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D

Denis Leclerc

université laval

33H-index
89Paper Count
2.8KCitation Count
Published Papers 34
Publication Date
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Engineering a Modular PapMV Nanoparticle Vaccine: Comparative Efficacy of a Covalent and a Non-Covalent N-Antigen Vaccine Against Emerging SARS-CoV-2 Variants
errVaccines
IF3.4
err2026-04-15
err0
errOAAI
errLéa-J. Blanchette; Marilène Bolduc; Tekeleselassie Woldemariam; Mitra Yousefi; Henintsoa Rabezanahary; Santa-M. Olivera-Ugarte; Caroline Garneau; Myriam Angers; Rong Shi; Louis Flamand; Mariana Baz; Silvia Vidal; Darryl Falzarano; Jean-François Lemay; Denis Leclerc
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errSave
PapMV nanoparticles: A novel pathway to SARS-CoV-2 protection, distinct from Imidazoquinolines
errNanomedicine: Nanotechnology, Biology and Medicine
IF0
err2025-12-05
err0
PREAI
errMarilène Bolduc; Philippe Saint-Louis; Damien Carignan; Caroline Garneau; Yann Breton; Martin Pelletier; Anne Rancourt; Masahiko S. Satoh; Sachiko Sato; Mégan Gilbert; Henintsoa Rabezanahary; Mariana Baz; Isabelle Dubuc; Louis Flamand; Denis Leclerc
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errSave
Systemic administration of a viral nanoparticle neoadjuvant prevents lung metastasis development through emergency myelopoiesis
errONCOIMMUNOLOGY
IF6.3
err2024-11-17
err0
errOAAI
errBourguignon, Lea; Hetu-Arbour, Roxann; Charpentier, Tania; Bolduc, Marilene; Leclerc, Denis; Heinonen, Krista M.; Lamarre, Alain
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Modulation of Antigen Display on PapMV Nanoparticles Influences Its Immunogenicity
errVACCINES
IF3.4
err2021-01-08
err6
errOAAI
errLaliberte-Gagne, Marie-Eve; Bolduc, Marilene; Garneau, Caroline; Olivera-Ugarte, Santa-Mariela; Savard, Pierre; Leclerc, Denis
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errSave
Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation
errVACCINES
IF3.4
err2020-11-04
err28
errOAAI
errFarnos, Omar; Venereo-Sanchez, Alina; Xu, Xingge; Chan, Cindy; Dash, Shantoshini; Chaabane, Hanan; Sauvageau, Janelle; Brahimi, Fouad; Saragovi, Uri; Leclerc, Denis; Kamen, Amine A.
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A Randomized Controlled Study to Evaluate the Safety and Reactogenicity of a Novel rVLP-Based Plant Virus Nanoparticle Adjuvant Combined with Seasonal Trivalent Influenza Vaccine Following Single Immunization in Healthy Adults 18-50 Years of Age
errVACCINES
IF3.4
err2020-07-20
err9
errOAAI
errLangley, Joanne; Pastural, Elodie; Halperin, Scott; McNeil, Shelly; ElSherif, May; MacKinnon-Cameron, Donna; Ye, Lingyun; Grange, Cecile; Thibodeau, Valerie; Cailhier, Jean-Francois; Lapointe, Rejean; McElhaney, Janet; Martin, Luis; Bolduc, Marilene; Laliberte-Gagne, Marie-Eve; Leclerc, Denis; Savard, Pierre
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errSave
Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform
errVACCINES
IF3.4
err2019-06-12
err17
errOAAI
errLaliberte-Gagne, Marie-Eve; Bolduc, Marilene; Therien, Ariane; Garneau, Caroline; Casault, Philippe; Savard, Pierre; Estaquier, Jerome; Leclerc, Denis
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Efficacy of a virus-Like Nanoparticle As Treatment for a Chronic Viral Infection Is Hindered by IRAK1 Regulation and Antibody Interference
errFRONTIERS IN IMMUNOLOGY
IF5.9
err2018-01-04
err4
errOAAI
errChartrand, Karine; Lebel, Marie-Eve; Tarrab, Esther; Savard, Pierre; Leclerc, Denis; Lamarre, Alain
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A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling
errJOURNAL OF NANOBIOTECHNOLOGY
IF12.6
err2017-07-18
err43
errOAAI
errTherien, Ariane; Bedard, Mikael; Carignan, Damien; Rioux, Gervais; Gauthier-Landry, Louis; Laliberte-Gagne, Marie-Eve; Bolduc, Marilene; Savard, Pierre; Leclerc, Denis
