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D

David J. Irwin

university of pennsylvania

75H-index
673Paper Count
2.5WCitation Count
Published Papers 236
Publication Date
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An acetylated Tau-174 CSF biomarker discriminates between TDP-43 and tau pathology in patients with frontotemporal lobar degeneration
errNature Medicine
IF50
err2026-04-15
err0
errOAAI
errMadison I. J. Honey; Yanaika S. Hok-A-Hin; Elisabeth H. Thijssen; Katheryn A. Q. Cousins; Babette van der Weijden; Lisanne in ‘t Veld; Erik Stoops; Sterre C. M. de Boer; Flora H. Duits; Julie F. H. de Houwer; Tjado H. J. Morrema; Daniel Alcolea; Ignacio Illán-Gala; Juan Fortea; Alberto Lleó; Adam L. Boxer; David J. Irwin; Edward B. Lee; Leslie Shaw; Corey T. McMillan; David A. Wolk; Jeroen J. M. Hoozemans; Wiesje M. van der Flier; Emma van der Ende; Harro Seelaar; Inge M. W. Verberk; Li Gan; Yolande Pijnenburg; Charlotte E. Teunissen
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Association between Plasma P-tau217 and Alzheimer's Copathology and Cognitive Decline in Parkinson's Disease
errAnnals of Neurology
IF7.7
err2026-03-18
err0
errOAAI
errThomas F. Tropea DO; Patricia Aldea Stevenson; Matthew Flitter; David Meehan; Amanda Morris; Ming Lu MD, MS, MPH; Leonardo Iaccarino PhD; Emily C. Collins PhD; Michael E. Hodsdon MD, PhD; David Irwin MD; Meredith Spindler MD; Andres Deik MD; Nabila Dahodwala MD; Katheryn A.Q. Cousins PhD; David A. Wolk MD; Leslie Shaw PhD; Daniel Weintraub MD; Edward B. Lee MD, PhD; Alice Chen-Plotkin MD; Mark Mintun MD; Andrew Siderowf MD
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Individualized Atrophy-Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed-Effects Modeling
errAnnals of Neurology
IF7.7
err2026-01-29
err0
errOAAI
errShubir Dutt PhD; Dana Leichter BS; Yann Cobigo PhD; Amy Wolf BS; John Kornak PhD; Annie Clark MS; Lucy L. Russell PhD; Arabella Bouzigues MSc; David M. Cash PhD; Martina Bocchetta PhD; Molly Olzinski BS; Brian Appleby MD; Ece Bayram MD, PhD; Barbara Borroni MD; Andrea Bozoki MD; Chris R. Butler PhD; David Clark MD; Rhian S. Convery MSc; R. Ryan Darby MD; Alexandre de Mendonça PhD; Bradford Dickerson MD; Kimiko Domoto-Reilly MD; Simon Ducharme MD; Eve Ferry-Bolder BA; Elizabeth Finger MD; Phoebe H. Foster BSc; Douglas R. Galasko MD; Daniela Galimberti PhD; Alexander Gerhard MD; Nupur Ghoshal MD; Caroline Graff PhD; Neill Graff-Radford MD; Ian M. Grant MD; Chadwick M. Hales MD, PhD; Lawrence S. Honig MD, PhD; Ging-Yuek Hsiung MD; Edward D. Huey MD; David Irwin MD; Lize C. Jiskoot PhD; Walter Kremers PhD; Justin Y. Kwan MD; Robert Laforce MD; Isabelle Le Ber PhD; Gabriel C. Léger MD; Johannes Levin MD; Irene Litvan MD, MSc; Ian R. Mackenzie MD; Mario Masellis PhD; Mario F. Mendez MD, PhD; Fermin Moreno PhD; Chiadi Onyike MD, MHS; Markus Otto MD; Belen Pascual PhD; Peter Pressman MD; Rosa Rademakers PhD; Eliana Marisa Ramos PhD; Aaron Ritter MD; Erik D. Roberson MD, PhD; James B. Rowe PhD; Raquel Sanchez-Valle MD; Isabel Santana PhD; Harro Seelaar PhD; Allison Snyder MD; Sandro Sorbi PhD; Matthis Synofzik MD; Maria Carmela Tartaglia MD; Pietro Tiraboschi MD; John C. van Swieten MD, PhD; Marijne Vandebergh PhD; Rik Vandenberghe MD; Hilary W. Heuer PhD; Bruce L. Miller MD; William W. Seeley MD; Maria Luisa Gorno-Tempini MD; Joel H. Kramer PsyD; Leah Forsberg PhD; Kejal Kantarci MD; Bradley F. Boeve MD; Adam L. Boxer MD, PhD; Jonathan D. Rohrer PhD; Howard J. Rosen MD; Adam M. Staffaroni PhD; FTD Prevention Initiative (FPI) investigators
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errSave
Where do PDD and DLB SYNdromes fit in neuronal alpha-SYNuclein biological frameworks?
