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SaveFunctional and Structural Characterization of Treatment-Emergent Nirmatrelvir Resistance Mutations at Low Frequencies in the Main Protease (Mpro) Reveals a Unique Evolutionary Route for SARS-CoV-2 to Gain Resistance
Deschenes, Natalie M.; Perez-Vargas, Jimena; Zhong, Zoe; Thomas, Merrilee; Kenward, Calem; Mosimann, Wesley A.; Worrall, Liam J.; Waglechner, Nicholas; Li, Angel XinLiu; Maguire, Finlay; Aftanas, Patryk; Smith, Jason R.; Lim, Jared; Young, Robert N.; Cherkasov, Artem; Farooqi, Lubna; Moinuddin, Adnan; Siddiqi, Lina; Malik, Imaan; Lefebvre, Maxime; Paetzel, Mark; Strynadka, Natalie C. J.; Jean, Francois; McGeer, Allison; Kozak, Robert A. Share Save Share Save A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariantsPerez-Vargas, Jimena; Worrall, Liam J.; Olmstead, Andrea D.; Ton, Anh-Tien; Lee, Jaeyong; Villanueva, Ivan; Thompson, Connor A. H.; Dudek, Svenja; Ennis, Siobhan; Smith, Jason R.; Shapira, Tirosh; De Guzman, Joshua; Gang, Shutong; Ban, Fuqiang; Vuckovic, Marija; Bielecki, Michael; Kovacic, Suzana; Kenward, Calem; Hong, Christopher Yee; Gordon, Danielle G.; Levett, Paul N.; Krajden, Mel; Leduc, Richard; Boudreault, Pierre-Luc; Niikura, Masahiro; Paetzel, Mark; Young, Robert N.; Cherkasov, Artem; Strynadka, Natalie C. J.; Jean, Francois Share Save X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturationLee, Jaeyong; Kenward, Calem; Worrall, Liam J.; Vuckovic, Marija; Gentile, Francesco; Ton, Anh-Tien; Ng, Myles; Cherkasov, Artem; Strynadka, Natalie C. J.; Paetzel, Mark Share Save Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing siteLee, Jaeyong; Worrall, Liam J.; Vuckovic, Marija; Rosell, Federico I.; Gentile, Francesco; Ton, Anh-Tien; Caveney, Nathanael A.; Ban, Fuqiang; Cherkasov, Artem; Paetzel, Mark; Strynadka, Natalie C. J. Share Save Share Save Share Save Share Save Share Save Share Save Share Save Share Save Share Save Share Save Novel avian influenza H7N3 strain outbreak, British ColumbiaHirst, M; Astell, CR; Griffith, M; Coughlin, SM; Moksa, M; Zeng, T; Smailus, DE; Holt, RA; Jones, S; Marra, MA; Petric, M; Krajden, M; Lawrence, D; Mak, A; Chow, R; Skowronski, DM; Tweed, SA; Goh, S; Brunham, RC; Robinson, J; Bowes, V; Sojonky, K; Byrne, SK; Li, Y; Kobasa, D; Booth, T; Paetzel, M Share Save Share Save Share Save Share Save Share Save 
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