Kim Newton - Publications, H-index & Citations

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Kim Newton

Genentech

58H-index

122Paper Count

2.2WCitation Count

Published Papers 50

Publication Date

Gasdermin D-mediated delivery of caspase inhibitors to suppress pyroptosis

Nature

IF48.5

2026-08-03

PREAI

Katarzyna M. Groborz; Melissa E. Truong; Irma Stowe; Katherine E. Wickliffe; Bettina Lee; Stefan Bauernfried; Robert S. Jones; Emile Plise; Elizabeth S. Levy; Ponien Kou; Wyne P. Lee; Juan Zhang; Hanna Budayeva; Christopher M. Rose; Julia Nguyen; Malgorzata Kalinka; Marcin Drag; Nobuhiko Kayagaki; Kim Newton; Marcin Poreba; Vishva M. Dixit

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cFLIP suppresses caspase-1- and MLKL-independent perinatal lethality driven by auto-processing impaired caspase-8 D387A

Cell Death & Differentiation

IF0

2025-12-12

OAAI

Kim Newton; Katherine E. Wickliffe; Allie Maltzman; Debra L. Dugger; Juan Reyes Jr; Natasha Bacarro; Søren Warming; Neha Rohatgi; Rohit Reja; Joshua D. Webster; Vishva M. Dixit

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Author Correction: Activity of caspase-8 determines plasticity between cell death pathways

Nature

IF48.5

2025-12-04

OAAI

Kim Newton; Katherine E. Wickliffe; Allie Maltzman; Debra L. Dugger; Rohit Reja; Yue Zhang; Merone Roose-Girma; Zora Modrusan; Meredith S. Sagolla; Joshua D. Webster; Vishva M. Dixit

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Author Correction: Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

Nature

IF48.5

2025-12-03

OAAI

Kim Newton; Katherine E. Wickliffe; Debra L. Dugger; Allie Maltzman; Merone Roose-Girma; Monika Dohse; László Kőműves; Joshua D. Webster; Vishva M. Dixit

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Author Correction: Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

Nature

IF48.5

2025-11-27

OAAI

Nobuhiko Kayagaki; Irma B. Stowe; Kamela Alegre; Ishan Deshpande; Shuang Wu; Zhonghua Lin; Opher S. Kornfeld; Bettina L. Lee; Juan Zhang; John Liu; Eric Suto; Wyne P. Lee; Kellen Schneider; WeiYu Lin; Dhaya Seshasayee; Tushar Bhangale; Cecile Chalouni; Matthew C. Johnson; Prajakta Joshi; Jan Mossemann; Sarah Zhao; Danish Ali; Neil M. Goldenberg; Blayne A. Sayed; Benjamin E. Steinberg; Kim Newton; Joshua D. Webster; Ryan L. Kelly; Vishva M. Dixit

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Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors

Nature Immunology

IF27.6

2025-11-21

PREAI

Svetlana Altshuler-Keylin; Nicole Caduff; Isabel E. Ishizuka; Rohit Reja; Katherine Nutsch; Chan Gao; Joy Wang; Ulrike Kaufmann; Mayra Cruz Tleugabulova; Elizabeth Dixon; Hannah Little-Hooy; Rachana Pradhan; Rosa Barreira da Silva; Teresita L. Arenzana; Min Xu; Mark S. Wilson; Jill Schartner; Soyoung A. Oh; Kim Newton; Vishva M. Dixit; Sascha Rutz

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Enteropathogenic bacteria evade ROCK-driven epithelial cell extrusion

Nature

IF48.5

2025-10-22

OAAI

Giovanni Luchetti; Marin V. Miner; Rachael M. Peterson; William P. Scott; Praveen Krishnamoorthy; Eric M. Kofoed; Angel G. Jimenez; Hua Zhang; Man Wah Tan; Rohit Reja; Tommy K. Cheung; Elizabeth Skippington; Yuxin Liang; Christopher M. Rose; Nobuhiko Kayagaki; Kim Newton; Isabella Rauch; Vishva M. Dixit

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N4BP1 coordinates ubiquitin-dependent crosstalk within the I k B kinase family to limit Toll-like receptor signaling and inflammation

IMMUNITY

IF26.3

2024-05-01

PREAI

Gitlin, Alexander D.; Maltzman, Allie; Kanno, Yuzuka; Heger, Klaus; Reja, Rohit; Schubert, Alexander F.; Wierciszewski, Linsey J.; Pantua, Homer; Kapadia, Sharookh B.; Harris, Seth F.; Webster, Joshua D.; Newton, Kim; Dixit, Vishva M.