errJournal of Neural Transmission
IF4
err2025-12-04
err0
errOAAI
errDavid J. Irwin
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errSave
The potential of TDP-43 PET ligands for a biological diagnosis of TDP-43 proteinopathies
errNature Communications
IF15.7
err2025-10-24
err0
errOAAI
errDavid J. Irwin
errShare
errSave
Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease
errBRAIN
IF11.7
err2025-10-01
err2
PREAI
errde Bruin, Hannah; Groot, Colin; Barthel, Henryk; Bischof, Gerard N.; Blazhenets, Ganna; Boellaard, Ronald; Boon, Baayla D. C.; Brendel, Matthias; Cash, David M.; Coath, William; Day, Gregory S.; Dickerson, Bradford C.; Doering, Elena; Drzezga, Alexander; van Dyck, Christopher H.; van Eimeren, Thilo; van der Flier, Wiesje M.; Fredericks, Carolyn A.; Fryer, Tim D.; van de Giessen, Elsmarieke; Gordon, Brian A.; Graff-Radford, Jonathan; Grinberg, Lea T.; Hansson, Oskar; Hobbs, Diana A.; Hoenig, Merle C.; Hoglinger, Gunter; Irwin, David J.; Jones, P. Simon; Josephs, Keith A.; Katsumi, Yuta; La Joie, Renaud; Lee, Edward B.; Levin, Johannes; Malpetti, Maura; Mcginnis, Scott M.; Mecca, Adam P.; Mohanty, Rosaleena; Nasrallah, Ilya M.; O'Brien, John T.; O'Dell, Ryan S.; Palleis, Carla; Perneczky, Robert; Phillips, Jeffrey S.; Putcha, Deepti; Rabinovici, Gil D.; Rahmouni, Nesrine; Rosa-Neto, Pedro; Rowe, James B.; Rullmann, Michael; Sabri, Osama; Saur, Dorothee; Schildan, Andreas; Schott, Jonathan M.; Schroeter, Matthias L.; Seeley, William W.; Servaes, Stijn; Sintini, Irene; Smith, Ruben; Spina, Salvatore; Stevenson, Jenna; Stomrud, Erik; Strandberg, Olof; Therriault, Joseph; Tideman, Pontus; Touroutoglou, Alexandra; Trainer, Anne E.; Visser, Denise; Wekselman, Fattin; Weston, Philip S. J.; Whitwell, Jennifer L.; Wolk, David A.; Yong, Keir; Pijnenburg, Yolande A. L.; Franzmeier, Nicolai; Ossenkoppele, Rik
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Performance of 123I-ioflupane SPECT striatal binding in dementia with Lewy bodies
errAlzheimer's & Dementia
IF11.1
err2025-09-16
err0
errOAAI
errEmily F. Maly; Frank P. DiFilippo; Brittany Lapin; Yadi Li; Sarah Berman; Andrea C. Bozoki; Jori E. Fleisher; James E. Galvin; David J. Irwin; Carol F. Lippa; Irene Litvan; Debby W. Tsuang; Cyrus P. Zabetian; Angela S. Taylor; Lynn M. Bekris; Oscar L. Lopez; Douglas Galasko; James B. Leverenz
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errSave
Large-scale CSF proteome profiling identifies biomarkers for accurate diagnosis of frontotemporal dementia
errMolecular Neurodegeneration
IF17.5
err2025-08-28
err0
errOAAI
errYanaika S. Hok-A-Hin; Lisa Vermunt; Carel F.W. Peeters; Emma L. van der Ende; Sterre C.M. de Boer; Lieke H. Meeter; Julie de Houwer; Harro Seelaar; John C. van Swieten; William T. Hu; Alberto Lleó; Daniel Alcolea; Sebastiaan Engelborghs; Anne Sieben; Alice Chen-Plotkin; David J. Irwin; Wiesje M. van der Flier; Yolande A.L. Pijnenburg; Charlotte E. Teunissen; Marta del Campo
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errSave
Comparison of plasma p-tau217/Aβ42, p-tau217, and Aβ42/Aβ40 biomarkers by race to detect Alzheimer's disease
errAlzheimer's & Dementia
IF11.1
err2025-08-13
err0
errOAAI
