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Hilal A. Lashuel

ecole polytechnique federale de lausanne

92H-index
333Paper Count
2.8WCitation Count
Published Papers 159
Publication Date
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Modeling Parkinson’s pathology in human iPSC dopaminergic neurons uncovers key mechanisms of Lewy body formation and heterogeneity
errScience Advances
IF12.5
err2026-07-10
err0
errOAAI
errAnne-Laure Mahul-Mellier; Lukas van den Heuvel; Maxime Teixeira; Manel L. N. Boussouf; Gaspard Oudinot; Amélie Thonet; Davide Speri; Yllza Jasiqi; Christina Ulrich; Razan Sheta; Walid Idi; Mary Croisier; Stéphanie Clerc-Rosset; Jérôme Blanc; Graham Knott; Abid Oueslati; Hilal A. Lashuel
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errSave
Cracking the code of native amyloid fibrils: advances and next steps to enable pathology-informed therapeutic and diagnostic
errNATURE STRUCTURAL & MOLECULAR BIOLOGY
IF10.1
err2026-04-20
err0
PREAI
errHilal A. Lashuel
errShare
errSave
A genomics health strategy for the Arabian Gulf
errNature Medicine
IF50
err2026-03-04
err0
PREAI
errHamad Ali; Barrak Alahmad; Abdullah Alibrahim; Dana Marafi; Hind Alsharhan; Salman Al Sabah; Almundher Al-Maawali; Khalid A. Fakhro; Hilal A. Lashuel; Fowzan S. Alkuraya; Omer S. Alkhnbashi; Alawi Alsheikh-Ali; Fahd Al-Mulla; Ahmad Abou Tayoun
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errSave
Integrating the genome and exposome for precision health in Kuwait
errNature Reviews Genetics
IF52
err2025-07-31
err0
PREAI
errHamad Ali; Barrak Alahmad; Faisal H. Al-Refaei; Ahmad Abou Tayoun; Hilal A. Lashuel; Salman Al Sabah; Fahd Al-Mulla
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errSave
Nanoplasmonic Infrared Microarray Sensor Enabling Structural Protein Biomarker-Based Drug Screening for Neurodegenerative Diseases
errAdvanced Science
IF14.1
err2025-07-28
err0
errOAAI
errDeepthy Kavungal; Enzo Morro; Senthil T Kumar; Berkay Dagli; Hilal A Lashuel; Hatice Altug
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errSave
Self-driving microscopy detects the onset of protein aggregation and enables intelligent Brillouin imaging
errNature Communications
IF15.7
err2025-07-24
err0
errOAAI
errKhalid A. Ibrahim; Camille Cathala; Carlo Bevilacqua; Lely Feletti; Robert Prevedel; Hilal A. Lashuel; Aleksandra Radenovic
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errSave
Bridging borders for resilience in cancer control in the Middle East: a strategic alliance of Saudi Arabia, Qatar, and Jordan
errlancet oncology
IF0
err2025-06-11
err0
PREAI
errHanan Jafar; Saleh A Alessy; Murugan Subramanian; Hikmat Abdel-Razeq; Mohammed Bin Hamed Al-Thani; Feras Al-Fararjeh; Khalid Al-Rumaihi; Laith Al-Showbaki; Salha Bujassoum Al Bader; Kamal Al-rabi; Abdullah Ali Alsharm; Ali Abdullah Alqarni; Ali Al-Zahrani; Yaser Rayyan; Hilal Lashuel; Asem Mansour; Laila Tutunji; Lotfi Chouchane; Saleh A Alqahtani; Abdalla Awidi
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errSave
Qatar national cancer care and research: pioneering strategies for global health excellence
errlancet oncology
IF0
err2025-06-11
err0
PREAI
errMohammed Bin Hamed Al-Thani; Murugan Subramanian; Najeeb Halabi; Salha Bujassoum Al Bader; Jingxuan Shan; Khalid Rashid Al-Rumaihi; M Walid Qoronfleh; Hilal A Lashuel; Lotfi Chouchane
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errSave
Huntingtin inclusion bodies have distinct immunophenotypes and ubiquitination profiles in the Huntington's disease human cerebral cortex
errSCIENTIFIC REPORTS
IF3.9
err2025-05-03
err0
errOAAI
errSwanson, Molly E. V.; Tan, Adelie Y. S.; Tippett, Lynette J.; Turner, Clinton P.; Curtis, Maurice A.; Scotter, Emma L.; Lashuel, Hilal A.; Dragunow, Mike; Faull, Richard L. M.; Murray, Helen C.; Singh-Bains, Malvindar K.
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errSave
Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use
errSCIENCE ADVANCES
IF12.5
err2025-04-04
err0
PREAI
errLashuel, Hilal A.; Surmeier, D. James; Simuni, Tanya; Merchant, Kalpana; Caughey, Byron; Soto, Claudio; Fares, Mohamed-Bilal; Heym, Roland G.; Melki, Ronald
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errSave
Multi-Targeting Macrocyclic Peptides as Nanomolar Inhibitors of Self- and Cross-Seeded Amyloid Self-Assembly of α-Synuclein
