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H

Harry T. Orr

University of Minnesota

94H-index
346Paper Count
3.2WCitation Count
Published Papers 107
Publication Date
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Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1
errNeurobiology of Disease
IF5.6
err2026-03-17
err0
errOAAI
errAlyssa Soles; Jessica Grittner; Kaia Douglas; Praseuth Yang; Lisa Duvick; Brennon O'Callaghan; Ryan Barnett; Christine Chau; Roj Cosiquien; Orion Rainwater; Shannah Serres; Brendan Dougherty; Harry T. Orr; Marija Cvetanovic
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Repeat-associated non-AUG translation as a common mechanism for the polyGln ataxias
errCell Reports
IF6.9
err2025-12-19
err0
errOAAI
errMonica Banez-Coronel; Tao Zu; Madeline Aldridge; Shu Guo; Ramadan Ajredini; Deborah Morrison; Alexis B. Tays; Lisa A. Duvick; Olga Pletnikova; Anthony T. Yachnis; Juan C. Troncoso; Henry L. Paulson; Hayley S. McLoughlin; Tetsuo Ashizawa; S.H. Subramony; Harry T. Orr; Laura P.W. Ranum
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An expanded polyglutamine in ATAXIN1 results in a loss-of-function that exacerbates severity of Multiple Sclerosis in an EAE mouse model
errJOURNAL OF NEUROINFLAMMATION
IF10.1
err2025-04-30
err0
errOAAI
errTalukdar, Gourango; Duvick, Lisa; Yang, Praseuth; O'Callaghan, Brennon; Fuchs, Gavin J.; Cvetanovic, Marija; Orr, Harry T.
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Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients
errSCIENCE TRANSLATIONAL MEDICINE
IF14.6
err2024-11-06
err0
PREAI
errBartelt, Luke C.; Switonski, Pawel M.; Adamek, Grazyna; Longo, Fabiana; Carvalho, Juliana; Duvick, Lisa A.; Jarrah, Sabrina I.; Mcloughlin, Hayley S.; Scoles, Daniel R.; Pulst, Stefan M.; Orr, Harry T.; Hull, Court; Lowe, Craig B.; La Spada, Albert R.
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Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1
errHUMAN MOLECULAR GENETICS
IF3.2
err2024-10-30
err0
errOAAI
errMorrison, Logan M.; Huang, Haoran; Handler, Hillary P.; Fu, Min; Jones, Deborah M.; Bushart, David D.; Pappas, Samuel S.; Orr, Harry T.; Shakkottai, Vikram G.
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Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells
errNEUROBIOLOGY OF DISEASE
IF5.6
err2024-10-01
err0
errOAAI
errSheeler, Carrie; Labrada, Emmanuel; Duvick, Lisa; Thompson, Leslie M.; Zhang, Ying; Orr, Harry T.; Cvetanovic, Marija
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Mapping SCA1 regional vulnerabilities reveals neural and skeletal muscle contributions to disease
errJCI INSIGHT
IF6.1
err2024-03-21
err0
errOAAI
errDuvick, Lisa; Southern, W. Michael; Benzow, Kellie A.; Burch, Zoe N.; Handler, Hillary P.; Mitchell, Jason S.; Kuivinen, Hannah; Gadiparthi, Udaya; Yang, Praseuth; Soles, Alyssa; Sheeler, Carrie A.; Rainwater, Orion; Serres, Shannah; Lind, Erin B.; Nichols-Meade, Tessa; You, Yun; O'Callaghan, Brennon; Zoghbi, Huda Y.; Cvetanovic, Marija; Wheeler, Vanessa C.; Ervasti, James M.; Koob, Michael D.; Orr, Harry T.
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errSave
Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1
errNEURON
IF15
err2024-02-01
err5
errOAAI
errTejwani, Leon; Ravindra, Neal G.; Lee, Changwoo; Cheng, Yubao; Nguyen, Billy; Luttik, Kimberly; Ni, Luhan; Zhang, Shupei; Morrison, Logan M.; Gionco, John; Xiang, Yangfei; Yoon, Jennifer; Ro, Hannah; Haidery, Fatema; Grijalva, Rosalie M.; Bae, Eunwoo; Kim, Kristen; Martuscello, Regina T.; Orr, Harry T.; Zoghbi, Huda Y.; Mcloughlin, Hayley S.; Ranum, Laura P. W.; Shakkottai, Vikram G.; Faust, Phyllis L.; Wang, Siyuan; van Dijk, David; Lim, Janghoo
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errSave
HD and SCA1: Tales from two 30-year journeys since gene discovery
errNEURON
IF15
err2023-11-01
err3
PREAI
errThompson, Leslie M.; Orr, Harry T.
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errSave
Regional sex differences in neurochemical profiles of healthy mice measured by magnetic resonance spectroscopy at 9.4 tesla
errFRONTIERS IN NEUROSCIENCE
IF3.2
err2023-10-25
err2
errOAAI
errTkac, Ivan; Xie, Tiankai; Shah, Nitya; Larson, Sarah; Dubinsky, Janet M.; Gomez-Pastor, Rocio; McLoughlin, Hayley S.; Orr, Harry T.; Eberly, Lynn E.; Oz, Gulin
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errSave