errKatheryn A. Q. Cousins; Magdalena Korecka; Yang Wan; Amberley Vulaj; Christopher Brown; Thomas F. Tropea; Edward B. Lee; Duygu Tosun; Susan M. Landau; Ozioma C. Okonkwo; Monica Rivera Mindt; Michael W. Weiner; David J. Irwin; David A. Wolk; Leslie M. Shaw; and the Alzheimer's Disease Neuroimaging Initiative
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errSave
Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia
errneuroimage clinical
IF0
err2025-07-24
err0
errOAAI
errMelanie A. Matyi; Hamsanandini Radhakrishnan; Christopher A. Olm; Jeffrey S. Phillips; Philip A. Cook; Emma Rhodes; James C. Gee; David J. Irwin; Corey T. McMillan; Lauren Massimo
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errSave
Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G
errAlzheimer's & Dementia
IF11.1
err2025-07-18
err0
errOAAI
errRyohei Watanabe; John D. Papatriantafyllou; Kengo Maeda; Geoffrey K. Aguirre; Masahiro Ando; Bernice Benoit; Murray Grossman; David J. Irwin
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errSave
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
errNeuron
IF15
err2025-07-18
err0
errOAAI
errMelissa E. Murray; Colin Smith; Vilas Menon; C. Dirk Keene; Ed Lein; Michael Hawrylycz; Adriano Aguzzi; Brett Benedetti; Katja Brose; Kelsey Caetano-Anolles; Maria Inmaculada Cobos Sillero; John F. Crary; Philip L. De Jager; Arline Faustin; Margaret E. Flanagan; Ozgun Gokce; Seth G.N. Grant; Lea T. Grinberg; David A. Gutman; Elizabeth M.C. Hillman; Zhi Huang; David J. Irwin; David T. Jones; Alifiya Kapasi; Celeste M. Karch; Walter T. Kukull; Tammaryn Lashley; Edward B. Lee; Thomas Lehner; Laura Parkkinen; Maria Pedersen; Dominique Pritchett; Matthew H. Rutledge; Julie A. Schneider; William W. Seeley; Claire E. Shepherd; Tara L. Spires-Jones; Judith A. Steen; Margaret Sutherland; Sanja Vickovic; Bin Zhang; David J. Stewart; Michael J. Keiser; Jacob W. Vogel; Brittany N. Dugger; Hemali Phatnani
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errSave
Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia
errALZHEIMERS & DEMENTIA
IF11.1
err2025-04-25
err1
errOAAI
errLiu, XL; de Boer, SCM; Cortez, K; Poos, JM; Illán-Gala, I; Heuer, H; Forsberg, LK; Casaletto, K; Memel, M; Appleby, BS; Barmada, S; Bozoki, A; Clark, D; Cobigo, Y; Darby, R; Dickerson, BC; Domoto-Reilly, K; Galasko, DR; Geschwind, DH; Ghoshal, N; Graff-Radford, NR; Grant, IM; Hsiung, GYR; Honig, LS; Huey, ED; Irwin, D; Kantarci, K; Léger, GC; Litvan, I; Mackenzie, IR; Masdeu, JC; Mendez, MF; Onyike, CU; Pascual, B; Pressman, P; Bayram, E; Ramos, EM; Roberson, ED; Rogalski, E; Bouzigues, A; Russell, LL; Foster, PH; Ferry-Bolder, E; Masellis, M; van Swieten, J; Jiskoot, L; Seelaar, H; Sanchez-Valle, R; Laforce, R; Graff, C; Galimberti, D; Vandenberghe, R; de Mendonça, A; Tiraboschi, P; Santana, I; Gerhard, A; Levin, J; Sorbi, S; Otto, M; Pasquier, F; Ducharme, S; Butler, CR; Le Ber, I; Finger, E; Rowe, JB; Synofzik, M; Moreno, F; Borroni, B; Boeve, BF; Boxer, AL; Rosen, HJ; Pijnenburg, YAL; Rohrer, JD; Tartaglia, MC
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errSave
Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
errNATURE COMMUNICATIONS
IF15.7
err2025-04-25
err0
errOAAI