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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1

CELL DEATH AND DIFFERENTIATION

IF15.4

2024-03-28

OAAI

Solon, Margaret; Ge, Nianfeng; Hambro, Shannon; Haller, Susan; Jiang, Jian; Baca, Miriam; Preston, Jessica; Maltzman, Allie; Wickliffe, Katherine E.; Liang, Yuxin; Reja, Rohit; Nickles, Dorothee; Newton, Kim; Webster, Joshua D.

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Control of Cell Death in Health and Disease

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE

IF34.5

2024-01-24

OAAI

Kayagaki, Nobuhiko; Webster, Joshua D.; Newton, Kim

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Caspase cleavage of RIPK3 after Asp333 is dispensable for mouse embryogenesis

CELL DEATH AND DIFFERENTIATION

IF15.4

2024-01-08

OAAI

Newton, Kim; Wickliffe, Katherine E.; Maltzman, Allie; Dugger, Debra L.; Webster, Joshua D.; Guo, Hongyan; Dixit, Vishva M.

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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury

AMERICAN JOURNAL OF TRANSPLANTATION

IF8.2

2023-05-17

OAAI

Kayagaki, Nobuhiko; Stowe, Irma B.; Alegre, Kamela; Deshpande, Ishan; Wu, Shuang; Lin, Zhonghua; Kornfeld, Opher S.; Lee, Bettina L.; Zhang, Juan; Liu, John; Suto, Eric; Lee, Wyne P.; Schneider, Kellen; Lin, WeiYu; Seshasayee, Dhaya; Bhangale, Tushar; Chalouni, Cecile; Johnson, Matthew C.; Joshi, Prajakta; Mossemann, Jan; Zhao, Sarah; Ali, Danish; Goldenberg, Neil M.; Sayed, Blayne A.; Steinberg, Benjamin E.; Newton, Kim; Webster, Joshua D.; Kelly, Ryan L.; Dixit, Vishva M.

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XIAP deletion sensitizes mice to TNF-induced and RIP1-mediated death

CELL DEATH & DISEASE

IF9.6

2023-04-11

OAAI

Witt, Axel; Goncharov, Tatiana; Lee, Yujung Michelle; Kist, Matthias; Dohse, Monika; Eastham, Jeff; Dugger, Debra; Newton, Kim; Webster, Joshua D.; Vucic, Domagoj

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Myodegeneration in EDA-A2 transgenic mice is prevented by XEDAR deficiency

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

OAAI

Newton, K; French, DM; Yan, MH; Frantz, GD; Dixit, VM

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Kinase RIP3 is dispensable for normal NF-KBs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and toll-like receptors 2 and 4

MOLECULAR AND CELLULAR BIOLOGY

IF2.7

2023-03-27

524

OAAI

Newton, K; Sun, XQ; Dixit, VM

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Deubiquitinases in cell death and inflammation

BIOCHEMICAL JOURNAL

IF4.3

2022-05-24

OAAI

Newton, Kim; Gitlin, Alexander D.

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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

CELL DEATH AND DIFFERENTIATION

IF15.4

2020-09-30

OAAI

Kist, Matthias; Komuves, Laszlo G.; Goncharov, Tatiana; Dugger, Debra L.; Yu, Charles; Roose-Girma, Merone; Newton, Kim; Webster, Joshua D.; Vucic, Domagoj

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Multitasking Kinase RIPK1 Regulates Cell Death and Inflammation

cold spring harbor perspectives in medicine

IF8.4

2019-08-19

OAAI

Newton, Kim

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Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

ELIFE

IF0

2019-07-09

OAAI

Lim, Junghyun; Park, Hyunjoo; Heisler, Jason; Maculins, Timurs; Roose-Girma, Merone; Xu, Min; Mckenzie, Brent; Campagne, Menno van Lookeren; Newton, Kim; Murthy, Aditya

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RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

CELL DEATH AND DIFFERENTIATION

IF15.4

2019-05-17

116

OAAI

Patel, Snahel; Webster, Joshua D.; Varfolomeev, Eugene; Kwon, Youngsu C.; Cheng, Jason H.; Zhang, Juan; Dugger, Debra L.; Wickliffe, Kate E.; Maltzman, Allie; Sujatha-Bhaskar, Swathi; Kohli, Pawan Bir; Ramaswamy, Sreema; Deshmukh, Gauri; Liederer, Bianca M.; Fong, Rina; Hamilton, Greg; Lupardus, Patrick; Caplazi, Patrick; Lee, Wyne P.; Campagne, Menno van Lookeren; Johnson, Adam; McKenzie, Brent S.; Junttila, Melissa R.; Newton, Kim; Vucic, Domagoj

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Research Directions