The PERK pathway: beneficial or detrimental for neurodegenerative diseases and tumor growth and cancer
errHUMAN MOLECULAR GENETICS
IF3.2
err2023-06-29
err3
PREAI
errTalukdar, Gourango; Orr, Harry T.; Lei, Zhixin
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Generation and characterization of LANP/pp32 null mice
errMOLECULAR AND CELLULAR BIOLOGY
IF2.7
err2023-03-27
err41
errOAAI
errOpal, P; Garcia, JJ; McCall, AE; Xu, BS; Weeber, EJ; Sweatt, JD; Orr, HT; Zoghbi, HY
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errSave
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1 (vol 111, pg 481, 2023)
errNEURON
IF15
err2023-03-01
err3
errOAAI
errCoffin, Stephanie L.; Durham, Mark A.; Nitschke, Larissa; Xhako, Eder; Brown, Amanda M.; Revelli, Jean-Pierre; Gonzalez, Esmeralda Villavicencio; Lin, Tao; Handler, Hillary P.; Dai, Yanwan; Trostle, Alexander J.; Wan, Ying-Wooi; Liu, Zhandong; V. Sillitoe, Roy; Orr, Harry T.; Zoghbi, Huda Y.
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errSave
Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1
errNEURON
IF15
err2023-02-01
err15
errOAAI
errCoffin, Stephanie L.; Durham, Mark A.; Nitschke, Larissa; Xhako, Eder; Brown, Amanda M.; Revelli, Jean-Pierre; Gonzalez, Esmeralda Villavicencio; Lin, Tao; Handler, Hillary P.; Dai, Yanwan; Trostle, Alexander J.; Wan, Ying-Wooi; Liu, Zhandong; V. Sillitoe, Roy; Orr, Harry T.; Zoghbi, Huda Y.
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errSave
Decreasing mutant ATXN1 nuclear localization improves a spectrum of SCA1-like phenotypes and brain region transcriptomic profiles
errNEURON
IF15
err2023-02-01
err15
errOAAI
errHandler, Hillary P.; Duvick, Lisa; Mitchell, Jason S.; Cvetanovic, Marija; Reighard, Molly; Soles, Alyssa; Mather, Kathleen B.; Rainwater, Orion; Serres, Shannah; Nichols-Meade, Tessa; Coffin, Stephanie L.; You, Yun; Ruis, Brian L.; Callaghan, Brenno; Henzler, Christine; Zoghbi, Huda Y.; Orr, Harry T.
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Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine- expanded ataxin-1
errJOURNAL OF CLINICAL INVESTIGATION
IF13.6
err2022-05-02
err7
errOAAI
errLee, Won-Seok; Al-Ramahi, Ismael; Jeong, Hyun-Hwan; Jang, Youjin; Lin, Tao; Adamski, Carolyn J.; Lavery, Laura A.; Rath, Smruti; Richman, Ronald; Bondar, Vitaliy V.; Alcala, Elizabeth; Revelli, Jean-Pierre; Orr, Harry T.; Liu, Zhandong; Botas, Juan; Zoghbi, Huda Y.
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Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model
errJCI INSIGHT
IF6.1
err2022-04-22
err8
errOAAI
errOrengo, James P.; Nitschke, Larissa; van der Heijden, Meike E.; Ciaburri, Nicholas A.; Orr, Harry T.; Zoghbi, Huda Y.
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Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition
errMOLECULAR PSYCHIATRY
IF10.1
err2022-03-17
err27
errOAAI
errLiu, Dong; Nanclares, Carmen; Simbriger, Konstanze; Fang, Kun; Lorsung, Ethan; Le, Nam; Amorim, Ines Silva; Chalkiadaki, Kleanthi; Pathak, Salil Saurav; Li, Jin; Gewirtz, Jonathan C.; Jin, Victor X.; Kofuji, Paulo; Araque, Alfonso; Orr, Harry T.; Gkogkas, Christos G.; Cao, Ruifeng
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Stephen T. Warren, Ph.D. (1953-2021): A remembrance OBITUARY
errAMERICAN JOURNAL OF HUMAN GENETICS
IF8.1
err2022-01-01
err0
errOAAI
errNelson, David L.; Clark, Janelle; Garber, Kathryn; Glover, Thomas; Hassold, Terry; Jin, Peng; Orr, Harry T.; Sherman, Stephanie L.; Zoghbi, Huda; Warren, Karen L.
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Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice
errCELL REPORTS
IF6.9
err2021-10-01
err12
errOAAI
errWozniak, Emily A. L.; Chen, Zhao; Paul, Sharan; Yang, Praseuth; Figueroa, Karla P.; Friedrich, Jill; Tschumperlin, Tyler; Berken, Michael; Ingram, Melissa; Henzler, Christine; Pulst, Stefan M.; Orr, Harry T.
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Research Directions

No research directions
Co-authors
Cooperation Journals
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Virginia M.‐Y. Lee
H-index: 200 · Papers: 920
S
Stephen S. Rich
H-index: 160 · Papers: 1.9K
李金 cover
李金 (Jin Li)
H-index: 149 · Papers: 4.5K
D
David C. Rubinsztein
H-index: 143 · Papers: 526
H
Huda Y. Zoghbi
H-index: 135 · Papers: 566
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