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Genomic characterization of endocrine resistance in ER+HER2+breast cancers in the POETIC Trial Cheang, Maggie Chon U.; Zhu, Xixuan; Sipos, Orsolya; Alataki, Anastasia; Feldbauer, Mikayla; Lopez-Knowles, Elena; Tovey, Holly; Kilburn, Lucy; Sirven, Milana Bergamino; Patel, Dhrusti; Xiao, Hui; Maxwell, Perry; Skene, Anthony; Holcombe, Chris; Salto-Tellez, Manuel; Turner, Nicholas; Dodson, Andrew; Smith, Ian; Robertson, John; Bliss, Judith; Schuster, Gene; Salgado, Roberto; Dowsett, Mitch; Hoadley, Katherine A. Share Save
Impact of Baseline Oestradiol and Testosterone on the Preventive Effect of Anastrozole Cuzick, Jack; Chu, Kim; Keevil, Brian; Howell, Antony; Bonanni, Bernardo; Gareth, Evans; Holli, Kaija; Loibl, Sibylle; Zdenkowski, Nicholas; Cummings, Steven; Dowsett, Mitch Share Save
Targeting Transcriptional Regulation with a CDK9 Inhibitor Suppresses Growth of Endocrine- and Palbociclib-Resistant ER+ Breast Cancers Soosainathan, Arany; Iravani, Marjan; El-Botty, Rania; Alexander, John; Sourd, Laura; Morisset, Ludivine; Painsec, Pierre; Orha, Rebecca; Nikitorowicz-Buniak, Joanna; Pancholi, Sunil; Haider, Syed; Dowsett, Mitch; Marangoni, Elisabetta; Martin, Lesley-Ann; Isacke, Clare M. Share Save
Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor-Positive Breast Cancer Hermida-Prado, Francisco; Xie, Yingtian; Sherman, Shira; Nagy, Zsuzsanna; Russo, Douglas; Akhshi, Tara; Chu, Zhengtao; Feit, Avery; Campisi, Marco; Chen, Minyue; Nardone, Agostina; Guarducci, Cristina; Lim, Klothilda; Font-Tello, Alba; Lee, Irene; Garcia-Pedrero, Juana; Canadas, Israel; Agudo, Judith; Huang, Ying; Sella, Tal; Jin, Qingchun; Tayob, Nabihah; Mittendorf, Elizabeth A.; Tolaney, Sara M.; Qiu, Xintao; Long, Henry; Symmans, William F.; Lin, Jia-Ren; Santagata, Sandro; Bedrosian, Isabelle; Yardley, Denise A.; Mayer, Ingrid A.; Richardson, Edward T.; Oliveira, Giacomo; Wu, Catherine J.; Schuster, Eugene F.; Dowsett, Mitch; Welm, Alana L.; Barbie, David; Metzger, Otto; Jeselsohn, Rinath Share Save
Molecular profiling of aromatase inhibitor sensitive and resistant ER+HER2-postmenopausal breast cancers Schuster, Eugene F.; Lopez-Knowles, Elena; Alataki, Anastasia; Zabaglo, Lila; Folkerd, Elizabeth; Evans, David; Sidhu, Kally; Cheang, Maggie Chon U.; Tovey, Holly; Salto-Tellez, Manuel; Maxwell, Perry; Robertson, John; Smith, Ian; Bliss, Judith M.; Dowsett, Mitch Share Save
Clinico-pathologic relationships with Ki67 and its change with short-term aromatase inhibitor treatment in primary ER plus breast cancer: further results from the POETIC trial (CRUK/07/015) Bliss, Judith M.; Tovey, Holly; Evans, Abigail; Holcombe, Chris; Horgan, Kieran; Mallon, Elizabeth; Vidya, Raghavan; Skene, Anthony; Dodson, Andrew; Hills, Margaret; Detre, Simone; Zabaglo, Lila; Banerji, Jane; Kilburn, Lucy P.; Morden, James P.; Robertson, John F. R.; Smith, Ian; Dowsett, Mitch Share Save
Deconstructing the molecular characteristics of ER+HER2+early breast cancer in the POETIC trial using multiplex immunofluorescence and gene expression profiles Zhu, Xixuan; Xiao, Hui; Lopez-Knowles, Elena; Sirven, Milana A. Bergamino; Alataki, Anastasia; Maxwell, Perry; Tovey, Holly; Kilburn, Lucy; Holcombe, Chris; Skene, Anthony; Smith, Ian; Robertson, John; Hoadley, Katherine A.; Salgado, Roberto; Bliss, Judith; Turner, Nicholas; Salto-Tellez, Manuel; Schuster, Gene; Dowsett, Mitch; Cheang, Maggie Chon U. Share Save
Immune cell infiltration associated with poor anti-proliferative response to aromatase inhibitors in postmenopausal women with primary ER-positive HER2-negative breast cancer Alataki, Anastasia; Schuster, Gene; Zabaglo, Lila; Maxwell, Perry; Lopez-Knowles, Elena; Folkerd, Elizabeth; Evans, David; Sidhu, Kally; Tovey, Holly; Turner, Nicholas; Johnston, Stephen; Cheang, Maggie Chon U.; Robertson, John; Salto-Tellez, Manuel; Smith, Ian; Bliss, Judith; Dowsett, Mitch Share Save
