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Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma Marasco, Michelangelo; Kumar, Dinesh; Seale, Tessa; Borrego, Santiago Garcia; Kaplun, Esther; Aricescu, Ilinca; Cole, Soren; Qeriqi, Besnik; Qiu, Juan; Chen, Xiaoping; Bahr, Amber; Fidele, Deborah; Hofmann, Marco H.; Gerlach, Daniel; Savarese, Fabio; Merghoub, Taha; Wolchok, Jedd D.; Yao, Zhan; de Stanchina, Elisa; Solit, David; Misale, Sandra; Rosen, Neal Share Save
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer Kitai, Hidenori; Choi, Philip H.; Yang, Yu C.; Boyer, Jacob A.; Whaley, Adele; Pancholi, Priya; Thant, Claire; Reiter, Jason; Chen, Kevin; Markov, Vladimir; Taniguchi, Hirokazu; Yamaguchi, Rui; Ebi, Hiromichi; Evans, James; Jiang, Jingjing; Lee, Bianca; Wildes, David; de Stanchina, Elisa; Smith, Jacqueline A. M.; Singh, Mallika; Rosen, Neal Share Save
A Next-Generation BRAF Inhibitor Overcomes Resistance to BRAF Inhibition in Patients with BRAF-Mutant Cancers Using Pharmacokinetics-Informed Dose Escalation Yaeger, Rona; McKean, Meredith A.; Haq, Rizwan; Beck, J. Thaddeus; Taylor, Matthew H.; Cohen, Jonathan E.; Bowles, Daniel W.; Gadgeel, Shirish M.; Mihalcioiu, Catalin; Papadopoulos, Kyriakos P.; Diamond, Eli L.; Sturtz, Keren B.; Feng, Gang; Drescher, Stefanie K.; Reddy, Micaela B.; Sengupta, Bhaswati; Maity, Arnab K.; Brown, Suzy A.; Singh, Anurag; Brown, Eric N.; Baer, Brian R.; Wong, Jim; Mou, Tung-Chung; Wu, Wen-, I; Kahn, Dean R.; Gadal, Sunyana; Rosen, Neal; Gaudino, John J.; Lee, Patrice A.; Hartley, Dylan P.; Rothenberg, S. Michael Share Save
Phase 1 trial of PF-07799933 ( ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers Yaeger, Rona; McKean, Meredith; Haq, Rizwan; Beck, Joseph T.; Taylor, Matthew H.; Cohen, Jonathan; Bowles, Daniel; Gadgeel, Shirish M.; Mihalcioiu, Catalin; Papadopoulos, Kyriakos P.; Diamond, Eli L.; Sturtz, Keren B.; Feng, Gang; Drescher, Stefanie K.; Reddy, Micaela B.; Sengupta, Bhaswati; Maity, Arnab K.; Brown, Suzy A.; Singh, Anurag; Brown, Eric N.; Baer, Brian R.; Wong, Jim; Mou, Tung-Chung; Wu, Wen I.; Kahn, Dean; Gadal, Sunyana; Rosen, Neal; Gaudino, John J.; Lee, Patrice A.; Hartley, Dylan P.; Rothenberg, Stephen Michael Share Save
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Oncogenic signaling and responses to treatment in RAS mutant cancers are mutation-specific Marasco, Michelangelo; Kumar, Dinesh; Mezzadra, Riccardo; Luan, Wei; Aricescu, Ilinca; Yaeger, Rona; Markov, Vladimir; Zhu, Yu; de Stanchina, Elisa; Lowe, Scott; Misale, Sandra; Rosen, Neal Share Save
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Vertical MAPK pathway targeting in novel genetically engineered mouse and cell line models of NF1-altered melanoma: the mSK-Mel murine cohort Jones, Alexis M.; Hanrahan, Aphrothiti J.; Nissan, Moriah H.; Monette, Sebastien; Chen, Ziyu; Hu, Wenhuo; Misale, Sandra; Schulze, Isabell; Vasani, Naresh; Liu, Cailian; Yang, Xia; Abu-Akeel, Mohsen; de Stanchina, Elisa; Schultz, Nikolaus; Berger, Michael F.; Rosen, Neal; Merghoub, Taha; Solit, David B. Share Save
Molecular Characterization of Acquired Resistance to KRAS G12C-EGFR Inhibition in Colorectal Cancer Yaeger, Rona; Mezzadra, Riccardo; Sinopoli, Jenna; Bian, Yu; Marasco, Michelangelo; Kaplun, Esther; Gao, Yijun; Zhao, HuiYong; Paula, Arnaud Da Cruz; Zhu, Yingjie; Perez, Almudena Chaves; Chadalavada, Kalyani; Tse, Edison; Chowdhry, Sudhir; Bowker, Sydney; Chang, Qing; Qeriqi, Besnik; Weigelt, Britta; Nanjangud, Gouri J.; Berger, Michael F.; Der-Torossian, Hirak; Anderes, Kenna; Socci, Nicholas D.; Shia, Jinru; Murciano-Goroff, Yonina R.; Li, Bob; Christensen, James G.; Reis-Filho, Jorge S.; Solit, David B.; de Stanchina, Elisa; Lowe, Scott W.; Rosen, Neal; Misale, Sandra Share Save