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Complement Component 3 Regulates IFN-α Production by Plasmacytoid Dendritic Cells following TLR7 Activation by a Plant Virus-like Nanoparticle
errJOURNAL OF IMMUNOLOGY
IF3.4
err2017-01-01
err21
errOAAI
errLebel, Marie-Eve; Langlois, Marie-Pierre; Daudelin, Jean-Francois; Tarrab, Esther; Savard, Pierre; Leclerc, Denis; Lamarre, Alain
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errSave
Influence of PapMV nanoparticles on the kinetics of the antibody response to flu vaccine
errJOURNAL OF NANOBIOTECHNOLOGY
IF12.6
err2016-06-10
err11
errOAAI
errRioux, Gervais; Carignan, Damien; Russell, Alexis; Bolduc, Marilene; Gagne, Marie-Eve Laliberte; Savard, Pierre; Leclerc, Denis
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errSave
Potentiating Cancer Immunotherapy Using Papaya Mosaic Virus-Derived Nanoparticles
errNANO LETTERS
IF9.1
err2016-02-22
err111
errOAAI
errLebel, Marie-Eve; Chartrand, Karine; Tarrab, Esther; Savard, Pierre; Leclerc, Denis; Lamarre, Alain
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errSave
Nanoparticle Adjuvant Sensing by TLR7 Enhances CD8+ T Cell-Mediated Protection from Listeria Monocytogenes Infection
errJOURNAL OF IMMUNOLOGY
IF3.4
err2014-02-01
err63
errOAAI
errLebel, Marie-Eve; Daudelin, Jean-Francois; Chartrand, Karine; Tarrab, Esther; Kalinke, Ulrich; Savard, Pierre; Labrecque, Nathalie; Leclerc, Denis; Lamarre, Alain
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errSave
Mapping the surface-exposed regions of papaya mosaic virus nanoparticles
errFEBS JOURNAL
IF4.2
err2012-04-24
err9
errOAAI
errRioux, Gervais; Majeau, Nathalie; Leclerc, Denis
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errSave
Effect of pepsin-treated bovine and goat caseinomacropeptide on Escherichia coli and Lactobacillus rhamnosus in acidic conditions
errJOURNAL OF DAIRY SCIENCE
IF4.4
err2012-01-01
err28
errOAAI
errRobitaille, G.; Lapointe, C.; Leclerc, D.; Britten, M.
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IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive
errMOLECULAR IMMUNOLOGY
IF3
err2011-10-01
err28
PREAI
errGodin-Ethier, Jessica; Hanafi, Laila-Aicha; Duvignaud, Jean-Baptiste; Leclerc, Denis; Lapointe, Rejean
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Palmitoylation of Hepatitis C Virus Core Protein Is Important for Virion Production
errJOURNAL OF BIOLOGICAL CHEMISTRY
IF3.9
err2009-12-01
err48
errOAAI
errMajeau, Nathalie; Fromentin, Remi; Savard, Christian; Duval, Marie; Tremblay, Michel J.; Leclerc, Denis
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The F13 residue is critical for interaction among the coat protein subunits of papaya mosaic virus
errFEBS JOURNAL
IF4.2
err2008-02-25
err12
errOAAI
errGagne, M. E. Laliberte; Lecours, K.; Gagne, S.; Leclerc, D.
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errSave
Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation
errJOURNAL OF VIROLOGY
IF3.8
err2008-01-15
err82
errOAAI
errLacasse, Patrick; Denis, Jerome; Lapointe, Rejean; Leclerc, Denis; Lamarre, Alain
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errSave
Phosphorylation of the termini of Cauliflower mosaic virus precapsid protein is important for productive infection
errmolecular plant
IF3.4
err2007-06-01
err24
PREAI
errChampagne, Julie; Laliberte-Gagne, Marie-Eve; Leclerc, Denis
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errSave

Research Directions

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Co-authors
Cooperation Journals
F
Ferenc Nagy
H-index: 79 · Papers: 353
S
Scott A. Halperin
H-index: 74 · Papers: 585
U
Ulrich Kalinke
H-index: 72 · Papers: 356
U
Ulla Bonas
H-index: 66 · Papers: 132
T
Thomas Höhn
H-index: 65 · Papers: 262
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