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Systematic multi-trait AAV capsid engineering for efficient gene delivery Eid, Fatma-Elzahraa; Chen, Albert T.; Chan, Ken Y.; Huang, Qin; Zheng, Qingxia; Tobey, Isabelle G.; Pacouret, Simon; Brauer, Pamela P.; Keyes, Casey; Powell, Megan; Johnston, Jencilin; Zhao, Binhui; Lage, Kasper; Tarantal, Alice F.; Chan, Yujia A.; Deverman, Benjamin E. Share Save
CSMD1 regulates brain complement activity and circuit development Baum, Matthew L.; Wilton, Daniel K.; Fox, Rachel G.; Carey, Alanna; Hsu, Yu-Han H.; Hu, Ruilong; Jantti, Henna J.; Fahey, Jaclyn B.; Muthukumar, Allie K.; Salla, Nikkita; Crotty, William; Scott-Hewitt, Nicole; Bien, Elizabeth; Sabatini, David A.; Lanser, Toby B.; Frouin, Arnaud; Gergits, Frederick; Havik, Bjarte; Gialeli, Chrysostomi; Nacu, Eugene; Lage, Kasper; Blom, Anna M.; Eggan, Kevin; McCarroll, Steven A.; Johnson, Matthew B.; Stevens, Beth Share Save
Protein interaction networks in the vasculature prioritize genes and pathways underlying coronary artery disease Zhu, Qiuyu Martin; Hsu, Yu-Han H.; Lassen, Frederik H.; MacDonald, Bryan T.; Stead, Stephanie; Malolepsza, Edyta; Kim, April; Li, Taibo; Mizoguchi, Taiji; Schenone, Monica; Guzman, Gaelen; Tanenbaum, Benjamin; Fornelos, Nadine; Carr, Steven A.; Gupta, Rajat M.; Ellinor, Patrick T.; Lage, Kasper Share Save
Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases Weeks, Elle M. M.; Ulirsch, Jacob C. C.; Cheng, Nathan Y. Y.; Trippe, Brian L. L.; Fine, Rebecca S. S.; Miao, Jenkai; Patwardhan, Tejal A. A.; Kanai, Masahiro; Nasser, Joseph; Fulco, Charles P. P.; Tashman, Katherine C. C.; Aguet, Francois; Li, Taibo; Ordovas-Montanes, Jose; Smillie, Christopher S. S.; Biton, Moshe; Shalek, Alex K. K.; Ananthakrishnan, Ashwin N. N.; Xavier, Ramnik J. J.; Regev, Aviv; Gupta, Rajat M. M.; Lage, Kasper; Ardlie, Kristin G. G.; Hirschhorn, Joel N. N.; Lander, Eric S. S.; Engreitz, Jesse M. M.; Finucane, Hilary K. K. Share Save
Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders Pintacuda, Greta; Hsu, Yu-Han H.; Tsafou, Kalliopi; Li, Ka Wan; Martin, Jacqueline M.; Riseman, Jackson; Biagini, Julia C.; Ching, Joshua K. T.; Mena, Daya; Gonzalez-Lozano, Miguel A.; Egri, Shawn B.; Jaffe, Jake; Smit, August B.; Fornelos, Nadine; Eggan, Kevin C.; Lage, Kasper Share Save
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INTERACTION STUDIES OF RISK PROTEINS IN HUMAN INDUCED NEURONS REVEAL CONVERGENT BIOLOGY AND NOVEL MECHANISMS UNDERLYING AUTISM SPECTRUM DISORDERS Lage, Kasper; Pintacuda, Greta; Hsu, Yu-Han; Tsafou, Kalliopi; Li, Ka-Wan; Martin, Jacqueline; Gonzalez-Lozano, Miguel; Biagini, Julia; Ching, Joshua; Riseman, Jackson; Egri, Shawn; Jaffe, Jake; Smit, August; Fornelos, Nadine; Eggan, Kevin Share Save
COMBINING PROTEOMICS WITH GENETICS TO ELUCIDATE THE MOLECULAR MECHANISMS UNDERLYING NEURODEVELOPMENTAL AND NEUROPSYCHIATRIC DISEASES IN HUMAN NEURONS Pintacuda, Greta; Hsu, Yu-Han; Martin, Jacqueline M.; Ratanatharathorn, Andrew; Maihofer, Adam X.; Chaby, Lauren; Lasseter, Heather; Haas, Magali; Jeromin, Andreas; Nievergelt, Caroline M.; Fornelos, Nadine; Smit, August B.; Koenen, Karestan C.; Lage, Kasper; Eggan, Kevin Share Save
ZBTB33 Is Mutated in Clonal Hematopoiesis and Myelodysplastic Syndromes and Impacts RNA Splicing Beauchamp, Ellen M.; Leventhal, Matthew; Bernard, Elsa; Hoppe, Emma R.; Todisco, Gabriele; Creignou, Maria; Galli, Anna; Castellano, Cecilia A.; McConkey, Marie; Tarun, Akansha; Wong, Waihay; Schenone, Monica; Stanclift, Caroline; Tanenbaum, Benjamin; Malolepsza, Edyta; Nilsson, Bjorn; Bick, Alexander G.; Weinstock, Joshua S.; Miller, Mendy; Niroula, Abhishek; Dunford, Andrew; Taylor-Weiner, Amaro; Wood, Timothy; Barbera, Alex; Anand, Shankara; Psaty, Bruce M.; Desai, Pinkal; Cho, Michael H.; Johnson, Andrew D.; Loos, Ruth; MacArthur, Daniel G.; Lek, Monkol; Neuberg, Donna S.; Lage, Kasper; Carr, Steven A.; Hellstrom-Lindberg, Eva; Malcovati, Luca; Papaemmanuil, Elli; Stewart, Chip; Getz, Gad; Bradley, Robert K.; Jaiswal, Siddhartha; Ebert, Benjamin L. Share Save
