Not logged in Advanced imaging, immune profiling and nanoparticle immunotherapy distribution in H3K27M-mutated Diffuse Midline Glioma models: identifying and translating MRI signatures Sinn, Ralph; Samaras, Georgios; Grassl, Niklas; Boztepe, Berin; Fischer, Manuel; Weidenfeld, Ina; Scheck, Jonas; Hofmann, Nina; Mack, Norman; Abdollahi, Amir; Heiland, Sabine; Bendszus, Martin; Platten, Michael; Zuckermann, Marc; Sahm, Katharina; Breckwoldt, Michael Share Save
A simplified preparation method for single-nucleus RNA-sequencing using long-term frozen brain tumor tissues Ernst, Kati J.; Okonechnikov, Konstantin; Bageritz, Josephine; Perera, Ashwyn A.; Mallm, Jan-Philipp; Wittmann, Andrea; Maass, Kendra K.; Leible, Svenja; Boutros, Michael; Pfister, Stefan M.; Zuckermann, Marc; Jones, David T. W. Share Save
Loss of Elp1 in cerebellar granule cell progenitors models ataxia phenotype of Familial Dysautonomia Arnskoetter, Frederik; da Silva, Patricia Benites Goncalves; Schouw, Mackenna E.; Lukasch, Chiara; Bianchini, Luca; Sieber, Laura; Garcia-Lopez, Jesus; Ahmad, Shiekh Tanveer; Li, Yiran; Lin, Hong; Joshi, Piyush; Spaenig, Lisa; Rados, Magdalena; Roiuk, Mykola; Sepp, Mari; Zuckermann, Marc; Northcott, Paul A.; Patrizi, Annarita; Kutscher, Lena M. Share Save
Capmatinib is an effective treatment for MET-fusion driven pediatric high-grade glioma and synergizes with radiotherapy Zuckermann, Marc; He, Chen; Andrews, Jared; Bagchi, Aditi; Sloan-Henry, Roketa; Bianski, Brandon; Xie, Jia; Wang, Yingzhe; Twarog, Nathaniel; Onar-Thomas, Arzu; Ernst, Kati J.; Yang, Lei; Li, Yong; Zhu, Xiaoyan; Ocasio, Jennifer K.; Budd, Kaitlin M.; Dalton, James; Li, Xiaoyu; Chepyala, Divyabharathi; Zhang, Junyuan; Xu, Ke; Hover, Laura; Roach, Jordan T.; Chan, Kenneth Chun-Ho; Hofmann, Nina; Mckinnon, Peter J.; Pfister, Stefan M.; Shelat, Anang A.; Rankovic, Zoran; Freeman, Burgess B.; Chiang, Jason; Jones, David T. W.; Tinkle, Christopher L.; Baker, Suzanne J. Share Save
Mapping pediatric brain tumors to their origins in the developing cerebellum Okonechnikov, Konstantin; Joshi, Piyush; Sepp, Mari; Leiss, Kevin; Sarropoulos, Ioannis; Murat, Florent; Sill, Martin; Beck, Pengbo; Chan, Kenneth Chun-Ho; Korshunov, Andrey; Sah, Felix; Deng, Maximilian Y.; Sturm, Dominik; DeSisto, John; Donson, Andrew M.; Foreman, Nicholas K.; Green, Adam L.; Robinson, Giles; Orr, Brent A.; Gao, Qingsong; Darrow, Emily; Hadley, Jennifer L.; Northcott, Paul A.; Gojo, Johannes; Kawauchi, Daisuke; Hovestadt, Volker; Filbin, Mariella G.; von Deimling, Andreas; Zuckermann, Marc; Pajtler, Kristian W.; Kool, Marcel; Jones, David T. W.; Jaeger, Natalie; Kutscher, Lena M.; Kaessmann, Henrik; Pfister, Stefan M. Share Save
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The first-in-class ERK inhibitor ulixertinib shows promising activity in mitogen-activated protein kinase (MAPK)-driven pediatric low-grade glioma models Sigaud, Romain; Roesch, Lisa; Gatzweiler, Charlotte; Benzel, Julia; von Soosten, Laura; Peterziel, Heike; Selt, Florian; Najafi, Sara; Ayhan, Simay; Gerloff, Xenia F.; Hofmann, Nina; Buedenbender, Isabel; Schmitt, Lukas; Foerster, Kathrin, I; Burhenne, Juergen; Haefeli, Walter E.; Korshunov, Andrey; Sahm, Felix; van Tilburg, Cornelis M.; Jones, David T. W.; Pfister, Stefan M.; Knoerzer, Deborah; Kreider, Brent L.; Sauter, Max; Pajtler, Kristian W.; Zuckermann, Marc; Oehme, Ina; Witt, Olaf; Milde, Till Share Save
Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes Clarke, Matthew; Mackay, Alan; Ismer, Britta; Pickles, Jessica C.; Tatevossian, Ruth G.; Newman, Scott; Bale, Tejus A.; Stoler, Iris; Izquierdo, Elisa; Temelso, Sara; Carvalho, Diana M.; Molinari, Valeria; Burford, Anna; Howell, Louise; Virasami, Alex; Fairchild, Amy R.; Avery, Aimee; Chalker, Jane; Kristiansen, Mark; Haupfear, Kelly; Dalton, James D.; Orisme, Wilda; Wen, Ji; Hubank, Michael; Kurian, Kathreena M.; Rowe, Catherine; Maybury, Mellissa; Crosier, Stephen; Knipstein, Jeffrey; Schueller, Ulrich; Kordes, Uwe; Kram, David E.; Snuderl, Matija; Bridges, Leslie; Martin, Andrew J.; Doey, Lawrence J.; Al-Sarraj, Safa; Chandler, Christopher; Zebian, Bassel; Cairns, Claire; Natrajan, Rachael; Boult, Jessica K. R.; Robinson, Simon P.; Sill, Martin; Dunkel, Ira J.; Gilheeney, Stephen W.; Rosenblum, Marc K.; Hughes, Debbie; Proszek, Paula Z.; Macdonald, Tobey J.; Preusser, Matthias; Haberler, Christine; Slavc, Irene; Packer, Roger; Ng, Ho-Keung; Caspi, Shani; Popovi, Mara; Kotnik, Barbara Faganel; Wood, Matthew D.; Baird, Lissa; Davare, Monika Ashok; Solomon, David A.; Olsen, Thale Kristin; Brandal, Petter; Farrell, Michael; Cryan, Jane B.; Capra, Michael; Karremann, Michael; Schittenhelm, Jens; Schuhmann, Martin U.; Ebinger, Martin; Dinjens, Winand N. M.; Kerl, Kornelius; Hettmer, Simone; Pietsch, Torsten; Andreiuolo, Felipe; Driever, Pablo Hernaiz; Korshunov, Andrey; Hiddingh, Lotte; Worst, Barbara C.; Sturm, Dominik; Zuckermann, Marc; Witt, Olaf; Bloom, Tabitha; Mitchell, Clare; Miele, Evelina; Colafati, Giovanna Stefania; Diomedi-Camassei, Francesca; Bailey, Simon; Moore, Andrew S.; Hassall, Timothy E. G.; Lowis, Stephen P.; Tsoli, Maria; Cowley, Mark J.; Ziegler, David S.; Karajannis, Matthias A.; Aquilina, Kristian; Hargrave, Darren R.; Carceller, Fernando; Marshall, Lynley, V; von Deimling, Andreas; Kramm, Christof M.; Pfister, Stefan M.; Sahm, Felix; Baker, Suzanne J.; Mastronuzzi, Angela; Carai, Andrea; Vinci, Maria; Capper, David; Popov, Sergey; Ellison, David W.; Jacques, Thomas S.; Jones, David T. W.; Jones, Chris Share Save
YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis Pajtler, Kristian W.; Wei, Yiju; Okonechnikov, Konstantin; Silva, Patricia B. G.; Vouri, Mikaella; Zhang, Lei; Brabetz, Sebastian; Sieber, Laura; Gulley, Melissa; Mauermann, Monika; Wedig, Tatjana; Mack, Norman; Kawasawa, Yuka Imamura; Sharma, Tanvi; Zuckermann, Marc; Andreiuolo, Felipe; Holland, Eric; Maass, Kendra; Koerkel-Qu, Huiqin; Liu, Hai-Kun; Sahm, Felix; Capper, David; Bunt, Jens; Richards, Linda J.; Jones, David T. W.; Korshunov, Andrey; Chavez, Lukas; Lichter, Peter; Hoshino, Mikio; Pfister, Stefan M.; Kool, Marcel; Li, Wei; Kawauchi, Daisuke Share Save
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Somatic CRISPR/Cas9-mediated gene editing enables versatile brain tumor modeling Zuckermann, Marc; Ismer, Britta; Hovestadt, Volker; Knobbe-Thomsen, Christiane B.; Zapatka, Marc; Northcott, Paul A.; Roussel, Martine F.; Reifenberger, Guido; Lichter, Peter; Pfister, Stefan M.; Kawauchi, Daisuke; Gronych, Jan; Jones, David T. Share Save
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme Feng, Weijun; Kawauchi, Daisuke; Koerkel-Qu, Huiqin; Deng, Huan; Serger, Elisabeth; Sieber, Laura; Ariel Lieberman, Jenna; Jimeno-Gonzalez, Silvia; Lambo, Sander; Hanna, Bola S.; Harim, Yassin; Jansen, Malin; Neuerburg, Anna; Friesen, Olga; Zuckermann, Marc; Rajendran, Vijayanad; Gronych, Jan; Ayrault, Olivier; Korshunov, Andrey; Jones, David T. W.; Kool, Marcel; Northcott, Paul A.; Lichter, Peter; Cortes-Ledesma, Felipe; Pfister, Stefan M.; Liu, Hai-Kun Share Save
Somatic CRISPR/Cas9-mediated tumor suppressor disruption enables versatile brain tumor modeling Zuckermann, Marc; Hovestadt, Volker; Knobbe-Thomsen, Christiane B.; Zapatka, Marc; Northcott, Paul A.; Schramm, Kathrin; Belic, Jelena; Jones, David T. W.; Tschida, Barbara; Moriarity, Branden; Largaespada, David; Roussel, Martine F.; Korshunov, Andrey; Reifenberger, Guido; Pfister, Stefan M.; Lichter, Peter; Kawauchi, Daisuke; Gronych, Jan Share Save
Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling Zuckermann, Marc; Hovestadt, Volker; Knobbe-Thomsen, Christiane B.; Zapatka, Marc; Northcott, Paul A.; Schramm, Kathrin; Belic, Jelena; Jones, David T. W.; Tschida, Barbara; Moriarity, Branden; Largaespada, David; Roussel, Martine F.; Korshunov, Andrey; Reifenberger, Guido; Pfister, Stefan M.; Lichter, Peter; Kawauchi, Daisuke; Gronych, Jan Share Save
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