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation Chen, Sisi; Vedula, Rahul S.; Cuevas-Navarro, Antonio; Lu, Bin; Hogg, Simon J.; Wang, Eric; Benbarche, Salima; Knorr, Katherine; Kim, Won Jun; Stanley, Robert F.; Cho, Hana; Erickson, Caroline; Singer, Michael; Cui, Dan; Tittley, Steven; Durham, Benjamin H.; Pavletich, Tatiana S.; Fiala, Elise; Walsh, Michael F.; Inoue, Daichi; Monette, Sebastien; Taylor, Justin; Rosen, Neal; McCormick, Frank; Lindsley, R. Coleman; Castel, Pau; Abdel-Wahab, Omar Share Save
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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1 Su, Wenjing; Mukherjee, Radha; Yaeger, Rona; Son, Jieun; Xu, Jianing; Na, Na; Timaul, Neilawattie Merna; Hechtman, Jaclyn; Paroder, Viktoriya; Lin, Mika; Mattar, Marissa; Qiu, Juan; Chang, Qing; Zhao, Huiyong; Zhang, Jonathan; Little, Megan; Adachi, Yuta; Han, Sae-Won; Taylor, Barry S.; Ebi, Hiromichi; Abdel-Wahab, Omar; de Stanchina, Elisa; Rudin, Charles M.; Janne, Pasi A.; McCormick, Frank; Yao, Zhan; Rosen, Neal Share Save
Genomic analysis of 733 HER2+breast cancers identifies recurrent pathways alterations associated with anti-HER2 resistance and new therapeutic vulnerabilities Ferraro, Emanuela; Smith, Alison; Safonov, Anton; De Lara, Paulino Tallon; Bernado, Cristina; Lahuerta, Enrique J. Arenas; Arribas, Joaquin; Solit, David; Reis-Filho, Jorge S.; Rosen, Neal; Norton, Larry; Modi, Shanu; Robson, Mark E.; Dang, Chau T.; Curigliano, Giuseppe; Chandarlapaty, Sarat; Razavi, Pedram Share Save
Phase 1 Clinical Trial of Trametinib and Ponatinib in Patients With NSCLC Harboring KRAS Mutations Arbour, Kathryn C.; Manchado, Eusebio; Bott, Matthew J.; Ahn, Linda; Tobi, Yosef; Ni, Andy Ai; Yu, Helena A.; Shannon, Alyssa; Ladanyi, Marc; Perron, Victoria; Ginsberg, Michelle S.; Johnson, Amanda; Holodny, Andrei; Kris, Mark G.; Rudin, Charles M.; Lito, Piro; Rosen, Neal; Lowe, Scott; Riely, Gregory J. Share Save
HER2+breast cancers evade anti-HER2 therapy via a switch in driver pathway Smith, Alison E.; Ferraro, Emanuela; Safonov, Anton; Morales, Cristina Bernado; Lahuerta, Enrique J. Arenas; Li, Qing; Kulick, Amanda; Ross, Dara; Solit, David B.; de Stanchina, Elisa; Reis-Filho, Jorge; Rosen, Neal; Arribas, Joaquin; Razavi, Pedram; Chandarlapaty, Sarat Share Save
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Selective inhibitors of mTORC1 activate 4EBP1 and suppress tumor growth (vol 17, pg 1065, 2021) Lee, Bianca J.; Boyer, Jacob A.; Burnett, G. Leslie; Thottumkara, Arun P.; Tibrewal, Nidhi; Wilson, Stacy L.; Hsieh, Tientien; Marquez, Abby; Lorenzana, Edward G.; Evans, James W.; Hulea, Laura; Kiss, Gert; Liu, Hui; Lee, Dong; Larsson, Ola; McLaughlan, Shannon; Topisirovic, Ivan; Wang, Zhengping; Wang, Zhican; Zhao, Yongyuan; Wildes, David; Aggen, James B.; Singh, Mallika; Gill, Adrian L.; Smith, Jacqueline A. M.; Rosen, Neal Share Save
INK4 Tumor Suppressor Proteins Mediate Resistance to CDK4/6 Kinase Inhibitors Li, Qing; Jiang, Baishan; Guo, Jiaye; Shao, Hong; Del Priore, Isabella S.; Chang, Qing; Kudo, Rei; Li, Zhiqiang; Razavi, Pedram; Liu, Bo; Boghossian, Andrew S.; Rees, Matthew G.; Ronan, Melissa M.; Roth, Jennifer A.; Donovan, Katherine A.; Palafox, Marta; Reis-Filho, Jorge S.; de Stanchina, Elisa; Fischer, Eric S.; Rosen, Neal; Serra, Violeta; Koff, Andrew; Chodera, John D.; Gray, Nathanael S.; Chandarlapaty, Sarat Share Save
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