Genoppi is an open-source software for robust and standardized integration of proteomic and genetic data Pintacuda, Greta; Lassen, Frederik H.; Hsu, Yu-Han H.; Kim, April; Martin, Jacqueline M.; Malolepsza, Edyta; Lim, Justin K.; Fornelos, Nadine; Eggan, Kevin C.; Lage, Kasper Share Save
Targeting acute myeloid leukemia dependency on VCP-mediated DNA repair through a selective second-generation small-molecule inhibitor Roux, Blandine; Vaganay, Camille; Vargas, Jesse D.; Alexe, Gabriela; Benaksas, Chaima; Pardieu, Bryann; Fenouille, Nina; Ellegast, Jana M.; Malolepsza, Edyta; Ling, Frank; Rol, Gaetano Soda; Ross, Linda; Pikman, Yana; Conwa, Amy S. Y.; Tang, Yangzhong; Wu, Tony; Anderson, Daniel J.; Le Moigne, Ronan; Zhou, Ha N-Jie; Luciano, Frederic; Hartigan, Christina R.; Galinsky, Ilene; DeAngelo, Daniel J.; Stone, Richard M.; Auberger, Patrick; Schenone, Monica; Rr, Steven A. Ca; Guirouilh-Barbat, Josee; Lopez, Bernard; Khaled, Mehdi; Lage, Kasper; Hermine, Olivier; Hemann, Michael T.; Puissant, Alexandre; Stegmaier, Kimberly; Benajiba, Lina Share Save
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Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML Tothova, Zuzana; Valton, Anne-Laure; Gorelov, Rebecca A.; Vallurupalli, Mounica; Krill-Burger, John M.; Holmes, Amie; Landers, Catherine C.; Haydu, J. Erika; Malolepsza, Edyta; Hartigan, Christina; Donahue, Melanie; Popova, Katerina D.; Koochaki, Sebastian; Venev, Sergey V.; Rivera, Jeanne; Chen, Edwin; Lage, Kasper; Schenone, Monica; D'Andrea, Alan D.; Carr, Steven A.; Morgan, Elizabeth A.; Dekker, Job; Ebert, Benjamin L. Share Save
Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants Iqbal, Sumaiya; Perez-Palma, Eduardo; Jespersen, Jakob B.; May, Patrick; Hoksza, David; Heyne, Henrike O.; Ahmed, Shehab S.; Rifat, Zaara T.; Rahman, M. Sohel; Lage, Kasper; Palotie, Aarno; Cottrell, Jeffrey R.; Wagner, Florence F.; Daly, Mark J.; Campbell, Arthur J.; Lal, Dennis Share Save
BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain (vol 10, pg 333, 2020) Pourhaghighi, Reza; Ash, Peter E. A.; Phanse, Sadhna; Goebels, Florian; Hu, Lucas Z. M.; Chen, Siwei; Zhang, Yingying; Wierbowski, Shayne D.; Boudeau, Samantha; Moutaoufik, Mohamed T.; Malty, Ramy H.; Malolepsza, Edyta; Tsafou, Kalliopi; Nathan, Aparna; Cromar, Graham; Guo, Hongbo; Al Abdullatif, Ali; Apicco, Daniel J.; Becker, Lindsay A.; Gitler, Aaron D.; Pulst, Stefan M.; Youssef, Ahmed; Hekman, Ryan; Havugimana, Pierre C.; White, Carl A.; Blum, Benjamin C.; Ratti, Antonia; Bryant, Camron D.; Parkinson, John; Lage, Kasper; Babu, Mohan; Yu, Haiyuan; Bader, Gary D.; Wolozin, Benjamin; Emili, Andrew Share Save
TCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci Davis, Erica E.; Balasubramanian, Ravikumar; Kupchinsky, Zachary A.; Keefe, David L., Jr.; Plummer, Lacey; Khan, Kamal; Meczekalski, Blazej; Heath, Karen E.; Lopez-Gonzalez, Vanesa; Ballesta-Martinez, Mary J.; Margabanthu, Gomathi; Price, Susan; Greening, James; Brauner, Raja; Valenzuela, Irene; Cusco, Ivon; Fernandez-Alvarez, Paula; Wierman, Margaret E.; Li, Taibo; Lage, Kasper; Barroso, Priscila Sales; Chan, Yee-Ming; Crowley, William F.; Katsanis, Nicholas Share Save
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