D. Brown; Brian K. Coombes; Regina Barzilay; Jonathan M. Stokes

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Discovery and artificial intelligence-guided mechanistic elucidation of a narrow-spectrum antibiotic

Nature Microbiology

IF19.4

2025-10-03

PREAI

Denise B. Catacutan; Vian Tran; Autumn Arnold; Jeremie Alexander; Gabriele Corso; Yeganeh Yousefi; Megan M. Tu; Stewart McLellan; Dominique Tertigas; Jakob Magolan; Michael G. Surette; Eric D. Brown; Brian K. Coombes; Regina Barzilay; Jonathan M. Stokes

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Cryo-EM analyses unveil details of mechanism and targocil-II mediated inhibition of S. aureus WTA transporter TarGH

NATURE COMMUNICATIONS

IF15.7

2025-04-04

OAAI

Li, Franco K. K.; Peters, Shaun C.; Worrall, Liam J.; Sun, Tianjun; Hu, Jinhong; Vuckovic, Marija; Farha, Maya; Palacios, Armando; Caveney, Nathanael A.; Brown, Eric D.; Strynadka, Natalie C. J.

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Important challenges to finding new leads for new antibiotics

CURRENT OPINION IN MICROBIOLOGY

IF7.5

2025-02-01

OAAI

Farha, Maya A.; Tu, Megan M.; Brown, Eric D.

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High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics

ACS INFECTIOUS DISEASES

IF3.8

2024-10-22

PREAI

Weber, Brent S.; Ritchie, Nikki E.; Hilker, Simon; Chan, Derek C. K.; Peukert, Carsten; Deisinger, Julia P.; Ives, Rowan; Ardal, Christine; Burrows, Lori L.; Broenstrup, Mark; Magolan, Jakob; Raivio, Tracy L.; Brown, Eric D.

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A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor

CELL REPORTS

IF6.9

2024-04-01

OAAI

French, Shawn; Guo, Amelia Bing Ya; Ellis, Michael J.; Deisinger, Julia P.; Johnson, Jarrod W.; Rachwalski, Kenneth; Piquette, Zoe A.; Lluka, Telmah; Zary, Miranda; Gamage, Sineli; Magolan, Jakob; Brown, Eric D.

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Cryo-EM analysis of S. aureus TarL, a polymerase in wall teichoic acid biogenesis central to virulence and antibiotic resistance

SCIENCE ADVANCES

IF12.5

2024-03-01

OAAI

Li, Franco K. K.; Worrall, Liam J.; Gale, Robert T.; Brown, Eric D.; Strynadka, Natalie C. J.

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A mobile CRISPRi collection enables genetic interaction studies for the essential genes of Escherichia coli

CELL REPORTS METHODS

IF4.5

2024-01-01

OAAI

Rachwalski, Kenneth; Tu, Megan M.; Madden, Sean J.; French, Shawn; Hansen, Drew M.; Brown, Eric D.

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A standardized nomenclature for resistance-modifying agents in the Comprehensive Antibiotic Resistance Database

MICROBIOLOGY SPECTRUM

IF3.8

2023-12-12

OAAI

Smith, Keaton W.; Alcock, Brian P.; French, Shawn; Farha, Maya A.; Raphenya, Amogelang R.; Brown, Eric D.; Mcarthur, Andrew G.

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Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

PLOS GENETICS

IF3.7

2023-11-02

OAAI

Yaeger, Luke N.; French, Shawn; Brown, Eric D.; Cote, Jean Philippe; Burrows, Lori L.

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Nutrient stress is a target for new antibiotics

TRENDS IN MICROBIOLOGY

IF14.9

2023-06-01

PREAI

Carfrae, Lindsey A.; Brown, Eric D.

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Food for thought: Opportunities to target carbon metabolism in antibacterial drug discovery

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

IF4.8

2023-04-02

PREAI

Tong, Madeline; Brown, Eric D.

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A Bifunctional Spray Coating Reduces Contamination on Surfaces by Repelling and Killing Pathogens

ACS APPLIED MATERIALS & INTERFACES

IF8.2

2023-03-16

PREAI

Abu Jarad, Noor; Rachwalski, Kenneth; Bayat, Fereshteh; Khan, Shadman; Shakeri, Amid; MacLachlan, Roderick; Villegas, Martin; Brown, Eric D.; Hosseinidoust, Zeinab; Didar, Tohid F.; Soleymani, Leyla

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An Omniphobic Spray Coating Created from Hierarchical Structures Prevents the Contamination of High-Touch Surfaces with Pathogens

SMALL

IF12.1

2023-01-01

PREAI

Abu Jarad, Noor; Rachwalski, Kenneth; Bayat, Fereshteh; Khan, Shadman; Shakeri, Amid; MacLachlan, Roderick; Villegas, Martin; Brown, Eric D.; Soleymani, Leyla; Didar, Tohid F.

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Screening under infection-relevant conditions reveals chemical sensitivity in multidrug resistant invasive non-typhoidal Salmonella (iNTS)

RSC CHEMICAL BIOLOGY

IF3.1

2023-01-01

OAAI

Tsai, Caressa N. N.; Massicotte, Marie-Ange; MacNair, Craig R. R.; Perry, Jordyn N. N.; Brown, Eric D. D.; Coombes, Brian K. K.

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CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

NUCLEIC ACIDS RESEARCH

IF13.1

2022-10-20

485

OAAI

Alcock, Brian P.; Huynh, William; Chalil, Romeo; Smith, Keaton W.; Raphenya, Amogelang R.; Wlodarski, Mateusz A.; Edalatmand, Arman; Petkau, Aaron; Syed, Sohaib A.; Tsang, Kara K.; Baker, Sheridan J. C.; Dave, Mugdha; McCarthy, Madeline C.; Mukiri, Karyn M.; Nasir, Jalees A.; Golbon, Bahar; Imtiaz, Hamna; Jiang, Xingjian; Kaur, Komal; Kwong, Megan; Liang, Zi Cheng; Niu, Keyu C.; Shan, Prabakar; Yang, Jasmine Y. J.; Gray, Kristen L.; Hoad, Gemma R.; Jia, Baofeng; Bhando, Timsy; Carfrae, Lindsey A.; Farha, Maya A.; French, Shawn; Gordzevich, Rodion; Rachwalski, Kenneth; Tu, Megan M.; Bordeleau, Emily; Dooley, Damion; Griffiths, Emma; Zubyk, Haley L.; Brown, Eric D.; Maguire, Finlay; Beiko, Robert G.; Hsiao, William W. L.; Brinkman, Fiona S. L.; Van Domselaar, Gary; McArthur, Andrew G.

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Research Directions