Low plasma estradiol, low expression of estrogen responsive genes and TP53 mutations are associated with poor anti-proliferative response to aromatase inhibitors Schuster, Eugene F.; Lopez-Knowles, Elena; Alataki, Anastasia; Zabaglo, Lila; Folkerd, Elizabeth; Evans, David; Sidhu, Kally; Tovey, Holly; Maxwell, Perry; Turner, Nicholas; Johnston, Stephen; Salto-Tellez, Manuel; Cheang, Maggie Chon U.; Robertson, John; Smith, Ian; Bliss, Judith; Dowsett, Mitch Share Save
Multi-parametric algorithm integrating on-treatment Ki67 value and standard clinicopathological variables to predict risk of recurrences for women > 70 years old with early ER+HER2-tumours in POETIC trial Cheang, Maggie Chon U.; Dewan, Monisha; Kilburn, Lucy; Morani, Gabriele; Zabaglo, Lila; Sidhu, Kally; Tovey, Holly; Zhu, Xixuan; Holcombe, Chris; Skene, Anthony; Smith, Ian; Robertson, John; Ring, Alistair; Turner, Nicholas; Bliss, Judith; Dowsett, Mitch Share Save
Elacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen-receptor positive endocrine-resistant and fulvestrant-resistant breast cancer Pancholi, Sunil; Simigdala, Nikiana; Ribas, Ricardo; Schuster, Eugene; Leal, Mariana Ferreira; Nikitorowicz-Buniak, Joanna; Rega, Camilla; Bihani, Teeru; Patel, Hitisha; Johnston, Stephen R.; Dowsett, Mitch; Martin, Lesley-Ann Share Save
Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study Acs, Balazs; Leung, Samuel C. Y.; Kidwell, Kelley M.; Arun, Indu; Augulis, Renaldas; Badve, Sunil S.; Bai, Yalai; Bane, Anita L.; Bartlett, John M. S.; Bayani, Jane; Bigras, Gilbert; Blank, Annika; Buikema, Henk; Chang, Martin C.; Dietz, Robin L.; Dodson, Andrew; Fineberg, Susan; Focke, Cornelia M.; Gao, Dongxia; Gown, Allen M.; Gutierrez, Carolina; Hartman, Johan; Kos, Zuzana; Laenkholm, Anne-Vibeke; Laurinavicius, Arvydas; Levenson, Richard M.; Mahboubi-Ardakani, Rustin; Mastropasqua, Mauro G.; Nofech-Mozes, Sharon; Osborne, C. Kent; Penault-Llorca, Frederique M.; Piper, Tammy; Quintayo, Mary Anne; Rau, Tilman T.; Reinhard, Stefan; Robertson, Stephanie; Salgado, Roberto; Sugie, Tomoharu; van der Vegt, Bert; Viale, Giuseppe; Zabaglo, Lila A.; Hayes, Daniel F.; Dowsett, Mitch; Nielsen, Torsten O.; Rimm, David L. Share Save
Relationship between ER expression by IHC or mRNA with Ki67 response to aromatase inhibition: a POETIC study Lopez-Knowles, Elena; Detre, Simone; Hills, Margaret; Schuster, Eugene F.; Cheang, Maggie C. U.; Tovey, Holly; Kilburn, Lucy S.; Bliss, Judith M.; Robertson, John; Mallon, Elizabeth; Skene, Anthony; Evans, Abigail; Smith, Ian; Dowsett, Mitch Share Save
HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer Bergamino, Milana A.; Lopez-Knowles, Elena; Morani, Gabriele; Tovey, Holly; Kilburn, Lucy; Schuster, Eugene F.; Alataki, Anastasia; Hills, Margaret; Xiao, Hui; Holcombe, Chris; Skene, Anthony; Robertson, John F.; Smith, Ian E.; Bliss, Judith M.; Dowsett, Mitch; Cheang, Maggie C. U. Share Save
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Comparison of StemPrintER with Oncotype DX Recurrence Score for predicting risk of breast cancer distant recurrence after endocrine therapy Pece, Salvatore; Sestak, Ivana; Montani, Francesca; Tillhon, Micol; Maisonneuve, Patrick; Freddi, Stefano; Chu, Kim; Colleoni, Marco; Veronesi, Paolo; Disalvatore, Davide; Viale, Giuseppe; Buus, Richard; Cuzick, Jack; Dowsett, Mitch; Di Fiore, Pier Paolo Share Save
Overlapping molecular features (proliferation, immune signatures andTP53mutations) associated with palbociclib resistance inER+HER2-primary breast cancer Schuster, Eugene F.; Xiao, Hui; Cheang, Maggie; Lopez-Knowles, Elena; Kilburn, Lucy; Korchina, Viktoriya; Salvi, Sejal; Jacobs, Samuel A.; Finnigan, Melanie; Wheeler, David A.; Puhalla, Shannon; Muzny, Donna; Doddapaneni, Harsha; Pogue-Geile, Katherine; Liu, Yuan; Bliss, Judith; Johnston, Stephen; Dowsett, Mitch; Rimawi, Mothaffar Share Save
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