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Philip J. Santangelo

Georgia Institute of Technology and Emory University

49H-index
179Paper Count
7.4KCitation Count
Published Papers 82
Publication Date
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Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection
errNature Communications
IF15.7
err2025-11-25
err0
errOAAI
errJae Yeon Joo; Peng Xiao; Susan P. John; Daryll Vanover; Hannah E. Peck; Loren E. Sasser; Deepanwita Bose; Younghun Jung; Jaehyeon Hwang; Chiara Zurla; Francois Villinger; Philip J. Santangelo
errShare
errSave
Integrated epigenetic and genetic programming of primary human T cells
errNature Biotechnology
IF41.7
err2025-10-21
err0
errOAAI
errLaine Goudy; Alvin Ha; Ashir A. Borah; Jennifer M. Umhoefer; Lauren Chow; Carinna Tran; Aidan Winters; Alexis Talbot; Rosmely Hernandez; Zhongmei Li; Sanjana Subramanya; Abolfazl Arab; Nupura Kale; Jae Hyun J. Lee; Joseph J. Muldoon; Chang Liu; Ralf Schmidt; Philip Santangelo; Julia Carnevale; Justin Eyquem; Brian R. Shy; Alex Marson; Luke A. Gilbert
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errSave
Sensitizing solid tumors to CAR-mediated cytotoxicity by lipid nanoparticle delivery of synthetic antigens
errNATURE CANCER
IF28.5
err2025-05-16
err0
PREAI
errGamboa, Lena; Zamat, Ali H.; Thiveaud, Chloe A.; Lee, Hee Jun; Kulaksizoglu, Elif; Zha, Zizhen; Campbell, Noah S.; Chan, Ching Shen; Fabrega, Sydney; Oliver, S. Abbey; Su, Fang-Yi; Phuengkham, Hathaichanok; Vanover, Daryll; Peck, Hannah E.; Sivakumar, Anirudh; Dahotre, Shreyas N.; Harris, Adrian M.; Santangelo, Philip J.; Kwong, Gabriel A.
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errSave
Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses
errNATURE COMMUNICATIONS
IF15.7
err2025-04-12
err0
errOAAI
errHuayamares, Sebastian G.; Lian, Liming; Rab, Regina; Hou, Yuning; Radmand, Afsane; Kim, Hyejin; Zenhausern, Ryan; Achyut, Bhagelu R.; Ross, Melissa Gilbert; Lokugamage, Melissa P.; Loughrey, David; Peck, Hannah E.; Echeverri, Elisa Schrader; Sanchez, Alejandro J. Da Silva; Shajii, Aram; Li, Andrea; Tiegreen, Karen E.; Santangelo, Philip J.; Sorscher, Eric J.; Dahlman, James E.
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errSave
Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys
errNATURE BIOTECHNOLOGY
IF41.7
err2024-11-22
err0
PREAI
errKim, Hyejin; Zenhausern, Ryan; Gentry, Kara; Lian, Liming; Huayamares, Sebastian G.; Radmand, Afsane; Loughrey, David; Podilapu, Ananda R.; Hatit, Marine Z. C.; Ni, Huanzhen; Li, Andrea; Shajii, Aram; Peck, Hannah E.; Han, Keyi; Hua, Xuanwen; Jia, Shu; Martinez, Michele; Lee, Charles; Santangelo, Philip J.; Tarantal, Alice; Dahlman, James E.
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errSave
Lipid nanoparticles deliver mRNA to the blood-brain barrier
errNANO RESEARCH
IF9
err2024-08-01
err0
PREAI
errKuzminich, Yanina; Shakked, Avraham; Calkins, Randi; Rudden, Sebastian; Jones, Camille; Doan, Jessie; Jang, Bora; Echeverri, Elisa Schrader; Zenhausern, Ryan; Lian, Liming; Loughrey, David; Peck, Hannah E.; Wiese, Rachelle; Koveal, Dorothy; Santangelo, Philip J.; Dahlman, James E.
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errSave
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA
errPLOS PATHOGENS
IF4.9
err2024-07-05
err1
errOAAI
errChaves, Lorena C. S.; Orr-Burks, Nichole; Vanover, Daryll; Mosur, Varun V.; Hosking, Sarah R.; Kumar, Pramod E. K.; Jeong, Hyeyoon; Jung, Younghun; Assumpcao, Jose A. F.; Peck, Hannah E.; Nelson, Sarah L.; Burke, Kaitlyn N.; Garrison, McKinzie A.; Arthur, Robert A.; Claussen, Henry; Heaton, Nicholas S.; Lafontaine, Eric R.; Hogan, Robert J.; Zurla, Chiara; Santangelo, Philip J.
