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施

施一公 (Yigong Shi)

School of Life Sciences

117H-index
422Paper Count
5.3WCitation Count
Published Papers 140
Publication Date
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Phosphoantigen-driven dissociation of butyrophilin oligomers activates γδ T cells
errCell Discovery
IF12.5
err2026-08-11
err0
errOAAI
errWeizhi Xin; Bangdong Huang; Weijie Gao; Wenjia Zhang; Yundi Hu; Yuehua Liu; Enyuan Liang; Jin Chen; Yigong Shi; Qiang Su; Qiang Zhou
errShare
errSave
Structural basis of lipid-dependent allosteric gating mechanisms for PC1-PC2 ion channel
errNature Communications
IF15.7
err2026-07-08
err0
errOAAI
errMengying Chen; Zhifei Wang; Yan Shi; Gaoxingyu Huang; Tiago D. C. Morais; Akhilraj R. Pillai; Yan Wang; Moushumi Afroza Mou; Dan Jing; Rongyan Fan; Fayang Zhou; Zhangsuo Liu; Qiang Su; Yong Yu; Yigong Shi
errShare
errSave
Inhibitors supercharge kinase turnover through native proteolytic circuits
errNature
IF48.5
err2025-11-26
err0
errOAAI
errNatalie S. Scholes; Martino Bertoni; Arnau Comajuncosa-Creus; Katharina Kladnik; Xuefei Guo; Fabian Frommelt; Matthias Hinterndorfer; Hlib Razumkov; Polina Prokofeva; Martin P. Schwalm; Florian Born; Sandra Roehm; Hana Imrichova; Brianda L. Santini; Eleonora Barone; Caroline Schätz; Miquel Muñoz i Ordoño; Severin Lechner; Andrea Rukavina; Iciar Serrano; Miriam Abele; Anna Koren; Stefan Kubicek; Stefan Knapp; Nathanael S. Gray; Giulio Superti-Furga; Bernhard Kuster; Yigong Shi; Patrick Aloy; Georg E. Winter
errShare
errSave
Structural basis of BAX pore formation
errScience
IF45.8
err2025-06-26
err0
PREAI
errYing Zhang; Lu Tian; Gaoxingyu Huang; Xiaofei Ge; Fang Kong; Pengqi Wang; Yige Xu; Yigong Shi
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errSave
Analysis of electromagnetic response of cells and lipid membranes using a model-free method (vol 152, 108444, 2023)
errBIOELECTROCHEMISTRY
IF4.5
err2025-02-01
err0
PREAI
errLu, Yingxian; Tang, Xiaping; Zhao, Yanyu; Jiang, Tianyu; Zhou, Jiayao; Wang, Xiaofei; Huang, Bing; Liu, Lingyu; Deng, Hu; Huang, Yujing; Shi, Yigong
errShare
errSave
Structural basis of human γ-secretase inhibition by anticancer clinical compounds
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-12-09
err0
PREAI
errGuo, Xuefei; Li, Haotian; Lu, Xiaoli; Liu, Hao; Kaicheng, U.; Yan, Chuangye; Lei, Jianlin; Huang, Jing; Zhou, Rui; Shi, Yigong
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errSave
Filament structures unveil the dynamic organization of human acetyl-CoA carboxylase
errSCIENCE ADVANCES
IF12.5
err2024-10-11
err0
errOAAI
errZhou, Fayang; Zhang, Yuanyuan; Zhu, Yuyao; Zhou, Qiang; Shi, Yigong; Hu, Qi
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errSave
Molecular basis for the activation of human spliceosome
errNATURE COMMUNICATIONS
IF15.7
err2024-07-27
err1
errOAAI
errZhan, Xiechao; Lu, Yichen; Shi, Yigong
errShare
errSave
A microfabricated lab-on-chip with three-dimensional electrodes for microscopic observation of bioelectromagnetic effects of cells (vol 154, 108554, 2023)
errBIOELECTROCHEMISTRY
IF4.5
err2024-06-01
err0
PREAI
errLu, Yingxian; Shi, Yigong
errShare
errSave
Structural insights into human exon-defined spliceosome prior to activation
errCELL RESEARCH
IF25.9
err2024-04-24
err2
errOAAI
errZhang, Wenyu; Zhang, Xiaofeng; Zhan, Xiechao; Bai, Rui; Lei, Jianlin; Yan, Chuangye; Shi, Yigong
errShare
errSave