errPottier, Cyril; Kuecuekali, Fahri; Baker, Matt; Batzler, Anthony; Jenkins, Gregory D.; van Blitterswijk, Marka; Vicente, Cristina T.; De Coster, Wouter; Wynants, Sarah; van de Walle, Pieter; Ross, Owen A.; Murray, Melissa E.; Faura, Julia; Haggarty, Stephen J.; van Rooij, Jeroen GJ.; Mol, Merel O.; Hsiung, Ging-Yuek R.; Graff, Caroline; Oeijerstedt, Linn; Neumann, Manuela; Asmann, Yan; Mcdonnell, Shannon K.; Baheti, Saurabh; Josephs, Keith A.; Whitwell, Jennifer L.; Bieniek, Kevin F.; Forsberg, Leah; Heuer, Hilary; Lago, Argentina Lario; Geier, Ethan G.; Yokoyama, Jennifer S.; Oddi, Alexis P.; Flanagan, Margaret; Mao, Qinwen; Hodges, John R.; Kwok, John B.; Domoto-Reilly, Kimiko; Synofzik, Matthis; Wilke, Carlo; Onyike, Chiadi; Dickerson, Bradford C.; Evers, Bret M.; Dugger, Brittany N.; Munoz, David G.; Keith, Julia; Zinman, Lorne; Rogaeva, Ekaterina; Suh, Eunran; Gefen, Tamar; Geula, Changiz; Weintraub, Sandra; Diehl-Schmid, Janine; Farlow, Martin R.; Edbauer, Dieter; Woodruff, Bryan K.; Caselli, Richard J.; Donker Kaat, Laura L.; Huey, Edward D.; Reiman, Eric M.; Mead, Simon; King, Andrew; Roeber, Sigrun; Nana, Alissa L.; Ertekin-Taner, Nilufer; Knopman, David S.; Petersen, Ronald C.; Petrucelli, Leonard; Uitti, Ryan J.; Wszolek, Zbigniew K.; Ramos, Eliana Marisa; Grinberg, Lea T.; Tempini, Maria Luisa Gorno; Rosen, Howard J.; Spina, Salvatore; Piguet, Olivier; Grossman, Murray; Trojanowski, John Q.; Keene, C. Dirk; Jin, Lee-Way; Prudlo, Johannes; Geschwind, Daniel H.; Rissman, Robert A.; Cruchaga, Carlos; Ghetti, Bernardino; Halliday, Glenda M.; Beach, Thomas G.; Serrano, Geidy E.; Arzberger, Thomas; Herms, Jochen; Boxer, Adam L.; Honig, Lawrence S.; Vonsattel, Jean P.; Lopez, Oscar L.; Kofler, Julia; White, Charles L.; Gearing, Marla; Glass, Jonathan; Rohrer, Jonathan D.; Irwin, David J.; Lee, Edward B.; Van Deerlin, Vivianna; Castellani, Rudolph; Mesulam, Marsel M.; Tartaglia, Maria C.; Finger, Elizabeth C.; Troakes, Claire; Al-Sarraj, Safa; Dalgard, Clifton L.; Miller, Bruce L.; Seelaar, Harro; Graff-Radford, Neill R.; Boeve, Bradley F.; Mackenzie, Ian RA.; van Swieten, John C.; Seeley, William W.; Sleegers, Kristel; Dickson, Dennis W.; Biernacka, Joanna M.; Rademakers, Rosa
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Comprehensive cross-sectional and longitudinal comparisons of plasma glial fibrillary acidic protein and neurofilament light across FTD spectrum disorders
errMOLECULAR NEURODEGENERATION
IF17.5
err2025-03-12
err0
errOAAI
errSheth, Udit; Oijerstedt, Linn; Heckman, Michael G.; White, Launia J.; Heuer, Hilary W.; Lario Lago, Argentina; Forsberg, Leah K.; Faber, Kelley M.; Foroud, Tatiana M.; Rademakers, Rosa; Ramos, Eliana Marisa; Appleby, Brian S.; Bozoki, Andrea C.; Darby, R. Ryan; Dickerson, Bradford C.; Domoto-Reilly, Kimiko; Galasko, Douglas R.; Ghoshal, Nupur; Graff-Radford, Neill R.; Grant, Ian M.; Hales, Chadwick M.; Hsiung, Ging-Yuek Robin; Huey, Edward D.; Irwin, David; Kwan, Justin Y.; Litvan, Irene; Mackenzie, Ian R.; Masdeu, Joseph C.; Mendez, Mario F.; Onyike, Chiadi U.; Pascual, Belen; Pressman, Peter S.; Roberson, Erik D.; Snyder, Allison; Tartaglia, M. Carmela; Seeley, William W.; Dickson, Dennis W.; Rosen, Howard J.; Boeve, Bradley F.; Boxer, Adam L.; Petrucelli, Leonard; Gendron, Tania F.