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errSave
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18
errNATURE BIOMEDICAL ENGINEERING
IF26.6
err2024-05-02
err1
errOAAI
errWolfson, David W.; Kim, Nam Kyun; Lee, Ki Hong; Beyersdorf, Jared P.; Langberg, Jonathan J.; Fernandez, Natasha; Choi, Dahim; Zureick, Nadine; Kim, Tae Yun; Bae, Seongho; Gu, Jin-Mo; Kirschman, Jonathan L.; Fan, Jinqi; Sheng, Christina Y.; Sen, Danielle Gottlieb; Mettler, Bret; Sung, Jung Hoon; Yoon, Young-sup; Park, Sung-Jin; Santangelo, Philip J.; Cho, Hee Cheol
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errSave
Substituting Poly(ethylene glycol) Lipids with Poly(2-ethyl-2-oxazoline) Lipids Improves Lipid Nanoparticle Repeat Dosing
errADVANCED HEALTHCARE MATERIALS
IF9.6
err2024-03-10
err6
PREAI
errSanchez, Alejandro J. Da Silva; Loughrey, David; Echeverri, Elisa Schrader; Huayamares, Sebastian G.; Radmand, Afsane; Paunovska, Kalina; Hatit, Marine; Tiegreen, Karen E.; Santangelo, Philip J.; Dahlman, James E.
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errSave
Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody
errANTIBODIES
IF2.7
err2024-03-06
err1
errOAAI
errNador, Ellena; Xia, Chaoshuang; Santangelo, Philip J.; Whaley, Kevin J.; Costello, Catherine E.; Anderson, Deborah J.
errShare
errSave
Cationic cholesterol- dependent LNP delivery to lung stem cells, the liver, and heart
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-03-04
err9
errOAAI
errRadmand, Afsane; Kim, Hyejin; Beyersdorf, Jared; Dobrowolski, Curtis N.; Zenhausern, Ryan; Paunovska, Kalina; Huayamares, Sebastian G.; Hua, Xuanwen; Han, Keyi; Loughrey, David; Hatit, Marine Z. C.; Del Cid, Ada; Ni, Huanzhen; Shajii, Aram; Li, Andrea; Muralidharan, Abinaya; Peck, Hannah E.; Tiegreen, Karen E.; Jia, Shu; Santangelo, Philip J.; Dahlman, James E.
errShare
errSave
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo (vol 7, e162290, 2022)
errJCI INSIGHT
IF6.1
err2023-11-22
err1
errOAAI
errSamer, Sadia; Thomas, Yanique; Arainga, Mariluz; Carter, Crystal; Shirreff, Lisa M.; Arif, Muhammad S.; Avita, Juan M.; Frank, Ines; McRaven, Michael D.; Thuruthiyil, Christopher T.; Heybeli, Veli B.; Anderson, Meegan R.; Owen, Benjamin; Gaisin, Arsen; Bose, Deepanwita; Simons, Lacy M.; Hultquist, Judd F.; Arthos, James; Cicala, Claudia; Sereti, Irini; Santangelo, Philip J.; Lorenzo-Redondo, Ramon; Hope, Thomas J.; Villinger, Francois J.; Martinelli, Elena
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errSave
A direct contact pig influenza challenge model for assessing protective efficacy of monoclonal antibodies
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2023-10-27
err1
errOAAI
errMcnee, Adam; Vanover, Daryll; Rijal, Pramila; Paudyal, Basudev; Lean, Fabian Z. X.; Macloughlin, Ronan; Nunez, Alejandro; Townsend, Alain; Santangelo, Philip J.; Tchilian, Elma
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errSave
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo
errNANO LETTERS
IF9.1
err2023-01-26
err32
errOAAI
errRadmand, Afsane; Lokugamage, Melissa P.; Kim, Hyejin; Dobrowolski, Curtis; Zenhausern, Ryan; Loughrey, David; Huayamares, Sebastian G.; Hatit, Marine Z. C.; Ni, Huanzhen; Del Cid, Ada; Sanchez, Alejandro J. Da Silva; Paunovska, Kalina; Echeverri, Elisa Schrader; Shajii, Aram; Peck, Hannah; Santangelo, Philip J.; Dahlman, James E.