Impact of specific electromagnetic radiation on wakefulness in mice
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-04-01
err3
errOAAI
errDeng, Hu; Liu, Lingyu; Tang, Xiaping; Lu, Yingxian; Wang, Xiaofei; Zhao, Yanyu; Shi, Yigong
errShare
errSave
Molecular and structural basis of the dual regulation of the polycystin-2 ion channel by smallmolecule ligands
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-03-14
err2
errOAAI
errWang, Zhifei; Chen, Mengying; Su, Qiang; Morais, Tiago D. C.; Wang, Yan; Nazginov, Elianna; Pillai, Akhilraj R.; Qian, Feng; Shi, Yigong; Yu, Yong
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errSave
Dark and Dronc activation in Drosophila melanogaster
errPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IF9.1
err2024-02-21
err0
PREAI
errTian, Lu; Li, Yini; Shi, Yigong
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errSave
Familial Alzheimer mutations stabilize synaptotoxic y-secretase-substrate complexes
errCELL REPORTS
IF6.9
err2024-02-01
err8
errOAAI
errDevkota, Sujan; Zhou, Rui; Nagarajan, Vaishnavi; Maesako, Masato; Do, Hung; Noorani, Arshad; Overmeyer, Caitlin; Bhattarai, Sanjay; Douglas, Justin T.; Saraf, Anita; Miao, Yinglong; Ackley, Brian D.; Shi, Yigong; Wolfe, Michael S.
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errSave
Structural insights into branch site proofreading by human spliceosome
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2024-01-09
err9
errOAAI
errZhang, Xiaofeng; Zhan, Xiechao; Bian, Tong; Yang, Fenghua; Li, Pan; Lu, Yichen; Xing, Zhihan; Fan, Rongyan; Zhang, Qiangfeng Cliff; Shi, Yigong
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errSave
THUMPD2 catalyzes the N2-methylation of U6 snRNA of the spliceosome catalytic center and regulates pre-mRNA splicing and retinal degeneration
errNUCLEIC ACIDS RESEARCH
IF13.1
err2024-01-02
err3
errOAAI
errYang, Wen-Qing; Ge, Jian-Yang; Zhang, Xiaofeng; Zhu, Wen-Yu; Lin, Lin; Shi, Yigong; Xu, Beisi; Liu, Ru-Juan
errShare
errSave
A microfabricated lab-on-chip with three-dimensional electrodes for microscopic observation of bioelectromagnetic effects of cells
errBIOELECTROCHEMISTRY
IF4.5
err2023-12-01
err8
PREAI
errLu, Yingxian; Shi, Yigong
errShare
errSave
Preferential Regulation of Γ-Secretase-Mediated Cleavage of APP by Ganglioside GM1 Reveals a Potential Therapeutic Target for Alzheimer's Disease
errADVANCED SCIENCE
IF14.1
err2023-09-27
err7
errOAAI
errWang, Xiaotong; Zhou, Rui; Sun, Xiaqin; Li, Jun; Wang, Jinxin; Yue, Weihua; Wang, Lifang; Liu, Hesheng; Shi, Yigong; Zhang, Dai
errShare
errSave
Analysis of electromagnetic response of cells and lipid membranes using a model-free method
errBIOELECTROCHEMISTRY
IF4.5
err2023-08-01
err5
PREAI
errLu, Yingxian; Tang, Xiaping; Zhao, Yanyu; Jiang, Tianyu; Zhou, Jiayao; Wang, Xiaofei; Huang, Bing; Liu, Lingyu; Deng, Hu; Huang, Yujing; Shi, Yigong
errShare
errSave
Structural insights into CED-3 activation
errLIFE SCIENCE ALLIANCE
IF2.9
err2023-07-04
err3
errOAAI
errLi, Yini; Tian, Lu; Zhang, Ying; Shi, Yigong
errShare
errSave

Research Directions

主要运用结构生物学生物化学和生物物理的手段研究RNA剪接细胞凋亡等细胞内生物大分子机器的结构与功能γ-分泌酶介导的阿尔茨海默症的分子机制
Co-authors
Cooperation Journals
P
Paul Greengard
H-index: 206 · Papers: 1.1K
J
Joan Massagué
H-index: 201 · Papers: 571
朱
朱健康 (Jian‐Kang Zhu)
H-index: 192 · Papers: 749
H
Harvey F. Lodish
H-index: 164 · Papers: 837
V
Vishva M. Dixit
H-index: 156 · Papers: 414
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