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Disparate and shared transcriptomic signatures associated with cortical atrophy in genetic behavioral variant frontotemporal degeneration
errMOLECULAR NEURODEGENERATION
IF17.5
err2025-02-07
err0
errOAAI
errShen, Ting; Vogel, Jacob W.; Van Deerlin, Vivianna M.; Suh, Eunran; Dratch, Laynie; Phillips, Jeffrey S.; Massimo, Lauren; Lee, Edward B.; Irwin, David J.; Mcmillan, Corey T.
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errSave
Clinical criteria for limbic-predominant age-related TDP-43 encephalopathy
errALZHEIMERS & DEMENTIA
IF0
err2025-01-14
err5
errOAAI
errWolk, DA; Nelson, PT; Apostolova, L; Arfanakis, K; Boyle, PA; Carlsson, CM; Corriveau-Lecavalier, N; Dacks, P; Dickerson, BC; Domoto-Reilly, K; Dugger, BN; Edelmayer, R; Fardo, DW; Grothe, MJ; Hohman, TJ; Irwin, DJ; Jicha, GA; Jones, DT; Kawas, CH; Lee, EB; Lincoln, K; Maestre, GE; Mormino, EC; Onyike, CU; Petersen, RC; Rabinovici, GD; Rademakers, R; Raman, R; Rascovsky, K; Rissman, RA; Rogalski, E; Scheltens, P; Sperling, RA; Yang, HS; Yu, L; Zetterberg, H; Schneider, JA
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errSave
Posterior hippocampal sparing in Lewy body disorders with Alzheimer's copathology: An in vivo MRI study
errNEUROIMAGE-CLINICAL
IF3.6
err2025-01-01
err0
errOAAI
errCohen, Jesse S.; Phillips, Jeffrey; Das, Sandhitsu R.; Olm, Christopher A.; Radhakrishnan, Hamsanandini; Rhodes, Emma; Cousins, Katheryn A. Q.; Xie, Sharon X.; Nasrallah, Ilya M.; Yushkevich, Paul A.; Wolk, David A.; Lee, Edward B.; Weintraub, Daniel; Irwin, David J.; Mcmillan, Corey T.
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errSave
Cumulative incidence of motor and cognitive features in the amyotrophic lateral sclerosis-frontotemporal degeneration spectrum
errBRAIN COMMUNICATIONS
IF4.5
err2025-01-01
err0
errOAAI
errSpencer, Barbara E.; Xie, Sharon X.; Ohm, Daniel T.; Elman, Lauren; Quinn, Colin C.; Amado, Defne A.; Baer, Michael; Lee, Edward B.; Van Deerlin, Vivianna M.; Dratch, Laynie; Massimo, Lauren; Irwin, David J.; Mcmillan, Corey T.
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errSave
Psychotropic medication usage in sporadic versus genetic behavioral-variant frontotemporal dementia
errALZHEIMERS & DEMENTIA
IF11.1
err2024-12-23
err0
errOAAI
errVargas-Gonzalez, Juan-Camilo; Dimal, Nico; Cortez, Kasey; Heuer, Hilary; Forsberg, Leah K.; Appleby, Brian S.; Barmada, Sami; Bozoki, Andrea; Clark, David; Cobigo, Yann; Darby, R. Ryan; Dickerson, Bradford C.; Domoto-Reilly, Kimiko; Galasko, Douglas R.; Geschwind, Daniel H.; Ghoshal, Nupur; Graff-Radford, Neill R.; Grant, Ian M.; Irwin, David; Hsiung, Ging-Yuek Robin; Honig, Lawrence S.; Kantarci, Kejal; Leger, Gabriel C.; Litvan, Irene; Mackenzie, Ian R.; Masdeu, Joseph C.; Mendez, Mario F.; Onyike, Chiadi U.; Pascual, Belen; Pressman, Peter; Ramos, Eliana Marisa; Roberson, Erik D.; Rogalski, Emily; Boeve, Brad F.; Boxer, Adam L.; Rosen, Howie J.; Tartaglia, Maria Carmela; ALLFTD Consortium Investigators
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Research Directions

No research directions
Co-authors
Cooperation Journals
J
John Q. Trojanowski
H-index: 255 · Papers: 1.8K
D
Dennis W. Dickson
H-index: 218 · Papers: 2.3K
K
Kaj Blennow
H-index: 214 · Papers: 3.6K
B
Bruce L. Miller
H-index: 201 · Papers: 2.1K
V
Virginia M.‐Y. Lee
H-index: 200 · Papers: 919
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