errANGEWANDTE CHEMIE-INTERNATIONAL EDITION
IF16.9
err2025-01-31
err0
errOAAI
errHornung, Simon; Vogl, Dominik P.; Naltsas, Denise; Volta, Beatrice Dalla; Ballmann, Markus; Marcon, Beatrice; Syed, Muhammed Muazzam Kamil; Wu, Yiyang; Spanopoulou, Anna; Feederle, Regina; Heidrich, Luzia; Bernhagen, Juergen; Koeglsperger, Thomas; Hoeglinger, Guenter U.; Rammes, Gerhard; Lashuel, Hilal A.; Kapurniotu, Aphrodite
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errSave
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
errSCIENCE ADVANCES
IF12.5
err2024-11-01
err0
errOAAI
errSokratian, Arpine; Zhou, Ye; Tatli, Meltem; Burbidge, Kevin J.; Xu, Enquan; Viverette, Elizabeth; Donzelli, Sonia; Duda, Addison M.; Yuan, Yuan; Li, Huizhong; Strader, Samuel; Patel, Nirali; Shiell, Lauren; Malankhanova, Tuyana; Chen, Olivia; Mazzulli, Joseph R.; Perera, Lalith; Stahlberg, Henning; Borgnia, Mario; Bartesaghi, Alberto; Lashuel, Hilal A.; West, Andrew B.
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errSave
A Versatile Method for Site-Specific Chemical Installation of Aromatic Posttranslational Modification Analogs into Proteins
errJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
IF15.6
err2024-09-03
err0
errOAAI
errLin, Xiaoxi; Mandal, Shaswati; Nithun, Raj V.; Kolla, Rajasekhar; Bouri, Bouchra; Lashuel, Hilal A.; Jbara, Muhammad
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errSave
Research Priorities on the Role of α-Synuclein in Parkinson's Disease Pathogenesis
errMOVEMENT DISORDERS
IF7.6
err2024-06-30
err4
errOAAI
errBurre, Jacqueline; Edwards, Robert H.; Halliday, Glenda; Lang, Anthony E.; Lashuel, Hilal A.; Melki, Ronald; Murayama, Shigeo; Outeiro, Tiago F.; Papa, Stella M.; Stefanis, Leonidas; Woerman, Amanda L.; Surmeier, Dalton James; Kalia, Lorraine V.; Takahashi, Ryosuke
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Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates (vol 14, 3939, 2023)
errNATURE COMMUNICATIONS
IF15.7
err2024-05-30
err0
errOAAI
errLimorenko, Galina; Tatli, Meltem; Kolla, Rajasekhar; Nazarov, Sergey; Weil, Marie-Theres; Schoendorf, David C.; Geist, Daniela; Reinhardt, Peter; Ehrnhoefer, Dagmar E.; Stahlberg, Henning; Gasparini, Laura; Lashuel, Hilal A.
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Differential Effects of Post-translational Modifications on the Membrane Interaction of Huntingtin Protein
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2024-05-16
err1
errOAAI
errZhang, Zhidian; Gehin, Charlotte; Abriata, Luciano A.; Dal Peraro, Matteo; Lashuel, Hilal
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errSave
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology(Feb, 10.1038/s41589-024-01551-2, 2024)
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-02-27
err0
errOAAI
errBalana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R.
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errSave
O-GlcNAc forces an α-synuclein amyloid strain with notably diminished seeding and pathology
errNATURE CHEMICAL BIOLOGY
IF13.7
err2024-02-12
err19
errOAAI
errBalana, Aaron T.; Mahul-Mellier, Anne-Laure; Nguyen, Binh A.; Horvath, Mian; Javed, Afraah; Hard, Eldon R.; Jasiqi, Yllza; Singh, Preeti; Afrin, Shumaila; Pedretti, Rose; Singh, Virender; Lee, Virginia M. -Y.; Luk, Kelvin C.; Saelices, Lorena; Lashuel, Hilal A.; Pratt, Matthew R.
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errSave
Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro
errACS CHEMICAL NEUROSCIENCE
IF3.9
err2023-12-20
err2
errOAAI
errYang, Lixin; Jasiqi, Yllza; Lashuel, Hilal
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errSave
Deep Learning-Assisted Single-Molecule Detection of Protein Post-translational Modifications with a Biological Nanopore
errACS NANO
IF16
err2023-12-19
err11
errOAAI
errCao, Chan; Magalhaes, Pedro; Krapp, Lucien F.; Juarez, Juan F. Bada; Mayer, Simon Finn; Rukes, Verena; Chiki, Anass; Lashuel, Hilal A.; Dal Peraro, Matteo
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Research Directions

No research directions
Co-authors
Cooperation Journals
V
Virginia M.‐Y. Lee
H-index: 200 · Papers: 919
E
Eliezer Masliah
H-index: 195 · Papers: 1.2K
H
Henrik Zetterberg
H-index: 190 · Papers: 3.7K
J
Johan Auwerx
H-index: 183 · Papers: 914
A
Anthony E. Lang
H-index: 166 · Papers: 1.5K
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