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errSave
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure
errNANO LETTERS
IF9.1
err2022-12-15
err24
PREAI
errPaunovska, Kalina; Da Silva Sanchez, Alejandro J.; Lokugamage, Melissa P.; Loughrey, David; Echeverri, Elisa Schrader; Cristian, Ana; Hatit, Marine Z. C.; Santangelo, Philip J.; Zhao, Kun; Dahlman, James E.
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errSave
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung
errNATURE MATERIALS
IF38.5
err2022-11-28
err73
errOAAI
errRotolo, Laura; Vanover, Daryll; Bruno, Nicholas C.; Peck, Hannah E.; Zurla, Chiara; Murray, Jackelyn; Noel, Richard K.; O'Farrell, Laura; Arainga, Mariluz; Orr-Burks, Nichole; Joo, Jae Yeon; Chaves, Lorena C. S.; Jung, Younghun; Beyersdorf, Jared; Gumber, Sanjeev; Guerrero-Ferreira, Ricardo; Cornejo, Santiago; Thoresen, Merrilee; Olivier, Alicia K.; Kuo, Katie M.; Gumbart, James C.; Woolums, Amelia R.; Villinger, Francois; Lafontaine, Eric R.; Hogan, Robert J.; Finn, M. G.; Santangelo, Philip J.
errShare
errSave
Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo
errJCI INSIGHT
IF6.1
err2022-11-08
err12
errOAAI
errSamer, Sadia; Thomas, Yanique; Arainga, Mariluz; Carter, Crystal; Shirreff, Lisa M.; Arif, Muhammad S.; Avita, Juan M.; Frank, Ines; McRaven, Michael D.; Thuruthiyil, Christopher T.; Heybeli, Veli B.; Anderson, Meegan R.; Owen, Benjamin; Gaisin, Arsen; Bose, Deepanwita; Simons, Lacy M.; Hultquist, Judd F.; Arthos, James; Cicala, Claudia; Sereti, Irini; Santangelo, Philip J.; Lorenzo-Redondo, Ramon; Hope, Thomas J.; Villinger, Francois J.; Martinelli, Elena
errShare
errSave
Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection
errADVANCED SCIENCE
IF14.1
err2022-10-31
err13
errOAAI
errVanover, Daryll; Zurla, Chiara; Peck, Hannah E.; Orr-Burks, Nichole; Joo, Jae Yeon; Murray, Jackelyn; Holladay, Nathan; Hobbs, Ryan A.; Jung, Younghun; Chaves, Lorena C. S.; Rotolo, Laura; Lifland, Aaron W.; Olivier, Alicia K.; Li, Dapeng; Saunders, Kevin O.; Sempowski, Gregory D.; Crowe, James E., Jr.; Haynes, Barton F.; Lafontaine, Eric R.; Hogan, Robert J.; Santangelo, Philip J.
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errSave
p38MAPK guards the integrity of endosomal compartments through regulating necrotic death
errSCIENTIFIC REPORTS
IF3.9
err2022-09-29
err0
errOAAI
errYao, Jia; Atasheva, Svetlana; Toy, Randall; Blanchard, Emmeline L.; Santangelo, Philip J.; Roy, Krishnendu; Mocarski, Edward S.; Shayakhmetov, Dmitry M.
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errSave
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo
errNATURE COMMUNICATIONS
IF15.7
err2022-08-15
err87
errOAAI
errNi, Huanzhen; Hatit, Marine Z. C.; Zhao, Kun; Loughrey, David; Lokugamage, Melissa P.; Peck, Hannah E.; Del Cid, Ada; Muralidharan, Abinaya; Kim, YongTae; Santangelo, Philip J.; Dahlman, James E.
errShare
errSave

Research Directions

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Co-authors
Cooperation Journals
A
Anthony S. Fauci
H-index: 185 · Papers: 1.1K
R
Rafi Ahmed
H-index: 162 · Papers: 764
B
Barton F. Haynes
H-index: 144 · Papers: 834
B
Barney S. Graham
H-index: 139 · Papers: 640
C
Charles Lee
H-index: 133 · Papers: 705
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