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SaveExploiting biparatopic binding to deliver novel, differentiated ALPP/ALPPL2 targeting protein drug conjugates
Cotton, Graham; McLean, Estelle G.; Trumper, Paul; Wappett, Mark; Gatdula, Stephanie; Bell, Stacey; Papadakos, Greg; Lucas, Kieron; Burton, Stephanie; Saladino, Chiara; Parau, Georgiana; McCann, Aidan; Thom, Jennifer; Cranston, Aaron N.; Harrison, Tim Share Save Exploiting a multi-center pre-clinical mouse PDX mini trial to identify new clinical opportunities for protein-drug conjugates (PDCs) targeting ROR1Cranston, Aaron N.; Wappett, Mark; McLean, Estelle G.; Saladino, Chiara; McCann, Aidan; Kung, Wei-Wei; Thom, Jennifer; Trumper, Paul; Porter, Andy; Barelle, Caroline; Harrison, Tim; Cotton, Graham Share Save Share Save Low host immune pressure may be associated with the development of hepatocellular carcinoma: a longitudinal analysis of complete genomes of the HBV 1762T, 1764A mutantJiang, Zhi-Hua; Chen, Qin-Yan; Jia, Hui-Hua; Wang, Xue-Yan; Zhang, Lu-Juan; Huang, Xiao-Qian; Harrison, Tim J.; Jackson, J. Brooks; Wu, Li; Fang, Zhong-Liao Share Save Development of novel protein drug conjugates (PDCs) for the selective targeting of ALPP/ALPPL2 expressing tumorsCotton, Graham; Trumper, Paul; McLean, Estelle; Wappett, Mark; Bell, Stacey; Papadakos, Greg; Thom, Jennifer; Saladino, Chiara; Cranston, Aaron; Parau, Georgiana; Gatdula, Stephanie; Burton, Stephanie; McCann, Aidan; Harrison, Tim Share Save Share Save Share Save Development of first-in-class small molecule inhibitors of FLIP which activate caspase-8, the nodal regulator of apoptosis, necroptosis and pyroptosisLongley, Daniel B.; Higgins, Catherine; Fox, Jennifer; Roberts, Jamie Z.; Boffey, Ray; Williams, Sophie; Perrior, Trevor; Page, Martin J.; Harrison, Tim Share Save Exploiting the properties of VNAR domains for the development of novel efficacious protein drug conjugates targeting the oncofetal protein ROR1Cotton, Graham; Thom, Jennifer; Trumper, Paul; Kamenski, Andrei; Bell, Stacey; Wappett, Mark; Barelle, Caroline; Kovaleva, Marina; Campion, Alicia; Persiani, Elisa; Porter, Andrew; McLean, Estelle; McCann, Aidan; Saladino, Chiara; Cranston, Aaron; Harrison, Tim Share Save Antitumor activity of the novel oral highly selective Weel inhibitor Debio 0123O'Dowd, Colin; Gavory, Gerald; Burkamp, Frank; Treder, Adam; Boyd, Caroline; Harrison, Tim; Massiere, Frederic; Gluck, Astrid; Chardonnens, Christophe; Zaffalon, Andrea; Rigotti, Stefania; Mader, Robert; Vuagniaux, Gregoire; Chessex, Anne Vaslin Share Save Targeting the ubiquitin-proteasome system by small molecule inhibition of the DUBomeHarrison, Tim; Jacq, Xavier; O'Dowd, Colin; Gavory, Gerald; Barker, Oliver; Bell, Christina; Burkamp, Frank; Burton, Stephanie; Cassidy, Eamon; Helm, Matthew; Hewitt, Peter; Page, Natalie; Rountree, Shane; Rozycka, Ewelina; Shepherd, Steven; Whitehead, Steven; Wappett, Mark Share Save Discovery and development of first-in-class orally bioavailable USP19 inhibitorsJacq, Xavier; Gavory, Gerald; O'Dowd, Colin; Cranston, Aaron; Baker, Oliver; Bell, Christina; Burton, Stephanie; Cassidy, Eamon; Costa, Joana; Henderson, Ashling; Helm, Matthew; Hewitt, Peter; Hughes, Caroline; McFarland, Mary; Miel, Hugues; Proctor, Lauren; Roundtree, Shane; Church, Rachel; Rozycka, Ewelina; Wappett, Mark; Whitehead, Steven; Harrison, Tim; Bedard, Nathalie; Wing, Simon S. Share Save RALB GTPase: A critical regulator of DR5 cell surface expression and TRAIL sensitivity in RAS mutant colorectal cancerKhawaja, Hajrah; Roberts, Jamie Z.; Javadi, Arman; O'Reilly, Paul; McArt, Darragh; Allen, Wendy L.; Morrison, Markus; Kennedy, Richard; Vitale, Nicolas; Johnston, Patrick G.; Harrison, Tim; Longley, Daniel B.; Evergren, Emma; Van Schaeybroeck, Sandra Share Save Share Save Novel subgenotype D11 of hepatitis B virus in NaPo County, Guangxi, bordering VietnamRen, Chuang-Chuang; Chen, Qin-Yan; Wang, Xue-Yan; Harrison, Tim J.; Yang, Qing-Li; Hu, Li-Ping; Liu, Hua-Bing; He, Xiang; Jia, Hui-Hua; Fang, Zhong-Liao Share Save Asymptomatic hepatitis B carriers who were vaccinated at birthWang, Xueyan; Chen, Qinyan; Li, Hai; Wang, Chao; Hu, Liping; Yang, Qingli; Ren, Chuangchuang; Liu, Huabing; Zheng, Zhigang; Harrison, Tim J.; Fang, Zhong-Liao Share Save Locus 5p13.1 may be associated with the selection of cancer-related HBV core promoter mutationsChen, Qin-Yan; Hu, Yan-Ling; Wang, Xue-Yan; Harrison, Tim J.; Wang, Chao; Hu, Li-Ping; Yang, Qing-Li; Ren, Chuang-Chuang; Jia, Hui-Hua; Fang, Zhong-Liao Share Save High Prevalence of HBV Lamivudine-Resistant Mutations in HBV/HIV Co-Infected Patients on Antiretroviral Therapy in the Area with the Highest Prevalence of HIV/HBV Co-Infection in ChinaJia, Hui-Hua; Li, Kai-Wen; Chen, Qin-Yan; Wang, Xue-Yan; Harrison, Tim J.; Liang, Shu-Jia; Yang, Qing-Li; Wang, Chao; Hu, Li-Ping; Ren, Chuang-Chuang; Fang, Zhong-Liao Share Save Accessing the cancer DUBome with UbiPlex: A bespoke drug discovery platform for deubiquitinase enzymesGavory, Gerald; O'Dowd, Colin; Barker, Oliver; Bell, Christina; Burkamp, Frank; Burton, Stephanie; Cassidy, Eamon; Costa, Joana; Dossang, Anthony; Helm, Matt; Henderson, Ashling; Hewitt, Peter; Hughes, Caroline; McFarland, Mary; Miel, Hugues; Page, Natalie; Proctor, Lauren; Rountree, Shane; Rozycka, Ewelina; Shepherd, Steven; Treder, Adam; Wappett, Mark; Whitehead, Steven; Harrison, Tim Share Save 
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